Eudravigilance C-19 - Astrazeneca
Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)
PT |
Décès 4877 (%) |
Mise en jeu du pronostic vital 9211 (%) |
Invalidité ou incapacité 24244 (%) |
Anomalies congénitales 157 (%) |
Hospitalisation 24779 (%) |
Médicalement significatif 160991 (%) |
Cas Graves 224259 (%) |
|---|---|---|---|---|---|---|---|
| Abdominal discomfort | 12 (0.25) | 18 (0.20) | 163 (0.67) | 0 | 59 (0.24) | 1075 (0.67) | 1335 (0.60) |
| Abdominal distension | 11 (0.23) | 13 (0.14) | 96 (0.40) | 1 (0.64) | 39 (0.16) | 410 (0.25) | 574 (0.26) |
| Abdominal pain | 99 (2.03) | 170 (1.85) | 616 (2.54) | 2 (1.27) | 494 (1.99) | 3079 (1.91) | 4520 (2.02) |
| Abdominal pain lower | 0 | 7 (0.08) | 28 (0.12) | 0 | 53 (0.21) | 185 (0.11) | 275 (0.12) |
| Abdominal pain upper | 24 (0.49) | 71 (0.77) | 562 (2.32) | 2 (1.27) | 249 (1.00) | 3668 (2.28) | 4595 (2.05) |
| Abdominal rigidity | 2 (0.04) | 1 (0.01) | 11 (0.05) | 0 | 4 (0.02) | 39 (0.02) | 57 (0.03) |
| Abnormal dreams | 1 (0.02) | 3 (0.03) | 29 (0.12) | 0 | 4 (0.02) | 237 (0.15) | 274 (0.12) |
| Abnormal loss of weight | 2 (0.04) | 6 (0.07) | 25 (0.10) | 0 | 7 (0.03) | 40 (0.02) | 81 (0.04) |
| Abortion spontaneous | 3 (0.06) | 14 (0.15) | 23 (0.09) | 69 (43.95) | 37 (0.15) | 171 (0.11) | 321 (0.14) |
| Abscess | 0 | 1 (0.01) | 7 (0.03) | 0 | 15 (0.06) | 28 (0.02) | 54 (0.02) |
| Acne | 1 (0.02) | 3 (0.03) | 8 (0.03) | 0 | 4 (0.02) | 81 (0.05) | 98 (0.04) |
| Activated partial thromboplastin time prolonged | 3 (0.06) | 46 (0.50) | 6 (0.02) | 0 | 28 (0.11) | 46 (0.03) | 131 (0.06) |
| Acute coronary syndrome | 29 (0.59) | 23 (0.25) | 0 | 0 | 61 (0.25) | 6 (0.00) | 120 (0.05) |
| Acute disseminated encephalomyelitis | 3 (0.06) | 10 (0.11) | 8 (0.03) | 0 | 23 (0.09) | 8 (0.00) | 55 (0.02) |
| Acute kidney injury | 26 (0.53) | 39 (0.42) | 11 (0.05) | 0 | 74 (0.30) | 29 (0.02) | 194 (0.09) |
| Acute myocardial infarction | 109 (2.23) | 129 (1.40) | 3 (0.01) | 0 | 146 (0.59) | 25 (0.02) | 427 (0.19) |
| Acute respiratory distress syndrome | 44 (0.90) | 13 (0.14) | 0 | 0 | 65 (0.26) | 59 (0.04) | 187 (0.08) |
| Acute respiratory failure | 29 (0.59) | 10 (0.11) | 0 | 0 | 26 (0.10) | 1 (0.00) | 68 (0.03) |
| Administration site pain | 0 | 20 (0.22) | 19 (0.08) | 1 (0.64) | 6 (0.02) | 29 (0.02) | 76 (0.03) |
| Adverse drug reaction | 0 | 2 (0.02) | 18 (0.07) | 1 (0.64) | 5 (0.02) | 80 (0.05) | 107 (0.05) |
| Adverse event following immunisation | 110 (2.26) | 0 | 1 (0.00) | 0 | 1 (0.00) | 0 | 112 (0.05) |
| Ageusia | 15 (0.31) | 14 (0.15) | 160 (0.66) | 0 | 79 (0.32) | 671 (0.42) | 943 (0.42) |
| Agitation | 14 (0.29) | 22 (0.24) | 35 (0.14) | 0 | 25 (0.10) | 123 (0.08) | 229 (0.10) |
| Allergy to vaccine | 0 | 6 (0.07) | 5 (0.02) | 0 | 3 (0.01) | 40 (0.02) | 54 (0.02) |
| Alopecia | 0 | 12 (0.13) | 56 (0.23) | 1 (0.64) | 12 (0.05) | 270 (0.17) | 353 (0.16) |
| Altered state of consciousness | 15 (0.31) | 7 (0.08) | 5 (0.02) | 0 | 27 (0.11) | 21 (0.01) | 85 (0.04) |
| Amenorrhoea | 0 | 9 (0.10) | 47 (0.19) | 2 (1.27) | 10 (0.04) | 271 (0.17) | 339 (0.15) |
| Amnesia | 2 (0.04) | 52 (0.56) | 132 (0.54) | 0 | 93 (0.38) | 241 (0.15) | 527 (0.23) |
| Anaemia | 12 (0.25) | 30 (0.33) | 35 (0.14) | 0 | 65 (0.26) | 107 (0.07) | 260 (0.12) |
| Anal incontinence | 2 (0.04) | 6 (0.07) | 12 (0.05) | 0 | 14 (0.06) | 19 (0.01) | 55 (0.02) |
| Anaphylactic reaction | 10 (0.21) | 357 (3.88) | 23 (0.09) | 0 | 263 (1.06) | 555 (0.34) | 1225 (0.55) |
| Anaphylactic shock | 8 (0.16) | 66 (0.72) | 13 (0.05) | 0 | 61 (0.25) | 100 (0.06) | 255 (0.11) |
| Anaphylactoid reaction | 0 | 6 (0.07) | 2 (0.01) | 0 | 7 (0.03) | 60 (0.04) | 75 (0.03) |
| Anger | 1 (0.02) | 6 (0.07) | 10 (0.04) | 0 | 1 (0.00) | 51 (0.03) | 71 (0.03) |
| Angina pectoris | 5 (0.10) | 48 (0.52) | 51 (0.21) | 1 (0.64) | 90 (0.36) | 177 (0.11) | 383 (0.17) |
| Angioedema | 0 | 64 (0.69) | 28 (0.12) | 0 | 61 (0.25) | 486 (0.30) | 653 (0.29) |
| Anosmia | 16 (0.33) | 8 (0.09) | 66 (0.27) | 0 | 54 (0.22) | 215 (0.13) | 365 (0.16) |
| Anxiety | 3 (0.06) | 47 (0.51) | 245 (1.01) | 0 | 152 (0.61) | 836 (0.52) | 1292 (0.58) |
| Aortic thrombosis | 11 (0.23) | 15 (0.16) | 1 (0.00) | 0 | 19 (0.08) | 5 (0.00) | 59 (0.03) |
| Apathy | 0 | 1 (0.01) | 25 (0.10) | 0 | 11 (0.04) | 47 (0.03) | 86 (0.04) |
| Aphasia | 26 (0.53) | 67 (0.73) | 56 (0.23) | 0 | 107 (0.43) | 172 (0.11) | 472 (0.21) |
| Aphonia | 1 (0.02) | 8 (0.09) | 18 (0.07) | 0 | 11 (0.04) | 73 (0.05) | 113 (0.05) |
| Aphthous ulcer | 1 (0.02) | 1 (0.01) | 5 (0.02) | 0 | 5 (0.02) | 49 (0.03) | 62 (0.03) |
| Appendicitis | 2 (0.04) | 16 (0.17) | 4 (0.02) | 0 | 42 (0.17) | 20 (0.01) | 84 (0.04) |
| Application site pain | 3 (0.06) | 7 (0.08) | 5 (0.02) | 0 | 11 (0.04) | 70 (0.04) | 99 (0.04) |
| Areflexia | 1 (0.02) | 11 (0.12) | 16 (0.07) | 0 | 23 (0.09) | 1 (0.00) | 57 (0.03) |
| Arrhythmia | 11 (0.23) | 36 (0.39) | 43 (0.18) | 0 | 200 (0.81) | 365 (0.23) | 670 (0.30) |
| Arterial thrombosis | 11 (0.23) | 33 (0.36) | 7 (0.03) | 0 | 26 (0.10) | 24 (0.01) | 108 (0.05) |
| Arthralgia | 40 (0.82) | 195 (2.12) | 4247 (17.52) | 3 (1.91) | 643 (2.59) | 16442 (10.21) | 21629 (9.64) |
| Arthritis | 0 | 6 (0.07) | 167 (0.69) | 0 | 34 (0.14) | 370 (0.23) | 582 (0.26) |
| Arthritis reactive | 0 | 1 (0.01) | 27 (0.11) | 0 | 9 (0.04) | 32 (0.02) | 69 (0.03) |
| Asthenia | 127 (2.60) | 198 (2.15) | 1091 (4.50) | 1 (0.64) | 830 (3.35) | 3983 (2.47) | 6318 (2.82) |
| Asthenopia | 0 | 3 (0.03) | 46 (0.19) | 0 | 10 (0.04) | 220 (0.14) | 280 (0.12) |
| Asthma | 3 (0.06) | 38 (0.41) | 105 (0.43) | 0 | 53 (0.21) | 428 (0.27) | 630 (0.28) |
| Ataxia | 2 (0.04) | 12 (0.13) | 22 (0.09) | 0 | 48 (0.19) | 19 (0.01) | 111 (0.05) |
| Atrial fibrillation | 19 (0.39) | 94 (1.02) | 41 (0.17) | 0 | 217 (0.88) | 266 (0.17) | 659 (0.29) |
| Atrial flutter | 0 | 6 (0.07) | 8 (0.03) | 0 | 21 (0.08) | 26 (0.02) | 64 (0.03) |
| Autoimmune disorder | 2 (0.04) | 12 (0.13) | 27 (0.11) | 0 | 21 (0.08) | 47 (0.03) | 113 (0.05) |
| Axillary mass | 0 | 1 (0.01) | 8 (0.03) | 0 | 3 (0.01) | 40 (0.02) | 53 (0.02) |
| Axillary pain | 0 | 1 (0.01) | 60 (0.25) | 0 | 15 (0.06) | 463 (0.29) | 541 (0.24) |
| Back pain | 34 (0.70) | 103 (1.12) | 808 (3.33) | 2 (1.27) | 331 (1.34) | 3939 (2.45) | 5238 (2.34) |
| Balance disorder | 7 (0.14) | 55 (0.60) | 292 (1.20) | 0 | 143 (0.58) | 592 (0.37) | 1108 (0.49) |
| Bedridden | 3 (0.06) | 5 (0.05) | 55 (0.23) | 0 | 9 (0.04) | 95 (0.06) | 173 (0.08) |
| Bell's palsy | 1 (0.02) | 18 (0.20) | 142 (0.59) | 0 | 146 (0.59) | 395 (0.25) | 707 (0.32) |
| Bladder pain | 0 | 1 (0.01) | 9 (0.04) | 0 | 5 (0.02) | 43 (0.03) | 59 (0.03) |
| Blepharospasm | 0 | 1 (0.01) | 22 (0.09) | 0 | 6 (0.02) | 58 (0.04) | 87 (0.04) |
| Blindness | 2 (0.04) | 35 (0.38) | 140 (0.58) | 0 | 56 (0.23) | 215 (0.13) | 467 (0.21) |
| Blindness transient | 0 | 4 (0.04) | 9 (0.04) | 0 | 10 (0.04) | 47 (0.03) | 74 (0.03) |
| Blindness unilateral | 1 (0.02) | 10 (0.11) | 44 (0.18) | 0 | 17 (0.07) | 40 (0.02) | 115 (0.05) |
| Blister | 1 (0.02) | 16 (0.17) | 52 (0.21) | 0 | 27 (0.11) | 339 (0.21) | 442 (0.20) |
| Blood blister | 0 | 2 (0.02) | 10 (0.04) | 0 | 6 (0.02) | 53 (0.03) | 73 (0.03) |
| Blood fibrinogen increased | 2 (0.04) | 6 (0.07) | 2 (0.01) | 0 | 14 (0.06) | 17 (0.01) | 52 (0.02) |
| Blood glucose increased | 1 (0.02) | 7 (0.08) | 17 (0.07) | 0 | 17 (0.07) | 130 (0.08) | 178 (0.08) |
| Blood pressure decreased | 7 (0.14) | 25 (0.27) | 38 (0.16) | 0 | 54 (0.22) | 110 (0.07) | 239 (0.11) |
| Blood pressure fluctuation | 1 (0.02) | 16 (0.17) | 16 (0.07) | 0 | 20 (0.08) | 40 (0.02) | 101 (0.05) |
| Blood pressure increased | 10 (0.21) | 85 (0.92) | 95 (0.39) | 0 | 216 (0.87) | 355 (0.22) | 775 (0.35) |
| Blood pressure measurement | 0 | 10 (0.11) | 12 (0.05) | 0 | 17 (0.07) | 65 (0.04) | 104 (0.05) |
| Blood test abnormal | 0 | 5 (0.05) | 24 (0.10) | 0 | 29 (0.12) | 40 (0.02) | 99 (0.04) |
| Blood urine present | 1 (0.02) | 7 (0.08) | 5 (0.02) | 0 | 9 (0.04) | 63 (0.04) | 89 (0.04) |
| Body temperature | 0 | 1 (0.01) | 72 (0.30) | 0 | 11 (0.04) | 676 (0.42) | 763 (0.34) |
| Body temperature abnormal | 0 | 1 (0.01) | 9 (0.04) | 0 | 3 (0.01) | 52 (0.03) | 65 (0.03) |
| Body temperature decreased | 1 (0.02) | 3 (0.03) | 17 (0.07) | 0 | 5 (0.02) | 101 (0.06) | 128 (0.06) |
| Body temperature fluctuation | 0 | 3 (0.03) | 29 (0.12) | 0 | 1 (0.00) | 127 (0.08) | 160 (0.07) |
| Body temperature increased | 5 (0.10) | 14 (0.15) | 99 (0.41) | 1 (0.64) | 86 (0.35) | 821 (0.51) | 1028 (0.46) |
