Eudravigilance C-19 - Astrazeneca
Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)
PT |
Décès 3913 (%) |
Mise en jeu du pronostic vital 7988 (%) |
Invalidité ou incapacité 22634 (%) |
Anomalies congénitales 137 (%) |
Hospitalisation 21534 (%) |
Médicalement significatif 149600 (%) |
Cas Graves 205806 (%) |
|---|---|---|---|---|---|---|---|
| Abdominal discomfort | 7 (0.18) | 15 (0.19) | 158 (0.70) | 0 | 46 (0.21) | 1061 (0.71) | 1293 (0.63) |
| Abdominal distension | 6 (0.15) | 10 (0.13) | 87 (0.38) | 1 (0.73) | 32 (0.15) | 393 (0.26) | 531 (0.26) |
| Abdominal pain | 77 (1.97) | 139 (1.74) | 587 (2.59) | 1 (0.73) | 417 (1.94) | 3046 (2.04) | 4318 (2.10) |
| Abdominal pain lower | 0 | 7 (0.09) | 28 (0.12) | 0 | 50 (0.23) | 179 (0.12) | 265 (0.13) |
| Abdominal pain upper | 21 (0.54) | 64 (0.80) | 546 (2.41) | 2 (1.46) | 237 (1.10) | 3627 (2.42) | 4512 (2.19) |
| Abdominal rigidity | 2 (0.05) | 1 (0.01) | 11 (0.05) | 0 | 2 (0.01) | 37 (0.02) | 53 (0.03) |
| Abnormal dreams | 1 (0.03) | 3 (0.04) | 28 (0.12) | 0 | 4 (0.02) | 236 (0.16) | 272 (0.13) |
| Abnormal loss of weight | 1 (0.03) | 6 (0.08) | 22 (0.10) | 0 | 6 (0.03) | 36 (0.02) | 72 (0.03) |
| Abortion spontaneous | 3 (0.08) | 11 (0.14) | 19 (0.08) | 66 (48.18) | 33 (0.15) | 152 (0.10) | 286 (0.14) |
| Acne | 1 (0.03) | 3 (0.04) | 7 (0.03) | 0 | 4 (0.02) | 76 (0.05) | 92 (0.04) |
| Activated partial thromboplastin time prolonged | 3 (0.08) | 45 (0.56) | 7 (0.03) | 0 | 28 (0.13) | 45 (0.03) | 129 (0.06) |
| Acute coronary syndrome | 23 (0.59) | 23 (0.29) | 0 | 0 | 58 (0.27) | 3 (0.00) | 108 (0.05) |
| Acute kidney injury | 27 (0.69) | 33 (0.41) | 8 (0.04) | 0 | 68 (0.32) | 26 (0.02) | 172 (0.08) |
| Acute myocardial infarction | 84 (2.15) | 122 (1.53) | 2 (0.01) | 0 | 121 (0.56) | 22 (0.01) | 363 (0.18) |
| Acute respiratory distress syndrome | 16 (0.41) | 10 (0.13) | 0 | 0 | 22 (0.10) | 14 (0.01) | 65 (0.03) |
| Acute respiratory failure | 23 (0.59) | 9 (0.11) | 0 | 0 | 16 (0.07) | 1 (0.00) | 51 (0.02) |
| Administration site pain | 0 | 20 (0.25) | 18 (0.08) | 1 (0.73) | 6 (0.03) | 29 (0.02) | 75 (0.04) |
| Adverse drug reaction | 0 | 3 (0.04) | 17 (0.08) | 0 | 4 (0.02) | 80 (0.05) | 104 (0.05) |
| Adverse event following immunisation | 106 (2.71) | 0 | 0 | 0 | 0 | 0 | 106 (0.05) |
| Ageusia | 8 (0.20) | 13 (0.16) | 158 (0.70) | 0 | 70 (0.33) | 653 (0.44) | 905 (0.44) |
| Agitation | 12 (0.31) | 18 (0.23) | 34 (0.15) | 0 | 17 (0.08) | 120 (0.08) | 210 (0.10) |
| Allergy to vaccine | 0 | 6 (0.08) | 3 (0.01) | 0 | 3 (0.01) | 40 (0.03) | 52 (0.03) |
| Alopecia | 0 | 10 (0.13) | 44 (0.19) | 1 (0.73) | 7 (0.03) | 242 (0.16) | 305 (0.15) |
| Altered state of consciousness | 11 (0.28) | 4 (0.05) | 4 (0.02) | 0 | 16 (0.07) | 21 (0.01) | 64 (0.03) |
| Amenorrhoea | 0 | 7 (0.09) | 35 (0.15) | 2 (1.46) | 9 (0.04) | 250 (0.17) | 303 (0.15) |
| Amnesia | 2 (0.05) | 45 (0.56) | 119 (0.53) | 0 | 86 (0.40) | 226 (0.15) | 482 (0.23) |
| Anaemia | 12 (0.31) | 28 (0.35) | 28 (0.12) | 0 | 59 (0.27) | 99 (0.07) | 234 (0.11) |
| Anaphylactic reaction | 9 (0.23) | 344 (4.31) | 23 (0.10) | 0 | 238 (1.11) | 525 (0.35) | 1155 (0.56) |
| Anaphylactic shock | 7 (0.18) | 64 (0.80) | 12 (0.05) | 0 | 56 (0.26) | 95 (0.06) | 239 (0.12) |
| Anaphylactoid reaction | 0 | 6 (0.08) | 2 (0.01) | 0 | 7 (0.03) | 58 (0.04) | 73 (0.04) |
| Anger | 2 (0.05) | 6 (0.08) | 10 (0.04) | 0 | 1 (0.00) | 50 (0.03) | 70 (0.03) |
| Angina pectoris | 4 (0.10) | 44 (0.55) | 41 (0.18) | 1 (0.73) | 85 (0.39) | 159 (0.11) | 345 (0.17) |
| Angioedema | 0 | 41 (0.51) | 21 (0.09) | 0 | 54 (0.25) | 391 (0.26) | 519 (0.25) |
| Anosmia | 7 (0.18) | 7 (0.09) | 62 (0.27) | 0 | 48 (0.22) | 198 (0.13) | 326 (0.16) |
| Anxiety | 3 (0.08) | 40 (0.50) | 218 (0.96) | 0 | 130 (0.60) | 798 (0.53) | 1192 (0.58) |
| Aortic thrombosis | 11 (0.28) | 16 (0.20) | 0 | 0 | 18 (0.08) | 2 (0.00) | 54 (0.03) |
| Apathy | 0 | 1 (0.01) | 24 (0.11) | 0 | 11 (0.05) | 45 (0.03) | 83 (0.04) |
| Aphasia | 23 (0.59) | 63 (0.79) | 48 (0.21) | 0 | 95 (0.44) | 159 (0.11) | 425 (0.21) |
| Aphonia | 1 (0.03) | 5 (0.06) | 14 (0.06) | 0 | 9 (0.04) | 67 (0.04) | 97 (0.05) |
| Aphthous ulcer | 1 (0.03) | 1 (0.01) | 5 (0.02) | 0 | 3 (0.01) | 45 (0.03) | 55 (0.03) |
| Appendicitis | 2 (0.05) | 15 (0.19) | 3 (0.01) | 0 | 40 (0.19) | 18 (0.01) | 78 (0.04) |
| Application site pain | 1 (0.03) | 2 (0.03) | 4 (0.02) | 0 | 9 (0.04) | 68 (0.05) | 87 (0.04) |
| Areflexia | 1 (0.03) | 10 (0.13) | 16 (0.07) | 0 | 21 (0.10) | 1 (0.00) | 53 (0.03) |
| Arrhythmia | 8 (0.20) | 35 (0.44) | 40 (0.18) | 0 | 182 (0.85) | 341 (0.23) | 618 (0.30) |
| Arterial thrombosis | 11 (0.28) | 22 (0.28) | 6 (0.03) | 0 | 17 (0.08) | 20 (0.01) | 84 (0.04) |
| Arthralgia | 35 (0.89) | 181 (2.27) | 4041 (17.85) | 3 (2.19) | 605 (2.81) | 16196 (10.83) | 21108 (10.26) |
| Arthritis | 0 | 5 (0.06) | 151 (0.67) | 0 | 29 (0.13) | 344 (0.23) | 532 (0.26) |
| Arthritis reactive | 0 | 1 (0.01) | 24 (0.11) | 0 | 8 (0.04) | 27 (0.02) | 60 (0.03) |
| Asthenia | 100 (2.56) | 170 (2.13) | 1039 (4.59) | 1 (0.73) | 738 (3.43) | 3892 (2.60) | 6011 (2.92) |
| Asthenopia | 0 | 3 (0.04) | 46 (0.20) | 0 | 10 (0.05) | 217 (0.15) | 276 (0.13) |
| Asthma | 1 (0.03) | 35 (0.44) | 94 (0.42) | 0 | 51 (0.24) | 408 (0.27) | 592 (0.29) |
| Ataxia | 1 (0.03) | 12 (0.15) | 19 (0.08) | 0 | 40 (0.19) | 19 (0.01) | 98 (0.05) |
| Atrial fibrillation | 16 (0.41) | 86 (1.08) | 35 (0.15) | 0 | 210 (0.98) | 243 (0.16) | 606 (0.29) |
| Atrial flutter | 0 | 5 (0.06) | 5 (0.02) | 0 | 19 (0.09) | 24 (0.02) | 56 (0.03) |
| Autoimmune disorder | 1 (0.03) | 9 (0.11) | 22 (0.10) | 0 | 20 (0.09) | 37 (0.02) | 91 (0.04) |
| Axillary pain | 0 | 0 | 57 (0.25) | 0 | 15 (0.07) | 450 (0.30) | 524 (0.25) |
| Back pain | 26 (0.66) | 86 (1.08) | 766 (3.38) | 2 (1.46) | 296 (1.37) | 3878 (2.59) | 5073 (2.46) |
| Balance disorder | 6 (0.15) | 47 (0.59) | 266 (1.18) | 0 | 136 (0.63) | 569 (0.38) | 1041 (0.51) |
| Bedridden | 2 (0.05) | 4 (0.05) | 55 (0.24) | 0 | 9 (0.04) | 95 (0.06) | 172 (0.08) |
| Bell's palsy | 1 (0.03) | 13 (0.16) | 135 (0.60) | 0 | 139 (0.65) | 373 (0.25) | 664 (0.32) |
| Bladder pain | 0 | 1 (0.01) | 8 (0.04) | 0 | 4 (0.02) | 41 (0.03) | 55 (0.03) |
| Blepharospasm | 0 | 1 (0.01) | 20 (0.09) | 0 | 6 (0.03) | 55 (0.04) | 82 (0.04) |
| Blindness | 2 (0.05) | 31 (0.39) | 126 (0.56) | 0 | 52 (0.24) | 197 (0.13) | 423 (0.21) |
| Blindness transient | 0 | 4 (0.05) | 8 (0.04) | 0 | 10 (0.05) | 44 (0.03) | 69 (0.03) |
| Blindness unilateral | 1 (0.03) | 9 (0.11) | 40 (0.18) | 0 | 17 (0.08) | 35 (0.02) | 105 (0.05) |
| Blister | 1 (0.03) | 15 (0.19) | 48 (0.21) | 0 | 23 (0.11) | 323 (0.22) | 417 (0.20) |
| Blood blister | 0 | 3 (0.04) | 10 (0.04) | 0 | 6 (0.03) | 53 (0.04) | 74 (0.04) |
| Blood glucose increased | 1 (0.03) | 7 (0.09) | 17 (0.08) | 0 | 17 (0.08) | 127 (0.08) | 174 (0.08) |
| Blood pressure decreased | 7 (0.18) | 23 (0.29) | 36 (0.16) | 0 | 48 (0.22) | 102 (0.07) | 219 (0.11) |
| Blood pressure fluctuation | 1 (0.03) | 16 (0.20) | 15 (0.07) | 0 | 20 (0.09) | 39 (0.03) | 97 (0.05) |
| Blood pressure increased | 9 (0.23) | 84 (1.05) | 87 (0.38) | 0 | 198 (0.92) | 335 (0.22) | 726 (0.35) |
| Blood pressure measurement | 0 | 8 (0.10) | 12 (0.05) | 0 | 16 (0.07) | 64 (0.04) | 100 (0.05) |
| Blood test abnormal | 0 | 5 (0.06) | 23 (0.10) | 0 | 28 (0.13) | 37 (0.02) | 94 (0.05) |
| Blood urine present | 1 (0.03) | 4 (0.05) | 4 (0.02) | 0 | 8 (0.04) | 60 (0.04) | 81 (0.04) |
| Body temperature | 0 | 1 (0.01) | 69 (0.30) | 0 | 11 (0.05) | 674 (0.45) | 756 (0.37) |
| Body temperature abnormal | 0 | 1 (0.01) | 7 (0.03) | 0 | 3 (0.01) | 49 (0.03) | 60 (0.03) |
| Body temperature decreased | 1 (0.03) | 3 (0.04) | 17 (0.08) | 0 | 5 (0.02) | 98 (0.07) | 125 (0.06) |
| Body temperature fluctuation | 0 | 3 (0.04) | 27 (0.12) | 0 | 1 (0.00) | 124 (0.08) | 155 (0.08) |
| Body temperature increased | 5 (0.13) | 14 (0.18) | 96 (0.42) | 1 (0.73) | 83 (0.39) | 811 (0.54) | 1010 (0.49) |
| Bone pain | 1 (0.03) | 27 (0.34) | 218 (0.96) | 0 | 32 (0.15) | 764 (0.51) | 1045 (0.51) |
