Eudravigilance C-19 - Astrazeneca

Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)

PT

Décès

3913 (%)

Mise en jeu du pronostic vital

7988 (%)

Invalidité ou incapacité

22634 (%)

Anomalies congénitales

137 (%)

Hospitalisation

21534 (%)

Médicalement significatif

149600 (%)

Cas Graves

205806 (%)

Abdominal discomfort 7 (0.18) 15 (0.19) 158 (0.70) 0 46 (0.21) 1061 (0.71) 1293 (0.63)
Abdominal distension 6 (0.15) 10 (0.13) 87 (0.38) 1 (0.73) 32 (0.15) 393 (0.26) 531 (0.26)
Abdominal pain 77 (1.97) 139 (1.74) 587 (2.59) 1 (0.73) 417 (1.94) 3046 (2.04) 4318 (2.10)
Abdominal pain lower 0 7 (0.09) 28 (0.12) 0 50 (0.23) 179 (0.12) 265 (0.13)
Abdominal pain upper 21 (0.54) 64 (0.80) 546 (2.41) 2 (1.46) 237 (1.10) 3627 (2.42) 4512 (2.19)
Abdominal rigidity 2 (0.05) 1 (0.01) 11 (0.05) 0 2 (0.01) 37 (0.02) 53 (0.03)
Abnormal dreams 1 (0.03) 3 (0.04) 28 (0.12) 0 4 (0.02) 236 (0.16) 272 (0.13)
Abnormal loss of weight 1 (0.03) 6 (0.08) 22 (0.10) 0 6 (0.03) 36 (0.02) 72 (0.03)
Abortion spontaneous 3 (0.08) 11 (0.14) 19 (0.08) 66 (48.18) 33 (0.15) 152 (0.10) 286 (0.14)
Acne 1 (0.03) 3 (0.04) 7 (0.03) 0 4 (0.02) 76 (0.05) 92 (0.04)
Activated partial thromboplastin time prolonged 3 (0.08) 45 (0.56) 7 (0.03) 0 28 (0.13) 45 (0.03) 129 (0.06)
Acute coronary syndrome 23 (0.59) 23 (0.29) 0 0 58 (0.27) 3 (0.00) 108 (0.05)
Acute kidney injury 27 (0.69) 33 (0.41) 8 (0.04) 0 68 (0.32) 26 (0.02) 172 (0.08)
Acute myocardial infarction 84 (2.15) 122 (1.53) 2 (0.01) 0 121 (0.56) 22 (0.01) 363 (0.18)
Acute respiratory distress syndrome 16 (0.41) 10 (0.13) 0 0 22 (0.10) 14 (0.01) 65 (0.03)
Acute respiratory failure 23 (0.59) 9 (0.11) 0 0 16 (0.07) 1 (0.00) 51 (0.02)
Administration site pain 0 20 (0.25) 18 (0.08) 1 (0.73) 6 (0.03) 29 (0.02) 75 (0.04)
Adverse drug reaction 0 3 (0.04) 17 (0.08) 0 4 (0.02) 80 (0.05) 104 (0.05)
Adverse event following immunisation 106 (2.71) 0 0 0 0 0 106 (0.05)
Ageusia 8 (0.20) 13 (0.16) 158 (0.70) 0 70 (0.33) 653 (0.44) 905 (0.44)
Agitation 12 (0.31) 18 (0.23) 34 (0.15) 0 17 (0.08) 120 (0.08) 210 (0.10)
Allergy to vaccine 0 6 (0.08) 3 (0.01) 0 3 (0.01) 40 (0.03) 52 (0.03)
Alopecia 0 10 (0.13) 44 (0.19) 1 (0.73) 7 (0.03) 242 (0.16) 305 (0.15)
Altered state of consciousness 11 (0.28) 4 (0.05) 4 (0.02) 0 16 (0.07) 21 (0.01) 64 (0.03)
Amenorrhoea 0 7 (0.09) 35 (0.15) 2 (1.46) 9 (0.04) 250 (0.17) 303 (0.15)
Amnesia 2 (0.05) 45 (0.56) 119 (0.53) 0 86 (0.40) 226 (0.15) 482 (0.23)
Anaemia 12 (0.31) 28 (0.35) 28 (0.12) 0 59 (0.27) 99 (0.07) 234 (0.11)
Anaphylactic reaction 9 (0.23) 344 (4.31) 23 (0.10) 0 238 (1.11) 525 (0.35) 1155 (0.56)
Anaphylactic shock 7 (0.18) 64 (0.80) 12 (0.05) 0 56 (0.26) 95 (0.06) 239 (0.12)
Anaphylactoid reaction 0 6 (0.08) 2 (0.01) 0 7 (0.03) 58 (0.04) 73 (0.04)
Anger 2 (0.05) 6 (0.08) 10 (0.04) 0 1 (0.00) 50 (0.03) 70 (0.03)
Angina pectoris 4 (0.10) 44 (0.55) 41 (0.18) 1 (0.73) 85 (0.39) 159 (0.11) 345 (0.17)
Angioedema 0 41 (0.51) 21 (0.09) 0 54 (0.25) 391 (0.26) 519 (0.25)
Anosmia 7 (0.18) 7 (0.09) 62 (0.27) 0 48 (0.22) 198 (0.13) 326 (0.16)
Anxiety 3 (0.08) 40 (0.50) 218 (0.96) 0 130 (0.60) 798 (0.53) 1192 (0.58)
Aortic thrombosis 11 (0.28) 16 (0.20) 0 0 18 (0.08) 2 (0.00) 54 (0.03)
Apathy 0 1 (0.01) 24 (0.11) 0 11 (0.05) 45 (0.03) 83 (0.04)
Aphasia 23 (0.59) 63 (0.79) 48 (0.21) 0 95 (0.44) 159 (0.11) 425 (0.21)
Aphonia 1 (0.03) 5 (0.06) 14 (0.06) 0 9 (0.04) 67 (0.04) 97 (0.05)
Aphthous ulcer 1 (0.03) 1 (0.01) 5 (0.02) 0 3 (0.01) 45 (0.03) 55 (0.03)
Appendicitis 2 (0.05) 15 (0.19) 3 (0.01) 0 40 (0.19) 18 (0.01) 78 (0.04)
Application site pain 1 (0.03) 2 (0.03) 4 (0.02) 0 9 (0.04) 68 (0.05) 87 (0.04)
Areflexia 1 (0.03) 10 (0.13) 16 (0.07) 0 21 (0.10) 1 (0.00) 53 (0.03)
Arrhythmia 8 (0.20) 35 (0.44) 40 (0.18) 0 182 (0.85) 341 (0.23) 618 (0.30)
Arterial thrombosis 11 (0.28) 22 (0.28) 6 (0.03) 0 17 (0.08) 20 (0.01) 84 (0.04)
Arthralgia 35 (0.89) 181 (2.27) 4041 (17.85) 3 (2.19) 605 (2.81) 16196 (10.83) 21108 (10.26)
Arthritis 0 5 (0.06) 151 (0.67) 0 29 (0.13) 344 (0.23) 532 (0.26)
Arthritis reactive 0 1 (0.01) 24 (0.11) 0 8 (0.04) 27 (0.02) 60 (0.03)
Asthenia 100 (2.56) 170 (2.13) 1039 (4.59) 1 (0.73) 738 (3.43) 3892 (2.60) 6011 (2.92)
Asthenopia 0 3 (0.04) 46 (0.20) 0 10 (0.05) 217 (0.15) 276 (0.13)
Asthma 1 (0.03) 35 (0.44) 94 (0.42) 0 51 (0.24) 408 (0.27) 592 (0.29)
Ataxia 1 (0.03) 12 (0.15) 19 (0.08) 0 40 (0.19) 19 (0.01) 98 (0.05)
Atrial fibrillation 16 (0.41) 86 (1.08) 35 (0.15) 0 210 (0.98) 243 (0.16) 606 (0.29)
Atrial flutter 0 5 (0.06) 5 (0.02) 0 19 (0.09) 24 (0.02) 56 (0.03)
Autoimmune disorder 1 (0.03) 9 (0.11) 22 (0.10) 0 20 (0.09) 37 (0.02) 91 (0.04)
Axillary pain 0 0 57 (0.25) 0 15 (0.07) 450 (0.30) 524 (0.25)
Back pain 26 (0.66) 86 (1.08) 766 (3.38) 2 (1.46) 296 (1.37) 3878 (2.59) 5073 (2.46)
Balance disorder 6 (0.15) 47 (0.59) 266 (1.18) 0 136 (0.63) 569 (0.38) 1041 (0.51)
Bedridden 2 (0.05) 4 (0.05) 55 (0.24) 0 9 (0.04) 95 (0.06) 172 (0.08)
Bell's palsy 1 (0.03) 13 (0.16) 135 (0.60) 0 139 (0.65) 373 (0.25) 664 (0.32)
Bladder pain 0 1 (0.01) 8 (0.04) 0 4 (0.02) 41 (0.03) 55 (0.03)
Blepharospasm 0 1 (0.01) 20 (0.09) 0 6 (0.03) 55 (0.04) 82 (0.04)
Blindness 2 (0.05) 31 (0.39) 126 (0.56) 0 52 (0.24) 197 (0.13) 423 (0.21)
Blindness transient 0 4 (0.05) 8 (0.04) 0 10 (0.05) 44 (0.03) 69 (0.03)
Blindness unilateral 1 (0.03) 9 (0.11) 40 (0.18) 0 17 (0.08) 35 (0.02) 105 (0.05)
Blister 1 (0.03) 15 (0.19) 48 (0.21) 0 23 (0.11) 323 (0.22) 417 (0.20)
Blood blister 0 3 (0.04) 10 (0.04) 0 6 (0.03) 53 (0.04) 74 (0.04)
Blood glucose increased 1 (0.03) 7 (0.09) 17 (0.08) 0 17 (0.08) 127 (0.08) 174 (0.08)
Blood pressure decreased 7 (0.18) 23 (0.29) 36 (0.16) 0 48 (0.22) 102 (0.07) 219 (0.11)
Blood pressure fluctuation 1 (0.03) 16 (0.20) 15 (0.07) 0 20 (0.09) 39 (0.03) 97 (0.05)
Blood pressure increased 9 (0.23) 84 (1.05) 87 (0.38) 0 198 (0.92) 335 (0.22) 726 (0.35)
Blood pressure measurement 0 8 (0.10) 12 (0.05) 0 16 (0.07) 64 (0.04) 100 (0.05)
Blood test abnormal 0 5 (0.06) 23 (0.10) 0 28 (0.13) 37 (0.02) 94 (0.05)
Blood urine present 1 (0.03) 4 (0.05) 4 (0.02) 0 8 (0.04) 60 (0.04) 81 (0.04)
Body temperature 0 1 (0.01) 69 (0.30) 0 11 (0.05) 674 (0.45) 756 (0.37)
Body temperature abnormal 0 1 (0.01) 7 (0.03) 0 3 (0.01) 49 (0.03) 60 (0.03)
Body temperature decreased 1 (0.03) 3 (0.04) 17 (0.08) 0 5 (0.02) 98 (0.07) 125 (0.06)
Body temperature fluctuation 0 3 (0.04) 27 (0.12) 0 1 (0.00) 124 (0.08) 155 (0.08)
Body temperature increased 5 (0.13) 14 (0.18) 96 (0.42) 1 (0.73) 83 (0.39) 811 (0.54) 1010 (0.49)