| Bone pain | 2 (0.04) | 28 (0.30) | 231 (0.95) | 0 | 32 (0.13) | 782 (0.49) | 1078 (0.48) |
| Bradycardia | 12 (0.25) | 21 (0.23) | 17 (0.07) | 0 | 38 (0.15) | 55 (0.03) | 158 (0.07) |
| Bradyphrenia | 0 | 2 (0.02) | 19 (0.08) | 0 | 6 (0.02) | 64 (0.04) | 91 (0.04) |
| Brain injury | 16 (0.33) | 18 (0.20) | 5 (0.02) | 0 | 6 (0.02) | 9 (0.01) | 64 (0.03) |
| Brain oedema | 39 (0.80) | 15 (0.16) | 3 (0.01) | 0 | 13 (0.05) | 14 (0.01) | 88 (0.04) |
| Breast cancer | 0 | 7 (0.08) | 5 (0.02) | 0 | 6 (0.02) | 33 (0.02) | 52 (0.02) |
| Breast mass | 0 | 2 (0.02) | 6 (0.02) | 0 | 7 (0.03) | 40 (0.02) | 56 (0.02) |
| Breast pain | 0 | 0 | 44 (0.18) | 1 (0.64) | 30 (0.12) | 277 (0.17) | 353 (0.16) |
| Breast swelling | 0 | 0 | 8 (0.03) | 0 | 4 (0.02) | 40 (0.02) | 52 (0.02) |
| Bronchospasm | 0 | 7 (0.08) | 3 (0.01) | 0 | 16 (0.06) | 26 (0.02) | 53 (0.02) |
| Burning sensation | 0 | 31 (0.34) | 168 (0.69) | 2 (1.27) | 70 (0.28) | 626 (0.39) | 904 (0.40) |
| Bursitis | 0 | 2 (0.02) | 80 (0.33) | 0 | 9 (0.04) | 122 (0.08) | 213 (0.09) |
| C-reactive protein increased | 7 (0.14) | 11 (0.12) | 17 (0.07) | 0 | 64 (0.26) | 44 (0.03) | 156 (0.07) |
| COVID-19 | 278 (5.70) | 163 (1.77) | 215 (0.89) | 2 (1.27) | 689 (2.78) | 10453 (6.49) | 11824 (5.27) |
| COVID-19 immunisation | 4 (0.08) | 12 (0.13) | 62 (0.26) | 0 | 34 (0.14) | 138 (0.09) | 251 (0.11) |
| COVID-19 pneumonia | 66 (1.35) | 32 (0.35) | 13 (0.05) | 0 | 168 (0.68) | 26 (0.02) | 305 (0.14) |
| Candida infection | 1 (0.02) | 1 (0.01) | 6 (0.02) | 0 | 2 (0.01) | 46 (0.03) | 56 (0.02) |
| Cardiac arrest | 247 (5.06) | 92 (1.00) | 4 (0.02) | 0 | 15 (0.06) | 41 (0.03) | 419 (0.19) |
| Cardiac disorder | 4 (0.08) | 27 (0.29) | 10 (0.04) | 0 | 46 (0.19) | 41 (0.03) | 136 (0.06) |
| Cardiac failure | 63 (1.29) | 61 (0.66) | 21 (0.09) | 0 | 76 (0.31) | 26 (0.02) | 259 (0.12) |
| Cardiac flutter | 0 | 8 (0.09) | 30 (0.12) | 0 | 14 (0.06) | 169 (0.10) | 222 (0.10) |
| Cardio-respiratory arrest | 68 (1.39) | 18 (0.20) | 0 | 0 | 5 (0.02) | 4 (0.00) | 98 (0.04) |
| Cardiovascular disorder | 16 (0.33) | 8 (0.09) | 49 (0.20) | 0 | 45 (0.18) | 32 (0.02) | 154 (0.07) |
| Cellulitis | 3 (0.06) | 13 (0.14) | 39 (0.16) | 0 | 56 (0.23) | 287 (0.18) | 402 (0.18) |
| Cerebral artery thrombosis | 11 (0.23) | 17 (0.18) | 3 (0.01) | 0 | 10 (0.04) | 8 (0.00) | 52 (0.02) |
| Cerebral haemorrhage | 197 (4.04) | 146 (1.59) | 27 (0.11) | 0 | 116 (0.47) | 47 (0.03) | 559 (0.25) |
| Cerebral infarction | 42 (0.86) | 110 (1.19) | 34 (0.14) | 0 | 176 (0.71) | 53 (0.03) | 432 (0.19) |
| Cerebral ischaemia | 7 (0.14) | 13 (0.14) | 5 (0.02) | 0 | 27 (0.11) | 10 (0.01) | 67 (0.03) |
| Cerebral thrombosis | 54 (1.11) | 38 (0.41) | 4 (0.02) | 0 | 70 (0.28) | 41 (0.03) | 221 (0.10) |
| Cerebral venous sinus thrombosis | 103 (2.11) | 234 (2.54) | 20 (0.08) | 0 | 252 (1.02) | 75 (0.05) | 704 (0.31) |
| Cerebral venous thrombosis | 44 (0.90) | 53 (0.58) | 5 (0.02) | 0 | 81 (0.33) | 36 (0.02) | 229 (0.10) |
| Cerebrovascular accident | 191 (3.92) | 539 (5.85) | 252 (1.04) | 3 (1.91) | 767 (3.10) | 581 (0.36) | 2399 (1.07) |
| Chest discomfort | 16 (0.33) | 91 (0.99) | 297 (1.23) | 0 | 326 (1.32) | 1393 (0.87) | 2155 (0.96) |
| Chest pain | 107 (2.19) | 487 (5.29) | 871 (3.59) | 1 (0.64) | 1119 (4.52) | 3538 (2.20) | 6226 (2.78) |
| Chills | 65 (1.33) | 380 (4.13) | 5692 (23.48) | 7 (4.46) | 1285 (5.19) | 31777 (19.74) | 39264 (17.51) |
| Chromaturia | 3 (0.06) | 5 (0.05) | 13 (0.05) | 0 | 7 (0.03) | 75 (0.05) | 105 (0.05) |
| Chronic fatigue syndrome | 0 | 1 (0.01) | 85 (0.35) | 0 | 9 (0.04) | 64 (0.04) | 160 (0.07) |
| Chronic obstructive pulmonary disease | 20 (0.41) | 10 (0.11) | 6 (0.02) | 0 | 19 (0.08) | 23 (0.01) | 79 (0.04) |
| Circulatory collapse | 62 (1.27) | 47 (0.51) | 15 (0.06) | 0 | 77 (0.31) | 123 (0.08) | 348 (0.16) |
| Clumsiness | 0 | 1 (0.01) | 19 (0.08) | 0 | 6 (0.02) | 27 (0.02) | 54 (0.02) |
| Cluster headache | 2 (0.04) | 12 (0.13) | 96 (0.40) | 0 | 24 (0.10) | 494 (0.31) | 629 (0.28) |
| Coagulopathy | 21 (0.43) | 43 (0.47) | 34 (0.14) | 1 (0.64) | 52 (0.21) | 72 (0.04) | 231 (0.10) |
| Cognitive disorder | 3 (0.06) | 9 (0.10) | 98 (0.40) | 0 | 23 (0.09) | 106 (0.07) | 250 (0.11) |
| Cold sweat | 12 (0.25) | 32 (0.35) | 181 (0.75) | 1 (0.64) | 69 (0.28) | 1148 (0.71) | 1452 (0.65) |
| Cold-stimulus headache | 0 | 3 (0.03) | 15 (0.06) | 0 | 3 (0.01) | 54 (0.03) | 75 (0.03) |
| Colitis | 1 (0.02) | 3 (0.03) | 7 (0.03) | 0 | 27 (0.11) | 41 (0.03) | 79 (0.04) |
| Colitis ulcerative | 0 | 3 (0.03) | 20 (0.08) | 0 | 17 (0.07) | 73 (0.05) | 113 (0.05) |
| Coma | 27 (0.55) | 31 (0.34) | 3 (0.01) | 0 | 12 (0.05) | 3 (0.00) | 98 (0.04) |
| Condition aggravated | 15 (0.31) | 20 (0.22) | 148 (0.61) | 0 | 66 (0.27) | 302 (0.19) | 558 (0.25) |
| Confusional state | 52 (1.07) | 149 (1.62) | 429 (1.77) | 1 (0.64) | 284 (1.15) | 1320 (0.82) | 2274 (1.01) |
| Conjunctival haemorrhage | 0 | 4 (0.04) | 8 (0.03) | 0 | 7 (0.03) | 86 (0.05) | 106 (0.05) |
| Conjunctivitis | 1 (0.02) | 0 | 7 (0.03) | 0 | 7 (0.03) | 53 (0.03) | 68 (0.03) |
| Constipation | 3 (0.06) | 15 (0.16) | 91 (0.38) | 0 | 36 (0.15) | 272 (0.17) | 420 (0.19) |
| Contusion | 17 (0.35) | 83 (0.90) | 225 (0.93) | 0 | 180 (0.73) | 1597 (0.99) | 2128 (0.95) |
| Coordination abnormal | 5 (0.10) | 6 (0.07) | 32 (0.13) | 0 | 21 (0.08) | 82 (0.05) | 152 (0.07) |
| Coronary artery thrombosis | 18 (0.37) | 24 (0.26) | 0 | 0 | 11 (0.04) | 9 (0.01) | 66 (0.03) |
| Costochondritis | 0 | 1 (0.01) | 21 (0.09) | 0 | 10 (0.04) | 54 (0.03) | 86 (0.04) |
| Cough | 237 (4.86) | 143 (1.55) | 489 (2.02) | 2 (1.27) | 649 (2.62) | 2537 (1.58) | 4105 (1.83) |
| Crohn's disease | 0 | 1 (0.01) | 25 (0.10) | 0 | 12 (0.05) | 56 (0.03) | 94 (0.04) |
| Crying | 1 (0.02) | 7 (0.08) | 48 (0.20) | 0 | 11 (0.04) | 199 (0.12) | 266 (0.12) |
| Cutaneous vasculitis | 0 | 0 | 2 (0.01) | 0 | 24 (0.10) | 51 (0.03) | 79 (0.04) |
| Cyanosis | 25 (0.51) | 18 (0.20) | 18 (0.07) | 0 | 94 (0.38) | 88 (0.05) | 251 (0.11) |
| Cystitis | 1 (0.02) | 1 (0.01) | 11 (0.05) | 0 | 12 (0.05) | 81 (0.05) | 106 (0.05) |
| Deafness | 1 (0.02) | 9 (0.10) | 158 (0.65) | 0 | 32 (0.13) | 289 (0.18) | 491 (0.22) |
| Deafness neurosensory | 1 (0.02) | 1 (0.01) | 34 (0.14) | 0 | 1 (0.00) | 20 (0.01) | 60 (0.03) |
| Deafness unilateral | 0 | 2 (0.02) | 41 (0.17) | 0 | 8 (0.03) | 58 (0.04) | 110 (0.05) |
| Death | 746 (15.30) | 1 (0.01) | 0 | 0 | 0 | 2 (0.00) | 752 (0.34) |
| Decreased appetite | 76 (1.56) | 78 (0.85) | 850 (3.51) | 2 (1.27) | 278 (1.12) | 4740 (2.94) | 6061 (2.70) |
| Deep vein thrombosis | 79 (1.62) | 546 (5.93) | 115 (0.47) | 0 | 1120 (4.52) | 1955 (1.21) | 3939 (1.76) |
| Dehydration | 6 (0.12) | 18 (0.20) | 75 (0.31) | 0 | 88 (0.36) | 416 (0.26) | 610 (0.27) |
| Delirium | 9 (0.18) | 16 (0.17) | 81 (0.33) | 0 | 47 (0.19) | 326 (0.20) | 487 (0.22) |
| Delusion | 1 (0.02) | 2 (0.02) | 14 (0.06) | 0 | 8 (0.03) | 35 (0.02) | 63 (0.03) |
| Demyelination | 1 (0.02) | 5 (0.05) | 17 (0.07) | 0 | 16 (0.06) | 21 (0.01) | 62 (0.03) |
| Depressed level of consciousness | 29 (0.59) | 19 (0.21) | 13 (0.05) | 0 | 50 (0.20) | 60 (0.04) | 184 (0.08) |
| Depressed mood | 1 (0.02) | 9 (0.10) | 106 (0.44) | 0 | 11 (0.04) | 471 (0.29) | 599 (0.27) |
| Depression | 4 (0.08) | 31 (0.34) | 146 (0.60) | 0 | 25 (0.10) | 434 (0.27) | 645 (0.29) |
| Dermatitis | 0 | 5 (0.05) | 13 (0.05) | 0 | 8 (0.03) | 107 (0.07) | 134 (0.06) |
| Dermatitis allergic | 0 | 10 (0.11) | 18 (0.07) | 0 | 11 (0.04) | 182 (0.11) | 223 (0.10) |
| Dermatitis bullous | 1 (0.02) | 4 (0.04) | 5 (0.02) | 0 | 4 (0.02) | 46 (0.03) | 60 (0.03) |
| Diabetes mellitus | 7 (0.14) | 15 (0.16) | 19 (0.08) | 0 | 25 (0.10) | 79 (0.05) | 147 (0.07) |
| Diabetic ketoacidosis | 5 (0.10) | 14 (0.15) | 1 (0.00) | 0 | 17 (0.07) | 13 (0.01) | 54 (0.02) |
| Diarrhoea | 97 (1.99) | 137 (1.49) | 1009 (4.16) | 0 | 529 (2.13) | 6138 (3.81) | 7952 (3.55) |
| Diplegia | 5 (0.10) | 8 (0.09) | 25 (0.10) | 0 | 17 (0.07) | 41 (0.03) | 100 (0.04) |
| Diplopia | 1 (0.02) | 26 (0.28) | 105 (0.43) | 0 | 112 (0.45) | 219 (0.14) | 469 (0.21) |
| Discomfort | 5 (0.10) | 15 (0.16) | 89 (0.37) | 1 (0.64) | 52 (0.21) | 380 (0.24) | 550 (0.25) |
| Disorientation | 13 (0.27) | 19 (0.21) | 113 (0.47) | 0 | 91 (0.37) | 507 (0.31) | 756 (0.34) |
| Disseminated intravascular coagulation | 30 (0.62) | 26 (0.28) | 1 (0.00) | 0 | 15 (0.06) | 2 (0.00) | 78 (0.03) |