| Bradycardia | 10 (0.26) | 17 (0.21) | 16 (0.07) | 0 | 33 (0.15) | 53 (0.04) | 141 (0.07) |
| Bradyphrenia | 0 | 1 (0.01) | 17 (0.08) | 0 | 6 (0.03) | 62 (0.04) | 86 (0.04) |
| Brain injury | 15 (0.38) | 16 (0.20) | 5 (0.02) | 0 | 6 (0.03) | 7 (0.00) | 58 (0.03) |
| Brain oedema | 38 (0.97) | 15 (0.19) | 3 (0.01) | 0 | 8 (0.04) | 12 (0.01) | 80 (0.04) |
| Breast mass | 0 | 1 (0.01) | 4 (0.02) | 0 | 7 (0.03) | 39 (0.03) | 51 (0.02) |
| Breast pain | 0 | 0 | 38 (0.17) | 1 (0.73) | 29 (0.13) | 272 (0.18) | 341 (0.17) |
| Burning sensation | 0 | 28 (0.35) | 158 (0.70) | 2 (1.46) | 63 (0.29) | 600 (0.40) | 859 (0.42) |
| Bursitis | 0 | 2 (0.03) | 72 (0.32) | 0 | 9 (0.04) | 110 (0.07) | 193 (0.09) |
| C-reactive protein increased | 6 (0.15) | 11 (0.14) | 17 (0.08) | 0 | 59 (0.27) | 40 (0.03) | 145 (0.07) |
| COVID-19 | 166 (4.24) | 126 (1.58) | 125 (0.55) | 2 (1.46) | 493 (2.29) | 3437 (2.30) | 4368 (2.12) |
| COVID-19 immunisation | 2 (0.05) | 7 (0.09) | 43 (0.19) | 0 | 26 (0.12) | 127 (0.08) | 206 (0.10) |
| COVID-19 pneumonia | 51 (1.30) | 28 (0.35) | 13 (0.06) | 0 | 114 (0.53) | 23 (0.02) | 229 (0.11) |
| Candida infection | 1 (0.03) | 1 (0.01) | 6 (0.03) | 0 | 2 (0.01) | 43 (0.03) | 53 (0.03) |
| Cardiac arrest | 225 (5.75) | 82 (1.03) | 4 (0.02) | 0 | 14 (0.07) | 41 (0.03) | 383 (0.19) |
| Cardiac disorder | 4 (0.10) | 24 (0.30) | 10 (0.04) | 0 | 44 (0.20) | 32 (0.02) | 117 (0.06) |
| Cardiac failure | 59 (1.51) | 53 (0.66) | 15 (0.07) | 0 | 73 (0.34) | 24 (0.02) | 233 (0.11) |
| Cardiac flutter | 0 | 7 (0.09) | 25 (0.11) | 0 | 12 (0.06) | 156 (0.10) | 200 (0.10) |
| Cardio-respiratory arrest | 56 (1.43) | 17 (0.21) | 0 | 0 | 5 (0.02) | 3 (0.00) | 84 (0.04) |
| Cardiovascular disorder | 17 (0.43) | 8 (0.10) | 47 (0.21) | 0 | 46 (0.21) | 31 (0.02) | 152 (0.07) |
| Cellulitis | 2 (0.05) | 12 (0.15) | 35 (0.15) | 0 | 51 (0.24) | 280 (0.19) | 383 (0.19) |
| Cerebral haemorrhage | 185 (4.73) | 134 (1.68) | 24 (0.11) | 0 | 102 (0.47) | 44 (0.03) | 513 (0.25) |
| Cerebral infarction | 39 (1.00) | 104 (1.30) | 33 (0.15) | 0 | 163 (0.76) | 49 (0.03) | 402 (0.20) |
| Cerebral ischaemia | 7 (0.18) | 13 (0.16) | 5 (0.02) | 0 | 25 (0.12) | 11 (0.01) | 65 (0.03) |
| Cerebral thrombosis | 48 (1.23) | 34 (0.43) | 5 (0.02) | 0 | 64 (0.30) | 40 (0.03) | 203 (0.10) |
| Cerebral venous sinus thrombosis | 97 (2.48) | 223 (2.79) | 20 (0.09) | 0 | 227 (1.05) | 65 (0.04) | 648 (0.31) |
| Cerebral venous thrombosis | 41 (1.05) | 53 (0.66) | 4 (0.02) | 0 | 68 (0.32) | 35 (0.02) | 212 (0.10) |
| Cerebrovascular accident | 162 (4.14) | 489 (6.12) | 231 (1.02) | 3 (2.19) | 671 (3.12) | 526 (0.35) | 2136 (1.04) |
| Chest discomfort | 11 (0.28) | 78 (0.98) | 279 (1.23) | 0 | 307 (1.43) | 1353 (0.90) | 2055 (1.00) |
| Chest pain | 88 (2.25) | 418 (5.23) | 765 (3.38) | 1 (0.73) | 982 (4.56) | 3368 (2.25) | 5710 (2.77) |
| Chills | 54 (1.38) | 365 (4.57) | 5627 (24.86) | 7 (5.11) | 1238 (5.75) | 31588 (21.11) | 38936 (18.92) |
| Chromaturia | 3 (0.08) | 4 (0.05) | 9 (0.04) | 0 | 6 (0.03) | 73 (0.05) | 97 (0.05) |
| Chronic fatigue syndrome | 0 | 1 (0.01) | 80 (0.35) | 0 | 8 (0.04) | 60 (0.04) | 150 (0.07) |
| Chronic obstructive pulmonary disease | 16 (0.41) | 9 (0.11) | 6 (0.03) | 0 | 18 (0.08) | 20 (0.01) | 70 (0.03) |
| Circulatory collapse | 62 (1.58) | 47 (0.59) | 15 (0.07) | 0 | 74 (0.34) | 114 (0.08) | 333 (0.16) |
| Clumsiness | 0 | 1 (0.01) | 16 (0.07) | 0 | 5 (0.02) | 28 (0.02) | 51 (0.02) |
| Cluster headache | 3 (0.08) | 10 (0.13) | 89 (0.39) | 0 | 23 (0.11) | 486 (0.32) | 611 (0.30) |
| Coagulopathy | 22 (0.56) | 40 (0.50) | 31 (0.14) | 1 (0.73) | 48 (0.22) | 66 (0.04) | 215 (0.10) |
| Cognitive disorder | 4 (0.10) | 9 (0.11) | 89 (0.39) | 0 | 20 (0.09) | 101 (0.07) | 231 (0.11) |
| Cold sweat | 11 (0.28) | 31 (0.39) | 180 (0.80) | 1 (0.73) | 67 (0.31) | 1141 (0.76) | 1438 (0.70) |
| Cold-stimulus headache | 0 | 3 (0.04) | 14 (0.06) | 0 | 4 (0.02) | 54 (0.04) | 75 (0.04) |
| Colitis | 1 (0.03) | 3 (0.04) | 7 (0.03) | 0 | 24 (0.11) | 39 (0.03) | 74 (0.04) |
| Colitis ulcerative | 0 | 3 (0.04) | 14 (0.06) | 0 | 15 (0.07) | 68 (0.05) | 100 (0.05) |
| Coma | 26 (0.66) | 31 (0.39) | 3 (0.01) | 0 | 10 (0.05) | 3 (0.00) | 90 (0.04) |
| Condition aggravated | 14 (0.36) | 16 (0.20) | 132 (0.58) | 0 | 57 (0.26) | 282 (0.19) | 506 (0.25) |
| Confusional state | 52 (1.33) | 140 (1.75) | 404 (1.78) | 1 (0.73) | 252 (1.17) | 1292 (0.86) | 2172 (1.06) |
| Conjunctival haemorrhage | 0 | 2 (0.03) | 8 (0.04) | 0 | 7 (0.03) | 80 (0.05) | 98 (0.05) |
| Conjunctivitis | 1 (0.03) | 0 | 7 (0.03) | 0 | 4 (0.02) | 50 (0.03) | 62 (0.03) |
| Constipation | 3 (0.08) | 15 (0.19) | 80 (0.35) | 0 | 33 (0.15) | 266 (0.18) | 399 (0.19) |
| Contusion | 18 (0.46) | 76 (0.95) | 209 (0.92) | 0 | 173 (0.80) | 1553 (1.04) | 2051 (1.00) |
| Coordination abnormal | 5 (0.13) | 5 (0.06) | 28 (0.12) | 0 | 18 (0.08) | 80 (0.05) | 140 (0.07) |
| Coronary artery thrombosis | 14 (0.36) | 23 (0.29) | 0 | 0 | 11 (0.05) | 6 (0.00) | 58 (0.03) |
| Costochondritis | 0 | 1 (0.01) | 16 (0.07) | 0 | 10 (0.05) | 51 (0.03) | 78 (0.04) |
| Cough | 149 (3.81) | 137 (1.72) | 475 (2.10) | 1 (0.73) | 501 (2.33) | 2466 (1.65) | 3769 (1.83) |
| Crohn's disease | 0 | 1 (0.01) | 25 (0.11) | 0 | 11 (0.05) | 54 (0.04) | 91 (0.04) |
| Crying | 1 (0.03) | 7 (0.09) | 47 (0.21) | 0 | 10 (0.05) | 199 (0.13) | 264 (0.13) |
| Cutaneous vasculitis | 0 | 0 | 0 | 0 | 23 (0.11) | 43 (0.03) | 67 (0.03) |
| Cyanosis | 17 (0.43) | 16 (0.20) | 17 (0.08) | 0 | 70 (0.33) | 83 (0.06) | 209 (0.10) |
| Cystitis | 1 (0.03) | 1 (0.01) | 10 (0.04) | 0 | 9 (0.04) | 78 (0.05) | 99 (0.05) |
| Deafness | 1 (0.03) | 8 (0.10) | 144 (0.64) | 0 | 26 (0.12) | 266 (0.18) | 447 (0.22) |
| Deafness neurosensory | 1 (0.03) | 1 (0.01) | 28 (0.12) | 0 | 1 (0.00) | 19 (0.01) | 52 (0.03) |
| Deafness unilateral | 0 | 1 (0.01) | 36 (0.16) | 0 | 8 (0.04) | 54 (0.04) | 99 (0.05) |
| Death | 687 (17.56) | 2 (0.03) | 0 | 0 | 0 | 2 (0.00) | 692 (0.34) |
| Decreased appetite | 63 (1.61) | 69 (0.86) | 825 (3.64) | 1 (0.73) | 240 (1.11) | 4697 (3.14) | 5928 (2.88) |
| Deep vein thrombosis | 68 (1.74) | 485 (6.07) | 104 (0.46) | 0 | 1029 (4.78) | 1818 (1.22) | 3614 (1.76) |
| Dehydration | 3 (0.08) | 14 (0.18) | 74 (0.33) | 0 | 84 (0.39) | 416 (0.28) | 597 (0.29) |
| Delirium | 9 (0.23) | 15 (0.19) | 79 (0.35) | 0 | 43 (0.20) | 322 (0.22) | 473 (0.23) |
| Delusion | 3 (0.08) | 2 (0.03) | 14 (0.06) | 0 | 8 (0.04) | 35 (0.02) | 63 (0.03) |
| Demyelination | 1 (0.03) | 4 (0.05) | 16 (0.07) | 0 | 14 (0.07) | 17 (0.01) | 54 (0.03) |
| Depressed level of consciousness | 22 (0.56) | 19 (0.24) | 13 (0.06) | 0 | 34 (0.16) | 55 (0.04) | 154 (0.07) |
| Depressed mood | 1 (0.03) | 9 (0.11) | 100 (0.44) | 0 | 11 (0.05) | 461 (0.31) | 583 (0.28) |
| Depression | 4 (0.10) | 24 (0.30) | 137 (0.61) | 0 | 21 (0.10) | 418 (0.28) | 609 (0.30) |
| Dermatitis | 0 | 2 (0.03) | 11 (0.05) | 0 | 8 (0.04) | 98 (0.07) | 120 (0.06) |
| Dermatitis allergic | 0 | 9 (0.11) | 18 (0.08) | 0 | 7 (0.03) | 169 (0.11) | 204 (0.10) |
| Diabetes mellitus | 1 (0.03) | 10 (0.13) | 15 (0.07) | 0 | 17 (0.08) | 72 (0.05) | 117 (0.06) |
| Diarrhoea | 76 (1.94) | 120 (1.50) | 979 (4.33) | 0 | 452 (2.10) | 6069 (4.06) | 7732 (3.76) |
| Diplegia | 1 (0.03) | 6 (0.08) | 23 (0.10) | 0 | 15 (0.07) | 34 (0.02) | 83 (0.04) |
| Diplopia | 1 (0.03) | 22 (0.28) | 94 (0.42) | 0 | 107 (0.50) | 211 (0.14) | 440 (0.21) |
| Discomfort | 3 (0.08) | 16 (0.20) | 87 (0.38) | 1 (0.73) | 46 (0.21) | 367 (0.25) | 527 (0.26) |
| Disorientation | 10 (0.26) | 13 (0.16) | 109 (0.48) | 0 | 81 (0.38) | 505 (0.34) | 730 (0.35) |
| Disseminated intravascular coagulation | 28 (0.72) | 26 (0.33) | 1 (0.00) | 0 | 15 (0.07) | 2 (0.00) | 75 (0.04) |
| Dissociation | 0 | 2 (0.03) | 10 (0.04) | 0 | 3 (0.01) | 44 (0.03) | 59 (0.03) |
| Disturbance in attention | 1 (0.03) | 23 (0.29) | 200 (0.88) | 0 | 107 (0.50) | 503 (0.34) | 842 (0.41) |
| Diverticulitis | 3 (0.08) | 4 (0.05) | 6 (0.03) | 0 | 18 (0.08) | 23 (0.02) | 54 (0.03) |