Bone pain 1 (0.03) 27 (0.34) 218 (0.96) 0 32 (0.15) 764 (0.51) 1045 (0.51)
Bradycardia 10 (0.26) 17 (0.21) 16 (0.07) 0 33 (0.15) 53 (0.04) 141 (0.07)
Bradyphrenia 0 1 (0.01) 17 (0.08) 0 6 (0.03) 62 (0.04) 86 (0.04)
Brain injury 15 (0.38) 16 (0.20) 5 (0.02) 0 6 (0.03) 7 (0.00) 58 (0.03)
Brain oedema 38 (0.97) 15 (0.19) 3 (0.01) 0 8 (0.04) 12 (0.01) 80 (0.04)
Breast mass 0 1 (0.01) 4 (0.02) 0 7 (0.03) 39 (0.03) 51 (0.02)
Breast pain 0 0 38 (0.17) 1 (0.73) 29 (0.13) 272 (0.18) 341 (0.17)
Burning sensation 0 28 (0.35) 158 (0.70) 2 (1.46) 63 (0.29) 600 (0.40) 859 (0.42)
Bursitis 0 2 (0.03) 72 (0.32) 0 9 (0.04) 110 (0.07) 193 (0.09)
C-reactive protein increased 6 (0.15) 11 (0.14) 17 (0.08) 0 59 (0.27) 40 (0.03) 145 (0.07)
COVID-19 166 (4.24) 126 (1.58) 125 (0.55) 2 (1.46) 493 (2.29) 3437 (2.30) 4368 (2.12)
COVID-19 immunisation 2 (0.05) 7 (0.09) 43 (0.19) 0 26 (0.12) 127 (0.08) 206 (0.10)
COVID-19 pneumonia 51 (1.30) 28 (0.35) 13 (0.06) 0 114 (0.53) 23 (0.02) 229 (0.11)
Candida infection 1 (0.03) 1 (0.01) 6 (0.03) 0 2 (0.01) 43 (0.03) 53 (0.03)
Cardiac arrest 225 (5.75) 82 (1.03) 4 (0.02) 0 14 (0.07) 41 (0.03) 383 (0.19)
Cardiac disorder 4 (0.10) 24 (0.30) 10 (0.04) 0 44 (0.20) 32 (0.02) 117 (0.06)
Cardiac failure 59 (1.51) 53 (0.66) 15 (0.07) 0 73 (0.34) 24 (0.02) 233 (0.11)
Cardiac flutter 0 7 (0.09) 25 (0.11) 0 12 (0.06) 156 (0.10) 200 (0.10)
Cardio-respiratory arrest 56 (1.43) 17 (0.21) 0 0 5 (0.02) 3 (0.00) 84 (0.04)
Cardiovascular disorder 17 (0.43) 8 (0.10) 47 (0.21) 0 46 (0.21) 31 (0.02) 152 (0.07)
Cellulitis 2 (0.05) 12 (0.15) 35 (0.15) 0 51 (0.24) 280 (0.19) 383 (0.19)
Cerebral haemorrhage 185 (4.73) 134 (1.68) 24 (0.11) 0 102 (0.47) 44 (0.03) 513 (0.25)
Cerebral infarction 39 (1.00) 104 (1.30) 33 (0.15) 0 163 (0.76) 49 (0.03) 402 (0.20)
Cerebral ischaemia 7 (0.18) 13 (0.16) 5 (0.02) 0 25 (0.12) 11 (0.01) 65 (0.03)
Cerebral thrombosis 48 (1.23) 34 (0.43) 5 (0.02) 0 64 (0.30) 40 (0.03) 203 (0.10)
Cerebral venous sinus thrombosis 97 (2.48) 223 (2.79) 20 (0.09) 0 227 (1.05) 65 (0.04) 648 (0.31)
Cerebral venous thrombosis 41 (1.05) 53 (0.66) 4 (0.02) 0 68 (0.32) 35 (0.02) 212 (0.10)
Cerebrovascular accident 162 (4.14) 489 (6.12) 231 (1.02) 3 (2.19) 671 (3.12) 526 (0.35) 2136 (1.04)
Chest discomfort 11 (0.28) 78 (0.98) 279 (1.23) 0 307 (1.43) 1353 (0.90) 2055 (1.00)
Chest pain 88 (2.25) 418 (5.23) 765 (3.38) 1 (0.73) 982 (4.56) 3368 (2.25) 5710 (2.77)
Chills 54 (1.38) 365 (4.57) 5627 (24.86) 7 (5.11) 1238 (5.75) 31588 (21.11) 38936 (18.92)
Chromaturia 3 (0.08) 4 (0.05) 9 (0.04) 0 6 (0.03) 73 (0.05) 97 (0.05)
Chronic fatigue syndrome 0 1 (0.01) 80 (0.35) 0 8 (0.04) 60 (0.04) 150 (0.07)
Chronic obstructive pulmonary disease 16 (0.41) 9 (0.11) 6 (0.03) 0 18 (0.08) 20 (0.01) 70 (0.03)
Circulatory collapse 62 (1.58) 47 (0.59) 15 (0.07) 0 74 (0.34) 114 (0.08) 333 (0.16)
Clumsiness 0 1 (0.01) 16 (0.07) 0 5 (0.02) 28 (0.02) 51 (0.02)
Cluster headache 3 (0.08) 10 (0.13) 89 (0.39) 0 23 (0.11) 486 (0.32) 611 (0.30)
Coagulopathy 22 (0.56) 40 (0.50) 31 (0.14) 1 (0.73) 48 (0.22) 66 (0.04) 215 (0.10)
Cognitive disorder 4 (0.10) 9 (0.11) 89 (0.39) 0 20 (0.09) 101 (0.07) 231 (0.11)
Cold sweat 11 (0.28) 31 (0.39) 180 (0.80) 1 (0.73) 67 (0.31) 1141 (0.76) 1438 (0.70)
Cold-stimulus headache 0 3 (0.04) 14 (0.06) 0 4 (0.02) 54 (0.04) 75 (0.04)
Colitis 1 (0.03) 3 (0.04) 7 (0.03) 0 24 (0.11) 39 (0.03) 74 (0.04)
Colitis ulcerative 0 3 (0.04) 14 (0.06) 0 15 (0.07) 68 (0.05) 100 (0.05)
Coma 26 (0.66) 31 (0.39) 3 (0.01) 0 10 (0.05) 3 (0.00) 90 (0.04)
Condition aggravated 14 (0.36) 16 (0.20) 132 (0.58) 0 57 (0.26) 282 (0.19) 506 (0.25)
Confusional state 52 (1.33) 140 (1.75) 404 (1.78) 1 (0.73) 252 (1.17) 1292 (0.86) 2172 (1.06)
Conjunctival haemorrhage 0 2 (0.03) 8 (0.04) 0 7 (0.03) 80 (0.05) 98 (0.05)
Conjunctivitis 1 (0.03) 0 7 (0.03) 0 4 (0.02) 50 (0.03) 62 (0.03)
Constipation 3 (0.08) 15 (0.19) 80 (0.35) 0 33 (0.15) 266 (0.18) 399 (0.19)
Contusion 18 (0.46) 76 (0.95) 209 (0.92) 0 173 (0.80) 1553 (1.04) 2051 (1.00)
Coordination abnormal 5 (0.13) 5 (0.06) 28 (0.12) 0 18 (0.08) 80 (0.05) 140 (0.07)
Coronary artery thrombosis 14 (0.36) 23 (0.29) 0 0 11 (0.05) 6 (0.00) 58 (0.03)
Costochondritis 0 1 (0.01) 16 (0.07) 0 10 (0.05) 51 (0.03) 78 (0.04)
Cough 149 (3.81) 137 (1.72) 475 (2.10) 1 (0.73) 501 (2.33) 2466 (1.65) 3769 (1.83)
Crohn's disease 0 1 (0.01) 25 (0.11) 0 11 (0.05) 54 (0.04) 91 (0.04)
Crying 1 (0.03) 7 (0.09) 47 (0.21) 0 10 (0.05) 199 (0.13) 264 (0.13)
Cutaneous vasculitis 0 0 0 0 23 (0.11) 43 (0.03) 67 (0.03)
Cyanosis 17 (0.43) 16 (0.20) 17 (0.08) 0 70 (0.33) 83 (0.06) 209 (0.10)
Cystitis 1 (0.03) 1 (0.01) 10 (0.04) 0 9 (0.04) 78 (0.05) 99 (0.05)
Deafness 1 (0.03) 8 (0.10) 144 (0.64) 0 26 (0.12) 266 (0.18) 447 (0.22)
Deafness neurosensory 1 (0.03) 1 (0.01) 28 (0.12) 0 1 (0.00) 19 (0.01) 52 (0.03)
Deafness unilateral 0 1 (0.01) 36 (0.16) 0 8 (0.04) 54 (0.04) 99 (0.05)
Death 687 (17.56) 2 (0.03) 0 0 0 2 (0.00) 692 (0.34)
Decreased appetite 63 (1.61) 69 (0.86) 825 (3.64) 1 (0.73) 240 (1.11) 4697 (3.14) 5928 (2.88)
Deep vein thrombosis 68 (1.74) 485 (6.07) 104 (0.46) 0 1029 (4.78) 1818 (1.22) 3614 (1.76)
Dehydration 3 (0.08) 14 (0.18) 74 (0.33) 0 84 (0.39) 416 (0.28) 597 (0.29)
Delirium 9 (0.23) 15 (0.19) 79 (0.35) 0 43 (0.20) 322 (0.22) 473 (0.23)
Delusion 3 (0.08) 2 (0.03) 14 (0.06) 0 8 (0.04) 35 (0.02) 63 (0.03)
Demyelination 1 (0.03) 4 (0.05) 16 (0.07) 0 14 (0.07) 17 (0.01) 54 (0.03)
Depressed level of consciousness 22 (0.56) 19 (0.24) 13 (0.06) 0 34 (0.16) 55 (0.04) 154 (0.07)
Depressed mood 1 (0.03) 9 (0.11) 100 (0.44) 0 11 (0.05) 461 (0.31) 583 (0.28)
Depression 4 (0.10) 24 (0.30) 137 (0.61) 0 21 (0.10) 418 (0.28) 609 (0.30)
Dermatitis 0 2 (0.03) 11 (0.05) 0 8 (0.04) 98 (0.07) 120 (0.06)
Dermatitis allergic 0 9 (0.11) 18 (0.08) 0 7 (0.03) 169 (0.11) 204 (0.10)
Diabetes mellitus 1 (0.03) 10 (0.13) 15 (0.07) 0 17 (0.08) 72 (0.05) 117 (0.06)
Diarrhoea 76 (1.94) 120 (1.50) 979 (4.33) 0 452 (2.10) 6069 (4.06) 7732 (3.76)
Diplegia 1 (0.03) 6 (0.08) 23 (0.10) 0 15 (0.07) 34 (0.02) 83 (0.04)
Diplopia 1 (0.03) 22 (0.28) 94 (0.42) 0 107 (0.50) 211 (0.14) 440 (0.21)
Discomfort 3 (0.08) 16 (0.20) 87 (0.38) 1 (0.73) 46 (0.21) 367 (0.25) 527 (0.26)
Disorientation 10 (0.26) 13 (0.16) 109 (0.48) 0 81 (0.38) 505 (0.34) 730 (0.35)
Disseminated intravascular coagulation 28 (0.72) 26 (0.33) 1 (0.00) 0 15 (0.07) 2 (0.00) 75 (0.04)
Dissociation 0 2 (0.03) 10 (0.04) 0 3 (0.01) 44 (0.03) 59 (0.03)
Disturbance in attention 1 (0.03) 23 (0.29) 200 (0.88) 0 107 (0.50) 503 (0.34) 842 (0.41)