| Dissociation | 0 | 2 (0.02) | 11 (0.05) | 0 | 3 (0.01) | 45 (0.03) | 61 (0.03) |
| Disturbance in attention | 1 (0.02) | 26 (0.28) | 218 (0.90) | 0 | 112 (0.45) | 517 (0.32) | 884 (0.39) |
| Diverticulitis | 3 (0.06) | 4 (0.04) | 6 (0.02) | 0 | 23 (0.09) | 25 (0.02) | 61 (0.03) |
| Dizziness | 71 (1.46) | 430 (4.67) | 2780 (11.47) | 5 (3.18) | 1613 (6.51) | 15413 (9.57) | 20419 (9.11) |
| Dizziness exertional | 0 | 1 (0.01) | 17 (0.07) | 0 | 1 (0.00) | 76 (0.05) | 95 (0.04) |
| Dizziness postural | 2 (0.04) | 7 (0.08) | 228 (0.94) | 0 | 55 (0.22) | 1481 (0.92) | 1775 (0.79) |
| Drug hypersensitivity | 0 | 8 (0.09) | 5 (0.02) | 0 | 6 (0.02) | 38 (0.02) | 57 (0.03) |
| Drug ineffective | 16 (0.33) | 14 (0.15) | 21 (0.09) | 0 | 54 (0.22) | 167 (0.10) | 276 (0.12) |
| Dry eye | 0 | 3 (0.03) | 42 (0.17) | 0 | 16 (0.06) | 192 (0.12) | 253 (0.11) |
| Dry mouth | 1 (0.02) | 11 (0.12) | 118 (0.49) | 0 | 44 (0.18) | 729 (0.45) | 906 (0.40) |
| Dry skin | 0 | 2 (0.02) | 38 (0.16) | 0 | 13 (0.05) | 230 (0.14) | 283 (0.13) |
| Dry throat | 1 (0.02) | 4 (0.04) | 24 (0.10) | 0 | 7 (0.03) | 153 (0.10) | 189 (0.08) |
| Dysaesthesia | 0 | 3 (0.03) | 7 (0.03) | 0 | 24 (0.10) | 44 (0.03) | 82 (0.04) |
| Dysarthria | 28 (0.57) | 69 (0.75) | 100 (0.41) | 0 | 172 (0.69) | 234 (0.15) | 623 (0.28) |
| Dysgeusia | 3 (0.06) | 13 (0.14) | 153 (0.63) | 1 (0.64) | 30 (0.12) | 1046 (0.65) | 1254 (0.56) |
| Dyskinesia | 4 (0.08) | 4 (0.04) | 29 (0.12) | 0 | 19 (0.08) | 78 (0.05) | 141 (0.06) |
| Dysmenorrhoea | 0 | 2 (0.02) | 115 (0.47) | 1 (0.64) | 25 (0.10) | 882 (0.55) | 1028 (0.46) |
| Dyspepsia | 4 (0.08) | 21 (0.23) | 94 (0.39) | 0 | 33 (0.13) | 551 (0.34) | 707 (0.32) |
| Dysphagia | 17 (0.35) | 42 (0.46) | 50 (0.21) | 1 (0.64) | 78 (0.31) | 174 (0.11) | 381 (0.17) |
| Dysphonia | 1 (0.02) | 20 (0.22) | 42 (0.17) | 0 | 31 (0.13) | 106 (0.07) | 202 (0.09) |
| Dyspnoea | 515 (10.56) | 911 (9.89) | 1284 (5.30) | 1 (0.64) | 2202 (8.89) | 4905 (3.05) | 10057 (4.48) |
| Dyspnoea exertional | 8 (0.16) | 22 (0.24) | 31 (0.13) | 0 | 73 (0.29) | 72 (0.04) | 219 (0.10) |
| Dysstasia | 1 (0.02) | 13 (0.14) | 48 (0.20) | 0 | 19 (0.08) | 81 (0.05) | 169 (0.08) |
| Dysuria | 2 (0.04) | 5 (0.05) | 15 (0.06) | 0 | 25 (0.10) | 67 (0.04) | 117 (0.05) |
| Ear discomfort | 0 | 2 (0.02) | 26 (0.11) | 0 | 18 (0.07) | 80 (0.05) | 129 (0.06) |
| Ear infection | 1 (0.02) | 5 (0.05) | 21 (0.09) | 0 | 8 (0.03) | 104 (0.06) | 142 (0.06) |
| Ear pain | 0 | 16 (0.17) | 266 (1.10) | 0 | 66 (0.27) | 1404 (0.87) | 1756 (0.78) |
| Ear swelling | 0 | 1 (0.01) | 2 (0.01) | 0 | 8 (0.03) | 50 (0.03) | 61 (0.03) |
| Ecchymosis | 0 | 9 (0.10) | 7 (0.03) | 0 | 38 (0.15) | 53 (0.03) | 114 (0.05) |
| Eczema | 1 (0.02) | 7 (0.08) | 32 (0.13) | 0 | 17 (0.07) | 198 (0.12) | 255 (0.11) |
| Electric shock sensation | 1 (0.02) | 3 (0.03) | 25 (0.10) | 0 | 8 (0.03) | 73 (0.05) | 110 (0.05) |
| Embolism | 32 (0.66) | 100 (1.09) | 30 (0.12) | 0 | 80 (0.32) | 112 (0.07) | 360 (0.16) |
| Emotional disorder | 0 | 0 | 16 (0.07) | 0 | 2 (0.01) | 66 (0.04) | 85 (0.04) |
| Emotional distress | 0 | 6 (0.07) | 21 (0.09) | 0 | 5 (0.02) | 57 (0.04) | 91 (0.04) |
| Encephalitis | 5 (0.10) | 36 (0.39) | 13 (0.05) | 0 | 66 (0.27) | 19 (0.01) | 141 (0.06) |
| Endometriosis | 0 | 0 | 8 (0.03) | 0 | 7 (0.03) | 54 (0.03) | 69 (0.03) |
| Enuresis | 0 | 2 (0.02) | 8 (0.03) | 0 | 2 (0.01) | 42 (0.03) | 54 (0.02) |
| Epilepsy | 6 (0.12) | 55 (0.60) | 52 (0.21) | 0 | 137 (0.55) | 201 (0.12) | 459 (0.20) |
| Epistaxis | 12 (0.25) | 82 (0.89) | 149 (0.61) | 1 (0.64) | 191 (0.77) | 1177 (0.73) | 1626 (0.73) |
| Erectile dysfunction | 1 (0.02) | 7 (0.08) | 30 (0.12) | 0 | 5 (0.02) | 43 (0.03) | 86 (0.04) |
| Eructation | 1 (0.02) | 5 (0.05) | 18 (0.07) | 0 | 3 (0.01) | 66 (0.04) | 93 (0.04) |
| Erythema | 7 (0.14) | 69 (0.75) | 169 (0.70) | 2 (1.27) | 168 (0.68) | 1656 (1.03) | 2090 (0.93) |
| Erythema multiforme | 0 | 5 (0.05) | 1 (0.00) | 0 | 11 (0.04) | 49 (0.03) | 67 (0.03) |
| Exercise tolerance decreased | 0 | 8 (0.09) | 21 (0.09) | 0 | 23 (0.09) | 39 (0.02) | 100 (0.04) |
| Exposure during pregnancy | 5 (0.10) | 7 (0.08) | 3 (0.01) | 4 (2.55) | 20 (0.08) | 40 (0.02) | 91 (0.04) |
| Exposure via breast milk | 0 | 1 (0.01) | 4 (0.02) | 0 | 0 | 52 (0.03) | 57 (0.03) |
| Extensive swelling of vaccinated limb | 0 | 4 (0.04) | 182 (0.75) | 0 | 6 (0.02) | 40 (0.02) | 233 (0.10) |
| Extrasystoles | 1 (0.02) | 7 (0.08) | 28 (0.12) | 1 (0.64) | 20 (0.08) | 127 (0.08) | 186 (0.08) |
| Eye disorder | 0 | 2 (0.02) | 9 (0.04) | 0 | 9 (0.04) | 30 (0.02) | 52 (0.02) |
| Eye haemorrhage | 0 | 2 (0.02) | 24 (0.10) | 0 | 15 (0.06) | 91 (0.06) | 136 (0.06) |
| Eye injury | 0 | 5 (0.05) | 20 (0.08) | 0 | 4 (0.02) | 25 (0.02) | 55 (0.02) |
| Eye irritation | 0 | 6 (0.07) | 35 (0.14) | 0 | 10 (0.04) | 142 (0.09) | 194 (0.09) |
| Eye movement disorder | 0 | 6 (0.07) | 12 (0.05) | 0 | 9 (0.04) | 32 (0.02) | 61 (0.03) |
| Eye pain | 2 (0.04) | 43 (0.47) | 453 (1.87) | 0 | 107 (0.43) | 2213 (1.37) | 2825 (1.26) |
| Eye pruritus | 0 | 10 (0.11) | 25 (0.10) | 0 | 12 (0.05) | 167 (0.10) | 215 (0.10) |
| Eye swelling | 0 | 16 (0.17) | 48 (0.20) | 0 | 28 (0.11) | 356 (0.22) | 449 (0.20) |
| Eyelid oedema | 1 (0.02) | 2 (0.02) | 7 (0.03) | 0 | 14 (0.06) | 35 (0.02) | 60 (0.03) |
| Eyelid ptosis | 1 (0.02) | 5 (0.05) | 16 (0.07) | 0 | 19 (0.08) | 40 (0.02) | 85 (0.04) |
| Face oedema | 1 (0.02) | 21 (0.23) | 10 (0.04) | 0 | 29 (0.12) | 72 (0.04) | 134 (0.06) |
| Facial pain | 0 | 5 (0.05) | 60 (0.25) | 0 | 16 (0.06) | 191 (0.12) | 274 (0.12) |
| Facial paralysis | 13 (0.27) | 49 (0.53) | 126 (0.52) | 0 | 210 (0.85) | 321 (0.20) | 754 (0.34) |
| Facial paresis | 5 (0.10) | 27 (0.29) | 49 (0.20) | 0 | 106 (0.43) | 101 (0.06) | 297 (0.13) |
| Faeces discoloured | 0 | 2 (0.02) | 8 (0.03) | 0 | 8 (0.03) | 30 (0.02) | 51 (0.02) |
| Fall | 27 (0.55) | 46 (0.50) | 58 (0.24) | 0 | 110 (0.44) | 188 (0.12) | 452 (0.20) |
| Fatigue | 146 (2.99) | 506 (5.49) | 7870 (32.46) | 5 (3.18) | 1594 (6.43) | 35059 (21.78) | 45307 (20.20) |
| Fear | 0 | 6 (0.07) | 18 (0.07) | 0 | 5 (0.02) | 38 (0.02) | 68 (0.03) |
| Febrile convulsion | 2 (0.04) | 4 (0.04) | 17 (0.07) | 0 | 22 (0.09) | 103 (0.06) | 151 (0.07) |
| Feeding disorder | 3 (0.06) | 9 (0.10) | 53 (0.22) | 0 | 11 (0.04) | 147 (0.09) | 226 (0.10) |
| Feeling abnormal | 15 (0.31) | 55 (0.60) | 429 (1.77) | 0 | 116 (0.47) | 2073 (1.29) | 2709 (1.21) |
| Feeling cold | 7 (0.14) | 43 (0.47) | 464 (1.91) | 0 | 125 (0.50) | 3710 (2.30) | 4353 (1.94) |
| Feeling drunk | 0 | 1 (0.01) | 17 (0.07) | 0 | 2 (0.01) | 82 (0.05) | 102 (0.05) |
| Feeling hot | 5 (0.10) | 42 (0.46) | 201 (0.83) | 0 | 114 (0.46) | 1552 (0.96) | 1929 (0.86) |
| Feeling of body temperature change | 4 (0.08) | 3 (0.03) | 118 (0.49) | 0 | 26 (0.10) | 655 (0.41) | 807 (0.36) |
| Fibrin D dimer increased | 40 (0.82) | 74 (0.80) | 16 (0.07) | 0 | 308 (1.24) | 165 (0.10) | 759 (0.34) |
| Fibromyalgia | 0 | 3 (0.03) | 102 (0.42) | 0 | 15 (0.06) | 189 (0.12) | 312 (0.14) |
| Flank pain | 2 (0.04) | 3 (0.03) | 19 (0.08) | 0 | 19 (0.08) | 59 (0.04) | 108 (0.05) |
| Flatulence | 0 | 5 (0.05) | 38 (0.16) | 0 | 10 (0.04) | 277 (0.17) | 332 (0.15) |
| Fluid retention | 2 (0.04) | 5 (0.05) | 18 (0.07) | 0 | 10 (0.04) | 51 (0.03) | 86 (0.04) |
| Flushing | 1 (0.02) | 20 (0.22) | 67 (0.28) | 0 | 46 (0.19) | 450 (0.28) | 587 (0.26) |
| Food aversion | 0 | 1 (0.01) | 9 (0.04) | 0 | 3 (0.01) | 41 (0.03) | 54 (0.02) |
| Formication | 0 | 1 (0.01) | 12 (0.05) | 0 | 6 (0.02) | 67 (0.04) | 86 (0.04) |
| Freezing phenomenon | 0 | 2 (0.02) | 12 (0.05) | 0 | 5 (0.02) | 114 (0.07) | 133 (0.06) |
| Gait disturbance | 12 (0.25) | 47 (0.51) | 251 (1.04) | 1 (0.64) | 173 (0.70) | 329 (0.20) | 841 (0.38) |
| Gait inability | 5 (0.10) | 17 (0.18) | 104 (0.43) | 0 | 44 (0.18) | 110 (0.07) | 297 (0.13) |
| Gastritis | 2 (0.04) | 3 (0.03) | 31 (0.13) | 0 | 16 (0.06) | 71 (0.04) | 124 (0.06) |
| Gastroenteritis viral | 1 (0.02) | 0 | 4 (0.02) | 0 | 3 (0.01) | 49 (0.03) | 58 (0.03) |
| Gastrointestinal disorder | 0 | 1 (0.01) | 30 (0.12) | 0 | 8 (0.03) | 44 (0.03) | 85 (0.04) |
| Gastrointestinal haemorrhage | 16 (0.33) | 11 (0.12) | 7 (0.03) | 0 | 12 (0.05) | 15 (0.01) | 66 (0.03) |
| Gastrointestinal pain | 0 | 0 | 54 (0.22) | 0 | 35 (0.14) | 232 (0.14) | 322 (0.14) |
| Gastrooesophageal reflux disease | 1 (0.02) | 1 (0.01) | 40 (0.16) | 0 | 10 (0.04) | 147 (0.09) | 201 (0.09) |
| General physical health deterioration | 24 (0.49) | 13 (0.14) | 15 (0.06) | 0 | 56 (0.23) | 21 (0.01) | 139 (0.06) |