| Dizziness | 69 (1.76) | 396 (4.96) | 2693 (11.90) | 4 (2.92) | 1538 (7.14) | 15205 (10.16) | 19991 (9.71) |
| Dizziness exertional | 0 | 1 (0.01) | 14 (0.06) | 0 | 1 (0.00) | 77 (0.05) | 93 (0.05) |
| Dizziness postural | 1 (0.03) | 7 (0.09) | 216 (0.95) | 0 | 52 (0.24) | 1467 (0.98) | 1744 (0.85) |
| Drug hypersensitivity | 0 | 7 (0.09) | 5 (0.02) | 0 | 4 (0.02) | 36 (0.02) | 52 (0.03) |
| Drug ineffective | 13 (0.33) | 13 (0.16) | 18 (0.08) | 0 | 43 (0.20) | 130 (0.09) | 221 (0.11) |
| Dry eye | 0 | 1 (0.01) | 37 (0.16) | 0 | 14 (0.07) | 188 (0.13) | 240 (0.12) |
| Dry mouth | 0 | 10 (0.13) | 114 (0.50) | 0 | 43 (0.20) | 720 (0.48) | 890 (0.43) |
| Dry skin | 0 | 1 (0.01) | 33 (0.15) | 0 | 11 (0.05) | 219 (0.15) | 264 (0.13) |
| Dry throat | 1 (0.03) | 4 (0.05) | 23 (0.10) | 0 | 6 (0.03) | 153 (0.10) | 187 (0.09) |
| Dysaesthesia | 0 | 2 (0.03) | 7 (0.03) | 0 | 22 (0.10) | 44 (0.03) | 78 (0.04) |
| Dysarthria | 24 (0.61) | 68 (0.85) | 88 (0.39) | 0 | 156 (0.72) | 230 (0.15) | 586 (0.28) |
| Dysgeusia | 3 (0.08) | 13 (0.16) | 147 (0.65) | 1 (0.73) | 28 (0.13) | 1035 (0.69) | 1232 (0.60) |
| Dyskinesia | 2 (0.05) | 4 (0.05) | 25 (0.11) | 0 | 18 (0.08) | 76 (0.05) | 132 (0.06) |
| Dysmenorrhoea | 0 | 2 (0.03) | 92 (0.41) | 1 (0.73) | 23 (0.11) | 819 (0.55) | 939 (0.46) |
| Dyspepsia | 4 (0.10) | 19 (0.24) | 88 (0.39) | 0 | 31 (0.14) | 544 (0.36) | 690 (0.34) |
| Dysphagia | 14 (0.36) | 39 (0.49) | 43 (0.19) | 1 (0.73) | 70 (0.33) | 167 (0.11) | 352 (0.17) |
| Dysphonia | 1 (0.03) | 19 (0.24) | 40 (0.18) | 0 | 25 (0.12) | 100 (0.07) | 187 (0.09) |
| Dyspnoea | 369 (9.43) | 772 (9.66) | 1155 (5.10) | 1 (0.73) | 1741 (8.08) | 4703 (3.14) | 8935 (4.34) |
| Dyspnoea exertional | 5 (0.13) | 17 (0.21) | 31 (0.14) | 0 | 66 (0.31) | 65 (0.04) | 193 (0.09) |
| Dysstasia | 0 | 10 (0.13) | 48 (0.21) | 0 | 18 (0.08) | 76 (0.05) | 157 (0.08) |
| Dysuria | 2 (0.05) | 3 (0.04) | 13 (0.06) | 0 | 18 (0.08) | 64 (0.04) | 103 (0.05) |
| Ear discomfort | 0 | 2 (0.03) | 24 (0.11) | 0 | 18 (0.08) | 75 (0.05) | 122 (0.06) |
| Ear infection | 1 (0.03) | 4 (0.05) | 21 (0.09) | 0 | 7 (0.03) | 100 (0.07) | 134 (0.07) |
| Ear pain | 0 | 13 (0.16) | 253 (1.12) | 0 | 63 (0.29) | 1390 (0.93) | 1723 (0.84) |
| Ear swelling | 0 | 1 (0.01) | 2 (0.01) | 0 | 8 (0.04) | 47 (0.03) | 58 (0.03) |
| Ecchymosis | 0 | 8 (0.10) | 6 (0.03) | 0 | 35 (0.16) | 49 (0.03) | 105 (0.05) |
| Eczema | 0 | 6 (0.08) | 25 (0.11) | 0 | 15 (0.07) | 183 (0.12) | 229 (0.11) |
| Electric shock sensation | 1 (0.03) | 2 (0.03) | 20 (0.09) | 0 | 7 (0.03) | 71 (0.05) | 101 (0.05) |
| Embolism | 31 (0.79) | 97 (1.21) | 28 (0.12) | 0 | 70 (0.33) | 109 (0.07) | 341 (0.17) |
| Emotional disorder | 0 | 0 | 15 (0.07) | 0 | 2 (0.01) | 66 (0.04) | 83 (0.04) |
| Emotional distress | 0 | 6 (0.08) | 20 (0.09) | 0 | 4 (0.02) | 54 (0.04) | 86 (0.04) |
| Encephalitis | 4 (0.10) | 35 (0.44) | 11 (0.05) | 0 | 59 (0.27) | 18 (0.01) | 129 (0.06) |
| Endometriosis | 0 | 0 | 8 (0.04) | 0 | 6 (0.03) | 49 (0.03) | 63 (0.03) |
| Enuresis | 0 | 2 (0.03) | 8 (0.04) | 0 | 2 (0.01) | 40 (0.03) | 52 (0.03) |
| Epilepsy | 5 (0.13) | 52 (0.65) | 46 (0.20) | 0 | 124 (0.58) | 193 (0.13) | 426 (0.21) |
| Epistaxis | 12 (0.31) | 76 (0.95) | 138 (0.61) | 0 | 180 (0.84) | 1149 (0.77) | 1565 (0.76) |
| Erectile dysfunction | 1 (0.03) | 6 (0.08) | 25 (0.11) | 0 | 5 (0.02) | 39 (0.03) | 76 (0.04) |
| Eructation | 1 (0.03) | 5 (0.06) | 17 (0.08) | 0 | 3 (0.01) | 65 (0.04) | 91 (0.04) |
| Erythema | 5 (0.13) | 58 (0.73) | 156 (0.69) | 2 (1.46) | 157 (0.73) | 1627 (1.09) | 2023 (0.98) |
| Erythema multiforme | 0 | 4 (0.05) | 1 (0.00) | 0 | 10 (0.05) | 37 (0.02) | 52 (0.03) |
| Exercise tolerance decreased | 0 | 7 (0.09) | 19 (0.08) | 0 | 22 (0.10) | 36 (0.02) | 92 (0.04) |
| Exposure during pregnancy | 3 (0.08) | 3 (0.04) | 2 (0.01) | 4 (2.92) | 12 (0.06) | 35 (0.02) | 64 (0.03) |
| Exposure via breast milk | 0 | 1 (0.01) | 4 (0.02) | 0 | 0 | 50 (0.03) | 55 (0.03) |
| Extensive swelling of vaccinated limb | 0 | 4 (0.05) | 175 (0.77) | 0 | 6 (0.03) | 37 (0.02) | 223 (0.11) |
| Extrasystoles | 1 (0.03) | 7 (0.09) | 23 (0.10) | 1 (0.73) | 19 (0.09) | 123 (0.08) | 176 (0.09) |
| Eye haemorrhage | 0 | 1 (0.01) | 21 (0.09) | 0 | 15 (0.07) | 84 (0.06) | 124 (0.06) |
| Eye injury | 0 | 5 (0.06) | 19 (0.08) | 0 | 4 (0.02) | 24 (0.02) | 52 (0.03) |
| Eye irritation | 0 | 5 (0.06) | 33 (0.15) | 0 | 10 (0.05) | 141 (0.09) | 190 (0.09) |
| Eye movement disorder | 0 | 6 (0.08) | 11 (0.05) | 0 | 9 (0.04) | 32 (0.02) | 60 (0.03) |
| Eye pain | 1 (0.03) | 35 (0.44) | 432 (1.91) | 0 | 96 (0.45) | 2183 (1.46) | 2753 (1.34) |
| Eye pruritus | 0 | 9 (0.11) | 22 (0.10) | 0 | 12 (0.06) | 164 (0.11) | 208 (0.10) |
| Eye swelling | 0 | 14 (0.18) | 45 (0.20) | 0 | 26 (0.12) | 348 (0.23) | 434 (0.21) |
| Eyelid oedema | 1 (0.03) | 0 | 6 (0.03) | 0 | 13 (0.06) | 33 (0.02) | 54 (0.03) |
| Eyelid ptosis | 1 (0.03) | 5 (0.06) | 14 (0.06) | 0 | 17 (0.08) | 37 (0.02) | 77 (0.04) |
| Face oedema | 0 | 11 (0.14) | 9 (0.04) | 0 | 19 (0.09) | 65 (0.04) | 105 (0.05) |
| Facial pain | 0 | 4 (0.05) | 55 (0.24) | 0 | 15 (0.07) | 182 (0.12) | 258 (0.13) |
| Facial paralysis | 12 (0.31) | 43 (0.54) | 110 (0.49) | 0 | 182 (0.85) | 298 (0.20) | 675 (0.33) |
| Facial paresis | 3 (0.08) | 25 (0.31) | 45 (0.20) | 0 | 97 (0.45) | 97 (0.06) | 275 (0.13) |
| Fall | 24 (0.61) | 45 (0.56) | 52 (0.23) | 0 | 105 (0.49) | 178 (0.12) | 423 (0.21) |
| Fatigue | 116 (2.96) | 427 (5.35) | 7576 (33.47) | 5 (3.65) | 1435 (6.66) | 34570 (23.11) | 44230 (21.49) |
| Fear | 0 | 5 (0.06) | 17 (0.08) | 0 | 5 (0.02) | 35 (0.02) | 63 (0.03) |
| Febrile convulsion | 2 (0.05) | 4 (0.05) | 14 (0.06) | 0 | 19 (0.09) | 93 (0.06) | 134 (0.07) |
| Feeding disorder | 3 (0.08) | 6 (0.08) | 49 (0.22) | 0 | 11 (0.05) | 145 (0.10) | 216 (0.10) |
| Feeling abnormal | 14 (0.36) | 54 (0.68) | 401 (1.77) | 0 | 110 (0.51) | 2047 (1.37) | 2642 (1.28) |
| Feeling cold | 6 (0.15) | 41 (0.51) | 453 (2.00) | 0 | 124 (0.58) | 3680 (2.46) | 4307 (2.09) |
| Feeling drunk | 0 | 1 (0.01) | 17 (0.08) | 0 | 2 (0.01) | 81 (0.05) | 101 (0.05) |
| Feeling hot | 5 (0.13) | 37 (0.46) | 193 (0.85) | 0 | 109 (0.51) | 1536 (1.03) | 1894 (0.92) |
| Feeling of body temperature change | 4 (0.10) | 3 (0.04) | 114 (0.50) | 0 | 27 (0.13) | 652 (0.44) | 801 (0.39) |
| Fibrin D dimer increased | 34 (0.87) | 73 (0.91) | 14 (0.06) | 0 | 291 (1.35) | 148 (0.10) | 712 (0.35) |
| Fibromyalgia | 0 | 3 (0.04) | 86 (0.38) | 0 | 14 (0.07) | 183 (0.12) | 288 (0.14) |
| Flank pain | 2 (0.05) | 3 (0.04) | 17 (0.08) | 0 | 17 (0.08) | 59 (0.04) | 102 (0.05) |
| Flatulence | 0 | 5 (0.06) | 37 (0.16) | 0 | 10 (0.05) | 273 (0.18) | 326 (0.16) |
| Fluid retention | 2 (0.05) | 2 (0.03) | 17 (0.08) | 0 | 9 (0.04) | 51 (0.03) | 81 (0.04) |
| Flushing | 1 (0.03) | 18 (0.23) | 64 (0.28) | 0 | 46 (0.21) | 440 (0.29) | 572 (0.28) |
| Food aversion | 0 | 1 (0.01) | 9 (0.04) | 0 | 3 (0.01) | 41 (0.03) | 54 (0.03) |
| Formication | 0 | 1 (0.01) | 12 (0.05) | 0 | 6 (0.03) | 64 (0.04) | 83 (0.04) |
| Freezing phenomenon | 0 | 2 (0.03) | 10 (0.04) | 0 | 5 (0.02) | 111 (0.07) | 128 (0.06) |
| Gait disturbance | 10 (0.26) | 36 (0.45) | 219 (0.97) | 1 (0.73) | 147 (0.68) | 310 (0.21) | 746 (0.36) |
| Gait inability | 5 (0.13) | 16 (0.20) | 95 (0.42) | 0 | 37 (0.17) | 109 (0.07) | 277 (0.13) |
| Gastritis | 2 (0.05) | 2 (0.03) | 29 (0.13) | 0 | 13 (0.06) | 69 (0.05) | 116 (0.06) |
| Gastroenteritis viral | 1 (0.03) | 0 | 4 (0.02) | 0 | 2 (0.01) | 49 (0.03) | 57 (0.03) |
| Gastrointestinal disorder | 0 | 1 (0.01) | 27 (0.12) | 0 | 8 (0.04) | 43 (0.03) | 80 (0.04) |
| Gastrointestinal haemorrhage | 13 (0.33) | 11 (0.14) | 7 (0.03) | 0 | 11 (0.05) | 15 (0.01) | 60 (0.03) |
| Gastrointestinal pain | 0 | 0 | 52 (0.23) | 0 | 35 (0.16) | 232 (0.16) | 320 (0.16) |
| Gastrooesophageal reflux disease | 1 (0.03) | 1 (0.01) | 39 (0.17) | 0 | 8 (0.04) | 144 (0.10) | 195 (0.09) |
| General physical health deterioration | 22 (0.56) | 11 (0.14) | 14 (0.06) | 0 | 54 (0.25) | 15 (0.01) | 124 (0.06) |