Diverticulitis 3 (0.08) 4 (0.05) 6 (0.03) 0 18 (0.08) 23 (0.02) 54 (0.03)
Dizziness 69 (1.76) 396 (4.96) 2693 (11.90) 4 (2.92) 1538 (7.14) 15205 (10.16) 19991 (9.71)
Dizziness exertional 0 1 (0.01) 14 (0.06) 0 1 (0.00) 77 (0.05) 93 (0.05)
Dizziness postural 1 (0.03) 7 (0.09) 216 (0.95) 0 52 (0.24) 1467 (0.98) 1744 (0.85)
Drug hypersensitivity 0 7 (0.09) 5 (0.02) 0 4 (0.02) 36 (0.02) 52 (0.03)
Drug ineffective 13 (0.33) 13 (0.16) 18 (0.08) 0 43 (0.20) 130 (0.09) 221 (0.11)
Dry eye 0 1 (0.01) 37 (0.16) 0 14 (0.07) 188 (0.13) 240 (0.12)
Dry mouth 0 10 (0.13) 114 (0.50) 0 43 (0.20) 720 (0.48) 890 (0.43)
Dry skin 0 1 (0.01) 33 (0.15) 0 11 (0.05) 219 (0.15) 264 (0.13)
Dry throat 1 (0.03) 4 (0.05) 23 (0.10) 0 6 (0.03) 153 (0.10) 187 (0.09)
Dysaesthesia 0 2 (0.03) 7 (0.03) 0 22 (0.10) 44 (0.03) 78 (0.04)
Dysarthria 24 (0.61) 68 (0.85) 88 (0.39) 0 156 (0.72) 230 (0.15) 586 (0.28)
Dysgeusia 3 (0.08) 13 (0.16) 147 (0.65) 1 (0.73) 28 (0.13) 1035 (0.69) 1232 (0.60)
Dyskinesia 2 (0.05) 4 (0.05) 25 (0.11) 0 18 (0.08) 76 (0.05) 132 (0.06)
Dysmenorrhoea 0 2 (0.03) 92 (0.41) 1 (0.73) 23 (0.11) 819 (0.55) 939 (0.46)
Dyspepsia 4 (0.10) 19 (0.24) 88 (0.39) 0 31 (0.14) 544 (0.36) 690 (0.34)
Dysphagia 14 (0.36) 39 (0.49) 43 (0.19) 1 (0.73) 70 (0.33) 167 (0.11) 352 (0.17)
Dysphonia 1 (0.03) 19 (0.24) 40 (0.18) 0 25 (0.12) 100 (0.07) 187 (0.09)
Dyspnoea 369 (9.43) 772 (9.66) 1155 (5.10) 1 (0.73) 1741 (8.08) 4703 (3.14) 8935 (4.34)
Dyspnoea exertional 5 (0.13) 17 (0.21) 31 (0.14) 0 66 (0.31) 65 (0.04) 193 (0.09)
Dysstasia 0 10 (0.13) 48 (0.21) 0 18 (0.08) 76 (0.05) 157 (0.08)
Dysuria 2 (0.05) 3 (0.04) 13 (0.06) 0 18 (0.08) 64 (0.04) 103 (0.05)
Ear discomfort 0 2 (0.03) 24 (0.11) 0 18 (0.08) 75 (0.05) 122 (0.06)
Ear infection 1 (0.03) 4 (0.05) 21 (0.09) 0 7 (0.03) 100 (0.07) 134 (0.07)
Ear pain 0 13 (0.16) 253 (1.12) 0 63 (0.29) 1390 (0.93) 1723 (0.84)
Ear swelling 0 1 (0.01) 2 (0.01) 0 8 (0.04) 47 (0.03) 58 (0.03)
Ecchymosis 0 8 (0.10) 6 (0.03) 0 35 (0.16) 49 (0.03) 105 (0.05)
Eczema 0 6 (0.08) 25 (0.11) 0 15 (0.07) 183 (0.12) 229 (0.11)
Electric shock sensation 1 (0.03) 2 (0.03) 20 (0.09) 0 7 (0.03) 71 (0.05) 101 (0.05)
Embolism 31 (0.79) 97 (1.21) 28 (0.12) 0 70 (0.33) 109 (0.07) 341 (0.17)
Emotional disorder 0 0 15 (0.07) 0 2 (0.01) 66 (0.04) 83 (0.04)
Emotional distress 0 6 (0.08) 20 (0.09) 0 4 (0.02) 54 (0.04) 86 (0.04)
Encephalitis 4 (0.10) 35 (0.44) 11 (0.05) 0 59 (0.27) 18 (0.01) 129 (0.06)
Endometriosis 0 0 8 (0.04) 0 6 (0.03) 49 (0.03) 63 (0.03)
Enuresis 0 2 (0.03) 8 (0.04) 0 2 (0.01) 40 (0.03) 52 (0.03)
Epilepsy 5 (0.13) 52 (0.65) 46 (0.20) 0 124 (0.58) 193 (0.13) 426 (0.21)
Epistaxis 12 (0.31) 76 (0.95) 138 (0.61) 0 180 (0.84) 1149 (0.77) 1565 (0.76)
Erectile dysfunction 1 (0.03) 6 (0.08) 25 (0.11) 0 5 (0.02) 39 (0.03) 76 (0.04)
Eructation 1 (0.03) 5 (0.06) 17 (0.08) 0 3 (0.01) 65 (0.04) 91 (0.04)
Erythema 5 (0.13) 58 (0.73) 156 (0.69) 2 (1.46) 157 (0.73) 1627 (1.09) 2023 (0.98)
Erythema multiforme 0 4 (0.05) 1 (0.00) 0 10 (0.05) 37 (0.02) 52 (0.03)
Exercise tolerance decreased 0 7 (0.09) 19 (0.08) 0 22 (0.10) 36 (0.02) 92 (0.04)
Exposure during pregnancy 3 (0.08) 3 (0.04) 2 (0.01) 4 (2.92) 12 (0.06) 35 (0.02) 64 (0.03)
Exposure via breast milk 0 1 (0.01) 4 (0.02) 0 0 50 (0.03) 55 (0.03)
Extensive swelling of vaccinated limb 0 4 (0.05) 175 (0.77) 0 6 (0.03) 37 (0.02) 223 (0.11)
Extrasystoles 1 (0.03) 7 (0.09) 23 (0.10) 1 (0.73) 19 (0.09) 123 (0.08) 176 (0.09)
Eye haemorrhage 0 1 (0.01) 21 (0.09) 0 15 (0.07) 84 (0.06) 124 (0.06)
Eye injury 0 5 (0.06) 19 (0.08) 0 4 (0.02) 24 (0.02) 52 (0.03)
Eye irritation 0 5 (0.06) 33 (0.15) 0 10 (0.05) 141 (0.09) 190 (0.09)
Eye movement disorder 0 6 (0.08) 11 (0.05) 0 9 (0.04) 32 (0.02) 60 (0.03)
Eye pain 1 (0.03) 35 (0.44) 432 (1.91) 0 96 (0.45) 2183 (1.46) 2753 (1.34)
Eye pruritus 0 9 (0.11) 22 (0.10) 0 12 (0.06) 164 (0.11) 208 (0.10)
Eye swelling 0 14 (0.18) 45 (0.20) 0 26 (0.12) 348 (0.23) 434 (0.21)
Eyelid oedema 1 (0.03) 0 6 (0.03) 0 13 (0.06) 33 (0.02) 54 (0.03)
Eyelid ptosis 1 (0.03) 5 (0.06) 14 (0.06) 0 17 (0.08) 37 (0.02) 77 (0.04)
Face oedema 0 11 (0.14) 9 (0.04) 0 19 (0.09) 65 (0.04) 105 (0.05)
Facial pain 0 4 (0.05) 55 (0.24) 0 15 (0.07) 182 (0.12) 258 (0.13)
Facial paralysis 12 (0.31) 43 (0.54) 110 (0.49) 0 182 (0.85) 298 (0.20) 675 (0.33)
Facial paresis 3 (0.08) 25 (0.31) 45 (0.20) 0 97 (0.45) 97 (0.06) 275 (0.13)
Fall 24 (0.61) 45 (0.56) 52 (0.23) 0 105 (0.49) 178 (0.12) 423 (0.21)
Fatigue 116 (2.96) 427 (5.35) 7576 (33.47) 5 (3.65) 1435 (6.66) 34570 (23.11) 44230 (21.49)
Fear 0 5 (0.06) 17 (0.08) 0 5 (0.02) 35 (0.02) 63 (0.03)
Febrile convulsion 2 (0.05) 4 (0.05) 14 (0.06) 0 19 (0.09) 93 (0.06) 134 (0.07)
Feeding disorder 3 (0.08) 6 (0.08) 49 (0.22) 0 11 (0.05) 145 (0.10) 216 (0.10)
Feeling abnormal 14 (0.36) 54 (0.68) 401 (1.77) 0 110 (0.51) 2047 (1.37) 2642 (1.28)
Feeling cold 6 (0.15) 41 (0.51) 453 (2.00) 0 124 (0.58) 3680 (2.46) 4307 (2.09)
Feeling drunk 0 1 (0.01) 17 (0.08) 0 2 (0.01) 81 (0.05) 101 (0.05)
Feeling hot 5 (0.13) 37 (0.46) 193 (0.85) 0 109 (0.51) 1536 (1.03) 1894 (0.92)
Feeling of body temperature change 4 (0.10) 3 (0.04) 114 (0.50) 0 27 (0.13) 652 (0.44) 801 (0.39)
Fibrin D dimer increased 34 (0.87) 73 (0.91) 14 (0.06) 0 291 (1.35) 148 (0.10) 712 (0.35)
Fibromyalgia 0 3 (0.04) 86 (0.38) 0 14 (0.07) 183 (0.12) 288 (0.14)
Flank pain 2 (0.05) 3 (0.04) 17 (0.08) 0 17 (0.08) 59 (0.04) 102 (0.05)
Flatulence 0 5 (0.06) 37 (0.16) 0 10 (0.05) 273 (0.18) 326 (0.16)
Fluid retention 2 (0.05) 2 (0.03) 17 (0.08) 0 9 (0.04) 51 (0.03) 81 (0.04)
Flushing 1 (0.03) 18 (0.23) 64 (0.28) 0 46 (0.21) 440 (0.29) 572 (0.28)
Food aversion 0 1 (0.01) 9 (0.04) 0 3 (0.01) 41 (0.03) 54 (0.03)
Formication 0 1 (0.01) 12 (0.05) 0 6 (0.03) 64 (0.04) 83 (0.04)
Freezing phenomenon 0 2 (0.03) 10 (0.04) 0 5 (0.02) 111 (0.07) 128 (0.06)
Gait disturbance 10 (0.26) 36 (0.45) 219 (0.97) 1 (0.73) 147 (0.68) 310 (0.21) 746 (0.36)
Gait inability 5 (0.13) 16 (0.20) 95 (0.42) 0 37 (0.17) 109 (0.07) 277 (0.13)
Gastritis 2 (0.05) 2 (0.03) 29 (0.13) 0 13 (0.06) 69 (0.05) 116 (0.06)
Gastroenteritis viral 1 (0.03) 0 4 (0.02) 0 2 (0.01) 49 (0.03) 57 (0.03)
Gastrointestinal disorder 0 1 (0.01) 27 (0.12) 0 8 (0.04) 43 (0.03) 80 (0.04)
Gastrointestinal haemorrhage 13 (0.33) 11 (0.14) 7 (0.03) 0 11 (0.05) 15 (0.01) 60 (0.03)
Gastrointestinal pain 0 0 52 (0.23) 0 35 (0.16) 232 (0.16) 320 (0.16)
Gastrooesophageal reflux disease 1 (0.03) 1 (0.01) 39 (0.17) 0 8 (0.04) 144 (0.10) 195 (0.09)
General physical health deterioration 22 (0.56) 11 (0.14) 14 (0.06) 0 54 (0.25) 15 (0.01) 124 (0.06)