| Generalised tonic-clonic seizure | 4 (0.08) | 33 (0.36) | 11 (0.05) | 0 | 57 (0.23) | 55 (0.03) | 166 (0.07) |
| Genital herpes | 0 | 0 | 9 (0.04) | 0 | 1 (0.00) | 52 (0.03) | 62 (0.03) |
| Giant cell arteritis | 2 (0.04) | 9 (0.10) | 9 (0.04) | 0 | 20 (0.08) | 42 (0.03) | 83 (0.04) |
| Gingival bleeding | 0 | 14 (0.15) | 14 (0.06) | 0 | 23 (0.09) | 108 (0.07) | 164 (0.07) |
| Gingival pain | 0 | 1 (0.01) | 21 (0.09) | 1 (0.64) | 2 (0.01) | 143 (0.09) | 168 (0.07) |
| Glossodynia | 0 | 2 (0.02) | 23 (0.09) | 0 | 3 (0.01) | 137 (0.09) | 165 (0.07) |
| Gout | 1 (0.02) | 2 (0.02) | 26 (0.11) | 0 | 7 (0.03) | 117 (0.07) | 153 (0.07) |
| Groin pain | 2 (0.04) | 8 (0.09) | 43 (0.18) | 0 | 18 (0.07) | 138 (0.09) | 211 (0.09) |
| Guillain-Barre syndrome | 22 (0.45) | 205 (2.23) | 212 (0.87) | 3 (1.91) | 661 (2.67) | 236 (0.15) | 1375 (0.61) |
| Haematemesis | 15 (0.31) | 17 (0.18) | 8 (0.03) | 0 | 43 (0.17) | 74 (0.05) | 164 (0.07) |
| Haematochezia | 3 (0.06) | 7 (0.08) | 9 (0.04) | 0 | 33 (0.13) | 93 (0.06) | 147 (0.07) |
| Haematoma | 6 (0.12) | 42 (0.46) | 41 (0.17) | 1 (0.64) | 103 (0.42) | 192 (0.12) | 396 (0.18) |
| Haematuria | 2 (0.04) | 9 (0.10) | 7 (0.03) | 0 | 26 (0.10) | 63 (0.04) | 114 (0.05) |
| Haemoglobin decreased | 5 (0.10) | 9 (0.10) | 6 (0.02) | 0 | 13 (0.05) | 16 (0.01) | 56 (0.02) |
| Haemoptysis | 14 (0.29) | 35 (0.38) | 9 (0.04) | 0 | 50 (0.20) | 80 (0.05) | 196 (0.09) |
| Haemorrhage | 27 (0.55) | 102 (1.11) | 83 (0.34) | 6 (3.82) | 110 (0.44) | 758 (0.47) | 1103 (0.49) |
| Haemorrhage intracranial | 48 (0.98) | 29 (0.31) | 6 (0.02) | 0 | 13 (0.05) | 14 (0.01) | 120 (0.05) |
| Haemorrhage urinary tract | 1 (0.02) | 10 (0.11) | 4 (0.02) | 0 | 8 (0.03) | 34 (0.02) | 58 (0.03) |
| Haemorrhagic stroke | 35 (0.72) | 34 (0.37) | 6 (0.02) | 0 | 25 (0.10) | 15 (0.01) | 119 (0.05) |
| Haemorrhoids | 1 (0.02) | 1 (0.01) | 8 (0.03) | 0 | 2 (0.01) | 47 (0.03) | 60 (0.03) |
| Hallucination | 1 (0.02) | 19 (0.21) | 145 (0.60) | 0 | 39 (0.16) | 653 (0.41) | 864 (0.39) |
| Hallucination, visual | 0 | 4 (0.04) | 8 (0.03) | 0 | 5 (0.02) | 44 (0.03) | 62 (0.03) |
| Hangover | 0 | 0 | 23 (0.09) | 0 | 2 (0.01) | 121 (0.08) | 148 (0.07) |
| Head discomfort | 2 (0.04) | 22 (0.24) | 174 (0.72) | 0 | 75 (0.30) | 499 (0.31) | 782 (0.35) |
| Head injury | 3 (0.06) | 17 (0.18) | 11 (0.05) | 0 | 14 (0.06) | 22 (0.01) | 71 (0.03) |
| Headache | 292 (5.99) | 1055 (11.45) | 9443 (38.95) | 17 (10.83) | 3970 (16.02) | 56135 (34.87) | 71181 (31.74) |
| Heart rate | 0 | 19 (0.21) | 79 (0.33) | 0 | 66 (0.27) | 746 (0.46) | 910 (0.41) |
| Heart rate abnormal | 1 (0.02) | 2 (0.02) | 10 (0.04) | 0 | 13 (0.05) | 47 (0.03) | 76 (0.03) |
| Heart rate decreased | 2 (0.04) | 14 (0.15) | 16 (0.07) | 0 | 29 (0.12) | 81 (0.05) | 142 (0.06) |
| Heart rate increased | 3 (0.06) | 77 (0.84) | 245 (1.01) | 3 (1.91) | 186 (0.75) | 1523 (0.95) | 2054 (0.92) |
| Heart rate irregular | 1 (0.02) | 17 (0.18) | 45 (0.19) | 1 (0.64) | 36 (0.15) | 159 (0.10) | 259 (0.12) |
| Heavy menstrual bleeding | 0 | 23 (0.25) | 256 (1.06) | 2 (1.27) | 102 (0.41) | 2562 (1.59) | 2950 (1.32) |
| Hemiparaesthesia | 1 (0.02) | 2 (0.02) | 4 (0.02) | 0 | 17 (0.07) | 32 (0.02) | 59 (0.03) |
| Hemiparesis | 34 (0.70) | 68 (0.74) | 46 (0.19) | 0 | 111 (0.45) | 120 (0.07) | 422 (0.19) |
| Hemiplegia | 8 (0.16) | 33 (0.36) | 23 (0.09) | 0 | 40 (0.16) | 58 (0.04) | 187 (0.08) |
| Hemiplegic migraine | 0 | 3 (0.03) | 21 (0.09) | 0 | 8 (0.03) | 22 (0.01) | 55 (0.02) |
| Heparin-induced thrombocytopenia test positive | 7 (0.14) | 8 (0.09) | 0 | 0 | 29 (0.12) | 2 (0.00) | 51 (0.02) |
| Hepatic pain | 0 | 3 (0.03) | 22 (0.09) | 0 | 3 (0.01) | 50 (0.03) | 78 (0.03) |
| Hepatitis | 1 (0.02) | 6 (0.07) | 2 (0.01) | 0 | 21 (0.08) | 28 (0.02) | 59 (0.03) |
| Herpes zoster | 0 | 17 (0.18) | 161 (0.66) | 0 | 115 (0.46) | 1246 (0.77) | 1539 (0.69) |
| Hospitalisation | 2 (0.04) | 3 (0.03) | 4 (0.02) | 0 | 61 (0.25) | 0 | 76 (0.03) |
| Hot flush | 2 (0.04) | 12 (0.13) | 188 (0.78) | 0 | 55 (0.22) | 1392 (0.86) | 1654 (0.74) |
| Hunger | 0 | 2 (0.02) | 3 (0.01) | 0 | 1 (0.00) | 46 (0.03) | 52 (0.02) |
| Hyperacusis | 0 | 8 (0.09) | 56 (0.23) | 0 | 23 (0.09) | 86 (0.05) | 173 (0.08) |
| Hyperaesthesia | 0 | 4 (0.04) | 34 (0.14) | 1 (0.64) | 25 (0.10) | 185 (0.11) | 250 (0.11) |
| Hyperglycaemia | 5 (0.10) | 16 (0.17) | 15 (0.06) | 0 | 26 (0.10) | 95 (0.06) | 161 (0.07) |
| Hyperhidrosis | 22 (0.45) | 87 (0.94) | 1028 (4.24) | 1 (0.64) | 300 (1.21) | 6605 (4.10) | 8071 (3.60) |
| Hyperpyrexia | 5 (0.10) | 13 (0.14) | 16 (0.07) | 0 | 43 (0.17) | 738 (0.46) | 816 (0.36) |
| Hypersensitivity | 10 (0.21) | 98 (1.06) | 187 (0.77) | 0 | 242 (0.98) | 969 (0.60) | 1521 (0.68) |
| Hypersomnia | 1 (0.02) | 7 (0.08) | 33 (0.14) | 0 | 14 (0.06) | 148 (0.09) | 206 (0.09) |
| Hypertension | 51 (1.05) | 168 (1.82) | 187 (0.77) | 1 (0.64) | 449 (1.81) | 876 (0.54) | 1779 (0.79) |
| Hypertensive crisis | 4 (0.08) | 13 (0.14) | 2 (0.01) | 0 | 66 (0.27) | 110 (0.07) | 201 (0.09) |
| Hyperthyroidism | 0 | 11 (0.12) | 13 (0.05) | 1 (0.64) | 12 (0.05) | 49 (0.03) | 87 (0.04) |
| Hyperventilation | 1 (0.02) | 4 (0.04) | 13 (0.05) | 0 | 26 (0.10) | 72 (0.04) | 118 (0.05) |
| Hypoacusis | 1 (0.02) | 6 (0.07) | 77 (0.32) | 0 | 21 (0.08) | 170 (0.11) | 277 (0.12) |
| Hypoaesthesia | 20 (0.41) | 163 (1.77) | 851 (3.51) | 1 (0.64) | 582 (2.35) | 3369 (2.09) | 5033 (2.24) |
| Hypoaesthesia oral | 1 (0.02) | 17 (0.18) | 50 (0.21) | 0 | 56 (0.23) | 349 (0.22) | 479 (0.21) |
| Hypoglycaemia | 7 (0.14) | 9 (0.10) | 8 (0.03) | 0 | 20 (0.08) | 67 (0.04) | 114 (0.05) |
| Hypokinesia | 2 (0.04) | 6 (0.07) | 38 (0.16) | 0 | 28 (0.11) | 54 (0.03) | 144 (0.06) |
| Hypomenorrhoea | 0 | 0 | 23 (0.09) | 0 | 2 (0.01) | 144 (0.09) | 169 (0.08) |
| Hypopnoea | 3 (0.06) | 15 (0.16) | 30 (0.12) | 0 | 9 (0.04) | 148 (0.09) | 208 (0.09) |
| Hypotension | 48 (0.98) | 78 (0.85) | 100 (0.41) | 0 | 164 (0.66) | 415 (0.26) | 839 (0.37) |
| Hypothermia | 8 (0.16) | 8 (0.09) | 10 (0.04) | 0 | 6 (0.02) | 71 (0.04) | 107 (0.05) |
| Hypothyroidism | 1 (0.02) | 4 (0.04) | 11 (0.05) | 0 | 6 (0.02) | 45 (0.03) | 69 (0.03) |
| Hypotonia | 2 (0.04) | 10 (0.11) | 13 (0.05) | 0 | 89 (0.36) | 32 (0.02) | 150 (0.07) |
| Hypovolaemic shock | 4 (0.08) | 3 (0.03) | 0 | 0 | 3 (0.01) | 62 (0.04) | 75 (0.03) |
| Hypoxia | 17 (0.35) | 32 (0.35) | 6 (0.02) | 0 | 47 (0.19) | 26 (0.02) | 144 (0.06) |
| Illness | 12 (0.25) | 56 (0.61) | 467 (1.93) | 1 (0.64) | 166 (0.67) | 3424 (2.13) | 4132 (1.84) |
| Immobile | 2 (0.04) | 6 (0.07) | 20 (0.08) | 0 | 11 (0.04) | 26 (0.02) | 67 (0.03) |
| Immune system disorder | 2 (0.04) | 3 (0.03) | 15 (0.06) | 0 | 9 (0.04) | 26 (0.02) | 57 (0.03) |
| Immune thrombocytopenia | 38 (0.78) | 143 (1.55) | 13 (0.05) | 0 | 309 (1.25) | 149 (0.09) | 693 (0.31) |
| Immunisation | 4 (0.08) | 6 (0.07) | 20 (0.08) | 0 | 9 (0.04) | 137 (0.09) | 176 (0.08) |
| Impaired work ability | 0 | 7 (0.08) | 119 (0.49) | 0 | 25 (0.10) | 141 (0.09) | 305 (0.14) |
| Incontinence | 3 (0.06) | 11 (0.12) | 24 (0.10) | 0 | 15 (0.06) | 40 (0.02) | 97 (0.04) |
| Increased tendency to bruise | 0 | 5 (0.05) | 29 (0.12) | 0 | 10 (0.04) | 65 (0.04) | 111 (0.05) |
| Infarction | 22 (0.45) | 17 (0.18) | 2 (0.01) | 0 | 29 (0.12) | 9 (0.01) | 81 (0.04) |
| Infection | 8 (0.16) | 23 (0.25) | 52 (0.21) | 0 | 59 (0.24) | 292 (0.18) | 444 (0.20) |
| Infectious mononucleosis | 0 | 0 | 19 (0.08) | 0 | 4 (0.02) | 34 (0.02) | 57 (0.03) |
| Inflammation | 6 (0.12) | 34 (0.37) | 160 (0.66) | 1 (0.64) | 77 (0.31) | 477 (0.30) | 764 (0.34) |
| Influenza | 5 (0.10) | 28 (0.30) | 565 (2.33) | 0 | 326 (1.32) | 4794 (2.98) | 5721 (2.55) |
| Influenza like illness | 24 (0.49) | 60 (0.65) | 1012 (4.17) | 0 | 501 (2.02) | 8167 (5.07) | 9785 (4.36) |
| Initial insomnia | 0 | 1 (0.01) | 5 (0.02) | 0 | 0 | 49 (0.03) | 55 (0.02) |
| Injected limb mobility decreased | 1 (0.02) | 1 (0.01) | 54 (0.22) | 0 | 2 (0.01) | 71 (0.04) | 129 (0.06) |
| Injection related reaction | 0 | 1 (0.01) | 36 (0.15) | 0 | 5 (0.02) | 448 (0.28) | 491 (0.22) |
| Injection site bruising | 0 | 1 (0.01) | 11 (0.05) | 0 | 1 (0.00) | 80 (0.05) | 94 (0.04) |
| Injection site erythema | 0 | 7 (0.08) | 62 (0.26) | 0 | 44 (0.18) | 353 (0.22) | 469 (0.21) |
| Injection site mass | 0 | 2 (0.02) | 54 (0.22) | 0 | 8 (0.03) | 779 (0.48) | 844 (0.38) |
| Injection site pain | 9 (0.18) | 30 (0.33) | 550 (2.27) | 0 | 232 (0.94) | 3169 (1.97) | 4001 (1.78) |