| Generalised tonic-clonic seizure | 4 (0.10) | 29 (0.36) | 10 (0.04) | 0 | 55 (0.26) | 51 (0.03) | 154 (0.07) |
| Genital herpes | 0 | 0 | 9 (0.04) | 0 | 1 (0.00) | 48 (0.03) | 58 (0.03) |
| Giant cell arteritis | 2 (0.05) | 8 (0.10) | 8 (0.04) | 0 | 20 (0.09) | 41 (0.03) | 80 (0.04) |
| Gingival bleeding | 0 | 14 (0.18) | 13 (0.06) | 0 | 20 (0.09) | 102 (0.07) | 154 (0.07) |
| Gingival pain | 0 | 1 (0.01) | 21 (0.09) | 1 (0.73) | 2 (0.01) | 142 (0.09) | 167 (0.08) |
| Glossodynia | 0 | 2 (0.03) | 19 (0.08) | 0 | 3 (0.01) | 135 (0.09) | 159 (0.08) |
| Gout | 1 (0.03) | 1 (0.01) | 24 (0.11) | 0 | 7 (0.03) | 115 (0.08) | 148 (0.07) |
| Groin pain | 2 (0.05) | 6 (0.08) | 39 (0.17) | 0 | 16 (0.07) | 137 (0.09) | 202 (0.10) |
| Guillain-Barre syndrome | 13 (0.33) | 190 (2.38) | 184 (0.81) | 1 (0.73) | 561 (2.61) | 190 (0.13) | 1166 (0.57) |
| Haematemesis | 14 (0.36) | 14 (0.18) | 8 (0.04) | 0 | 41 (0.19) | 59 (0.04) | 143 (0.07) |
| Haematochezia | 0 | 5 (0.06) | 8 (0.04) | 0 | 27 (0.13) | 86 (0.06) | 128 (0.06) |
| Haematoma | 3 (0.08) | 39 (0.49) | 32 (0.14) | 1 (0.73) | 97 (0.45) | 185 (0.12) | 367 (0.18) |
| Haematuria | 2 (0.05) | 9 (0.11) | 7 (0.03) | 0 | 23 (0.11) | 56 (0.04) | 104 (0.05) |
| Haemoglobin decreased | 5 (0.13) | 7 (0.09) | 6 (0.03) | 0 | 11 (0.05) | 15 (0.01) | 51 (0.02) |
| Haemoptysis | 11 (0.28) | 32 (0.40) | 8 (0.04) | 0 | 46 (0.21) | 78 (0.05) | 180 (0.09) |
| Haemorrhage | 26 (0.66) | 94 (1.18) | 79 (0.35) | 5 (3.65) | 100 (0.46) | 725 (0.48) | 1042 (0.51) |
| Haemorrhage intracranial | 41 (1.05) | 28 (0.35) | 6 (0.03) | 0 | 11 (0.05) | 12 (0.01) | 107 (0.05) |
| Haemorrhage urinary tract | 1 (0.03) | 10 (0.13) | 4 (0.02) | 0 | 7 (0.03) | 34 (0.02) | 56 (0.03) |
| Haemorrhagic stroke | 31 (0.79) | 30 (0.38) | 6 (0.03) | 0 | 23 (0.11) | 10 (0.01) | 104 (0.05) |
| Haemorrhoids | 1 (0.03) | 1 (0.01) | 7 (0.03) | 0 | 2 (0.01) | 45 (0.03) | 56 (0.03) |
| Hallucination | 1 (0.03) | 19 (0.24) | 143 (0.63) | 0 | 36 (0.17) | 640 (0.43) | 846 (0.41) |
| Hallucination, visual | 0 | 4 (0.05) | 6 (0.03) | 0 | 5 (0.02) | 42 (0.03) | 58 (0.03) |
| Hangover | 0 | 0 | 23 (0.10) | 0 | 2 (0.01) | 121 (0.08) | 147 (0.07) |
| Head discomfort | 2 (0.05) | 19 (0.24) | 167 (0.74) | 0 | 72 (0.33) | 483 (0.32) | 753 (0.37) |
| Head injury | 2 (0.05) | 16 (0.20) | 10 (0.04) | 0 | 14 (0.07) | 21 (0.01) | 67 (0.03) |
| Headache | 248 (6.34) | 981 (12.28) | 9214 (40.71) | 16 (11.68) | 3711 (17.23) | 55563 (37.14) | 69969 (34.00) |
| Heart rate | 0 | 19 (0.24) | 70 (0.31) | 0 | 63 (0.29) | 728 (0.49) | 880 (0.43) |
| Heart rate abnormal | 1 (0.03) | 2 (0.03) | 10 (0.04) | 0 | 10 (0.05) | 44 (0.03) | 70 (0.03) |
| Heart rate decreased | 2 (0.05) | 13 (0.16) | 15 (0.07) | 0 | 29 (0.13) | 78 (0.05) | 137 (0.07) |
| Heart rate increased | 3 (0.08) | 70 (0.88) | 232 (1.03) | 3 (2.19) | 176 (0.82) | 1496 (1.00) | 1994 (0.97) |
| Heart rate irregular | 1 (0.03) | 15 (0.19) | 37 (0.16) | 1 (0.73) | 29 (0.13) | 144 (0.10) | 227 (0.11) |
| Heavy menstrual bleeding | 0 | 17 (0.21) | 217 (0.96) | 2 (1.46) | 92 (0.43) | 2421 (1.62) | 2752 (1.34) |
| Hemiparaesthesia | 1 (0.03) | 2 (0.03) | 3 (0.01) | 0 | 17 (0.08) | 29 (0.02) | 55 (0.03) |
| Hemiparesis | 32 (0.82) | 65 (0.81) | 40 (0.18) | 0 | 90 (0.42) | 102 (0.07) | 362 (0.18) |
| Hemiplegia | 7 (0.18) | 31 (0.39) | 19 (0.08) | 0 | 33 (0.15) | 49 (0.03) | 164 (0.08) |
| Hemiplegic migraine | 0 | 3 (0.04) | 19 (0.08) | 0 | 8 (0.04) | 22 (0.01) | 53 (0.03) |
| Heparin-induced thrombocytopenia test positive | 7 (0.18) | 8 (0.10) | 0 | 0 | 29 (0.13) | 2 (0.00) | 51 (0.02) |
| Hepatic pain | 0 | 3 (0.04) | 20 (0.09) | 0 | 3 (0.01) | 49 (0.03) | 75 (0.04) |
| Hepatitis | 1 (0.03) | 6 (0.08) | 2 (0.01) | 0 | 20 (0.09) | 28 (0.02) | 58 (0.03) |
| Herpes zoster | 0 | 15 (0.19) | 145 (0.64) | 0 | 101 (0.47) | 1203 (0.80) | 1464 (0.71) |
| Hospitalisation | 1 (0.03) | 3 (0.04) | 3 (0.01) | 0 | 58 (0.27) | 0 | 72 (0.03) |
| Hot flush | 2 (0.05) | 8 (0.10) | 182 (0.80) | 0 | 55 (0.26) | 1383 (0.92) | 1635 (0.79) |
| Hunger | 0 | 2 (0.03) | 3 (0.01) | 0 | 1 (0.00) | 46 (0.03) | 52 (0.03) |
| Hyperacusis | 0 | 7 (0.09) | 54 (0.24) | 0 | 23 (0.11) | 85 (0.06) | 169 (0.08) |
| Hyperaesthesia | 0 | 4 (0.05) | 33 (0.15) | 0 | 25 (0.12) | 185 (0.12) | 248 (0.12) |
| Hyperglycaemia | 3 (0.08) | 13 (0.16) | 13 (0.06) | 0 | 20 (0.09) | 94 (0.06) | 147 (0.07) |
| Hyperhidrosis | 19 (0.49) | 82 (1.03) | 1018 (4.50) | 1 (0.73) | 288 (1.34) | 6570 (4.39) | 8003 (3.89) |
| Hyperpyrexia | 5 (0.13) | 13 (0.16) | 15 (0.07) | 0 | 39 (0.18) | 726 (0.49) | 799 (0.39) |
| Hypersensitivity | 7 (0.18) | 83 (1.04) | 177 (0.78) | 0 | 226 (1.05) | 910 (0.61) | 1416 (0.69) |
| Hypersomnia | 1 (0.03) | 5 (0.06) | 31 (0.14) | 0 | 13 (0.06) | 144 (0.10) | 197 (0.10) |
| Hypertension | 32 (0.82) | 155 (1.94) | 175 (0.77) | 1 (0.73) | 411 (1.91) | 845 (0.56) | 1662 (0.81) |
| Hypertensive crisis | 3 (0.08) | 12 (0.15) | 2 (0.01) | 0 | 66 (0.31) | 95 (0.06) | 182 (0.09) |
| Hyperthyroidism | 0 | 7 (0.09) | 12 (0.05) | 1 (0.73) | 12 (0.06) | 42 (0.03) | 74 (0.04) |
| Hyperventilation | 2 (0.05) | 2 (0.03) | 12 (0.05) | 0 | 25 (0.12) | 72 (0.05) | 114 (0.06) |
| Hypoacusis | 1 (0.03) | 5 (0.06) | 70 (0.31) | 0 | 19 (0.09) | 160 (0.11) | 257 (0.12) |
| Hypoaesthesia | 21 (0.54) | 151 (1.89) | 781 (3.45) | 0 | 541 (2.51) | 3279 (2.19) | 4813 (2.34) |
| Hypoaesthesia oral | 1 (0.03) | 16 (0.20) | 46 (0.20) | 0 | 54 (0.25) | 338 (0.23) | 461 (0.22) |
| Hypoglycaemia | 5 (0.13) | 8 (0.10) | 8 (0.04) | 0 | 20 (0.09) | 66 (0.04) | 109 (0.05) |
| Hypokinesia | 1 (0.03) | 5 (0.06) | 29 (0.13) | 0 | 23 (0.11) | 52 (0.03) | 125 (0.06) |
| Hypomenorrhoea | 0 | 0 | 18 (0.08) | 0 | 2 (0.01) | 133 (0.09) | 153 (0.07) |
| Hypopnoea | 3 (0.08) | 14 (0.18) | 30 (0.13) | 0 | 8 (0.04) | 143 (0.10) | 200 (0.10) |
| Hypotension | 42 (1.07) | 73 (0.91) | 100 (0.44) | 0 | 151 (0.70) | 403 (0.27) | 795 (0.39) |
| Hypothermia | 6 (0.15) | 6 (0.08) | 10 (0.04) | 0 | 5 (0.02) | 69 (0.05) | 100 (0.05) |
| Hypotonia | 1 (0.03) | 8 (0.10) | 12 (0.05) | 0 | 83 (0.39) | 30 (0.02) | 137 (0.07) |
| Hypovolaemic shock | 3 (0.08) | 3 (0.04) | 0 | 0 | 3 (0.01) | 61 (0.04) | 73 (0.04) |
| Hypoxia | 11 (0.28) | 31 (0.39) | 6 (0.03) | 0 | 38 (0.18) | 25 (0.02) | 123 (0.06) |
| Illness | 12 (0.31) | 48 (0.60) | 456 (2.01) | 1 (0.73) | 158 (0.73) | 3381 (2.26) | 4063 (1.97) |
| Immobile | 1 (0.03) | 5 (0.06) | 19 (0.08) | 0 | 10 (0.05) | 24 (0.02) | 60 (0.03) |
| Immune thrombocytopenia | 36 (0.92) | 139 (1.74) | 10 (0.04) | 0 | 283 (1.31) | 138 (0.09) | 643 (0.31) |
| Immunisation | 4 (0.10) | 2 (0.03) | 12 (0.05) | 0 | 3 (0.01) | 89 (0.06) | 110 (0.05) |
| Impaired work ability | 0 | 7 (0.09) | 106 (0.47) | 0 | 23 (0.11) | 140 (0.09) | 289 (0.14) |
| Incontinence | 3 (0.08) | 9 (0.11) | 22 (0.10) | 0 | 14 (0.07) | 39 (0.03) | 90 (0.04) |
| Increased tendency to bruise | 0 | 4 (0.05) | 25 (0.11) | 0 | 9 (0.04) | 60 (0.04) | 100 (0.05) |
| Infarction | 13 (0.33) | 13 (0.16) | 2 (0.01) | 0 | 27 (0.13) | 8 (0.01) | 65 (0.03) |
| Infection | 8 (0.20) | 18 (0.23) | 46 (0.20) | 0 | 56 (0.26) | 283 (0.19) | 418 (0.20) |
| Infectious mononucleosis | 0 | 0 | 18 (0.08) | 0 | 4 (0.02) | 34 (0.02) | 56 (0.03) |
| Inflammation | 7 (0.18) | 31 (0.39) | 139 (0.61) | 1 (0.73) | 72 (0.33) | 451 (0.30) | 707 (0.34) |
| Influenza | 2 (0.05) | 27 (0.34) | 558 (2.47) | 0 | 293 (1.36) | 4743 (3.17) | 5626 (2.73) |
| Influenza like illness | 23 (0.59) | 58 (0.73) | 991 (4.38) | 0 | 489 (2.27) | 8089 (5.41) | 9664 (4.70) |
| Initial insomnia | 0 | 1 (0.01) | 4 (0.02) | 0 | 0 | 47 (0.03) | 52 (0.03) |
| Injected limb mobility decreased | 1 (0.03) | 1 (0.01) | 52 (0.23) | 0 | 2 (0.01) | 69 (0.05) | 125 (0.06) |
| Injection related reaction | 0 | 1 (0.01) | 36 (0.16) | 0 | 5 (0.02) | 448 (0.30) | 491 (0.24) |
| Injection site bruising | 0 | 1 (0.01) | 11 (0.05) | 0 | 1 (0.00) | 77 (0.05) | 91 (0.04) |
| Injection site erythema | 0 | 6 (0.08) | 59 (0.26) | 0 | 41 (0.19) | 346 (0.23) | 454 (0.22) |