Generalised tonic-clonic seizure 4 (0.10) 29 (0.36) 10 (0.04) 0 55 (0.26) 51 (0.03) 154 (0.07)
Genital herpes 0 0 9 (0.04) 0 1 (0.00) 48 (0.03) 58 (0.03)
Giant cell arteritis 2 (0.05) 8 (0.10) 8 (0.04) 0 20 (0.09) 41 (0.03) 80 (0.04)
Gingival bleeding 0 14 (0.18) 13 (0.06) 0 20 (0.09) 102 (0.07) 154 (0.07)
Gingival pain 0 1 (0.01) 21 (0.09) 1 (0.73) 2 (0.01) 142 (0.09) 167 (0.08)
Glossodynia 0 2 (0.03) 19 (0.08) 0 3 (0.01) 135 (0.09) 159 (0.08)
Gout 1 (0.03) 1 (0.01) 24 (0.11) 0 7 (0.03) 115 (0.08) 148 (0.07)
Groin pain 2 (0.05) 6 (0.08) 39 (0.17) 0 16 (0.07) 137 (0.09) 202 (0.10)
Guillain-Barre syndrome 13 (0.33) 190 (2.38) 184 (0.81) 1 (0.73) 561 (2.61) 190 (0.13) 1166 (0.57)
Haematemesis 14 (0.36) 14 (0.18) 8 (0.04) 0 41 (0.19) 59 (0.04) 143 (0.07)
Haematochezia 0 5 (0.06) 8 (0.04) 0 27 (0.13) 86 (0.06) 128 (0.06)
Haematoma 3 (0.08) 39 (0.49) 32 (0.14) 1 (0.73) 97 (0.45) 185 (0.12) 367 (0.18)
Haematuria 2 (0.05) 9 (0.11) 7 (0.03) 0 23 (0.11) 56 (0.04) 104 (0.05)
Haemoglobin decreased 5 (0.13) 7 (0.09) 6 (0.03) 0 11 (0.05) 15 (0.01) 51 (0.02)
Haemoptysis 11 (0.28) 32 (0.40) 8 (0.04) 0 46 (0.21) 78 (0.05) 180 (0.09)
Haemorrhage 26 (0.66) 94 (1.18) 79 (0.35) 5 (3.65) 100 (0.46) 725 (0.48) 1042 (0.51)
Haemorrhage intracranial 41 (1.05) 28 (0.35) 6 (0.03) 0 11 (0.05) 12 (0.01) 107 (0.05)
Haemorrhage urinary tract 1 (0.03) 10 (0.13) 4 (0.02) 0 7 (0.03) 34 (0.02) 56 (0.03)
Haemorrhagic stroke 31 (0.79) 30 (0.38) 6 (0.03) 0 23 (0.11) 10 (0.01) 104 (0.05)
Haemorrhoids 1 (0.03) 1 (0.01) 7 (0.03) 0 2 (0.01) 45 (0.03) 56 (0.03)
Hallucination 1 (0.03) 19 (0.24) 143 (0.63) 0 36 (0.17) 640 (0.43) 846 (0.41)
Hallucination, visual 0 4 (0.05) 6 (0.03) 0 5 (0.02) 42 (0.03) 58 (0.03)
Hangover 0 0 23 (0.10) 0 2 (0.01) 121 (0.08) 147 (0.07)
Head discomfort 2 (0.05) 19 (0.24) 167 (0.74) 0 72 (0.33) 483 (0.32) 753 (0.37)
Head injury 2 (0.05) 16 (0.20) 10 (0.04) 0 14 (0.07) 21 (0.01) 67 (0.03)
Headache 248 (6.34) 981 (12.28) 9214 (40.71) 16 (11.68) 3711 (17.23) 55563 (37.14) 69969 (34.00)
Heart rate 0 19 (0.24) 70 (0.31) 0 63 (0.29) 728 (0.49) 880 (0.43)
Heart rate abnormal 1 (0.03) 2 (0.03) 10 (0.04) 0 10 (0.05) 44 (0.03) 70 (0.03)
Heart rate decreased 2 (0.05) 13 (0.16) 15 (0.07) 0 29 (0.13) 78 (0.05) 137 (0.07)
Heart rate increased 3 (0.08) 70 (0.88) 232 (1.03) 3 (2.19) 176 (0.82) 1496 (1.00) 1994 (0.97)
Heart rate irregular 1 (0.03) 15 (0.19) 37 (0.16) 1 (0.73) 29 (0.13) 144 (0.10) 227 (0.11)
Heavy menstrual bleeding 0 17 (0.21) 217 (0.96) 2 (1.46) 92 (0.43) 2421 (1.62) 2752 (1.34)
Hemiparaesthesia 1 (0.03) 2 (0.03) 3 (0.01) 0 17 (0.08) 29 (0.02) 55 (0.03)
Hemiparesis 32 (0.82) 65 (0.81) 40 (0.18) 0 90 (0.42) 102 (0.07) 362 (0.18)
Hemiplegia 7 (0.18) 31 (0.39) 19 (0.08) 0 33 (0.15) 49 (0.03) 164 (0.08)
Hemiplegic migraine 0 3 (0.04) 19 (0.08) 0 8 (0.04) 22 (0.01) 53 (0.03)
Heparin-induced thrombocytopenia test positive 7 (0.18) 8 (0.10) 0 0 29 (0.13) 2 (0.00) 51 (0.02)
Hepatic pain 0 3 (0.04) 20 (0.09) 0 3 (0.01) 49 (0.03) 75 (0.04)
Hepatitis 1 (0.03) 6 (0.08) 2 (0.01) 0 20 (0.09) 28 (0.02) 58 (0.03)
Herpes zoster 0 15 (0.19) 145 (0.64) 0 101 (0.47) 1203 (0.80) 1464 (0.71)
Hospitalisation 1 (0.03) 3 (0.04) 3 (0.01) 0 58 (0.27) 0 72 (0.03)
Hot flush 2 (0.05) 8 (0.10) 182 (0.80) 0 55 (0.26) 1383 (0.92) 1635 (0.79)
Hunger 0 2 (0.03) 3 (0.01) 0 1 (0.00) 46 (0.03) 52 (0.03)
Hyperacusis 0 7 (0.09) 54 (0.24) 0 23 (0.11) 85 (0.06) 169 (0.08)
Hyperaesthesia 0 4 (0.05) 33 (0.15) 0 25 (0.12) 185 (0.12) 248 (0.12)
Hyperglycaemia 3 (0.08) 13 (0.16) 13 (0.06) 0 20 (0.09) 94 (0.06) 147 (0.07)
Hyperhidrosis 19 (0.49) 82 (1.03) 1018 (4.50) 1 (0.73) 288 (1.34) 6570 (4.39) 8003 (3.89)
Hyperpyrexia 5 (0.13) 13 (0.16) 15 (0.07) 0 39 (0.18) 726 (0.49) 799 (0.39)
Hypersensitivity 7 (0.18) 83 (1.04) 177 (0.78) 0 226 (1.05) 910 (0.61) 1416 (0.69)
Hypersomnia 1 (0.03) 5 (0.06) 31 (0.14) 0 13 (0.06) 144 (0.10) 197 (0.10)
Hypertension 32 (0.82) 155 (1.94) 175 (0.77) 1 (0.73) 411 (1.91) 845 (0.56) 1662 (0.81)
Hypertensive crisis 3 (0.08) 12 (0.15) 2 (0.01) 0 66 (0.31) 95 (0.06) 182 (0.09)
Hyperthyroidism 0 7 (0.09) 12 (0.05) 1 (0.73) 12 (0.06) 42 (0.03) 74 (0.04)
Hyperventilation 2 (0.05) 2 (0.03) 12 (0.05) 0 25 (0.12) 72 (0.05) 114 (0.06)
Hypoacusis 1 (0.03) 5 (0.06) 70 (0.31) 0 19 (0.09) 160 (0.11) 257 (0.12)
Hypoaesthesia 21 (0.54) 151 (1.89) 781 (3.45) 0 541 (2.51) 3279 (2.19) 4813 (2.34)
Hypoaesthesia oral 1 (0.03) 16 (0.20) 46 (0.20) 0 54 (0.25) 338 (0.23) 461 (0.22)
Hypoglycaemia 5 (0.13) 8 (0.10) 8 (0.04) 0 20 (0.09) 66 (0.04) 109 (0.05)
Hypokinesia 1 (0.03) 5 (0.06) 29 (0.13) 0 23 (0.11) 52 (0.03) 125 (0.06)
Hypomenorrhoea 0 0 18 (0.08) 0 2 (0.01) 133 (0.09) 153 (0.07)
Hypopnoea 3 (0.08) 14 (0.18) 30 (0.13) 0 8 (0.04) 143 (0.10) 200 (0.10)
Hypotension 42 (1.07) 73 (0.91) 100 (0.44) 0 151 (0.70) 403 (0.27) 795 (0.39)
Hypothermia 6 (0.15) 6 (0.08) 10 (0.04) 0 5 (0.02) 69 (0.05) 100 (0.05)
Hypotonia 1 (0.03) 8 (0.10) 12 (0.05) 0 83 (0.39) 30 (0.02) 137 (0.07)
Hypovolaemic shock 3 (0.08) 3 (0.04) 0 0 3 (0.01) 61 (0.04) 73 (0.04)
Hypoxia 11 (0.28) 31 (0.39) 6 (0.03) 0 38 (0.18) 25 (0.02) 123 (0.06)
Illness 12 (0.31) 48 (0.60) 456 (2.01) 1 (0.73) 158 (0.73) 3381 (2.26) 4063 (1.97)
Immobile 1 (0.03) 5 (0.06) 19 (0.08) 0 10 (0.05) 24 (0.02) 60 (0.03)
Immune thrombocytopenia 36 (0.92) 139 (1.74) 10 (0.04) 0 283 (1.31) 138 (0.09) 643 (0.31)
Immunisation 4 (0.10) 2 (0.03) 12 (0.05) 0 3 (0.01) 89 (0.06) 110 (0.05)
Impaired work ability 0 7 (0.09) 106 (0.47) 0 23 (0.11) 140 (0.09) 289 (0.14)
Incontinence 3 (0.08) 9 (0.11) 22 (0.10) 0 14 (0.07) 39 (0.03) 90 (0.04)
Increased tendency to bruise 0 4 (0.05) 25 (0.11) 0 9 (0.04) 60 (0.04) 100 (0.05)
Infarction 13 (0.33) 13 (0.16) 2 (0.01) 0 27 (0.13) 8 (0.01) 65 (0.03)
Infection 8 (0.20) 18 (0.23) 46 (0.20) 0 56 (0.26) 283 (0.19) 418 (0.20)
Infectious mononucleosis 0 0 18 (0.08) 0 4 (0.02) 34 (0.02) 56 (0.03)
Inflammation 7 (0.18) 31 (0.39) 139 (0.61) 1 (0.73) 72 (0.33) 451 (0.30) 707 (0.34)
Influenza 2 (0.05) 27 (0.34) 558 (2.47) 0 293 (1.36) 4743 (3.17) 5626 (2.73)
Influenza like illness 23 (0.59) 58 (0.73) 991 (4.38) 0 489 (2.27) 8089 (5.41) 9664 (4.70)
Initial insomnia 0 1 (0.01) 4 (0.02) 0 0 47 (0.03) 52 (0.03)
Injected limb mobility decreased 1 (0.03) 1 (0.01) 52 (0.23) 0 2 (0.01) 69 (0.05) 125 (0.06)
Injection related reaction 0 1 (0.01) 36 (0.16) 0 5 (0.02) 448 (0.30) 491 (0.24)
Injection site bruising 0 1 (0.01) 11 (0.05) 0 1 (0.00) 77 (0.05) 91 (0.04)
Injection site erythema 0 6 (0.08) 59 (0.26) 0 41 (0.19) 346 (0.23) 454 (0.22)