| Injection site pruritus | 0 | 1 (0.01) | 20 (0.08) | 0 | 3 (0.01) | 170 (0.11) | 195 (0.09) |
| Injection site rash | 0 | 0 | 10 (0.04) | 1 (0.64) | 2 (0.01) | 151 (0.09) | 165 (0.07) |
| Injection site reaction | 3 (0.06) | 5 (0.05) | 1273 (5.25) | 0 | 38 (0.15) | 102 (0.06) | 1426 (0.64) |
| Injection site swelling | 1 (0.02) | 8 (0.09) | 65 (0.27) | 0 | 43 (0.17) | 180 (0.11) | 300 (0.13) |
| Injection site warmth | 0 | 2 (0.02) | 39 (0.16) | 0 | 6 (0.02) | 210 (0.13) | 258 (0.12) |
| Insomnia | 6 (0.12) | 43 (0.47) | 482 (1.99) | 0 | 92 (0.37) | 2143 (1.33) | 2776 (1.24) |
| Interchange of vaccine products | 7 (0.14) | 9 (0.10) | 21 (0.09) | 0 | 13 (0.05) | 134 (0.08) | 189 (0.08) |
| Intermenstrual bleeding | 0 | 3 (0.03) | 19 (0.08) | 0 | 19 (0.08) | 338 (0.21) | 380 (0.17) |
| International normalised ratio increased | 2 (0.04) | 10 (0.11) | 6 (0.02) | 0 | 5 (0.02) | 46 (0.03) | 71 (0.03) |
| Interstitial lung disease | 8 (0.16) | 9 (0.10) | 7 (0.03) | 0 | 12 (0.05) | 20 (0.01) | 57 (0.03) |
| Intestinal ischaemia | 21 (0.43) | 28 (0.30) | 3 (0.01) | 0 | 14 (0.06) | 10 (0.01) | 77 (0.03) |
| Intracranial pressure increased | 19 (0.39) | 12 (0.13) | 7 (0.03) | 0 | 14 (0.06) | 15 (0.01) | 75 (0.03) |
| Irritability | 4 (0.08) | 10 (0.11) | 29 (0.12) | 0 | 24 (0.10) | 216 (0.13) | 286 (0.13) |
| Irritable bowel syndrome | 0 | 3 (0.03) | 20 (0.08) | 0 | 11 (0.04) | 95 (0.06) | 130 (0.06) |
| Ischaemia | 5 (0.10) | 15 (0.16) | 9 (0.04) | 0 | 20 (0.08) | 6 (0.00) | 56 (0.02) |
| Ischaemic cerebral infarction | 4 (0.08) | 24 (0.26) | 4 (0.02) | 0 | 16 (0.06) | 4 (0.00) | 53 (0.02) |
| Ischaemic stroke | 43 (0.88) | 161 (1.75) | 71 (0.29) | 0 | 295 (1.19) | 77 (0.05) | 659 (0.29) |
| Jaundice | 7 (0.14) | 7 (0.08) | 1 (0.00) | 1 (0.64) | 27 (0.11) | 29 (0.02) | 74 (0.03) |
| Joint lock | 1 (0.02) | 1 (0.01) | 11 (0.05) | 0 | 4 (0.02) | 43 (0.03) | 60 (0.03) |
| Joint stiffness | 0 | 3 (0.03) | 87 (0.36) | 0 | 16 (0.06) | 288 (0.18) | 394 (0.18) |
| Joint swelling | 4 (0.08) | 22 (0.24) | 186 (0.77) | 0 | 68 (0.27) | 635 (0.39) | 922 (0.41) |
| Jugular vein thrombosis | 7 (0.14) | 24 (0.26) | 2 (0.01) | 0 | 30 (0.12) | 20 (0.01) | 87 (0.04) |
| Kidney infection | 1 (0.02) | 6 (0.07) | 12 (0.05) | 0 | 11 (0.04) | 41 (0.03) | 72 (0.03) |
| Labyrinthitis | 1 (0.02) | 2 (0.02) | 27 (0.11) | 0 | 20 (0.08) | 117 (0.07) | 168 (0.07) |
| Lacrimation increased | 0 | 3 (0.03) | 35 (0.14) | 0 | 21 (0.08) | 173 (0.11) | 232 (0.10) |
| Laryngeal oedema | 1 (0.02) | 24 (0.26) | 0 | 0 | 22 (0.09) | 46 (0.03) | 95 (0.04) |
| Lethargy | 31 (0.64) | 61 (0.66) | 415 (1.71) | 0 | 121 (0.49) | 3200 (1.99) | 3855 (1.72) |
| Limb discomfort | 2 (0.04) | 33 (0.36) | 234 (0.97) | 0 | 431 (1.74) | 1393 (0.87) | 2105 (0.94) |
| Limb injury | 2 (0.04) | 3 (0.03) | 92 (0.38) | 0 | 5 (0.02) | 199 (0.12) | 302 (0.13) |
| Lip dry | 0 | 2 (0.02) | 4 (0.02) | 0 | 2 (0.01) | 48 (0.03) | 56 (0.02) |
| Lip oedema | 2 (0.04) | 9 (0.10) | 4 (0.02) | 0 | 12 (0.05) | 39 (0.02) | 68 (0.03) |
| Lip swelling | 2 (0.04) | 44 (0.48) | 44 (0.18) | 0 | 65 (0.26) | 535 (0.33) | 691 (0.31) |
| Listless | 4 (0.08) | 0 | 16 (0.07) | 0 | 2 (0.01) | 84 (0.05) | 106 (0.05) |
| Livedo reticularis | 1 (0.02) | 4 (0.04) | 5 (0.02) | 0 | 10 (0.04) | 46 (0.03) | 70 (0.03) |
| Liver function test abnormal | 2 (0.04) | 6 (0.07) | 8 (0.03) | 0 | 16 (0.06) | 21 (0.01) | 62 (0.03) |
| Local reaction | 4 (0.08) | 1 (0.01) | 11 (0.05) | 0 | 30 (0.12) | 31 (0.02) | 78 (0.03) |
| Localised infection | 0 | 1 (0.01) | 5 (0.02) | 0 | 11 (0.04) | 73 (0.05) | 91 (0.04) |
| Loss of consciousness | 84 (1.72) | 173 (1.88) | 117 (0.48) | 0 | 352 (1.42) | 954 (0.59) | 1721 (0.77) |
| Loss of control of legs | 0 | 4 (0.04) | 10 (0.04) | 0 | 10 (0.04) | 36 (0.02) | 61 (0.03) |
| Loss of personal independence in daily activities | 0 | 6 (0.07) | 75 (0.31) | 0 | 7 (0.03) | 44 (0.03) | 138 (0.06) |
| Lower respiratory tract infection | 19 (0.39) | 25 (0.27) | 45 (0.19) | 0 | 36 (0.15) | 161 (0.10) | 294 (0.13) |
| Lung disorder | 3 (0.06) | 7 (0.08) | 7 (0.03) | 0 | 23 (0.09) | 8 (0.00) | 55 (0.02) |
| Lymph node pain | 1 (0.02) | 2 (0.02) | 50 (0.21) | 0 | 14 (0.06) | 384 (0.24) | 451 (0.20) |
| Lymphadenopathy | 3 (0.06) | 42 (0.46) | 459 (1.89) | 3 (1.91) | 150 (0.61) | 3098 (1.92) | 3768 (1.68) |
| Lymphoedema | 0 | 4 (0.04) | 11 (0.05) | 0 | 2 (0.01) | 49 (0.03) | 67 (0.03) |
| Malaise | 179 (3.67) | 326 (3.54) | 2801 (11.55) | 2 (1.27) | 912 (3.68) | 8671 (5.39) | 12987 (5.79) |
| Mass | 0 | 2 (0.02) | 7 (0.03) | 0 | 4 (0.02) | 38 (0.02) | 54 (0.02) |
| Maternal exposure during breast feeding | 1 (0.02) | 12 (0.13) | 62 (0.26) | 7 (4.46) | 12 (0.05) | 799 (0.50) | 896 (0.40) |
| Maternal exposure during pregnancy | 4 (0.08) | 21 (0.23) | 31 (0.13) | 56 (35.67) | 38 (0.15) | 184 (0.11) | 344 (0.15) |
| Memory impairment | 3 (0.06) | 18 (0.20) | 134 (0.55) | 0 | 49 (0.20) | 243 (0.15) | 460 (0.21) |
| Meningitis | 3 (0.06) | 6 (0.07) | 3 (0.01) | 0 | 27 (0.11) | 23 (0.01) | 66 (0.03) |
| Menstrual disorder | 1 (0.02) | 7 (0.08) | 82 (0.34) | 5 (3.18) | 22 (0.09) | 694 (0.43) | 812 (0.36) |
| Menstruation delayed | 0 | 5 (0.05) | 111 (0.46) | 1 (0.64) | 19 (0.08) | 1054 (0.65) | 1190 (0.53) |
| Menstruation irregular | 0 | 5 (0.05) | 112 (0.46) | 4 (2.55) | 22 (0.09) | 880 (0.55) | 1025 (0.46) |
| Mental fatigue | 0 | 10 (0.11) | 95 (0.39) | 0 | 12 (0.05) | 325 (0.20) | 443 (0.20) |
| Mental impairment | 2 (0.04) | 5 (0.05) | 44 (0.18) | 0 | 8 (0.03) | 84 (0.05) | 146 (0.07) |
| Mesenteric vein thrombosis | 12 (0.25) | 32 (0.35) | 2 (0.01) | 0 | 41 (0.17) | 10 (0.01) | 107 (0.05) |
| Micturition urgency | 1 (0.02) | 2 (0.02) | 13 (0.05) | 0 | 9 (0.04) | 52 (0.03) | 77 (0.03) |
| Middle insomnia | 0 | 2 (0.02) | 6 (0.02) | 0 | 3 (0.01) | 53 (0.03) | 65 (0.03) |
| Migraine | 4 (0.08) | 87 (0.94) | 1189 (4.90) | 0 | 303 (1.22) | 5341 (3.32) | 6939 (3.09) |
| Migraine with aura | 0 | 3 (0.03) | 73 (0.30) | 0 | 23 (0.09) | 258 (0.16) | 359 (0.16) |
| Miliaria | 0 | 1 (0.01) | 18 (0.07) | 0 | 3 (0.01) | 104 (0.06) | 127 (0.06) |
| Mobility decreased | 6 (0.12) | 12 (0.13) | 111 (0.46) | 0 | 83 (0.33) | 84 (0.05) | 311 (0.14) |
| Monoparesis | 3 (0.06) | 6 (0.07) | 31 (0.13) | 0 | 28 (0.11) | 103 (0.06) | 177 (0.08) |
| Monoplegia | 2 (0.04) | 10 (0.11) | 52 (0.21) | 0 | 39 (0.16) | 151 (0.09) | 262 (0.12) |
| Mood altered | 1 (0.02) | 2 (0.02) | 9 (0.04) | 0 | 5 (0.02) | 61 (0.04) | 81 (0.04) |
| Mood swings | 1 (0.02) | 4 (0.04) | 23 (0.09) | 0 | 2 (0.01) | 81 (0.05) | 111 (0.05) |
| Motion sickness | 0 | 2 (0.02) | 22 (0.09) | 0 | 4 (0.02) | 86 (0.05) | 115 (0.05) |
| Motor dysfunction | 3 (0.06) | 8 (0.09) | 17 (0.07) | 0 | 27 (0.11) | 18 (0.01) | 80 (0.04) |
| Mouth haemorrhage | 1 (0.02) | 6 (0.07) | 4 (0.02) | 0 | 9 (0.04) | 40 (0.02) | 64 (0.03) |
| Mouth swelling | 0 | 13 (0.14) | 8 (0.03) | 0 | 10 (0.04) | 82 (0.05) | 113 (0.05) |
| Mouth ulceration | 0 | 2 (0.02) | 56 (0.23) | 0 | 11 (0.04) | 374 (0.23) | 444 (0.20) |
| Movement disorder | 0 | 13 (0.14) | 41 (0.17) | 0 | 61 (0.25) | 62 (0.04) | 184 (0.08) |
| Multiple organ dysfunction syndrome | 57 (1.17) | 10 (0.11) | 0 | 0 | 6 (0.02) | 2 (0.00) | 82 (0.04) |
| Multiple sclerosis | 1 (0.02) | 0 | 25 (0.10) | 1 (0.64) | 14 (0.06) | 52 (0.03) | 95 (0.04) |
| Multiple sclerosis relapse | 0 | 0 | 24 (0.10) | 0 | 14 (0.06) | 58 (0.04) | 97 (0.04) |
| Muscle contractions involuntary | 0 | 1 (0.01) | 16 (0.07) | 0 | 2 (0.01) | 39 (0.02) | 58 (0.03) |
| Muscle fatigue | 2 (0.04) | 8 (0.09) | 160 (0.66) | 0 | 16 (0.06) | 697 (0.43) | 885 (0.39) |
| Muscle injury | 0 | 2 (0.02) | 9 (0.04) | 0 | 2 (0.01) | 41 (0.03) | 54 (0.02) |
| Muscle rigidity | 1 (0.02) | 2 (0.02) | 14 (0.06) | 0 | 10 (0.04) | 48 (0.03) | 75 (0.03) |
| Muscle spasms | 3 (0.06) | 64 (0.69) | 547 (2.26) | 3 (1.91) | 180 (0.73) | 2211 (1.37) | 3021 (1.35) |
| Muscle tightness | 0 | 6 (0.07) | 31 (0.13) | 1 (0.64) | 19 (0.08) | 140 (0.09) | 199 (0.09) |
| Muscle twitching | 1 (0.02) | 11 (0.12) | 96 (0.40) | 0 | 47 (0.19) | 287 (0.18) | 447 (0.20) |
| Muscular weakness | 22 (0.45) | 107 (1.16) | 618 (2.55) | 1 (0.64) | 319 (1.29) | 1352 (0.84) | 2463 (1.10) |
| Musculoskeletal chest pain | 1 (0.02) | 13 (0.14) | 66 (0.27) | 0 | 33 (0.13) | 280 (0.17) | 396 (0.18) |
| Musculoskeletal discomfort | 0 | 4 (0.04) | 17 (0.07) | 0 | 11 (0.04) | 89 (0.06) | 122 (0.05) |