| Injection site mass | 0 | 2 (0.03) | 54 (0.24) | 0 | 8 (0.04) | 778 (0.52) | 842 (0.41) |
| Injection site pain | 8 (0.20) | 24 (0.30) | 530 (2.34) | 0 | 225 (1.04) | 3143 (2.10) | 3941 (1.91) |
| Injection site pruritus | 0 | 1 (0.01) | 20 (0.09) | 0 | 3 (0.01) | 168 (0.11) | 193 (0.09) |
| Injection site rash | 0 | 0 | 10 (0.04) | 1 (0.73) | 2 (0.01) | 149 (0.10) | 162 (0.08) |
| Injection site reaction | 3 (0.08) | 4 (0.05) | 1247 (5.51) | 0 | 37 (0.17) | 89 (0.06) | 1385 (0.67) |
| Injection site swelling | 1 (0.03) | 7 (0.09) | 62 (0.27) | 0 | 43 (0.20) | 173 (0.12) | 289 (0.14) |
| Injection site warmth | 0 | 2 (0.03) | 39 (0.17) | 0 | 6 (0.03) | 209 (0.14) | 256 (0.12) |
| Insomnia | 5 (0.13) | 36 (0.45) | 458 (2.02) | 0 | 86 (0.40) | 2104 (1.41) | 2698 (1.31) |
| Intermenstrual bleeding | 0 | 3 (0.04) | 18 (0.08) | 0 | 17 (0.08) | 312 (0.21) | 351 (0.17) |
| International normalised ratio increased | 1 (0.03) | 10 (0.13) | 6 (0.03) | 0 | 5 (0.02) | 46 (0.03) | 70 (0.03) |
| Interstitial lung disease | 6 (0.15) | 9 (0.11) | 6 (0.03) | 0 | 13 (0.06) | 20 (0.01) | 55 (0.03) |
| Intestinal ischaemia | 21 (0.54) | 25 (0.31) | 3 (0.01) | 0 | 14 (0.07) | 9 (0.01) | 73 (0.04) |
| Intracranial pressure increased | 16 (0.41) | 8 (0.10) | 5 (0.02) | 0 | 11 (0.05) | 12 (0.01) | 59 (0.03) |
| Irritability | 3 (0.08) | 5 (0.06) | 26 (0.11) | 0 | 23 (0.11) | 212 (0.14) | 272 (0.13) |
| Irritable bowel syndrome | 0 | 2 (0.03) | 17 (0.08) | 0 | 11 (0.05) | 92 (0.06) | 123 (0.06) |
| Ischaemia | 5 (0.13) | 10 (0.13) | 9 (0.04) | 0 | 20 (0.09) | 7 (0.00) | 51 (0.02) |
| Ischaemic cerebral infarction | 4 (0.10) | 22 (0.28) | 4 (0.02) | 0 | 16 (0.07) | 4 (0.00) | 51 (0.02) |
| Ischaemic stroke | 41 (1.05) | 146 (1.83) | 65 (0.29) | 0 | 268 (1.24) | 72 (0.05) | 601 (0.29) |
| Jaundice | 6 (0.15) | 6 (0.08) | 1 (0.00) | 0 | 21 (0.10) | 29 (0.02) | 64 (0.03) |
| Joint lock | 1 (0.03) | 1 (0.01) | 9 (0.04) | 0 | 4 (0.02) | 41 (0.03) | 56 (0.03) |
| Joint stiffness | 0 | 3 (0.04) | 79 (0.35) | 0 | 14 (0.07) | 286 (0.19) | 382 (0.19) |
| Joint swelling | 4 (0.10) | 21 (0.26) | 169 (0.75) | 0 | 66 (0.31) | 609 (0.41) | 874 (0.42) |
| Jugular vein thrombosis | 7 (0.18) | 23 (0.29) | 2 (0.01) | 0 | 27 (0.13) | 20 (0.01) | 83 (0.04) |
| Kidney infection | 1 (0.03) | 6 (0.08) | 11 (0.05) | 0 | 11 (0.05) | 37 (0.02) | 67 (0.03) |
| Labyrinthitis | 1 (0.03) | 2 (0.03) | 27 (0.12) | 0 | 19 (0.09) | 112 (0.07) | 161 (0.08) |
| Lacrimation increased | 0 | 2 (0.03) | 33 (0.15) | 0 | 20 (0.09) | 168 (0.11) | 223 (0.11) |
| Laryngeal oedema | 1 (0.03) | 16 (0.20) | 0 | 0 | 13 (0.06) | 33 (0.02) | 65 (0.03) |
| Lethargy | 26 (0.66) | 58 (0.73) | 405 (1.79) | 0 | 108 (0.50) | 3162 (2.11) | 3782 (1.84) |
| Limb discomfort | 2 (0.05) | 26 (0.33) | 220 (0.97) | 0 | 423 (1.96) | 1354 (0.91) | 2034 (0.99) |
| Limb injury | 2 (0.05) | 3 (0.04) | 79 (0.35) | 0 | 5 (0.02) | 181 (0.12) | 271 (0.13) |
| Lip dry | 0 | 2 (0.03) | 4 (0.02) | 0 | 2 (0.01) | 46 (0.03) | 54 (0.03) |
| Lip oedema | 0 | 6 (0.08) | 4 (0.02) | 0 | 12 (0.06) | 39 (0.03) | 62 (0.03) |
| Lip swelling | 2 (0.05) | 40 (0.50) | 41 (0.18) | 0 | 63 (0.29) | 517 (0.35) | 664 (0.32) |
| Listless | 3 (0.08) | 0 | 16 (0.07) | 0 | 2 (0.01) | 83 (0.06) | 104 (0.05) |
| Livedo reticularis | 1 (0.03) | 3 (0.04) | 5 (0.02) | 0 | 10 (0.05) | 45 (0.03) | 68 (0.03) |
| Liver function test abnormal | 2 (0.05) | 6 (0.08) | 6 (0.03) | 0 | 15 (0.07) | 19 (0.01) | 57 (0.03) |
| Local reaction | 3 (0.08) | 1 (0.01) | 10 (0.04) | 0 | 30 (0.14) | 31 (0.02) | 75 (0.04) |
| Localised infection | 0 | 1 (0.01) | 5 (0.02) | 0 | 7 (0.03) | 71 (0.05) | 84 (0.04) |
| Loss of consciousness | 68 (1.74) | 163 (2.04) | 113 (0.50) | 0 | 319 (1.48) | 919 (0.61) | 1621 (0.79) |
| Loss of control of legs | 0 | 4 (0.05) | 8 (0.04) | 0 | 8 (0.04) | 35 (0.02) | 56 (0.03) |
| Loss of personal independence in daily activities | 0 | 6 (0.08) | 70 (0.31) | 0 | 6 (0.03) | 43 (0.03) | 130 (0.06) |
| Lower respiratory tract infection | 18 (0.46) | 19 (0.24) | 43 (0.19) | 0 | 35 (0.16) | 150 (0.10) | 268 (0.13) |
| Lymph node pain | 1 (0.03) | 1 (0.01) | 46 (0.20) | 0 | 12 (0.06) | 372 (0.25) | 432 (0.21) |
| Lymphadenopathy | 3 (0.08) | 34 (0.43) | 438 (1.94) | 3 (2.19) | 141 (0.65) | 3038 (2.03) | 3669 (1.78) |
| Lymphoedema | 0 | 3 (0.04) | 11 (0.05) | 0 | 2 (0.01) | 45 (0.03) | 62 (0.03) |
| Malaise | 176 (4.50) | 309 (3.87) | 2730 (12.06) | 2 (1.46) | 851 (3.95) | 8559 (5.72) | 12710 (6.18) |
| Maternal exposure during breast feeding | 1 (0.03) | 12 (0.15) | 59 (0.26) | 7 (5.11) | 12 (0.06) | 781 (0.52) | 874 (0.42) |
| Maternal exposure during pregnancy | 2 (0.05) | 16 (0.20) | 26 (0.11) | 54 (39.42) | 34 (0.16) | 167 (0.11) | 304 (0.15) |
| Memory impairment | 2 (0.05) | 16 (0.20) | 113 (0.50) | 0 | 44 (0.20) | 232 (0.16) | 418 (0.20) |
| Meningitis | 3 (0.08) | 6 (0.08) | 3 (0.01) | 0 | 24 (0.11) | 19 (0.01) | 58 (0.03) |
| Menstrual disorder | 1 (0.03) | 6 (0.08) | 73 (0.32) | 5 (3.65) | 19 (0.09) | 631 (0.42) | 736 (0.36) |
| Menstruation delayed | 0 | 4 (0.05) | 98 (0.43) | 1 (0.73) | 18 (0.08) | 984 (0.66) | 1105 (0.54) |
| Menstruation irregular | 0 | 3 (0.04) | 81 (0.36) | 4 (2.92) | 18 (0.08) | 793 (0.53) | 901 (0.44) |
| Mental fatigue | 0 | 8 (0.10) | 88 (0.39) | 0 | 12 (0.06) | 318 (0.21) | 427 (0.21) |
| Mental impairment | 2 (0.05) | 5 (0.06) | 38 (0.17) | 0 | 7 (0.03) | 82 (0.05) | 137 (0.07) |
| Mesenteric vein thrombosis | 11 (0.28) | 28 (0.35) | 2 (0.01) | 0 | 40 (0.19) | 11 (0.01) | 101 (0.05) |
| Micturition urgency | 1 (0.03) | 2 (0.03) | 13 (0.06) | 0 | 8 (0.04) | 52 (0.03) | 76 (0.04) |
| Middle insomnia | 0 | 2 (0.03) | 5 (0.02) | 0 | 2 (0.01) | 52 (0.03) | 62 (0.03) |
| Migraine | 4 (0.10) | 82 (1.03) | 1130 (4.99) | 0 | 290 (1.35) | 5244 (3.51) | 6763 (3.29) |
| Migraine with aura | 0 | 3 (0.04) | 69 (0.30) | 0 | 22 (0.10) | 253 (0.17) | 349 (0.17) |
| Miliaria | 0 | 1 (0.01) | 17 (0.08) | 0 | 3 (0.01) | 101 (0.07) | 123 (0.06) |
| Mobility decreased | 6 (0.15) | 9 (0.11) | 99 (0.44) | 0 | 77 (0.36) | 79 (0.05) | 281 (0.14) |
| Monoparesis | 2 (0.05) | 6 (0.08) | 27 (0.12) | 0 | 20 (0.09) | 95 (0.06) | 155 (0.08) |
| Monoplegia | 2 (0.05) | 10 (0.13) | 45 (0.20) | 0 | 30 (0.14) | 135 (0.09) | 228 (0.11) |
| Mood altered | 2 (0.05) | 2 (0.03) | 9 (0.04) | 0 | 4 (0.02) | 59 (0.04) | 78 (0.04) |
| Mood swings | 1 (0.03) | 4 (0.05) | 19 (0.08) | 0 | 2 (0.01) | 77 (0.05) | 103 (0.05) |
| Motion sickness | 0 | 2 (0.03) | 21 (0.09) | 0 | 3 (0.01) | 86 (0.06) | 113 (0.05) |
| Motor dysfunction | 3 (0.08) | 7 (0.09) | 16 (0.07) | 0 | 20 (0.09) | 17 (0.01) | 69 (0.03) |
| Mouth haemorrhage | 1 (0.03) | 6 (0.08) | 4 (0.02) | 0 | 8 (0.04) | 39 (0.03) | 62 (0.03) |
| Mouth swelling | 0 | 9 (0.11) | 8 (0.04) | 0 | 10 (0.05) | 78 (0.05) | 105 (0.05) |
| Mouth ulceration | 0 | 1 (0.01) | 56 (0.25) | 0 | 11 (0.05) | 368 (0.25) | 437 (0.21) |
| Movement disorder | 0 | 13 (0.16) | 37 (0.16) | 0 | 55 (0.26) | 59 (0.04) | 170 (0.08) |
| Multiple organ dysfunction syndrome | 56 (1.43) | 9 (0.11) | 0 | 0 | 5 (0.02) | 2 (0.00) | 79 (0.04) |
| Multiple sclerosis | 0 | 0 | 20 (0.09) | 1 (0.73) | 14 (0.07) | 48 (0.03) | 85 (0.04) |
| Multiple sclerosis relapse | 0 | 0 | 21 (0.09) | 0 | 14 (0.07) | 54 (0.04) | 90 (0.04) |
| Muscle contractions involuntary | 0 | 1 (0.01) | 15 (0.07) | 0 | 1 (0.00) | 34 (0.02) | 51 (0.02) |
| Muscle fatigue | 1 (0.03) | 8 (0.10) | 146 (0.65) | 0 | 15 (0.07) | 684 (0.46) | 855 (0.42) |
| Muscle rigidity | 1 (0.03) | 2 (0.03) | 12 (0.05) | 0 | 10 (0.05) | 46 (0.03) | 71 (0.03) |
| Muscle spasms | 3 (0.08) | 57 (0.71) | 516 (2.28) | 3 (2.19) | 170 (0.79) | 2156 (1.44) | 2918 (1.42) |
| Muscle tightness | 1 (0.03) | 7 (0.09) | 31 (0.14) | 1 (0.73) | 18 (0.08) | 134 (0.09) | 193 (0.09) |
| Muscle twitching | 0 | 10 (0.13) | 86 (0.38) | 0 | 42 (0.20) | 269 (0.18) | 410 (0.20) |
| Muscular weakness | 18 (0.46) | 84 (1.05) | 564 (2.49) | 1 (0.73) | 282 (1.31) | 1309 (0.88) | 2292 (1.11) |