Injection site mass 0 2 (0.03) 54 (0.24) 0 8 (0.04) 778 (0.52) 842 (0.41)
Injection site pain 8 (0.20) 24 (0.30) 530 (2.34) 0 225 (1.04) 3143 (2.10) 3941 (1.91)
Injection site pruritus 0 1 (0.01) 20 (0.09) 0 3 (0.01) 168 (0.11) 193 (0.09)
Injection site rash 0 0 10 (0.04) 1 (0.73) 2 (0.01) 149 (0.10) 162 (0.08)
Injection site reaction 3 (0.08) 4 (0.05) 1247 (5.51) 0 37 (0.17) 89 (0.06) 1385 (0.67)
Injection site swelling 1 (0.03) 7 (0.09) 62 (0.27) 0 43 (0.20) 173 (0.12) 289 (0.14)
Injection site warmth 0 2 (0.03) 39 (0.17) 0 6 (0.03) 209 (0.14) 256 (0.12)
Insomnia 5 (0.13) 36 (0.45) 458 (2.02) 0 86 (0.40) 2104 (1.41) 2698 (1.31)
Intermenstrual bleeding 0 3 (0.04) 18 (0.08) 0 17 (0.08) 312 (0.21) 351 (0.17)
International normalised ratio increased 1 (0.03) 10 (0.13) 6 (0.03) 0 5 (0.02) 46 (0.03) 70 (0.03)
Interstitial lung disease 6 (0.15) 9 (0.11) 6 (0.03) 0 13 (0.06) 20 (0.01) 55 (0.03)
Intestinal ischaemia 21 (0.54) 25 (0.31) 3 (0.01) 0 14 (0.07) 9 (0.01) 73 (0.04)
Intracranial pressure increased 16 (0.41) 8 (0.10) 5 (0.02) 0 11 (0.05) 12 (0.01) 59 (0.03)
Irritability 3 (0.08) 5 (0.06) 26 (0.11) 0 23 (0.11) 212 (0.14) 272 (0.13)
Irritable bowel syndrome 0 2 (0.03) 17 (0.08) 0 11 (0.05) 92 (0.06) 123 (0.06)
Ischaemia 5 (0.13) 10 (0.13) 9 (0.04) 0 20 (0.09) 7 (0.00) 51 (0.02)
Ischaemic cerebral infarction 4 (0.10) 22 (0.28) 4 (0.02) 0 16 (0.07) 4 (0.00) 51 (0.02)
Ischaemic stroke 41 (1.05) 146 (1.83) 65 (0.29) 0 268 (1.24) 72 (0.05) 601 (0.29)
Jaundice 6 (0.15) 6 (0.08) 1 (0.00) 0 21 (0.10) 29 (0.02) 64 (0.03)
Joint lock 1 (0.03) 1 (0.01) 9 (0.04) 0 4 (0.02) 41 (0.03) 56 (0.03)
Joint stiffness 0 3 (0.04) 79 (0.35) 0 14 (0.07) 286 (0.19) 382 (0.19)
Joint swelling 4 (0.10) 21 (0.26) 169 (0.75) 0 66 (0.31) 609 (0.41) 874 (0.42)
Jugular vein thrombosis 7 (0.18) 23 (0.29) 2 (0.01) 0 27 (0.13) 20 (0.01) 83 (0.04)
Kidney infection 1 (0.03) 6 (0.08) 11 (0.05) 0 11 (0.05) 37 (0.02) 67 (0.03)
Labyrinthitis 1 (0.03) 2 (0.03) 27 (0.12) 0 19 (0.09) 112 (0.07) 161 (0.08)
Lacrimation increased 0 2 (0.03) 33 (0.15) 0 20 (0.09) 168 (0.11) 223 (0.11)
Laryngeal oedema 1 (0.03) 16 (0.20) 0 0 13 (0.06) 33 (0.02) 65 (0.03)
Lethargy 26 (0.66) 58 (0.73) 405 (1.79) 0 108 (0.50) 3162 (2.11) 3782 (1.84)
Limb discomfort 2 (0.05) 26 (0.33) 220 (0.97) 0 423 (1.96) 1354 (0.91) 2034 (0.99)
Limb injury 2 (0.05) 3 (0.04) 79 (0.35) 0 5 (0.02) 181 (0.12) 271 (0.13)
Lip dry 0 2 (0.03) 4 (0.02) 0 2 (0.01) 46 (0.03) 54 (0.03)
Lip oedema 0 6 (0.08) 4 (0.02) 0 12 (0.06) 39 (0.03) 62 (0.03)
Lip swelling 2 (0.05) 40 (0.50) 41 (0.18) 0 63 (0.29) 517 (0.35) 664 (0.32)
Listless 3 (0.08) 0 16 (0.07) 0 2 (0.01) 83 (0.06) 104 (0.05)
Livedo reticularis 1 (0.03) 3 (0.04) 5 (0.02) 0 10 (0.05) 45 (0.03) 68 (0.03)
Liver function test abnormal 2 (0.05) 6 (0.08) 6 (0.03) 0 15 (0.07) 19 (0.01) 57 (0.03)
Local reaction 3 (0.08) 1 (0.01) 10 (0.04) 0 30 (0.14) 31 (0.02) 75 (0.04)
Localised infection 0 1 (0.01) 5 (0.02) 0 7 (0.03) 71 (0.05) 84 (0.04)
Loss of consciousness 68 (1.74) 163 (2.04) 113 (0.50) 0 319 (1.48) 919 (0.61) 1621 (0.79)
Loss of control of legs 0 4 (0.05) 8 (0.04) 0 8 (0.04) 35 (0.02) 56 (0.03)
Loss of personal independence in daily activities 0 6 (0.08) 70 (0.31) 0 6 (0.03) 43 (0.03) 130 (0.06)
Lower respiratory tract infection 18 (0.46) 19 (0.24) 43 (0.19) 0 35 (0.16) 150 (0.10) 268 (0.13)
Lymph node pain 1 (0.03) 1 (0.01) 46 (0.20) 0 12 (0.06) 372 (0.25) 432 (0.21)
Lymphadenopathy 3 (0.08) 34 (0.43) 438 (1.94) 3 (2.19) 141 (0.65) 3038 (2.03) 3669 (1.78)
Lymphoedema 0 3 (0.04) 11 (0.05) 0 2 (0.01) 45 (0.03) 62 (0.03)
Malaise 176 (4.50) 309 (3.87) 2730 (12.06) 2 (1.46) 851 (3.95) 8559 (5.72) 12710 (6.18)
Maternal exposure during breast feeding 1 (0.03) 12 (0.15) 59 (0.26) 7 (5.11) 12 (0.06) 781 (0.52) 874 (0.42)
Maternal exposure during pregnancy 2 (0.05) 16 (0.20) 26 (0.11) 54 (39.42) 34 (0.16) 167 (0.11) 304 (0.15)
Memory impairment 2 (0.05) 16 (0.20) 113 (0.50) 0 44 (0.20) 232 (0.16) 418 (0.20)
Meningitis 3 (0.08) 6 (0.08) 3 (0.01) 0 24 (0.11) 19 (0.01) 58 (0.03)
Menstrual disorder 1 (0.03) 6 (0.08) 73 (0.32) 5 (3.65) 19 (0.09) 631 (0.42) 736 (0.36)
Menstruation delayed 0 4 (0.05) 98 (0.43) 1 (0.73) 18 (0.08) 984 (0.66) 1105 (0.54)
Menstruation irregular 0 3 (0.04) 81 (0.36) 4 (2.92) 18 (0.08) 793 (0.53) 901 (0.44)
Mental fatigue 0 8 (0.10) 88 (0.39) 0 12 (0.06) 318 (0.21) 427 (0.21)
Mental impairment 2 (0.05) 5 (0.06) 38 (0.17) 0 7 (0.03) 82 (0.05) 137 (0.07)
Mesenteric vein thrombosis 11 (0.28) 28 (0.35) 2 (0.01) 0 40 (0.19) 11 (0.01) 101 (0.05)
Micturition urgency 1 (0.03) 2 (0.03) 13 (0.06) 0 8 (0.04) 52 (0.03) 76 (0.04)
Middle insomnia 0 2 (0.03) 5 (0.02) 0 2 (0.01) 52 (0.03) 62 (0.03)
Migraine 4 (0.10) 82 (1.03) 1130 (4.99) 0 290 (1.35) 5244 (3.51) 6763 (3.29)
Migraine with aura 0 3 (0.04) 69 (0.30) 0 22 (0.10) 253 (0.17) 349 (0.17)
Miliaria 0 1 (0.01) 17 (0.08) 0 3 (0.01) 101 (0.07) 123 (0.06)
Mobility decreased 6 (0.15) 9 (0.11) 99 (0.44) 0 77 (0.36) 79 (0.05) 281 (0.14)
Monoparesis 2 (0.05) 6 (0.08) 27 (0.12) 0 20 (0.09) 95 (0.06) 155 (0.08)
Monoplegia 2 (0.05) 10 (0.13) 45 (0.20) 0 30 (0.14) 135 (0.09) 228 (0.11)
Mood altered 2 (0.05) 2 (0.03) 9 (0.04) 0 4 (0.02) 59 (0.04) 78 (0.04)
Mood swings 1 (0.03) 4 (0.05) 19 (0.08) 0 2 (0.01) 77 (0.05) 103 (0.05)
Motion sickness 0 2 (0.03) 21 (0.09) 0 3 (0.01) 86 (0.06) 113 (0.05)
Motor dysfunction 3 (0.08) 7 (0.09) 16 (0.07) 0 20 (0.09) 17 (0.01) 69 (0.03)
Mouth haemorrhage 1 (0.03) 6 (0.08) 4 (0.02) 0 8 (0.04) 39 (0.03) 62 (0.03)
Mouth swelling 0 9 (0.11) 8 (0.04) 0 10 (0.05) 78 (0.05) 105 (0.05)
Mouth ulceration 0 1 (0.01) 56 (0.25) 0 11 (0.05) 368 (0.25) 437 (0.21)
Movement disorder 0 13 (0.16) 37 (0.16) 0 55 (0.26) 59 (0.04) 170 (0.08)
Multiple organ dysfunction syndrome 56 (1.43) 9 (0.11) 0 0 5 (0.02) 2 (0.00) 79 (0.04)
Multiple sclerosis 0 0 20 (0.09) 1 (0.73) 14 (0.07) 48 (0.03) 85 (0.04)
Multiple sclerosis relapse 0 0 21 (0.09) 0 14 (0.07) 54 (0.04) 90 (0.04)
Muscle contractions involuntary 0 1 (0.01) 15 (0.07) 0 1 (0.00) 34 (0.02) 51 (0.02)
Muscle fatigue 1 (0.03) 8 (0.10) 146 (0.65) 0 15 (0.07) 684 (0.46) 855 (0.42)
Muscle rigidity 1 (0.03) 2 (0.03) 12 (0.05) 0 10 (0.05) 46 (0.03) 71 (0.03)
Muscle spasms 3 (0.08) 57 (0.71) 516 (2.28) 3 (2.19) 170 (0.79) 2156 (1.44) 2918 (1.42)
Muscle tightness 1 (0.03) 7 (0.09) 31 (0.14) 1 (0.73) 18 (0.08) 134 (0.09) 193 (0.09)
Muscle twitching 0 10 (0.13) 86 (0.38) 0 42 (0.20) 269 (0.18) 410 (0.20)
Muscular weakness 18 (0.46) 84 (1.05) 564 (2.49) 1 (0.73) 282 (1.31) 1309 (0.88) 2292 (1.11)