| Musculoskeletal pain | 2 (0.04) | 9 (0.10) | 40 (0.16) | 0 | 43 (0.17) | 164 (0.10) | 260 (0.12) |
| Musculoskeletal stiffness | 6 (0.12) | 19 (0.21) | 447 (1.84) | 0 | 88 (0.36) | 1482 (0.92) | 2051 (0.91) |
| Myalgia | 66 (1.35) | 246 (2.67) | 5136 (21.18) | 4 (2.55) | 939 (3.79) | 19526 (12.13) | 25995 (11.59) |
| Myelitis | 0 | 4 (0.04) | 16 (0.07) | 0 | 49 (0.20) | 15 (0.01) | 87 (0.04) |
| Myelitis transverse | 1 (0.02) | 10 (0.11) | 64 (0.26) | 0 | 58 (0.23) | 40 (0.02) | 176 (0.08) |
| Myocardial infarction | 197 (4.04) | 352 (3.82) | 42 (0.17) | 0 | 235 (0.95) | 149 (0.09) | 1001 (0.45) |
| Myocardial ischaemia | 30 (0.62) | 5 (0.05) | 2 (0.01) | 0 | 8 (0.03) | 5 (0.00) | 57 (0.03) |
| Myocarditis | 17 (0.35) | 86 (0.93) | 77 (0.32) | 0 | 188 (0.76) | 270 (0.17) | 663 (0.30) |
| Myositis | 1 (0.02) | 8 (0.09) | 24 (0.10) | 0 | 10 (0.04) | 37 (0.02) | 83 (0.04) |
| Nasal congestion | 4 (0.08) | 7 (0.08) | 61 (0.25) | 0 | 20 (0.08) | 305 (0.19) | 398 (0.18) |
| Nasal discomfort | 0 | 0 | 8 (0.03) | 0 | 3 (0.01) | 75 (0.05) | 86 (0.04) |
| Nasopharyngitis | 26 (0.53) | 12 (0.13) | 160 (0.66) | 0 | 162 (0.65) | 1110 (0.69) | 1478 (0.66) |
| Nausea | 111 (2.28) | 319 (3.46) | 4602 (18.98) | 5 (3.18) | 1336 (5.39) | 24502 (15.22) | 30967 (13.81) |
| Neck pain | 9 (0.18) | 54 (0.59) | 464 (1.91) | 0 | 191 (0.77) | 2044 (1.27) | 2774 (1.24) |
| Nerve injury | 0 | 11 (0.12) | 67 (0.28) | 0 | 15 (0.06) | 89 (0.06) | 184 (0.08) |
| Nervous system disorder | 7 (0.14) | 16 (0.17) | 59 (0.24) | 1 (0.64) | 42 (0.17) | 58 (0.04) | 192 (0.09) |
| Nervousness | 0 | 7 (0.08) | 84 (0.35) | 0 | 20 (0.08) | 407 (0.25) | 519 (0.23) |
| Neuralgia | 2 (0.04) | 17 (0.18) | 328 (1.35) | 0 | 109 (0.44) | 906 (0.56) | 1365 (0.61) |
| Neurological symptom | 6 (0.12) | 11 (0.12) | 43 (0.18) | 0 | 29 (0.12) | 68 (0.04) | 160 (0.07) |
| Neuropathy peripheral | 0 | 9 (0.10) | 78 (0.32) | 0 | 33 (0.13) | 171 (0.11) | 293 (0.13) |
| Neutropenia | 0 | 9 (0.10) | 3 (0.01) | 0 | 17 (0.07) | 58 (0.04) | 89 (0.04) |
| Night sweats | 2 (0.04) | 15 (0.16) | 159 (0.66) | 0 | 42 (0.17) | 1294 (0.80) | 1516 (0.68) |
| Nightmare | 1 (0.02) | 6 (0.07) | 46 (0.19) | 0 | 5 (0.02) | 295 (0.18) | 353 (0.16) |
| Ocular discomfort | 2 (0.04) | 2 (0.02) | 19 (0.08) | 1 (0.64) | 20 (0.08) | 58 (0.04) | 103 (0.05) |
| Ocular hyperaemia | 1 (0.02) | 7 (0.08) | 34 (0.14) | 0 | 24 (0.10) | 231 (0.14) | 300 (0.13) |
| Odynophagia | 4 (0.08) | 2 (0.02) | 1 (0.00) | 1 (0.64) | 7 (0.03) | 42 (0.03) | 59 (0.03) |
| Oedema | 11 (0.23) | 33 (0.36) | 19 (0.08) | 0 | 75 (0.30) | 67 (0.04) | 214 (0.10) |
| Oedema peripheral | 15 (0.31) | 63 (0.68) | 63 (0.26) | 0 | 102 (0.41) | 208 (0.13) | 465 (0.21) |
| Off label use | 8 (0.16) | 12 (0.13) | 22 (0.09) | 0 | 18 (0.07) | 127 (0.08) | 193 (0.09) |
| Oligomenorrhoea | 0 | 0 | 14 (0.06) | 0 | 2 (0.01) | 48 (0.03) | 64 (0.03) |
| Ophthalmic herpes zoster | 0 | 1 (0.01) | 5 (0.02) | 0 | 11 (0.04) | 45 (0.03) | 62 (0.03) |
| Ophthalmic vein thrombosis | 1 (0.02) | 7 (0.08) | 9 (0.04) | 0 | 18 (0.07) | 26 (0.02) | 64 (0.03) |
| Optic neuritis | 0 | 4 (0.04) | 45 (0.19) | 0 | 44 (0.18) | 39 (0.02) | 136 (0.06) |
| Oral candidiasis | 3 (0.06) | 0 | 4 (0.02) | 0 | 5 (0.02) | 39 (0.02) | 52 (0.02) |
| Oral discomfort | 0 | 3 (0.03) | 9 (0.04) | 0 | 5 (0.02) | 81 (0.05) | 98 (0.04) |
| Oral herpes | 1 (0.02) | 4 (0.04) | 45 (0.19) | 0 | 14 (0.06) | 399 (0.25) | 464 (0.21) |
| Oral pain | 1 (0.02) | 1 (0.01) | 26 (0.11) | 1 (0.64) | 8 (0.03) | 207 (0.13) | 248 (0.11) |
| Oropharyngeal pain | 22 (0.45) | 44 (0.48) | 389 (1.60) | 2 (1.27) | 175 (0.71) | 2831 (1.76) | 3468 (1.55) |
| Orthostatic hypotension | 1 (0.02) | 4 (0.04) | 17 (0.07) | 0 | 9 (0.04) | 24 (0.01) | 55 (0.02) |
| Osteoarthritis | 0 | 2 (0.02) | 36 (0.15) | 0 | 6 (0.02) | 56 (0.03) | 103 (0.05) |
| Oxygen saturation | 13 (0.27) | 1 (0.01) | 1 (0.00) | 0 | 30 (0.12) | 17 (0.01) | 62 (0.03) |
| Oxygen saturation decreased | 52 (1.07) | 30 (0.33) | 26 (0.11) | 0 | 164 (0.66) | 109 (0.07) | 401 (0.18) |
| Pain | 62 (1.27) | 228 (2.48) | 2156 (8.89) | 4 (2.55) | 677 (2.73) | 11448 (7.11) | 14648 (6.53) |
| Pain in extremity | 61 (1.25) | 317 (3.44) | 2414 (9.96) | 4 (2.55) | 852 (3.44) | 13752 (8.54) | 17485 (7.80) |
| Pain in jaw | 1 (0.02) | 16 (0.17) | 94 (0.39) | 0 | 31 (0.13) | 400 (0.25) | 545 (0.24) |
| Pain of skin | 0 | 3 (0.03) | 121 (0.50) | 0 | 21 (0.08) | 640 (0.40) | 786 (0.35) |
| Pallor | 16 (0.33) | 35 (0.38) | 61 (0.25) | 0 | 40 (0.16) | 243 (0.15) | 409 (0.18) |
| Palpitations | 8 (0.16) | 216 (2.35) | 816 (3.37) | 1 (0.64) | 573 (2.31) | 3658 (2.27) | 5305 (2.37) |
| Pancreatitis | 7 (0.14) | 11 (0.12) | 3 (0.01) | 0 | 36 (0.15) | 35 (0.02) | 93 (0.04) |
| Pancreatitis acute | 3 (0.06) | 9 (0.10) | 2 (0.01) | 0 | 23 (0.09) | 13 (0.01) | 51 (0.02) |
| Panic attack | 1 (0.02) | 11 (0.12) | 51 (0.21) | 0 | 34 (0.14) | 223 (0.14) | 322 (0.14) |
| Papule | 0 | 0 | 8 (0.03) | 1 (0.64) | 3 (0.01) | 61 (0.04) | 73 (0.03) |
| Paraesthesia | 17 (0.35) | 258 (2.80) | 1057 (4.36) | 3 (1.91) | 914 (3.69) | 5426 (3.37) | 7739 (3.45) |
| Paraesthesia oral | 0 | 19 (0.21) | 58 (0.24) | 0 | 67 (0.27) | 462 (0.29) | 608 (0.27) |
| Paralysis | 12 (0.25) | 42 (0.46) | 96 (0.40) | 0 | 111 (0.45) | 197 (0.12) | 490 (0.22) |
| Paranasal sinus discomfort | 0 | 1 (0.01) | 8 (0.03) | 0 | 3 (0.01) | 50 (0.03) | 62 (0.03) |
| Paresis | 2 (0.04) | 9 (0.10) | 16 (0.07) | 0 | 37 (0.15) | 21 (0.01) | 87 (0.04) |
| Parosmia | 0 | 2 (0.02) | 38 (0.16) | 0 | 11 (0.04) | 202 (0.13) | 254 (0.11) |
| Partial seizures | 5 (0.10) | 9 (0.10) | 5 (0.02) | 0 | 18 (0.07) | 34 (0.02) | 74 (0.03) |
| Pelvic pain | 0 | 4 (0.04) | 37 (0.15) | 0 | 17 (0.07) | 123 (0.08) | 182 (0.08) |
| Pelvic venous thrombosis | 2 (0.04) | 14 (0.15) | 3 (0.01) | 0 | 19 (0.08) | 16 (0.01) | 61 (0.03) |
| Periarthritis | 0 | 3 (0.03) | 153 (0.63) | 0 | 5 (0.02) | 314 (0.20) | 475 (0.21) |
| Pericardial effusion | 4 (0.08) | 19 (0.21) | 8 (0.03) | 0 | 50 (0.20) | 39 (0.02) | 134 (0.06) |
| Pericarditis | 2 (0.04) | 40 (0.43) | 39 (0.16) | 0 | 225 (0.91) | 182 (0.11) | 499 (0.22) |
| Periorbital swelling | 0 | 2 (0.02) | 16 (0.07) | 0 | 8 (0.03) | 76 (0.05) | 103 (0.05) |
| Peripheral artery thrombosis | 9 (0.18) | 37 (0.40) | 6 (0.02) | 0 | 51 (0.21) | 41 (0.03) | 150 (0.07) |
| Peripheral coldness | 4 (0.08) | 24 (0.26) | 163 (0.67) | 0 | 43 (0.17) | 850 (0.53) | 1092 (0.49) |
| Peripheral ischaemia | 11 (0.23) | 12 (0.13) | 6 (0.02) | 0 | 32 (0.13) | 14 (0.01) | 79 (0.04) |
| Peripheral swelling | 24 (0.49) | 162 (1.76) | 615 (2.54) | 2 (1.27) | 256 (1.03) | 3361 (2.09) | 4461 (1.99) |
| Petechiae | 11 (0.23) | 54 (0.59) | 33 (0.14) | 0 | 188 (0.76) | 254 (0.16) | 562 (0.25) |
| Petit mal epilepsy | 0 | 6 (0.07) | 8 (0.03) | 0 | 6 (0.02) | 34 (0.02) | 55 (0.02) |
| Pharyngeal swelling | 2 (0.04) | 39 (0.42) | 38 (0.16) | 0 | 46 (0.19) | 170 (0.11) | 300 (0.13) |
| Phlebitis | 0 | 10 (0.11) | 10 (0.04) | 0 | 31 (0.13) | 107 (0.07) | 158 (0.07) |
| Photophobia | 6 (0.12) | 26 (0.28) | 216 (0.89) | 0 | 85 (0.34) | 687 (0.43) | 1026 (0.46) |
| Photopsia | 1 (0.02) | 11 (0.12) | 36 (0.15) | 0 | 20 (0.08) | 223 (0.14) | 292 (0.13) |
| Photosensitivity reaction | 0 | 4 (0.04) | 31 (0.13) | 0 | 14 (0.06) | 100 (0.06) | 150 (0.07) |
| Piloerection | 0 | 0 | 8 (0.03) | 0 | 3 (0.01) | 71 (0.04) | 83 (0.04) |
| Platelet count decreased | 34 (0.70) | 78 (0.85) | 32 (0.13) | 1 (0.64) | 138 (0.56) | 198 (0.12) | 516 (0.23) |
| Pleural effusion | 10 (0.21) | 36 (0.39) | 6 (0.02) | 0 | 53 (0.21) | 19 (0.01) | 138 (0.06) |
| Pleurisy | 0 | 2 (0.02) | 8 (0.03) | 0 | 33 (0.13) | 20 (0.01) | 65 (0.03) |
| Pleuritic pain | 0 | 19 (0.21) | 6 (0.02) | 0 | 17 (0.07) | 12 (0.01) | 56 (0.02) |
| Pneumonia | 103 (2.11) | 102 (1.11) | 32 (0.13) | 0 | 229 (0.92) | 102 (0.06) | 606 (0.27) |
| Pneumonia aspiration | 23 (0.47) | 8 (0.09) | 3 (0.01) | 0 | 8 (0.03) | 5 (0.00) | 52 (0.02) |
| Pneumonitis | 8 (0.16) | 10 (0.11) | 7 (0.03) | 0 | 25 (0.10) | 26 (0.02) | 78 (0.03) |
| Pollakiuria | 2 (0.04) | 11 (0.12) | 32 (0.13) | 0 | 20 (0.08) | 176 (0.11) | 241 (0.11) |
| Polymenorrhoea | 0 | 1 (0.01) | 35 (0.14) | 1 (0.64) | 9 (0.04) | 283 (0.18) | 329 (0.15) |
| Polymyalgia rheumatica | 0 | 4 (0.04) | 42 (0.17) | 0 | 15 (0.06) | 95 (0.06) | 157 (0.07) |
| Polyneuropathy | 2 (0.04) | 8 (0.09) | 12 (0.05) | 0 | 40 (0.16) | 51 (0.03) | 118 (0.05) |
| Poor peripheral circulation | 3 (0.06) | 1 (0.01) | 12 (0.05) | 0 | 2 (0.01) | 36 (0.02) | 55 (0.02) |