| Musculoskeletal chest pain | 1 (0.03) | 12 (0.15) | 62 (0.27) | 0 | 32 (0.15) | 276 (0.18) | 385 (0.19) |
| Musculoskeletal discomfort | 0 | 4 (0.05) | 15 (0.07) | 0 | 10 (0.05) | 84 (0.06) | 114 (0.06) |
| Musculoskeletal pain | 2 (0.05) | 9 (0.11) | 39 (0.17) | 0 | 42 (0.20) | 157 (0.10) | 250 (0.12) |
| Musculoskeletal stiffness | 5 (0.13) | 19 (0.24) | 419 (1.85) | 0 | 83 (0.39) | 1452 (0.97) | 1986 (0.96) |
| Myalgia | 42 (1.07) | 228 (2.85) | 4988 (22.04) | 4 (2.92) | 828 (3.85) | 19343 (12.93) | 25495 (12.39) |
| Myelitis | 0 | 4 (0.05) | 11 (0.05) | 0 | 46 (0.21) | 9 (0.01) | 72 (0.03) |
| Myelitis transverse | 1 (0.03) | 9 (0.11) | 53 (0.23) | 0 | 44 (0.20) | 34 (0.02) | 141 (0.07) |
| Myocardial infarction | 177 (4.52) | 317 (3.97) | 29 (0.13) | 0 | 215 (1.00) | 136 (0.09) | 894 (0.43) |
| Myocarditis | 13 (0.33) | 73 (0.91) | 50 (0.22) | 0 | 158 (0.73) | 147 (0.10) | 457 (0.22) |
| Myositis | 1 (0.03) | 6 (0.08) | 22 (0.10) | 0 | 9 (0.04) | 34 (0.02) | 75 (0.04) |
| Nasal congestion | 4 (0.10) | 6 (0.08) | 60 (0.27) | 0 | 17 (0.08) | 299 (0.20) | 387 (0.19) |
| Nasal discomfort | 0 | 0 | 8 (0.04) | 0 | 3 (0.01) | 72 (0.05) | 83 (0.04) |
| Nasopharyngitis | 21 (0.54) | 11 (0.14) | 156 (0.69) | 0 | 146 (0.68) | 1090 (0.73) | 1431 (0.70) |
| Nausea | 93 (2.38) | 303 (3.79) | 4511 (19.93) | 5 (3.65) | 1272 (5.91) | 24361 (16.28) | 30625 (14.88) |
| Neck pain | 8 (0.20) | 44 (0.55) | 438 (1.94) | 0 | 180 (0.84) | 2016 (1.35) | 2696 (1.31) |
| Nerve injury | 0 | 11 (0.14) | 59 (0.26) | 0 | 11 (0.05) | 83 (0.06) | 166 (0.08) |
| Nervous system disorder | 6 (0.15) | 12 (0.15) | 52 (0.23) | 1 (0.73) | 39 (0.18) | 54 (0.04) | 172 (0.08) |
| Nervousness | 0 | 7 (0.09) | 78 (0.34) | 0 | 20 (0.09) | 400 (0.27) | 506 (0.25) |
| Neuralgia | 1 (0.03) | 13 (0.16) | 298 (1.32) | 0 | 105 (0.49) | 872 (0.58) | 1291 (0.63) |
| Neurological symptom | 4 (0.10) | 9 (0.11) | 38 (0.17) | 0 | 23 (0.11) | 66 (0.04) | 143 (0.07) |
| Neuropathy peripheral | 0 | 8 (0.10) | 73 (0.32) | 0 | 27 (0.13) | 156 (0.10) | 266 (0.13) |
| Neutropenia | 0 | 9 (0.11) | 3 (0.01) | 0 | 17 (0.08) | 57 (0.04) | 88 (0.04) |
| Night sweats | 2 (0.05) | 16 (0.20) | 158 (0.70) | 0 | 41 (0.19) | 1270 (0.85) | 1488 (0.72) |
| Nightmare | 1 (0.03) | 5 (0.06) | 44 (0.19) | 0 | 5 (0.02) | 288 (0.19) | 343 (0.17) |
| Ocular discomfort | 2 (0.05) | 1 (0.01) | 17 (0.08) | 1 (0.73) | 18 (0.08) | 56 (0.04) | 96 (0.05) |
| Ocular hyperaemia | 1 (0.03) | 5 (0.06) | 31 (0.14) | 0 | 22 (0.10) | 225 (0.15) | 287 (0.14) |
| Odynophagia | 0 | 3 (0.04) | 1 (0.00) | 1 (0.73) | 5 (0.02) | 41 (0.03) | 52 (0.03) |
| Oedema | 9 (0.23) | 13 (0.16) | 13 (0.06) | 0 | 49 (0.23) | 59 (0.04) | 150 (0.07) |
| Oedema peripheral | 10 (0.26) | 38 (0.48) | 53 (0.23) | 0 | 81 (0.38) | 194 (0.13) | 390 (0.19) |
| Off label use | 2 (0.05) | 5 (0.06) | 4 (0.02) | 0 | 8 (0.04) | 34 (0.02) | 57 (0.03) |
| Oligomenorrhoea | 0 | 0 | 13 (0.06) | 0 | 2 (0.01) | 43 (0.03) | 58 (0.03) |
| Ophthalmic herpes zoster | 0 | 0 | 4 (0.02) | 0 | 11 (0.05) | 46 (0.03) | 61 (0.03) |
| Optic neuritis | 0 | 3 (0.04) | 36 (0.16) | 0 | 37 (0.17) | 37 (0.02) | 117 (0.06) |
| Oral discomfort | 0 | 3 (0.04) | 8 (0.04) | 0 | 5 (0.02) | 77 (0.05) | 93 (0.05) |
| Oral herpes | 0 | 4 (0.05) | 43 (0.19) | 0 | 12 (0.06) | 395 (0.26) | 455 (0.22) |
| Oral pain | 1 (0.03) | 1 (0.01) | 26 (0.11) | 1 (0.73) | 7 (0.03) | 201 (0.13) | 241 (0.12) |
| Oropharyngeal pain | 11 (0.28) | 38 (0.48) | 382 (1.69) | 1 (0.73) | 146 (0.68) | 2792 (1.87) | 3375 (1.64) |
| Orthostatic hypotension | 1 (0.03) | 4 (0.05) | 17 (0.08) | 0 | 9 (0.04) | 24 (0.02) | 55 (0.03) |
| Osteoarthritis | 0 | 2 (0.03) | 31 (0.14) | 0 | 6 (0.03) | 54 (0.04) | 94 (0.05) |
| Oxygen saturation decreased | 30 (0.77) | 25 (0.31) | 26 (0.11) | 0 | 99 (0.46) | 107 (0.07) | 303 (0.15) |
| Pain | 52 (1.33) | 204 (2.55) | 2059 (9.10) | 4 (2.92) | 634 (2.94) | 11237 (7.51) | 14250 (6.92) |
| Pain in extremity | 52 (1.33) | 273 (3.42) | 2279 (10.07) | 4 (2.92) | 775 (3.60) | 13481 (9.01) | 16931 (8.23) |
| Pain in jaw | 1 (0.03) | 14 (0.18) | 86 (0.38) | 0 | 29 (0.13) | 394 (0.26) | 527 (0.26) |
| Pain of skin | 0 | 3 (0.04) | 119 (0.53) | 0 | 19 (0.09) | 632 (0.42) | 774 (0.38) |
| Pallor | 11 (0.28) | 33 (0.41) | 56 (0.25) | 0 | 33 (0.15) | 238 (0.16) | 383 (0.19) |
| Palpitations | 7 (0.18) | 161 (2.02) | 712 (3.15) | 1 (0.73) | 522 (2.42) | 3484 (2.33) | 4912 (2.39) |
| Pancreatitis | 7 (0.18) | 10 (0.13) | 3 (0.01) | 0 | 35 (0.16) | 27 (0.02) | 83 (0.04) |
| Panic attack | 1 (0.03) | 12 (0.15) | 47 (0.21) | 0 | 32 (0.15) | 219 (0.15) | 312 (0.15) |
| Papule | 0 | 0 | 8 (0.04) | 1 (0.73) | 3 (0.01) | 61 (0.04) | 73 (0.04) |
| Paraesthesia | 13 (0.33) | 199 (2.49) | 947 (4.18) | 2 (1.46) | 827 (3.84) | 5318 (3.55) | 7361 (3.58) |
| Paraesthesia oral | 0 | 13 (0.16) | 56 (0.25) | 0 | 65 (0.30) | 455 (0.30) | 591 (0.29) |
| Paralysis | 10 (0.26) | 37 (0.46) | 84 (0.37) | 0 | 98 (0.46) | 187 (0.13) | 436 (0.21) |
| Paranasal sinus discomfort | 0 | 1 (0.01) | 8 (0.04) | 0 | 3 (0.01) | 49 (0.03) | 61 (0.03) |
| Paresis | 0 | 5 (0.06) | 10 (0.04) | 0 | 21 (0.10) | 19 (0.01) | 57 (0.03) |
| Parosmia | 0 | 2 (0.03) | 33 (0.15) | 0 | 10 (0.05) | 197 (0.13) | 242 (0.12) |
| Partial seizures | 4 (0.10) | 9 (0.11) | 5 (0.02) | 0 | 15 (0.07) | 33 (0.02) | 69 (0.03) |
| Pelvic pain | 0 | 3 (0.04) | 36 (0.16) | 0 | 13 (0.06) | 118 (0.08) | 171 (0.08) |
| Pelvic venous thrombosis | 2 (0.05) | 14 (0.18) | 3 (0.01) | 0 | 16 (0.07) | 16 (0.01) | 55 (0.03) |
| Periarthritis | 0 | 1 (0.01) | 124 (0.55) | 0 | 4 (0.02) | 283 (0.19) | 412 (0.20) |
| Pericardial effusion | 4 (0.10) | 18 (0.23) | 7 (0.03) | 0 | 46 (0.21) | 37 (0.02) | 124 (0.06) |
| Pericarditis | 2 (0.05) | 31 (0.39) | 34 (0.15) | 0 | 196 (0.91) | 159 (0.11) | 431 (0.21) |
| Periorbital swelling | 0 | 2 (0.03) | 15 (0.07) | 0 | 8 (0.04) | 75 (0.05) | 100 (0.05) |
| Peripheral artery thrombosis | 9 (0.23) | 23 (0.29) | 5 (0.02) | 0 | 41 (0.19) | 27 (0.02) | 110 (0.05) |
| Peripheral coldness | 4 (0.10) | 21 (0.26) | 154 (0.68) | 0 | 38 (0.18) | 838 (0.56) | 1062 (0.52) |
| Peripheral ischaemia | 10 (0.26) | 13 (0.16) | 3 (0.01) | 0 | 31 (0.14) | 12 (0.01) | 73 (0.04) |
| Peripheral swelling | 23 (0.59) | 146 (1.83) | 591 (2.61) | 2 (1.46) | 242 (1.12) | 3292 (2.20) | 4327 (2.10) |
| Petechiae | 7 (0.18) | 47 (0.59) | 30 (0.13) | 0 | 174 (0.81) | 243 (0.16) | 521 (0.25) |
| Petit mal epilepsy | 0 | 6 (0.08) | 8 (0.04) | 0 | 6 (0.03) | 34 (0.02) | 55 (0.03) |
| Pharyngeal swelling | 2 (0.05) | 36 (0.45) | 37 (0.16) | 0 | 47 (0.22) | 164 (0.11) | 290 (0.14) |
| Phlebitis | 0 | 4 (0.05) | 10 (0.04) | 0 | 29 (0.13) | 103 (0.07) | 146 (0.07) |
| Photophobia | 6 (0.15) | 22 (0.28) | 208 (0.92) | 0 | 82 (0.38) | 678 (0.45) | 1002 (0.49) |
| Photopsia | 1 (0.03) | 11 (0.14) | 37 (0.16) | 0 | 20 (0.09) | 213 (0.14) | 283 (0.14) |
| Photosensitivity reaction | 0 | 4 (0.05) | 30 (0.13) | 0 | 14 (0.07) | 99 (0.07) | 147 (0.07) |
| Piloerection | 0 | 0 | 8 (0.04) | 0 | 3 (0.01) | 71 (0.05) | 83 (0.04) |
| Platelet count decreased | 33 (0.84) | 68 (0.85) | 28 (0.12) | 1 (0.73) | 124 (0.58) | 191 (0.13) | 473 (0.23) |
| Pleural effusion | 9 (0.23) | 32 (0.40) | 5 (0.02) | 0 | 46 (0.21) | 18 (0.01) | 122 (0.06) |
| Pleurisy | 0 | 2 (0.03) | 8 (0.04) | 0 | 32 (0.15) | 20 (0.01) | 64 (0.03) |
| Pleuritic pain | 0 | 20 (0.25) | 6 (0.03) | 0 | 15 (0.07) | 11 (0.01) | 54 (0.03) |
| Pneumonia | 86 (2.20) | 95 (1.19) | 29 (0.13) | 0 | 207 (0.96) | 90 (0.06) | 539 (0.26) |
| Pneumonitis | 7 (0.18) | 10 (0.13) | 6 (0.03) | 0 | 22 (0.10) | 24 (0.02) | 71 (0.03) |
| Pollakiuria | 2 (0.05) | 9 (0.11) | 30 (0.13) | 0 | 18 (0.08) | 171 (0.11) | 230 (0.11) |
| Polymenorrhoea | 0 | 1 (0.01) | 29 (0.13) | 1 (0.73) | 9 (0.04) | 253 (0.17) | 293 (0.14) |
| Polymyalgia rheumatica | 0 | 4 (0.05) | 35 (0.15) | 0 | 12 (0.06) | 85 (0.06) | 137 (0.07) |
| Polyneuropathy | 2 (0.05) | 8 (0.10) | 8 (0.04) | 0 | 33 (0.15) | 43 (0.03) | 99 (0.05) |
| Poor quality sleep | 0 | 5 (0.06) | 71 (0.31) | 0 | 3 (0.01) | 427 (0.29) | 506 (0.25) |