Musculoskeletal chest pain 1 (0.03) 12 (0.15) 62 (0.27) 0 32 (0.15) 276 (0.18) 385 (0.19)
Musculoskeletal discomfort 0 4 (0.05) 15 (0.07) 0 10 (0.05) 84 (0.06) 114 (0.06)
Musculoskeletal pain 2 (0.05) 9 (0.11) 39 (0.17) 0 42 (0.20) 157 (0.10) 250 (0.12)
Musculoskeletal stiffness 5 (0.13) 19 (0.24) 419 (1.85) 0 83 (0.39) 1452 (0.97) 1986 (0.96)
Myalgia 42 (1.07) 228 (2.85) 4988 (22.04) 4 (2.92) 828 (3.85) 19343 (12.93) 25495 (12.39)
Myelitis 0 4 (0.05) 11 (0.05) 0 46 (0.21) 9 (0.01) 72 (0.03)
Myelitis transverse 1 (0.03) 9 (0.11) 53 (0.23) 0 44 (0.20) 34 (0.02) 141 (0.07)
Myocardial infarction 177 (4.52) 317 (3.97) 29 (0.13) 0 215 (1.00) 136 (0.09) 894 (0.43)
Myocarditis 13 (0.33) 73 (0.91) 50 (0.22) 0 158 (0.73) 147 (0.10) 457 (0.22)
Myositis 1 (0.03) 6 (0.08) 22 (0.10) 0 9 (0.04) 34 (0.02) 75 (0.04)
Nasal congestion 4 (0.10) 6 (0.08) 60 (0.27) 0 17 (0.08) 299 (0.20) 387 (0.19)
Nasal discomfort 0 0 8 (0.04) 0 3 (0.01) 72 (0.05) 83 (0.04)
Nasopharyngitis 21 (0.54) 11 (0.14) 156 (0.69) 0 146 (0.68) 1090 (0.73) 1431 (0.70)
Nausea 93 (2.38) 303 (3.79) 4511 (19.93) 5 (3.65) 1272 (5.91) 24361 (16.28) 30625 (14.88)
Neck pain 8 (0.20) 44 (0.55) 438 (1.94) 0 180 (0.84) 2016 (1.35) 2696 (1.31)
Nerve injury 0 11 (0.14) 59 (0.26) 0 11 (0.05) 83 (0.06) 166 (0.08)
Nervous system disorder 6 (0.15) 12 (0.15) 52 (0.23) 1 (0.73) 39 (0.18) 54 (0.04) 172 (0.08)
Nervousness 0 7 (0.09) 78 (0.34) 0 20 (0.09) 400 (0.27) 506 (0.25)
Neuralgia 1 (0.03) 13 (0.16) 298 (1.32) 0 105 (0.49) 872 (0.58) 1291 (0.63)
Neurological symptom 4 (0.10) 9 (0.11) 38 (0.17) 0 23 (0.11) 66 (0.04) 143 (0.07)
Neuropathy peripheral 0 8 (0.10) 73 (0.32) 0 27 (0.13) 156 (0.10) 266 (0.13)
Neutropenia 0 9 (0.11) 3 (0.01) 0 17 (0.08) 57 (0.04) 88 (0.04)
Night sweats 2 (0.05) 16 (0.20) 158 (0.70) 0 41 (0.19) 1270 (0.85) 1488 (0.72)
Nightmare 1 (0.03) 5 (0.06) 44 (0.19) 0 5 (0.02) 288 (0.19) 343 (0.17)
Ocular discomfort 2 (0.05) 1 (0.01) 17 (0.08) 1 (0.73) 18 (0.08) 56 (0.04) 96 (0.05)
Ocular hyperaemia 1 (0.03) 5 (0.06) 31 (0.14) 0 22 (0.10) 225 (0.15) 287 (0.14)
Odynophagia 0 3 (0.04) 1 (0.00) 1 (0.73) 5 (0.02) 41 (0.03) 52 (0.03)
Oedema 9 (0.23) 13 (0.16) 13 (0.06) 0 49 (0.23) 59 (0.04) 150 (0.07)
Oedema peripheral 10 (0.26) 38 (0.48) 53 (0.23) 0 81 (0.38) 194 (0.13) 390 (0.19)
Off label use 2 (0.05) 5 (0.06) 4 (0.02) 0 8 (0.04) 34 (0.02) 57 (0.03)
Oligomenorrhoea 0 0 13 (0.06) 0 2 (0.01) 43 (0.03) 58 (0.03)
Ophthalmic herpes zoster 0 0 4 (0.02) 0 11 (0.05) 46 (0.03) 61 (0.03)
Optic neuritis 0 3 (0.04) 36 (0.16) 0 37 (0.17) 37 (0.02) 117 (0.06)
Oral discomfort 0 3 (0.04) 8 (0.04) 0 5 (0.02) 77 (0.05) 93 (0.05)
Oral herpes 0 4 (0.05) 43 (0.19) 0 12 (0.06) 395 (0.26) 455 (0.22)
Oral pain 1 (0.03) 1 (0.01) 26 (0.11) 1 (0.73) 7 (0.03) 201 (0.13) 241 (0.12)
Oropharyngeal pain 11 (0.28) 38 (0.48) 382 (1.69) 1 (0.73) 146 (0.68) 2792 (1.87) 3375 (1.64)
Orthostatic hypotension 1 (0.03) 4 (0.05) 17 (0.08) 0 9 (0.04) 24 (0.02) 55 (0.03)
Osteoarthritis 0 2 (0.03) 31 (0.14) 0 6 (0.03) 54 (0.04) 94 (0.05)
Oxygen saturation decreased 30 (0.77) 25 (0.31) 26 (0.11) 0 99 (0.46) 107 (0.07) 303 (0.15)
Pain 52 (1.33) 204 (2.55) 2059 (9.10) 4 (2.92) 634 (2.94) 11237 (7.51) 14250 (6.92)
Pain in extremity 52 (1.33) 273 (3.42) 2279 (10.07) 4 (2.92) 775 (3.60) 13481 (9.01) 16931 (8.23)
Pain in jaw 1 (0.03) 14 (0.18) 86 (0.38) 0 29 (0.13) 394 (0.26) 527 (0.26)
Pain of skin 0 3 (0.04) 119 (0.53) 0 19 (0.09) 632 (0.42) 774 (0.38)
Pallor 11 (0.28) 33 (0.41) 56 (0.25) 0 33 (0.15) 238 (0.16) 383 (0.19)
Palpitations 7 (0.18) 161 (2.02) 712 (3.15) 1 (0.73) 522 (2.42) 3484 (2.33) 4912 (2.39)
Pancreatitis 7 (0.18) 10 (0.13) 3 (0.01) 0 35 (0.16) 27 (0.02) 83 (0.04)
Panic attack 1 (0.03) 12 (0.15) 47 (0.21) 0 32 (0.15) 219 (0.15) 312 (0.15)
Papule 0 0 8 (0.04) 1 (0.73) 3 (0.01) 61 (0.04) 73 (0.04)
Paraesthesia 13 (0.33) 199 (2.49) 947 (4.18) 2 (1.46) 827 (3.84) 5318 (3.55) 7361 (3.58)
Paraesthesia oral 0 13 (0.16) 56 (0.25) 0 65 (0.30) 455 (0.30) 591 (0.29)
Paralysis 10 (0.26) 37 (0.46) 84 (0.37) 0 98 (0.46) 187 (0.13) 436 (0.21)
Paranasal sinus discomfort 0 1 (0.01) 8 (0.04) 0 3 (0.01) 49 (0.03) 61 (0.03)
Paresis 0 5 (0.06) 10 (0.04) 0 21 (0.10) 19 (0.01) 57 (0.03)
Parosmia 0 2 (0.03) 33 (0.15) 0 10 (0.05) 197 (0.13) 242 (0.12)
Partial seizures 4 (0.10) 9 (0.11) 5 (0.02) 0 15 (0.07) 33 (0.02) 69 (0.03)
Pelvic pain 0 3 (0.04) 36 (0.16) 0 13 (0.06) 118 (0.08) 171 (0.08)
Pelvic venous thrombosis 2 (0.05) 14 (0.18) 3 (0.01) 0 16 (0.07) 16 (0.01) 55 (0.03)
Periarthritis 0 1 (0.01) 124 (0.55) 0 4 (0.02) 283 (0.19) 412 (0.20)
Pericardial effusion 4 (0.10) 18 (0.23) 7 (0.03) 0 46 (0.21) 37 (0.02) 124 (0.06)
Pericarditis 2 (0.05) 31 (0.39) 34 (0.15) 0 196 (0.91) 159 (0.11) 431 (0.21)
Periorbital swelling 0 2 (0.03) 15 (0.07) 0 8 (0.04) 75 (0.05) 100 (0.05)
Peripheral artery thrombosis 9 (0.23) 23 (0.29) 5 (0.02) 0 41 (0.19) 27 (0.02) 110 (0.05)
Peripheral coldness 4 (0.10) 21 (0.26) 154 (0.68) 0 38 (0.18) 838 (0.56) 1062 (0.52)
Peripheral ischaemia 10 (0.26) 13 (0.16) 3 (0.01) 0 31 (0.14) 12 (0.01) 73 (0.04)
Peripheral swelling 23 (0.59) 146 (1.83) 591 (2.61) 2 (1.46) 242 (1.12) 3292 (2.20) 4327 (2.10)
Petechiae 7 (0.18) 47 (0.59) 30 (0.13) 0 174 (0.81) 243 (0.16) 521 (0.25)
Petit mal epilepsy 0 6 (0.08) 8 (0.04) 0 6 (0.03) 34 (0.02) 55 (0.03)
Pharyngeal swelling 2 (0.05) 36 (0.45) 37 (0.16) 0 47 (0.22) 164 (0.11) 290 (0.14)
Phlebitis 0 4 (0.05) 10 (0.04) 0 29 (0.13) 103 (0.07) 146 (0.07)
Photophobia 6 (0.15) 22 (0.28) 208 (0.92) 0 82 (0.38) 678 (0.45) 1002 (0.49)
Photopsia 1 (0.03) 11 (0.14) 37 (0.16) 0 20 (0.09) 213 (0.14) 283 (0.14)
Photosensitivity reaction 0 4 (0.05) 30 (0.13) 0 14 (0.07) 99 (0.07) 147 (0.07)
Piloerection 0 0 8 (0.04) 0 3 (0.01) 71 (0.05) 83 (0.04)
Platelet count decreased 33 (0.84) 68 (0.85) 28 (0.12) 1 (0.73) 124 (0.58) 191 (0.13) 473 (0.23)
Pleural effusion 9 (0.23) 32 (0.40) 5 (0.02) 0 46 (0.21) 18 (0.01) 122 (0.06)
Pleurisy 0 2 (0.03) 8 (0.04) 0 32 (0.15) 20 (0.01) 64 (0.03)
Pleuritic pain 0 20 (0.25) 6 (0.03) 0 15 (0.07) 11 (0.01) 54 (0.03)
Pneumonia 86 (2.20) 95 (1.19) 29 (0.13) 0 207 (0.96) 90 (0.06) 539 (0.26)
Pneumonitis 7 (0.18) 10 (0.13) 6 (0.03) 0 22 (0.10) 24 (0.02) 71 (0.03)
Pollakiuria 2 (0.05) 9 (0.11) 30 (0.13) 0 18 (0.08) 171 (0.11) 230 (0.11)
Polymenorrhoea 0 1 (0.01) 29 (0.13) 1 (0.73) 9 (0.04) 253 (0.17) 293 (0.14)
Polymyalgia rheumatica 0 4 (0.05) 35 (0.15) 0 12 (0.06) 85 (0.06) 137 (0.07)
Polyneuropathy 2 (0.05) 8 (0.10) 8 (0.04) 0 33 (0.15) 43 (0.03) 99 (0.05)