| Poor quality sleep | 0 | 5 (0.05) | 78 (0.32) | 0 | 3 (0.01) | 434 (0.27) | 521 (0.23) |
| Portal vein thrombosis | 33 (0.68) | 69 (0.75) | 2 (0.01) | 0 | 102 (0.41) | 32 (0.02) | 259 (0.12) |
| Post viral fatigue syndrome | 0 | 0 | 60 (0.25) | 0 | 4 (0.02) | 78 (0.05) | 142 (0.06) |
| Postmenopausal haemorrhage | 0 | 0 | 6 (0.02) | 0 | 12 (0.05) | 221 (0.14) | 240 (0.11) |
| Premenstrual pain | 0 | 0 | 10 (0.04) | 0 | 0 | 55 (0.03) | 65 (0.03) |
| Presyncope | 6 (0.12) | 15 (0.16) | 93 (0.38) | 0 | 84 (0.34) | 440 (0.27) | 647 (0.29) |
| Productive cough | 9 (0.18) | 9 (0.10) | 29 (0.12) | 0 | 31 (0.13) | 120 (0.07) | 201 (0.09) |
| Pruritus | 5 (0.10) | 116 (1.26) | 461 (1.90) | 0 | 236 (0.95) | 4014 (2.49) | 4853 (2.16) |
| Psoriasis | 0 | 7 (0.08) | 41 (0.17) | 0 | 10 (0.04) | 141 (0.09) | 201 (0.09) |
| Psychotic disorder | 0 | 6 (0.07) | 7 (0.03) | 0 | 13 (0.05) | 27 (0.02) | 54 (0.02) |
| Pulmonary embolism | 330 (6.77) | 1318 (14.31) | 89 (0.37) | 0 | 2088 (8.43) | 990 (0.61) | 4955 (2.21) |
| Pulmonary infarction | 4 (0.08) | 28 (0.30) | 1 (0.00) | 0 | 31 (0.13) | 13 (0.01) | 87 (0.04) |
| Pulmonary oedema | 21 (0.43) | 24 (0.26) | 2 (0.01) | 0 | 19 (0.08) | 23 (0.01) | 102 (0.05) |
| Pulmonary pain | 0 | 18 (0.20) | 44 (0.18) | 0 | 22 (0.09) | 152 (0.09) | 239 (0.11) |
| Pulmonary thrombosis | 22 (0.45) | 23 (0.25) | 3 (0.01) | 0 | 62 (0.25) | 25 (0.02) | 143 (0.06) |
| Purpura | 5 (0.10) | 13 (0.14) | 11 (0.05) | 0 | 62 (0.25) | 90 (0.06) | 186 (0.08) |
| Pyrexia | 356 (7.30) | 824 (8.95) | 7464 (30.79) | 11 (7.01) | 2996 (12.09) | 41388 (25.71) | 53214 (23.73) |
| Q fever | 0 | 1 (0.01) | 13 (0.05) | 0 | 2 (0.01) | 82 (0.05) | 99 (0.04) |
| Rash | 15 (0.31) | 135 (1.47) | 517 (2.13) | 3 (1.91) | 442 (1.78) | 4099 (2.55) | 5234 (2.33) |
| Rash erythematous | 2 (0.04) | 9 (0.10) | 99 (0.41) | 0 | 39 (0.16) | 892 (0.55) | 1041 (0.46) |
| Rash macular | 1 (0.02) | 22 (0.24) | 36 (0.15) | 0 | 47 (0.19) | 385 (0.24) | 491 (0.22) |
| Rash maculo-papular | 0 | 3 (0.03) | 3 (0.01) | 0 | 5 (0.02) | 51 (0.03) | 65 (0.03) |
| Rash papular | 1 (0.02) | 4 (0.04) | 19 (0.08) | 0 | 12 (0.05) | 243 (0.15) | 282 (0.13) |
| Rash pruritic | 1 (0.02) | 11 (0.12) | 59 (0.24) | 0 | 45 (0.18) | 906 (0.56) | 1022 (0.46) |
| Rash vesicular | 0 | 4 (0.04) | 7 (0.03) | 0 | 12 (0.05) | 49 (0.03) | 73 (0.03) |
| Raynaud's phenomenon | 1 (0.02) | 0 | 20 (0.08) | 0 | 7 (0.03) | 98 (0.06) | 126 (0.06) |
| Rectal haemorrhage | 6 (0.12) | 14 (0.15) | 11 (0.05) | 0 | 31 (0.13) | 100 (0.06) | 165 (0.07) |
| Renal failure | 26 (0.53) | 30 (0.33) | 6 (0.02) | 0 | 28 (0.11) | 25 (0.02) | 125 (0.06) |
| Renal pain | 2 (0.04) | 18 (0.20) | 120 (0.49) | 0 | 49 (0.20) | 654 (0.41) | 844 (0.38) |
| Respiration abnormal | 6 (0.12) | 7 (0.08) | 9 (0.04) | 0 | 25 (0.10) | 60 (0.04) | 114 (0.05) |
| Respiratory arrest | 10 (0.21) | 16 (0.17) | 1 (0.00) | 0 | 11 (0.04) | 13 (0.01) | 55 (0.02) |
| Respiratory disorder | 11 (0.23) | 16 (0.17) | 113 (0.47) | 0 | 31 (0.13) | 29 (0.02) | 204 (0.09) |
| Respiratory distress | 17 (0.35) | 27 (0.29) | 13 (0.05) | 1 (0.64) | 143 (0.58) | 80 (0.05) | 304 (0.14) |
| Respiratory failure | 42 (0.86) | 41 (0.45) | 0 | 0 | 37 (0.15) | 16 (0.01) | 151 (0.07) |
| Respiratory rate increased | 5 (0.10) | 7 (0.08) | 6 (0.02) | 0 | 7 (0.03) | 65 (0.04) | 92 (0.04) |
| Restless legs syndrome | 0 | 7 (0.08) | 48 (0.20) | 0 | 10 (0.04) | 258 (0.16) | 324 (0.14) |
| Restlessness | 5 (0.10) | 6 (0.07) | 50 (0.21) | 0 | 32 (0.13) | 336 (0.21) | 432 (0.19) |
| Retching | 4 (0.08) | 6 (0.07) | 33 (0.14) | 0 | 24 (0.10) | 190 (0.12) | 260 (0.12) |
| Retinal artery occlusion | 0 | 3 (0.03) | 30 (0.12) | 0 | 19 (0.08) | 31 (0.02) | 86 (0.04) |
| Retinal detachment | 0 | 0 | 20 (0.08) | 0 | 38 (0.15) | 33 (0.02) | 92 (0.04) |
| Retinal migraine | 0 | 0 | 7 (0.03) | 0 | 2 (0.01) | 67 (0.04) | 76 (0.03) |
| Retinal vein occlusion | 0 | 3 (0.03) | 63 (0.26) | 0 | 17 (0.07) | 156 (0.10) | 240 (0.11) |
| Retinal vein thrombosis | 1 (0.02) | 0 | 14 (0.06) | 0 | 6 (0.02) | 49 (0.03) | 71 (0.03) |
| Rheumatoid arthritis | 1 (0.02) | 3 (0.03) | 77 (0.32) | 0 | 13 (0.05) | 156 (0.10) | 253 (0.11) |
| Rhinitis | 11 (0.23) | 7 (0.08) | 8 (0.03) | 0 | 33 (0.13) | 39 (0.02) | 101 (0.05) |
| Rhinorrhoea | 7 (0.14) | 8 (0.09) | 136 (0.56) | 0 | 40 (0.16) | 1052 (0.65) | 1248 (0.56) |
| Rotator cuff syndrome | 0 | 1 (0.01) | 27 (0.11) | 0 | 3 (0.01) | 73 (0.05) | 106 (0.05) |
| SARS-CoV-2 test negative | 1 (0.02) | 3 (0.03) | 13 (0.05) | 0 | 21 (0.08) | 12 (0.01) | 51 (0.02) |
| SARS-CoV-2 test positive | 17 (0.35) | 6 (0.07) | 5 (0.02) | 0 | 66 (0.27) | 43 (0.03) | 145 (0.06) |
| Salivary hypersecretion | 0 | 6 (0.07) | 13 (0.05) | 0 | 12 (0.05) | 46 (0.03) | 77 (0.03) |
| Sciatica | 0 | 3 (0.03) | 63 (0.26) | 0 | 11 (0.04) | 142 (0.09) | 219 (0.10) |
| Seasonal allergy | 1 (0.02) | 0 | 11 (0.05) | 0 | 3 (0.01) | 69 (0.04) | 84 (0.04) |
| Seizure | 63 (1.29) | 230 (2.50) | 194 (0.80) | 1 (0.64) | 483 (1.95) | 1074 (0.67) | 2109 (0.94) |
| Sensation of foreign body | 0 | 7 (0.08) | 8 (0.03) | 0 | 21 (0.08) | 44 (0.03) | 86 (0.04) |
| Sensitive skin | 0 | 3 (0.03) | 60 (0.25) | 0 | 5 (0.02) | 403 (0.25) | 473 (0.21) |
| Sensory disturbance | 0 | 11 (0.12) | 55 (0.23) | 0 | 135 (0.54) | 107 (0.07) | 316 (0.14) |
| Sensory loss | 0 | 23 (0.25) | 70 (0.29) | 0 | 46 (0.19) | 98 (0.06) | 243 (0.11) |
| Sepsis | 61 (1.25) | 43 (0.47) | 9 (0.04) | 0 | 47 (0.19) | 43 (0.03) | 231 (0.10) |
| Severe acute respiratory syndrome | 22 (0.45) | 1 (0.01) | 0 | 0 | 125 (0.50) | 29 (0.02) | 177 (0.08) |
| Shock | 10 (0.21) | 13 (0.14) | 5 (0.02) | 0 | 6 (0.02) | 41 (0.03) | 78 (0.03) |
| Shoulder injury related to vaccine administration | 0 | 0 | 47 (0.19) | 0 | 2 (0.01) | 60 (0.04) | 109 (0.05) |
| Sinus congestion | 0 | 4 (0.04) | 8 (0.03) | 0 | 4 (0.02) | 63 (0.04) | 79 (0.04) |
| Sinus headache | 0 | 2 (0.02) | 79 (0.33) | 0 | 11 (0.04) | 658 (0.41) | 751 (0.33) |
| Sinus pain | 0 | 6 (0.07) | 70 (0.29) | 0 | 5 (0.02) | 439 (0.27) | 521 (0.23) |
| Sinus tachycardia | 4 (0.08) | 9 (0.10) | 8 (0.03) | 0 | 36 (0.15) | 45 (0.03) | 104 (0.05) |
| Sinusitis | 1 (0.02) | 6 (0.07) | 48 (0.20) | 0 | 15 (0.06) | 263 (0.16) | 334 (0.15) |
| Skin burning sensation | 0 | 10 (0.11) | 81 (0.33) | 0 | 33 (0.13) | 365 (0.23) | 490 (0.22) |
| Skin discolouration | 7 (0.14) | 16 (0.17) | 24 (0.10) | 0 | 26 (0.10) | 121 (0.08) | 198 (0.09) |
| Skin disorder | 2 (0.04) | 5 (0.05) | 124 (0.51) | 0 | 20 (0.08) | 37 (0.02) | 188 (0.08) |
| Skin erosion | 0 | 0 | 5 (0.02) | 0 | 3 (0.01) | 42 (0.03) | 51 (0.02) |
| Skin exfoliation | 0 | 7 (0.08) | 23 (0.09) | 0 | 11 (0.04) | 88 (0.05) | 131 (0.06) |
| Skin haemorrhage | 2 (0.04) | 3 (0.03) | 9 (0.04) | 0 | 17 (0.07) | 31 (0.02) | 64 (0.03) |
| Skin irritation | 0 | 0 | 9 (0.04) | 0 | 8 (0.03) | 74 (0.05) | 91 (0.04) |
| Skin lesion | 1 (0.02) | 7 (0.08) | 5 (0.02) | 0 | 9 (0.04) | 32 (0.02) | 55 (0.02) |
| Skin reaction | 0 | 5 (0.05) | 20 (0.08) | 0 | 13 (0.05) | 128 (0.08) | 166 (0.07) |
| Skin sensitisation | 0 | 0 | 16 (0.07) | 0 | 0 | 69 (0.04) | 85 (0.04) |
| Skin swelling | 0 | 0 | 5 (0.02) | 0 | 6 (0.02) | 46 (0.03) | 58 (0.03) |
| Skin temperature | 0 | 0 | 10 (0.04) | 0 | 0 | 135 (0.08) | 145 (0.06) |
| Skin warm | 0 | 4 (0.04) | 30 (0.12) | 0 | 9 (0.04) | 304 (0.19) | 347 (0.15) |
| Sleep disorder | 3 (0.06) | 10 (0.11) | 109 (0.45) | 0 | 22 (0.09) | 309 (0.19) | 457 (0.20) |
| Sneezing | 1 (0.02) | 7 (0.08) | 32 (0.13) | 0 | 10 (0.04) | 314 (0.20) | 364 (0.16) |
| Somnolence | 28 (0.57) | 93 (1.01) | 239 (0.99) | 1 (0.64) | 219 (0.88) | 1412 (0.88) | 2020 (0.90) |
| Speech disorder | 11 (0.23) | 26 (0.28) | 52 (0.21) | 0 | 81 (0.33) | 86 (0.05) | 279 (0.12) |
| Spinal pain | 1 (0.02) | 9 (0.10) | 50 (0.21) | 0 | 21 (0.08) | 178 (0.11) | 265 (0.12) |
| Splenic infarction | 7 (0.14) | 9 (0.10) | 1 (0.00) | 0 | 23 (0.09) | 12 (0.01) | 58 (0.03) |
| Splenic vein thrombosis | 9 (0.18) | 16 (0.17) | 3 (0.01) | 0 | 11 (0.04) | 8 (0.00) | 53 (0.02) |
| Stomatitis | 0 | 0 | 10 (0.04) | 0 | 5 (0.02) | 57 (0.04) | 72 (0.03) |
| Stress | 0 | 2 (0.02) | 34 (0.14) | 0 | 5 (0.02) | 84 (0.05) | 126 (0.06) |
| Subarachnoid haemorrhage | 52 (1.07) | 71 (0.77) | 3 (0.01) | 0 | 49 (0.20) | 20 (0.01) | 209 (0.09) |
| Subdural haematoma | 7 (0.14) | 19 (0.21) | 2 (0.01) | 0 | 16 (0.06) | 12 (0.01) | 62 (0.03) |
| Sudden death | 202 (4.14) | 0 | 0 | 0 | 0 | 0 | 203 (0.09) |