| Portal vein thrombosis | 34 (0.87) | 63 (0.79) | 2 (0.01) | 0 | 95 (0.44) | 30 (0.02) | 244 (0.12) |
| Post viral fatigue syndrome | 0 | 0 | 55 (0.24) | 0 | 4 (0.02) | 74 (0.05) | 133 (0.06) |
| Postmenopausal haemorrhage | 0 | 0 | 6 (0.03) | 0 | 10 (0.05) | 197 (0.13) | 214 (0.10) |
| Premenstrual pain | 0 | 0 | 9 (0.04) | 0 | 0 | 51 (0.03) | 60 (0.03) |
| Presyncope | 5 (0.13) | 15 (0.19) | 89 (0.39) | 0 | 72 (0.33) | 429 (0.29) | 618 (0.30) |
| Productive cough | 7 (0.18) | 9 (0.11) | 28 (0.12) | 0 | 27 (0.13) | 110 (0.07) | 183 (0.09) |
| Pruritus | 3 (0.08) | 82 (1.03) | 439 (1.94) | 0 | 223 (1.04) | 3928 (2.63) | 4690 (2.28) |
| Psoriasis | 0 | 7 (0.09) | 34 (0.15) | 0 | 9 (0.04) | 129 (0.09) | 181 (0.09) |
| Pulmonary embolism | 314 (8.02) | 1244 (15.57) | 77 (0.34) | 0 | 1953 (9.07) | 922 (0.62) | 4627 (2.25) |
| Pulmonary infarction | 3 (0.08) | 26 (0.33) | 1 (0.00) | 0 | 28 (0.13) | 11 (0.01) | 79 (0.04) |
| Pulmonary oedema | 20 (0.51) | 23 (0.29) | 2 (0.01) | 0 | 19 (0.09) | 21 (0.01) | 97 (0.05) |
| Pulmonary pain | 0 | 17 (0.21) | 42 (0.19) | 0 | 18 (0.08) | 147 (0.10) | 227 (0.11) |
| Pulmonary thrombosis | 17 (0.43) | 17 (0.21) | 2 (0.01) | 0 | 50 (0.23) | 21 (0.01) | 114 (0.06) |
| Purpura | 5 (0.13) | 11 (0.14) | 10 (0.04) | 0 | 60 (0.28) | 87 (0.06) | 178 (0.09) |
| Pyrexia | 272 (6.95) | 749 (9.38) | 7337 (32.42) | 10 (7.30) | 2682 (12.45) | 40971 (27.39) | 52177 (25.35) |
| Q fever | 0 | 1 (0.01) | 13 (0.06) | 0 | 2 (0.01) | 81 (0.05) | 97 (0.05) |
| Rash | 14 (0.36) | 116 (1.45) | 488 (2.16) | 3 (2.19) | 418 (1.94) | 4008 (2.68) | 5063 (2.46) |
| Rash erythematous | 2 (0.05) | 8 (0.10) | 87 (0.38) | 0 | 37 (0.17) | 877 (0.59) | 1011 (0.49) |
| Rash macular | 1 (0.03) | 10 (0.13) | 36 (0.16) | 0 | 35 (0.16) | 379 (0.25) | 461 (0.22) |
| Rash maculo-papular | 0 | 2 (0.03) | 3 (0.01) | 0 | 4 (0.02) | 49 (0.03) | 59 (0.03) |
| Rash papular | 1 (0.03) | 3 (0.04) | 18 (0.08) | 0 | 11 (0.05) | 236 (0.16) | 272 (0.13) |
| Rash pruritic | 1 (0.03) | 9 (0.11) | 56 (0.25) | 0 | 42 (0.20) | 891 (0.60) | 999 (0.49) |
| Rash vesicular | 0 | 4 (0.05) | 7 (0.03) | 0 | 12 (0.06) | 47 (0.03) | 71 (0.03) |
| Raynaud's phenomenon | 1 (0.03) | 0 | 16 (0.07) | 0 | 6 (0.03) | 96 (0.06) | 119 (0.06) |
| Rectal haemorrhage | 6 (0.15) | 12 (0.15) | 6 (0.03) | 0 | 30 (0.14) | 95 (0.06) | 152 (0.07) |
| Renal failure | 20 (0.51) | 28 (0.35) | 5 (0.02) | 0 | 20 (0.09) | 20 (0.01) | 99 (0.05) |
| Renal pain | 2 (0.05) | 16 (0.20) | 118 (0.52) | 0 | 46 (0.21) | 650 (0.43) | 833 (0.40) |
| Respiration abnormal | 6 (0.15) | 5 (0.06) | 9 (0.04) | 0 | 23 (0.11) | 59 (0.04) | 107 (0.05) |
| Respiratory arrest | 10 (0.26) | 14 (0.18) | 1 (0.00) | 0 | 11 (0.05) | 13 (0.01) | 53 (0.03) |
| Respiratory disorder | 11 (0.28) | 16 (0.20) | 113 (0.50) | 0 | 30 (0.14) | 26 (0.02) | 199 (0.10) |
| Respiratory distress | 11 (0.28) | 21 (0.26) | 12 (0.05) | 1 (0.73) | 137 (0.64) | 78 (0.05) | 280 (0.14) |
| Respiratory failure | 34 (0.87) | 36 (0.45) | 0 | 0 | 31 (0.14) | 16 (0.01) | 130 (0.06) |
| Respiratory rate increased | 4 (0.10) | 6 (0.08) | 6 (0.03) | 0 | 6 (0.03) | 63 (0.04) | 86 (0.04) |
| Restless legs syndrome | 0 | 7 (0.09) | 46 (0.20) | 0 | 10 (0.05) | 251 (0.17) | 315 (0.15) |
| Restlessness | 5 (0.13) | 7 (0.09) | 49 (0.22) | 0 | 31 (0.14) | 335 (0.22) | 430 (0.21) |
| Retching | 4 (0.10) | 6 (0.08) | 33 (0.15) | 0 | 24 (0.11) | 188 (0.13) | 258 (0.13) |
| Retinal artery occlusion | 0 | 1 (0.01) | 27 (0.12) | 0 | 16 (0.07) | 30 (0.02) | 76 (0.04) |
| Retinal detachment | 0 | 0 | 19 (0.08) | 0 | 37 (0.17) | 28 (0.02) | 85 (0.04) |
| Retinal migraine | 0 | 0 | 7 (0.03) | 0 | 2 (0.01) | 64 (0.04) | 73 (0.04) |
| Retinal vein occlusion | 0 | 3 (0.04) | 60 (0.27) | 0 | 15 (0.07) | 143 (0.10) | 222 (0.11) |
| Retinal vein thrombosis | 1 (0.03) | 0 | 13 (0.06) | 0 | 5 (0.02) | 46 (0.03) | 66 (0.03) |
| Rheumatoid arthritis | 1 (0.03) | 2 (0.03) | 66 (0.29) | 0 | 13 (0.06) | 134 (0.09) | 217 (0.11) |
| Rhinitis | 6 (0.15) | 6 (0.08) | 7 (0.03) | 0 | 20 (0.09) | 36 (0.02) | 77 (0.04) |
| Rhinorrhoea | 1 (0.03) | 8 (0.10) | 133 (0.59) | 0 | 38 (0.18) | 1028 (0.69) | 1213 (0.59) |
| Rotator cuff syndrome | 0 | 1 (0.01) | 22 (0.10) | 0 | 3 (0.01) | 67 (0.04) | 94 (0.05) |
| SARS-CoV-2 test positive | 17 (0.43) | 5 (0.06) | 5 (0.02) | 0 | 63 (0.29) | 36 (0.02) | 133 (0.06) |
| Salivary hypersecretion | 0 | 6 (0.08) | 13 (0.06) | 0 | 11 (0.05) | 46 (0.03) | 76 (0.04) |
| Sciatica | 0 | 2 (0.03) | 57 (0.25) | 0 | 10 (0.05) | 137 (0.09) | 206 (0.10) |
| Seasonal allergy | 1 (0.03) | 0 | 11 (0.05) | 0 | 2 (0.01) | 68 (0.05) | 82 (0.04) |
| Seizure | 55 (1.41) | 193 (2.42) | 183 (0.81) | 1 (0.73) | 408 (1.89) | 982 (0.66) | 1878 (0.91) |
| Sensation of foreign body | 0 | 7 (0.09) | 9 (0.04) | 0 | 20 (0.09) | 40 (0.03) | 82 (0.04) |
| Sensitive skin | 0 | 3 (0.04) | 60 (0.27) | 0 | 5 (0.02) | 397 (0.27) | 465 (0.23) |
| Sensory disturbance | 0 | 10 (0.13) | 53 (0.23) | 0 | 134 (0.62) | 102 (0.07) | 306 (0.15) |
| Sensory loss | 0 | 22 (0.28) | 62 (0.27) | 0 | 41 (0.19) | 96 (0.06) | 227 (0.11) |
| Sepsis | 50 (1.28) | 39 (0.49) | 9 (0.04) | 0 | 42 (0.20) | 43 (0.03) | 209 (0.10) |
| Severe acute respiratory syndrome | 6 (0.15) | 1 (0.01) | 0 | 0 | 36 (0.17) | 9 (0.01) | 52 (0.03) |
| Shock | 10 (0.26) | 12 (0.15) | 5 (0.02) | 0 | 6 (0.03) | 40 (0.03) | 76 (0.04) |
| Shoulder injury related to vaccine administration | 0 | 0 | 34 (0.15) | 0 | 2 (0.01) | 53 (0.04) | 89 (0.04) |
| Sinus congestion | 0 | 4 (0.05) | 8 (0.04) | 0 | 4 (0.02) | 63 (0.04) | 79 (0.04) |
| Sinus headache | 0 | 2 (0.03) | 79 (0.35) | 0 | 11 (0.05) | 653 (0.44) | 746 (0.36) |
| Sinus pain | 0 | 7 (0.09) | 69 (0.30) | 0 | 5 (0.02) | 435 (0.29) | 517 (0.25) |
| Sinus tachycardia | 4 (0.10) | 9 (0.11) | 8 (0.04) | 0 | 33 (0.15) | 44 (0.03) | 100 (0.05) |
| Sinusitis | 1 (0.03) | 5 (0.06) | 45 (0.20) | 0 | 15 (0.07) | 251 (0.17) | 318 (0.15) |
| Skin burning sensation | 0 | 9 (0.11) | 78 (0.34) | 0 | 31 (0.14) | 361 (0.24) | 480 (0.23) |
| Skin discolouration | 6 (0.15) | 12 (0.15) | 21 (0.09) | 0 | 22 (0.10) | 115 (0.08) | 179 (0.09) |
| Skin disorder | 2 (0.05) | 5 (0.06) | 119 (0.53) | 0 | 19 (0.09) | 33 (0.02) | 178 (0.09) |
| Skin exfoliation | 0 | 5 (0.06) | 17 (0.08) | 0 | 7 (0.03) | 82 (0.05) | 112 (0.05) |
| Skin haemorrhage | 2 (0.05) | 3 (0.04) | 9 (0.04) | 0 | 16 (0.07) | 28 (0.02) | 60 (0.03) |
| Skin irritation | 0 | 0 | 7 (0.03) | 0 | 7 (0.03) | 73 (0.05) | 87 (0.04) |
| Skin reaction | 0 | 4 (0.05) | 19 (0.08) | 0 | 12 (0.06) | 126 (0.08) | 161 (0.08) |
| Skin sensitisation | 0 | 0 | 14 (0.06) | 0 | 0 | 68 (0.05) | 82 (0.04) |
| Skin swelling | 0 | 0 | 5 (0.02) | 0 | 6 (0.03) | 46 (0.03) | 58 (0.03) |
| Skin temperature | 0 | 0 | 10 (0.04) | 0 | 0 | 134 (0.09) | 144 (0.07) |
| Skin warm | 0 | 3 (0.04) | 26 (0.11) | 0 | 7 (0.03) | 303 (0.20) | 339 (0.16) |
| Sleep disorder | 3 (0.08) | 8 (0.10) | 101 (0.45) | 0 | 22 (0.10) | 301 (0.20) | 439 (0.21) |
| Sneezing | 1 (0.03) | 7 (0.09) | 32 (0.14) | 0 | 9 (0.04) | 302 (0.20) | 351 (0.17) |
| Somnolence | 26 (0.66) | 79 (0.99) | 231 (1.02) | 1 (0.73) | 205 (0.95) | 1394 (0.93) | 1957 (0.95) |
| Speech disorder | 10 (0.26) | 23 (0.29) | 47 (0.21) | 0 | 80 (0.37) | 81 (0.05) | 259 (0.13) |
| Spinal pain | 1 (0.03) | 8 (0.10) | 47 (0.21) | 0 | 20 (0.09) | 173 (0.12) | 253 (0.12) |
| Splenic infarction | 7 (0.18) | 8 (0.10) | 1 (0.00) | 0 | 23 (0.11) | 10 (0.01) | 56 (0.03) |
| Stomatitis | 0 | 0 | 10 (0.04) | 0 | 5 (0.02) | 55 (0.04) | 70 (0.03) |
| Stress | 0 | 2 (0.03) | 32 (0.14) | 0 | 4 (0.02) | 82 (0.05) | 121 (0.06) |
| Subarachnoid haemorrhage | 51 (1.30) | 67 (0.84) | 3 (0.01) | 0 | 45 (0.21) | 20 (0.01) | 196 (0.10) |
| Subdural haematoma | 7 (0.18) | 18 (0.23) | 2 (0.01) | 0 | 15 (0.07) | 8 (0.01) | 55 (0.03) |
| Sudden death | 182 (4.65) | 0 | 0 | 0 | 0 | 0 | 183 (0.09) |
| Sudden hearing loss | 0 | 0 | 37 (0.16) | 0 | 16 (0.07) | 87 (0.06) | 142 (0.07) |