Poor quality sleep 0 5 (0.06) 71 (0.31) 0 3 (0.01) 427 (0.29) 506 (0.25)
Portal vein thrombosis 34 (0.87) 63 (0.79) 2 (0.01) 0 95 (0.44) 30 (0.02) 244 (0.12)
Post viral fatigue syndrome 0 0 55 (0.24) 0 4 (0.02) 74 (0.05) 133 (0.06)
Postmenopausal haemorrhage 0 0 6 (0.03) 0 10 (0.05) 197 (0.13) 214 (0.10)
Premenstrual pain 0 0 9 (0.04) 0 0 51 (0.03) 60 (0.03)
Presyncope 5 (0.13) 15 (0.19) 89 (0.39) 0 72 (0.33) 429 (0.29) 618 (0.30)
Productive cough 7 (0.18) 9 (0.11) 28 (0.12) 0 27 (0.13) 110 (0.07) 183 (0.09)
Pruritus 3 (0.08) 82 (1.03) 439 (1.94) 0 223 (1.04) 3928 (2.63) 4690 (2.28)
Psoriasis 0 7 (0.09) 34 (0.15) 0 9 (0.04) 129 (0.09) 181 (0.09)
Pulmonary embolism 314 (8.02) 1244 (15.57) 77 (0.34) 0 1953 (9.07) 922 (0.62) 4627 (2.25)
Pulmonary infarction 3 (0.08) 26 (0.33) 1 (0.00) 0 28 (0.13) 11 (0.01) 79 (0.04)
Pulmonary oedema 20 (0.51) 23 (0.29) 2 (0.01) 0 19 (0.09) 21 (0.01) 97 (0.05)
Pulmonary pain 0 17 (0.21) 42 (0.19) 0 18 (0.08) 147 (0.10) 227 (0.11)
Pulmonary thrombosis 17 (0.43) 17 (0.21) 2 (0.01) 0 50 (0.23) 21 (0.01) 114 (0.06)
Purpura 5 (0.13) 11 (0.14) 10 (0.04) 0 60 (0.28) 87 (0.06) 178 (0.09)
Pyrexia 272 (6.95) 749 (9.38) 7337 (32.42) 10 (7.30) 2682 (12.45) 40971 (27.39) 52177 (25.35)
Q fever 0 1 (0.01) 13 (0.06) 0 2 (0.01) 81 (0.05) 97 (0.05)
Rash 14 (0.36) 116 (1.45) 488 (2.16) 3 (2.19) 418 (1.94) 4008 (2.68) 5063 (2.46)
Rash erythematous 2 (0.05) 8 (0.10) 87 (0.38) 0 37 (0.17) 877 (0.59) 1011 (0.49)
Rash macular 1 (0.03) 10 (0.13) 36 (0.16) 0 35 (0.16) 379 (0.25) 461 (0.22)
Rash maculo-papular 0 2 (0.03) 3 (0.01) 0 4 (0.02) 49 (0.03) 59 (0.03)
Rash papular 1 (0.03) 3 (0.04) 18 (0.08) 0 11 (0.05) 236 (0.16) 272 (0.13)
Rash pruritic 1 (0.03) 9 (0.11) 56 (0.25) 0 42 (0.20) 891 (0.60) 999 (0.49)
Rash vesicular 0 4 (0.05) 7 (0.03) 0 12 (0.06) 47 (0.03) 71 (0.03)
Raynaud's phenomenon 1 (0.03) 0 16 (0.07) 0 6 (0.03) 96 (0.06) 119 (0.06)
Rectal haemorrhage 6 (0.15) 12 (0.15) 6 (0.03) 0 30 (0.14) 95 (0.06) 152 (0.07)
Renal failure 20 (0.51) 28 (0.35) 5 (0.02) 0 20 (0.09) 20 (0.01) 99 (0.05)
Renal pain 2 (0.05) 16 (0.20) 118 (0.52) 0 46 (0.21) 650 (0.43) 833 (0.40)
Respiration abnormal 6 (0.15) 5 (0.06) 9 (0.04) 0 23 (0.11) 59 (0.04) 107 (0.05)
Respiratory arrest 10 (0.26) 14 (0.18) 1 (0.00) 0 11 (0.05) 13 (0.01) 53 (0.03)
Respiratory disorder 11 (0.28) 16 (0.20) 113 (0.50) 0 30 (0.14) 26 (0.02) 199 (0.10)
Respiratory distress 11 (0.28) 21 (0.26) 12 (0.05) 1 (0.73) 137 (0.64) 78 (0.05) 280 (0.14)
Respiratory failure 34 (0.87) 36 (0.45) 0 0 31 (0.14) 16 (0.01) 130 (0.06)
Respiratory rate increased 4 (0.10) 6 (0.08) 6 (0.03) 0 6 (0.03) 63 (0.04) 86 (0.04)
Restless legs syndrome 0 7 (0.09) 46 (0.20) 0 10 (0.05) 251 (0.17) 315 (0.15)
Restlessness 5 (0.13) 7 (0.09) 49 (0.22) 0 31 (0.14) 335 (0.22) 430 (0.21)
Retching 4 (0.10) 6 (0.08) 33 (0.15) 0 24 (0.11) 188 (0.13) 258 (0.13)
Retinal artery occlusion 0 1 (0.01) 27 (0.12) 0 16 (0.07) 30 (0.02) 76 (0.04)
Retinal detachment 0 0 19 (0.08) 0 37 (0.17) 28 (0.02) 85 (0.04)
Retinal migraine 0 0 7 (0.03) 0 2 (0.01) 64 (0.04) 73 (0.04)
Retinal vein occlusion 0 3 (0.04) 60 (0.27) 0 15 (0.07) 143 (0.10) 222 (0.11)
Retinal vein thrombosis 1 (0.03) 0 13 (0.06) 0 5 (0.02) 46 (0.03) 66 (0.03)
Rheumatoid arthritis 1 (0.03) 2 (0.03) 66 (0.29) 0 13 (0.06) 134 (0.09) 217 (0.11)
Rhinitis 6 (0.15) 6 (0.08) 7 (0.03) 0 20 (0.09) 36 (0.02) 77 (0.04)
Rhinorrhoea 1 (0.03) 8 (0.10) 133 (0.59) 0 38 (0.18) 1028 (0.69) 1213 (0.59)
Rotator cuff syndrome 0 1 (0.01) 22 (0.10) 0 3 (0.01) 67 (0.04) 94 (0.05)
SARS-CoV-2 test positive 17 (0.43) 5 (0.06) 5 (0.02) 0 63 (0.29) 36 (0.02) 133 (0.06)
Salivary hypersecretion 0 6 (0.08) 13 (0.06) 0 11 (0.05) 46 (0.03) 76 (0.04)
Sciatica 0 2 (0.03) 57 (0.25) 0 10 (0.05) 137 (0.09) 206 (0.10)
Seasonal allergy 1 (0.03) 0 11 (0.05) 0 2 (0.01) 68 (0.05) 82 (0.04)
Seizure 55 (1.41) 193 (2.42) 183 (0.81) 1 (0.73) 408 (1.89) 982 (0.66) 1878 (0.91)
Sensation of foreign body 0 7 (0.09) 9 (0.04) 0 20 (0.09) 40 (0.03) 82 (0.04)
Sensitive skin 0 3 (0.04) 60 (0.27) 0 5 (0.02) 397 (0.27) 465 (0.23)
Sensory disturbance 0 10 (0.13) 53 (0.23) 0 134 (0.62) 102 (0.07) 306 (0.15)
Sensory loss 0 22 (0.28) 62 (0.27) 0 41 (0.19) 96 (0.06) 227 (0.11)
Sepsis 50 (1.28) 39 (0.49) 9 (0.04) 0 42 (0.20) 43 (0.03) 209 (0.10)
Severe acute respiratory syndrome 6 (0.15) 1 (0.01) 0 0 36 (0.17) 9 (0.01) 52 (0.03)
Shock 10 (0.26) 12 (0.15) 5 (0.02) 0 6 (0.03) 40 (0.03) 76 (0.04)
Shoulder injury related to vaccine administration 0 0 34 (0.15) 0 2 (0.01) 53 (0.04) 89 (0.04)
Sinus congestion 0 4 (0.05) 8 (0.04) 0 4 (0.02) 63 (0.04) 79 (0.04)
Sinus headache 0 2 (0.03) 79 (0.35) 0 11 (0.05) 653 (0.44) 746 (0.36)
Sinus pain 0 7 (0.09) 69 (0.30) 0 5 (0.02) 435 (0.29) 517 (0.25)
Sinus tachycardia 4 (0.10) 9 (0.11) 8 (0.04) 0 33 (0.15) 44 (0.03) 100 (0.05)
Sinusitis 1 (0.03) 5 (0.06) 45 (0.20) 0 15 (0.07) 251 (0.17) 318 (0.15)
Skin burning sensation 0 9 (0.11) 78 (0.34) 0 31 (0.14) 361 (0.24) 480 (0.23)
Skin discolouration 6 (0.15) 12 (0.15) 21 (0.09) 0 22 (0.10) 115 (0.08) 179 (0.09)
Skin disorder 2 (0.05) 5 (0.06) 119 (0.53) 0 19 (0.09) 33 (0.02) 178 (0.09)
Skin exfoliation 0 5 (0.06) 17 (0.08) 0 7 (0.03) 82 (0.05) 112 (0.05)
Skin haemorrhage 2 (0.05) 3 (0.04) 9 (0.04) 0 16 (0.07) 28 (0.02) 60 (0.03)
Skin irritation 0 0 7 (0.03) 0 7 (0.03) 73 (0.05) 87 (0.04)
Skin reaction 0 4 (0.05) 19 (0.08) 0 12 (0.06) 126 (0.08) 161 (0.08)
Skin sensitisation 0 0 14 (0.06) 0 0 68 (0.05) 82 (0.04)
Skin swelling 0 0 5 (0.02) 0 6 (0.03) 46 (0.03) 58 (0.03)
Skin temperature 0 0 10 (0.04) 0 0 134 (0.09) 144 (0.07)
Skin warm 0 3 (0.04) 26 (0.11) 0 7 (0.03) 303 (0.20) 339 (0.16)
Sleep disorder 3 (0.08) 8 (0.10) 101 (0.45) 0 22 (0.10) 301 (0.20) 439 (0.21)
Sneezing 1 (0.03) 7 (0.09) 32 (0.14) 0 9 (0.04) 302 (0.20) 351 (0.17)
Somnolence 26 (0.66) 79 (0.99) 231 (1.02) 1 (0.73) 205 (0.95) 1394 (0.93) 1957 (0.95)
Speech disorder 10 (0.26) 23 (0.29) 47 (0.21) 0 80 (0.37) 81 (0.05) 259 (0.13)
Spinal pain 1 (0.03) 8 (0.10) 47 (0.21) 0 20 (0.09) 173 (0.12) 253 (0.12)
Splenic infarction 7 (0.18) 8 (0.10) 1 (0.00) 0 23 (0.11) 10 (0.01) 56 (0.03)
Stomatitis 0 0 10 (0.04) 0 5 (0.02) 55 (0.04) 70 (0.03)
Stress 0 2 (0.03) 32 (0.14) 0 4 (0.02) 82 (0.05) 121 (0.06)
Subarachnoid haemorrhage 51 (1.30) 67 (0.84) 3 (0.01) 0 45 (0.21) 20 (0.01) 196 (0.10)
Subdural haematoma 7 (0.18) 18 (0.23) 2 (0.01) 0 15 (0.07) 8 (0.01) 55 (0.03)
Sudden death 182 (4.65) 0 0 0 0 0 183 (0.09)
Sudden hearing loss 0 0 37 (0.16) 0 16 (0.07) 87 (0.06) 142 (0.07)
Suicidal ideation 2 (0.05) 16 (0.20) 16 (0.07) 0 5 (0.02) 89 (0.06) 133 (0.06)
Superficial vein thrombosis 1 (0.03) 24 (0.30) 14 (0.06) 0 76 (0.35) 267 (0.18) 392 (0.19)
Superior sagittal sinus thrombosis 14 (0.36) 24 (0.30) 3 (0.01) 0 19 (0.09) 10 (0.01) 74 (0.04)
Supraventricular tachycardia 0 5 (0.06) 7 (0.03) 0 23 (0.11) 23 (0.02) 58 (0.03)
Sweating fever 0 2 (0.03) 76 (0.34) 0 7 (0.03) 535 (0.36) 620 (0.30)
Swelling 3 (0.08) 50 (0.63) 186 (0.82) 1 (0.73) 112 (0.52) 1378 (0.92) 1733 (0.84)
Swelling face 1 (0.03) 37 (0.46) 76 (0.34) 0 113 (0.52) 641 (0.43) 875 (0.43)
Swelling of eyelid 0 3 (0.04) 8 (0.04) 0 12 (0.06) 61 (0.04) 84 (0.04)
Swollen tongue 1 (0.03) 55 (0.69) 40 (0.18) 0 61 (0.28) 335 (0.22) 495 (0.24)
Syncope 48 (1.23) 200 (2.50) 245 (1.08) 3 (2.19) 511 (2.37) 2014 (1.35) 3067 (1.49)
Tachycardia 21 (0.54) 169 (2.12) 240 (1.06) 0 473 (2.20) 1099 (0.73) 2042 (0.99)
Tachypnoea 9 (0.23) 7 (0.09) 8 (0.04) 0 14 (0.07) 21 (0.01) 61 (0.03)
Taste disorder 0 6 (0.08) 60 (0.27) 0 26 (0.12) 304 (0.20) 399 (0.19)
Tearfulness 0 1 (0.01) 18 (0.08) 0 0 70 (0.05) 89 (0.04)
Temperature intolerance 0 0 9 (0.04) 0 2 (0.01) 65 (0.04) 76 (0.04)
Tenderness 4 (0.10) 6 (0.08) 91 (0.40) 0 50 (0.23) 1068 (0.71) 1233 (0.60)
Tendonitis 0 1 (0.01) 37 (0.16) 0 0 64 (0.04) 102 (0.05)
Tension 1 (0.03) 4 (0.05) 4 (0.02) 0 1 (0.00) 40 (0.03) 52 (0.03)
Tension headache 1 (0.03) 10 (0.13) 137 (0.61) 0 52 (0.24) 975 (0.65) 1177 (0.57)
Testicular pain 0 0 8 (0.04) 0 2 (0.01) 58 (0.04) 68 (0.03)
Therapeutic response unexpected 0 0 9 (0.04) 0 3 (0.01) 57 (0.04) 70 (0.03)
Thirst 1 (0.03) 16 (0.20) 118 (0.52) 1 (0.73) 22 (0.10) 898 (0.60) 1058 (0.51)
Throat irritation 1 (0.03) 13 (0.16) 18 (0.08) 0 35 (0.16) 138 (0.09) 206 (0.10)
Throat tightness 0 24 (0.30) 24 (0.11) 0 43 (0.20) 136 (0.09) 228 (0.11)
Thrombocytopenia 262 (6.70) 571 (7.15) 59 (0.26) 0 1003 (4.66) 692 (0.46) 2850 (1.38)
Thrombophlebitis 4 (0.10) 30 (0.38) 26 (0.11) 0 46 (0.21) 236 (0.16) 349 (0.17)
Thrombosis 194 (4.96) 518 (6.48) 180 (0.80) 1 (0.73) 667 (3.10) 1189 (0.79) 2846 (1.38)
Thrombosis in device 2 (0.05) 22 (0.28) 2 (0.01) 0 16 (0.07) 18 (0.01) 60 (0.03)
Thunderclap headache 1 (0.03) 2 (0.03) 9 (0.04) 0 17 (0.08) 29 (0.02) 58 (0.03)
Tinnitus 1 (0.03) 32 (0.40) 582 (2.57) 1 (0.73) 147 (0.68) 2190 (1.46) 2964 (1.44)
Tongue oedema 2 (0.05) 11 (0.14) 3 (0.01) 0 20 (0.09) 35 (0.02) 73 (0.04)
Tonsillitis 0 2 (0.03) 9 (0.04) 0 5 (0.02) 57 (0.04) 73 (0.04)
Toothache 1 (0.03) 1 (0.01) 35 (0.15) 0 10 (0.05) 218 (0.15) 265 (0.13)
Transient ischaemic attack 7 (0.18) 129 (1.61) 49 (0.22) 0 339 (1.57) 332 (0.22) 863 (0.42)
Tremor 17 (0.43) 119 (1.49) 1052 (4.65) 1 (0.73) 336 (1.56) 7195 (4.81) 8735 (4.24)
Trigeminal neuralgia 0 1 (0.01) 35 (0.15) 0 26 (0.12) 94 (0.06) 157 (0.08)
Troponin increased 4 (0.10) 4 (0.05) 2 (0.01) 0 30 (0.14) 10 (0.01) 75 (0.04)
Unresponsive to stimuli 27 (0.69) 16 (0.20) 6 (0.03) 0 26 (0.12) 57 (0.04) 144 (0.07)
Urinary incontinence 3 (0.08) 13 (0.16) 33 (0.15) 0 25 (0.12) 71 (0.05) 150 (0.07)
Urinary retention 2 (0.05) 12 (0.15) 26 (0.11) 0 29 (0.13) 49 (0.03) 124 (0.06)
Urinary tract infection 11 (0.28) 11 (0.14) 25 (0.11) 0 43 (0.20) 166 (0.11) 270 (0.13)
Urticaria 1 (0.03) 71 (0.89) 129 (0.57) 0 164 (0.76) 1361 (0.91) 1727 (0.84)
Uterine haemorrhage 0 1 (0.01) 3 (0.01) 0 6 (0.03) 42 (0.03) 53 (0.03)
Vaccination complication 3 (0.08) 2 (0.03) 15 (0.07) 0 9 (0.04) 80 (0.05) 111 (0.05)
Vaccination failure 27 (0.69) 32 (0.40) 1 (0.00) 0 204 (0.95) 3186 (2.13) 3457 (1.68)
Vaccination site bruising 0 1 (0.01) 15 (0.07) 0 4 (0.02) 76 (0.05) 97 (0.05)
Vaccination site erythema 1 (0.03) 7 (0.09) 73 (0.32) 0 28 (0.13) 391 (0.26) 500 (0.24)
Vaccination site induration 0 0 13 (0.06) 0 2 (0.01) 51 (0.03) 66 (0.03)
Vaccination site inflammation 0 2 (0.03) 8 (0.04) 0 6 (0.03) 59 (0.04) 75 (0.04)
Vaccination site mass 0 2 (0.03) 33 (0.15) 0 7 (0.03) 265 (0.18) 309 (0.15)
Vaccination site movement impairment 0 1 (0.01) 54 (0.24) 0 18 (0.08) 71 (0.05) 144 (0.07)
Vaccination site oedema 0 2 (0.03) 24 (0.11) 0 2 (0.01) 43 (0.03) 71 (0.03)
Vaccination site pain 10 (0.26) 22 (0.28) 385 (1.70) 0 137 (0.64) 1783 (1.19) 2343 (1.14)
Vaccination site pruritus 0 1 (0.01) 23 (0.10) 0 10 (0.05) 85 (0.06) 119 (0.06)
Vaccination site rash 1 (0.03) 0 9 (0.04) 0 4 (0.02) 98 (0.07) 112 (0.05)
Vaccination site reaction 1 (0.03) 2 (0.03) 32 (0.14) 0 19 (0.09) 78 (0.05) 134 (0.07)
Vaccination site swelling 0 4 (0.05) 80 (0.35) 0 31 (0.14) 300 (0.20) 417 (0.20)
Vaccination site warmth 0 1 (0.01) 37 (0.16) 0 5 (0.02) 224 (0.15) 267 (0.13)
Vaginal discharge 0 1 (0.01) 6 (0.03) 0 5 (0.02) 40 (0.03) 52 (0.03)
Vaginal haemorrhage 0 16 (0.20) 46 (0.20) 5 (3.65) 47 (0.22) 648 (0.43) 764 (0.37)
Varicose vein 0 8 (0.10) 11 (0.05) 0 8 (0.04) 96 (0.06) 124 (0.06)
Vascular headache 0 3 (0.04) 19 (0.08) 0 3 (0.01) 47 (0.03) 73 (0.04)
Vascular pain 0 7 (0.09) 14 (0.06) 0 9 (0.04) 104 (0.07) 135 (0.07)
Vasculitis 8 (0.20) 24 (0.30) 16 (0.07) 0 35 (0.16) 98 (0.07) 189 (0.09)
Vasodilatation 0 5 (0.06) 18 (0.08) 1 (0.73) 9 (0.04) 86 (0.06) 120 (0.06)
Venous thrombosis 9 (0.23) 41 (0.51) 11 (0.05) 0 63 (0.29) 105 (0.07) 238 (0.12)
Venous thrombosis limb 5 (0.13) 32 (0.40) 5 (0.02) 0 59 (0.27) 119 (0.08) 221 (0.11)
Vertigo 1 (0.03) 56 (0.70) 477 (2.11) 0 268 (1.24) 1562 (1.04) 2381 (1.16)
Vertigo positional 0 1 (0.01) 25 (0.11) 0 26 (0.12) 96 (0.06) 149 (0.07)
Vestibular neuronitis 0 1 (0.01) 19 (0.08) 0 36 (0.17) 30 (0.02) 86 (0.04)
Viral infection 3 (0.08) 3 (0.04) 22 (0.10) 0 14 (0.07) 39 (0.03) 83 (0.04)
Vision blurred 11 (0.28) 86 (1.08) 493 (2.18) 0 277 (1.29) 1911 (1.28) 2803 (1.36)
Visual acuity reduced 0 3 (0.04) 16 (0.07) 0 7 (0.03) 46 (0.03) 73 (0.04)
Visual field defect 1 (0.03) 5 (0.06) 18 (0.08) 0 18 (0.08) 36 (0.02) 80 (0.04)
Visual impairment 9 (0.23) 44 (0.55) 221 (0.98) 0 218 (1.01) 541 (0.36) 1061 (0.52)
Vitreous detachment 0 0 9 (0.04) 0 3 (0.01) 55 (0.04) 67 (0.03)
Vitreous floaters 1 (0.03) 0 31 (0.14) 0 11 (0.05) 127 (0.08) 170 (0.08)
Vomiting 156 (3.99) 273 (3.42) 1386 (6.12) 0 966 (4.49) 8228 (5.50) 11084 (5.39)
Vomiting projectile 2 (0.05) 1 (0.01) 32 (0.14) 0 8 (0.04) 95 (0.06) 138 (0.07)
Weight decreased 4 (0.10) 14 (0.18) 69 (0.30) 0 43 (0.20) 140 (0.09) 275 (0.13)
Weight increased 0 1 (0.01) 13 (0.06) 0 7 (0.03) 40 (0.03) 61 (0.03)
Wheezing 3 (0.08) 41 (0.51) 64 (0.28) 0 41 (0.19) 379 (0.25) 536 (0.26)
Withdrawal syndrome 0 1 (0.01) 5 (0.02) 0 2 (0.01) 55 (0.04) 63 (0.03)
Yawning 0 1 (0.01) 7 (0.03) 0 0 44 (0.03) 53 (0.03)