| Suicidal ideation | 2 (0.05) | 16 (0.20) | 16 (0.07) | 0 | 5 (0.02) | 89 (0.06) | 133 (0.06) |
| Superficial vein thrombosis | 1 (0.03) | 24 (0.30) | 14 (0.06) | 0 | 76 (0.35) | 267 (0.18) | 392 (0.19) |
| Superior sagittal sinus thrombosis | 14 (0.36) | 24 (0.30) | 3 (0.01) | 0 | 19 (0.09) | 10 (0.01) | 74 (0.04) |
| Supraventricular tachycardia | 0 | 5 (0.06) | 7 (0.03) | 0 | 23 (0.11) | 23 (0.02) | 58 (0.03) |
| Sweating fever | 0 | 2 (0.03) | 76 (0.34) | 0 | 7 (0.03) | 535 (0.36) | 620 (0.30) |
| Swelling | 3 (0.08) | 50 (0.63) | 186 (0.82) | 1 (0.73) | 112 (0.52) | 1378 (0.92) | 1733 (0.84) |
| Swelling face | 1 (0.03) | 37 (0.46) | 76 (0.34) | 0 | 113 (0.52) | 641 (0.43) | 875 (0.43) |
| Swelling of eyelid | 0 | 3 (0.04) | 8 (0.04) | 0 | 12 (0.06) | 61 (0.04) | 84 (0.04) |
| Swollen tongue | 1 (0.03) | 55 (0.69) | 40 (0.18) | 0 | 61 (0.28) | 335 (0.22) | 495 (0.24) |
| Syncope | 48 (1.23) | 200 (2.50) | 245 (1.08) | 3 (2.19) | 511 (2.37) | 2014 (1.35) | 3067 (1.49) |
| Tachycardia | 21 (0.54) | 169 (2.12) | 240 (1.06) | 0 | 473 (2.20) | 1099 (0.73) | 2042 (0.99) |
| Tachypnoea | 9 (0.23) | 7 (0.09) | 8 (0.04) | 0 | 14 (0.07) | 21 (0.01) | 61 (0.03) |
| Taste disorder | 0 | 6 (0.08) | 60 (0.27) | 0 | 26 (0.12) | 304 (0.20) | 399 (0.19) |
| Tearfulness | 0 | 1 (0.01) | 18 (0.08) | 0 | 0 | 70 (0.05) | 89 (0.04) |
| Temperature intolerance | 0 | 0 | 9 (0.04) | 0 | 2 (0.01) | 65 (0.04) | 76 (0.04) |
| Tenderness | 4 (0.10) | 6 (0.08) | 91 (0.40) | 0 | 50 (0.23) | 1068 (0.71) | 1233 (0.60) |
| Tendonitis | 0 | 1 (0.01) | 37 (0.16) | 0 | 0 | 64 (0.04) | 102 (0.05) |
| Tension | 1 (0.03) | 4 (0.05) | 4 (0.02) | 0 | 1 (0.00) | 40 (0.03) | 52 (0.03) |
| Tension headache | 1 (0.03) | 10 (0.13) | 137 (0.61) | 0 | 52 (0.24) | 975 (0.65) | 1177 (0.57) |
| Testicular pain | 0 | 0 | 8 (0.04) | 0 | 2 (0.01) | 58 (0.04) | 68 (0.03) |
| Therapeutic response unexpected | 0 | 0 | 9 (0.04) | 0 | 3 (0.01) | 57 (0.04) | 70 (0.03) |
| Thirst | 1 (0.03) | 16 (0.20) | 118 (0.52) | 1 (0.73) | 22 (0.10) | 898 (0.60) | 1058 (0.51) |
| Throat irritation | 1 (0.03) | 13 (0.16) | 18 (0.08) | 0 | 35 (0.16) | 138 (0.09) | 206 (0.10) |
| Throat tightness | 0 | 24 (0.30) | 24 (0.11) | 0 | 43 (0.20) | 136 (0.09) | 228 (0.11) |
| Thrombocytopenia | 262 (6.70) | 571 (7.15) | 59 (0.26) | 0 | 1003 (4.66) | 692 (0.46) | 2850 (1.38) |
| Thrombophlebitis | 4 (0.10) | 30 (0.38) | 26 (0.11) | 0 | 46 (0.21) | 236 (0.16) | 349 (0.17) |
| Thrombosis | 194 (4.96) | 518 (6.48) | 180 (0.80) | 1 (0.73) | 667 (3.10) | 1189 (0.79) | 2846 (1.38) |
| Thrombosis in device | 2 (0.05) | 22 (0.28) | 2 (0.01) | 0 | 16 (0.07) | 18 (0.01) | 60 (0.03) |
| Thunderclap headache | 1 (0.03) | 2 (0.03) | 9 (0.04) | 0 | 17 (0.08) | 29 (0.02) | 58 (0.03) |
| Tinnitus | 1 (0.03) | 32 (0.40) | 582 (2.57) | 1 (0.73) | 147 (0.68) | 2190 (1.46) | 2964 (1.44) |
| Tongue oedema | 2 (0.05) | 11 (0.14) | 3 (0.01) | 0 | 20 (0.09) | 35 (0.02) | 73 (0.04) |
| Tonsillitis | 0 | 2 (0.03) | 9 (0.04) | 0 | 5 (0.02) | 57 (0.04) | 73 (0.04) |
| Toothache | 1 (0.03) | 1 (0.01) | 35 (0.15) | 0 | 10 (0.05) | 218 (0.15) | 265 (0.13) |
| Transient ischaemic attack | 7 (0.18) | 129 (1.61) | 49 (0.22) | 0 | 339 (1.57) | 332 (0.22) | 863 (0.42) |
| Tremor | 17 (0.43) | 119 (1.49) | 1052 (4.65) | 1 (0.73) | 336 (1.56) | 7195 (4.81) | 8735 (4.24) |
| Trigeminal neuralgia | 0 | 1 (0.01) | 35 (0.15) | 0 | 26 (0.12) | 94 (0.06) | 157 (0.08) |
| Troponin increased | 4 (0.10) | 4 (0.05) | 2 (0.01) | 0 | 30 (0.14) | 10 (0.01) | 75 (0.04) |
| Unresponsive to stimuli | 27 (0.69) | 16 (0.20) | 6 (0.03) | 0 | 26 (0.12) | 57 (0.04) | 144 (0.07) |
| Urinary incontinence | 3 (0.08) | 13 (0.16) | 33 (0.15) | 0 | 25 (0.12) | 71 (0.05) | 150 (0.07) |
| Urinary retention | 2 (0.05) | 12 (0.15) | 26 (0.11) | 0 | 29 (0.13) | 49 (0.03) | 124 (0.06) |
| Urinary tract infection | 11 (0.28) | 11 (0.14) | 25 (0.11) | 0 | 43 (0.20) | 166 (0.11) | 270 (0.13) |
| Urticaria | 1 (0.03) | 71 (0.89) | 129 (0.57) | 0 | 164 (0.76) | 1361 (0.91) | 1727 (0.84) |
| Uterine haemorrhage | 0 | 1 (0.01) | 3 (0.01) | 0 | 6 (0.03) | 42 (0.03) | 53 (0.03) |
| Vaccination complication | 3 (0.08) | 2 (0.03) | 15 (0.07) | 0 | 9 (0.04) | 80 (0.05) | 111 (0.05) |
| Vaccination failure | 27 (0.69) | 32 (0.40) | 1 (0.00) | 0 | 204 (0.95) | 3186 (2.13) | 3457 (1.68) |
| Vaccination site bruising | 0 | 1 (0.01) | 15 (0.07) | 0 | 4 (0.02) | 76 (0.05) | 97 (0.05) |
| Vaccination site erythema | 1 (0.03) | 7 (0.09) | 73 (0.32) | 0 | 28 (0.13) | 391 (0.26) | 500 (0.24) |
| Vaccination site induration | 0 | 0 | 13 (0.06) | 0 | 2 (0.01) | 51 (0.03) | 66 (0.03) |
| Vaccination site inflammation | 0 | 2 (0.03) | 8 (0.04) | 0 | 6 (0.03) | 59 (0.04) | 75 (0.04) |
| Vaccination site mass | 0 | 2 (0.03) | 33 (0.15) | 0 | 7 (0.03) | 265 (0.18) | 309 (0.15) |
| Vaccination site movement impairment | 0 | 1 (0.01) | 54 (0.24) | 0 | 18 (0.08) | 71 (0.05) | 144 (0.07) |
| Vaccination site oedema | 0 | 2 (0.03) | 24 (0.11) | 0 | 2 (0.01) | 43 (0.03) | 71 (0.03) |
| Vaccination site pain | 10 (0.26) | 22 (0.28) | 385 (1.70) | 0 | 137 (0.64) | 1783 (1.19) | 2343 (1.14) |
| Vaccination site pruritus | 0 | 1 (0.01) | 23 (0.10) | 0 | 10 (0.05) | 85 (0.06) | 119 (0.06) |
| Vaccination site rash | 1 (0.03) | 0 | 9 (0.04) | 0 | 4 (0.02) | 98 (0.07) | 112 (0.05) |
| Vaccination site reaction | 1 (0.03) | 2 (0.03) | 32 (0.14) | 0 | 19 (0.09) | 78 (0.05) | 134 (0.07) |
| Vaccination site swelling | 0 | 4 (0.05) | 80 (0.35) | 0 | 31 (0.14) | 300 (0.20) | 417 (0.20) |
| Vaccination site warmth | 0 | 1 (0.01) | 37 (0.16) | 0 | 5 (0.02) | 224 (0.15) | 267 (0.13) |
| Vaginal discharge | 0 | 1 (0.01) | 6 (0.03) | 0 | 5 (0.02) | 40 (0.03) | 52 (0.03) |
| Vaginal haemorrhage | 0 | 16 (0.20) | 46 (0.20) | 5 (3.65) | 47 (0.22) | 648 (0.43) | 764 (0.37) |
| Varicose vein | 0 | 8 (0.10) | 11 (0.05) | 0 | 8 (0.04) | 96 (0.06) | 124 (0.06) |
| Vascular headache | 0 | 3 (0.04) | 19 (0.08) | 0 | 3 (0.01) | 47 (0.03) | 73 (0.04) |
| Vascular pain | 0 | 7 (0.09) | 14 (0.06) | 0 | 9 (0.04) | 104 (0.07) | 135 (0.07) |
| Vasculitis | 8 (0.20) | 24 (0.30) | 16 (0.07) | 0 | 35 (0.16) | 98 (0.07) | 189 (0.09) |
| Vasodilatation | 0 | 5 (0.06) | 18 (0.08) | 1 (0.73) | 9 (0.04) | 86 (0.06) | 120 (0.06) |
| Venous thrombosis | 9 (0.23) | 41 (0.51) | 11 (0.05) | 0 | 63 (0.29) | 105 (0.07) | 238 (0.12) |
| Venous thrombosis limb | 5 (0.13) | 32 (0.40) | 5 (0.02) | 0 | 59 (0.27) | 119 (0.08) | 221 (0.11) |
| Vertigo | 1 (0.03) | 56 (0.70) | 477 (2.11) | 0 | 268 (1.24) | 1562 (1.04) | 2381 (1.16) |
| Vertigo positional | 0 | 1 (0.01) | 25 (0.11) | 0 | 26 (0.12) | 96 (0.06) | 149 (0.07) |
| Vestibular neuronitis | 0 | 1 (0.01) | 19 (0.08) | 0 | 36 (0.17) | 30 (0.02) | 86 (0.04) |
| Viral infection | 3 (0.08) | 3 (0.04) | 22 (0.10) | 0 | 14 (0.07) | 39 (0.03) | 83 (0.04) |
| Vision blurred | 11 (0.28) | 86 (1.08) | 493 (2.18) | 0 | 277 (1.29) | 1911 (1.28) | 2803 (1.36) |
| Visual acuity reduced | 0 | 3 (0.04) | 16 (0.07) | 0 | 7 (0.03) | 46 (0.03) | 73 (0.04) |
| Visual field defect | 1 (0.03) | 5 (0.06) | 18 (0.08) | 0 | 18 (0.08) | 36 (0.02) | 80 (0.04) |
| Visual impairment | 9 (0.23) | 44 (0.55) | 221 (0.98) | 0 | 218 (1.01) | 541 (0.36) | 1061 (0.52) |
| Vitreous detachment | 0 | 0 | 9 (0.04) | 0 | 3 (0.01) | 55 (0.04) | 67 (0.03) |
| Vitreous floaters | 1 (0.03) | 0 | 31 (0.14) | 0 | 11 (0.05) | 127 (0.08) | 170 (0.08) |
| Vomiting | 156 (3.99) | 273 (3.42) | 1386 (6.12) | 0 | 966 (4.49) | 8228 (5.50) | 11084 (5.39) |
| Vomiting projectile | 2 (0.05) | 1 (0.01) | 32 (0.14) | 0 | 8 (0.04) | 95 (0.06) | 138 (0.07) |
| Weight decreased | 4 (0.10) | 14 (0.18) | 69 (0.30) | 0 | 43 (0.20) | 140 (0.09) | 275 (0.13) |
| Weight increased | 0 | 1 (0.01) | 13 (0.06) | 0 | 7 (0.03) | 40 (0.03) | 61 (0.03) |
| Wheezing | 3 (0.08) | 41 (0.51) | 64 (0.28) | 0 | 41 (0.19) | 379 (0.25) | 536 (0.26) |
| Withdrawal syndrome | 0 | 1 (0.01) | 5 (0.02) | 0 | 2 (0.01) | 55 (0.04) | 63 (0.03) |
| Yawning | 0 | 1 (0.01) | 7 (0.03) | 0 | 0 | 44 (0.03) | 53 (0.03) |