| Sudden hearing loss | 0 | 1 (0.01) | 43 (0.18) | 0 | 20 (0.08) | 103 (0.06) | 169 (0.08) |
| Suicidal ideation | 1 (0.02) | 17 (0.18) | 16 (0.07) | 0 | 5 (0.02) | 93 (0.06) | 138 (0.06) |
| Superficial vein thrombosis | 1 (0.02) | 30 (0.33) | 14 (0.06) | 0 | 86 (0.35) | 275 (0.17) | 416 (0.19) |
| Superior sagittal sinus thrombosis | 16 (0.33) | 25 (0.27) | 3 (0.01) | 0 | 24 (0.10) | 11 (0.01) | 85 (0.04) |
| Supraventricular tachycardia | 0 | 5 (0.05) | 9 (0.04) | 0 | 28 (0.11) | 23 (0.01) | 66 (0.03) |
| Suspected COVID-19 | 2 (0.04) | 2 (0.02) | 5 (0.02) | 0 | 13 (0.05) | 38 (0.02) | 60 (0.03) |
| Sweating fever | 0 | 2 (0.02) | 77 (0.32) | 0 | 7 (0.03) | 536 (0.33) | 622 (0.28) |
| Swelling | 3 (0.06) | 60 (0.65) | 206 (0.85) | 1 (0.64) | 116 (0.47) | 1408 (0.87) | 1800 (0.80) |
| Swelling face | 1 (0.02) | 36 (0.39) | 82 (0.34) | 0 | 117 (0.47) | 664 (0.41) | 908 (0.40) |
| Swelling of eyelid | 0 | 3 (0.03) | 8 (0.03) | 0 | 13 (0.05) | 65 (0.04) | 89 (0.04) |
| Swollen tongue | 1 (0.02) | 61 (0.66) | 43 (0.18) | 0 | 63 (0.25) | 343 (0.21) | 514 (0.23) |
| Syncope | 53 (1.09) | 237 (2.57) | 267 (1.10) | 3 (1.91) | 574 (2.32) | 2114 (1.31) | 3304 (1.47) |
| Systemic lupus erythematosus | 0 | 6 (0.07) | 8 (0.03) | 0 | 8 (0.03) | 31 (0.02) | 53 (0.02) |
| Tachycardia | 30 (0.62) | 230 (2.50) | 297 (1.23) | 0 | 553 (2.23) | 1210 (0.75) | 2367 (1.06) |
| Tachypnoea | 10 (0.21) | 9 (0.10) | 10 (0.04) | 0 | 17 (0.07) | 22 (0.01) | 70 (0.03) |
| Taste disorder | 0 | 6 (0.07) | 61 (0.25) | 0 | 28 (0.11) | 308 (0.19) | 406 (0.18) |
| Tearfulness | 0 | 1 (0.01) | 18 (0.07) | 0 | 0 | 70 (0.04) | 89 (0.04) |
| Temperature intolerance | 0 | 0 | 9 (0.04) | 0 | 2 (0.01) | 65 (0.04) | 76 (0.03) |
| Tenderness | 4 (0.08) | 6 (0.07) | 94 (0.39) | 0 | 52 (0.21) | 1076 (0.67) | 1250 (0.56) |
| Tendonitis | 0 | 1 (0.01) | 41 (0.17) | 0 | 0 | 65 (0.04) | 108 (0.05) |
| Tension | 1 (0.02) | 4 (0.04) | 5 (0.02) | 0 | 2 (0.01) | 40 (0.02) | 54 (0.02) |
| Tension headache | 1 (0.02) | 10 (0.11) | 146 (0.60) | 0 | 56 (0.23) | 988 (0.61) | 1202 (0.54) |
| Testicular pain | 0 | 0 | 8 (0.03) | 0 | 3 (0.01) | 61 (0.04) | 72 (0.03) |
| Therapeutic response unexpected | 0 | 0 | 10 (0.04) | 0 | 3 (0.01) | 57 (0.04) | 71 (0.03) |
| Thirst | 1 (0.02) | 18 (0.20) | 121 (0.50) | 1 (0.64) | 22 (0.09) | 900 (0.56) | 1065 (0.47) |
| Throat irritation | 1 (0.02) | 14 (0.15) | 21 (0.09) | 0 | 35 (0.14) | 140 (0.09) | 212 (0.09) |
| Throat tightness | 0 | 29 (0.31) | 26 (0.11) | 0 | 44 (0.18) | 142 (0.09) | 242 (0.11) |
| Thrombocytopenia | 262 (5.37) | 591 (6.42) | 61 (0.25) | 0 | 1038 (4.19) | 753 (0.47) | 2989 (1.33) |
| Thrombophlebitis | 4 (0.08) | 42 (0.46) | 28 (0.12) | 0 | 48 (0.19) | 248 (0.15) | 377 (0.17) |
| Thrombosis | 200 (4.10) | 575 (6.24) | 201 (0.83) | 1 (0.64) | 736 (2.97) | 1286 (0.80) | 3117 (1.39) |
| Thrombosis in device | 2 (0.04) | 24 (0.26) | 1 (0.00) | 0 | 17 (0.07) | 17 (0.01) | 62 (0.03) |
| Thrombosis with thrombocytopenia syndrome | 23 (0.47) | 17 (0.18) | 0 | 0 | 38 (0.15) | 21 (0.01) | 121 (0.05) |
| Thunderclap headache | 1 (0.02) | 2 (0.02) | 9 (0.04) | 0 | 18 (0.07) | 30 (0.02) | 60 (0.03) |
| Tinnitus | 1 (0.02) | 41 (0.45) | 647 (2.67) | 1 (0.64) | 161 (0.65) | 2301 (1.43) | 3163 (1.41) |
| Tongue oedema | 2 (0.04) | 12 (0.13) | 3 (0.01) | 0 | 20 (0.08) | 39 (0.02) | 79 (0.04) |
| Tonsillitis | 0 | 2 (0.02) | 9 (0.04) | 0 | 6 (0.02) | 57 (0.04) | 74 (0.03) |
| Toothache | 1 (0.02) | 2 (0.02) | 36 (0.15) | 0 | 10 (0.04) | 224 (0.14) | 273 (0.12) |
| Transient ischaemic attack | 7 (0.14) | 135 (1.47) | 57 (0.24) | 0 | 350 (1.41) | 353 (0.22) | 910 (0.41) |
| Tremor | 20 (0.41) | 123 (1.34) | 1080 (4.45) | 1 (0.64) | 353 (1.42) | 7243 (4.50) | 8839 (3.94) |
| Trigeminal neuralgia | 0 | 1 (0.01) | 39 (0.16) | 0 | 27 (0.11) | 100 (0.06) | 168 (0.07) |
| Troponin increased | 4 (0.08) | 9 (0.10) | 3 (0.01) | 0 | 37 (0.15) | 12 (0.01) | 93 (0.04) |
| Unresponsive to stimuli | 27 (0.55) | 18 (0.20) | 7 (0.03) | 0 | 28 (0.11) | 63 (0.04) | 158 (0.07) |
| Urinary incontinence | 4 (0.08) | 10 (0.11) | 35 (0.14) | 0 | 32 (0.13) | 74 (0.05) | 162 (0.07) |
| Urinary retention | 2 (0.04) | 14 (0.15) | 27 (0.11) | 0 | 32 (0.13) | 53 (0.03) | 136 (0.06) |
| Urinary tract infection | 11 (0.23) | 12 (0.13) | 26 (0.11) | 0 | 47 (0.19) | 176 (0.11) | 287 (0.13) |
| Urticaria | 1 (0.02) | 95 (1.03) | 149 (0.61) | 0 | 172 (0.69) | 1415 (0.88) | 1834 (0.82) |
| Uterine haemorrhage | 0 | 2 (0.02) | 3 (0.01) | 0 | 8 (0.03) | 43 (0.03) | 57 (0.03) |
| Uveitis | 0 | 0 | 12 (0.05) | 0 | 7 (0.03) | 35 (0.02) | 54 (0.02) |
| Vaccination complication | 2 (0.04) | 2 (0.02) | 17 (0.07) | 0 | 9 (0.04) | 83 (0.05) | 115 (0.05) |
| Vaccination failure | 100 (2.05) | 53 (0.58) | 1 (0.00) | 0 | 342 (1.38) | 9932 (6.17) | 10437 (4.65) |
| Vaccination site bruising | 0 | 2 (0.02) | 15 (0.06) | 0 | 4 (0.02) | 76 (0.05) | 98 (0.04) |
| Vaccination site erythema | 1 (0.02) | 7 (0.08) | 78 (0.32) | 0 | 30 (0.12) | 400 (0.25) | 516 (0.23) |
| Vaccination site induration | 0 | 0 | 13 (0.05) | 0 | 2 (0.01) | 55 (0.03) | 70 (0.03) |
| Vaccination site inflammation | 0 | 2 (0.02) | 8 (0.03) | 0 | 7 (0.03) | 59 (0.04) | 76 (0.03) |
| Vaccination site mass | 0 | 2 (0.02) | 33 (0.14) | 0 | 7 (0.03) | 266 (0.17) | 310 (0.14) |
| Vaccination site movement impairment | 0 | 2 (0.02) | 56 (0.23) | 0 | 18 (0.07) | 74 (0.05) | 150 (0.07) |
| Vaccination site oedema | 0 | 2 (0.02) | 25 (0.10) | 0 | 3 (0.01) | 49 (0.03) | 79 (0.04) |
| Vaccination site pain | 12 (0.25) | 23 (0.25) | 404 (1.67) | 0 | 142 (0.57) | 1825 (1.13) | 2416 (1.08) |
| Vaccination site pruritus | 0 | 1 (0.01) | 24 (0.10) | 0 | 10 (0.04) | 89 (0.06) | 124 (0.06) |
| Vaccination site rash | 1 (0.02) | 0 | 9 (0.04) | 0 | 4 (0.02) | 100 (0.06) | 114 (0.05) |
| Vaccination site reaction | 1 (0.02) | 2 (0.02) | 32 (0.13) | 0 | 19 (0.08) | 94 (0.06) | 150 (0.07) |
| Vaccination site swelling | 0 | 4 (0.04) | 89 (0.37) | 0 | 32 (0.13) | 312 (0.19) | 439 (0.20) |
| Vaccination site warmth | 0 | 1 (0.01) | 41 (0.17) | 0 | 5 (0.02) | 229 (0.14) | 277 (0.12) |
| Vaginal discharge | 0 | 1 (0.01) | 6 (0.02) | 0 | 5 (0.02) | 43 (0.03) | 55 (0.02) |
| Vaginal haemorrhage | 0 | 20 (0.22) | 51 (0.21) | 6 (3.82) | 59 (0.24) | 673 (0.42) | 812 (0.36) |
| Varicose vein | 0 | 10 (0.11) | 12 (0.05) | 0 | 9 (0.04) | 97 (0.06) | 129 (0.06) |
| Vascular headache | 0 | 4 (0.04) | 21 (0.09) | 0 | 3 (0.01) | 50 (0.03) | 79 (0.04) |
| Vascular pain | 0 | 7 (0.08) | 15 (0.06) | 0 | 9 (0.04) | 106 (0.07) | 138 (0.06) |
| Vasculitis | 9 (0.18) | 29 (0.31) | 18 (0.07) | 0 | 42 (0.17) | 103 (0.06) | 210 (0.09) |
| Vasodilatation | 0 | 5 (0.05) | 18 (0.07) | 1 (0.64) | 10 (0.04) | 88 (0.05) | 123 (0.05) |
| Venous thrombosis | 8 (0.16) | 68 (0.74) | 19 (0.08) | 0 | 88 (0.36) | 118 (0.07) | 311 (0.14) |
| Venous thrombosis limb | 5 (0.10) | 41 (0.45) | 10 (0.04) | 0 | 66 (0.27) | 129 (0.08) | 253 (0.11) |
| Vertigo | 4 (0.08) | 60 (0.65) | 509 (2.10) | 0 | 288 (1.16) | 1596 (0.99) | 2479 (1.11) |
| Vertigo positional | 0 | 1 (0.01) | 27 (0.11) | 0 | 27 (0.11) | 98 (0.06) | 154 (0.07) |
| Vestibular neuronitis | 0 | 1 (0.01) | 20 (0.08) | 0 | 38 (0.15) | 30 (0.02) | 89 (0.04) |
| Viral infection | 3 (0.06) | 3 (0.03) | 23 (0.09) | 0 | 14 (0.06) | 40 (0.02) | 85 (0.04) |
| Vision blurred | 11 (0.23) | 97 (1.05) | 530 (2.19) | 0 | 304 (1.23) | 1952 (1.21) | 2924 (1.30) |
| Visual acuity reduced | 0 | 3 (0.03) | 22 (0.09) | 0 | 11 (0.04) | 47 (0.03) | 85 (0.04) |
| Visual field defect | 1 (0.02) | 5 (0.05) | 18 (0.07) | 0 | 21 (0.08) | 41 (0.03) | 88 (0.04) |
| Visual impairment | 10 (0.21) | 48 (0.52) | 258 (1.06) | 0 | 225 (0.91) | 568 (0.35) | 1139 (0.51) |
| Vitreous detachment | 0 | 0 | 9 (0.04) | 0 | 3 (0.01) | 60 (0.04) | 73 (0.03) |
| Vitreous floaters | 1 (0.02) | 0 | 33 (0.14) | 0 | 12 (0.05) | 133 (0.08) | 179 (0.08) |
| Vomiting | 185 (3.79) | 292 (3.17) | 1413 (5.83) | 0 | 1045 (4.22) | 8310 (5.16) | 11336 (5.05) |
| Vomiting projectile | 2 (0.04) | 2 (0.02) | 33 (0.14) | 0 | 8 (0.03) | 96 (0.06) | 141 (0.06) |
| Weight decreased | 4 (0.08) | 13 (0.14) | 75 (0.31) | 0 | 54 (0.22) | 150 (0.09) | 302 (0.13) |
| Weight increased | 0 | 3 (0.03) | 15 (0.06) | 0 | 7 (0.03) | 43 (0.03) | 68 (0.03) |
| Wheezing | 4 (0.08) | 42 (0.46) | 69 (0.28) | 0 | 44 (0.18) | 387 (0.24) | 556 (0.25) |
| Withdrawal syndrome | 0 | 1 (0.01) | 5 (0.02) | 0 | 2 (0.01) | 56 (0.03) | 64 (0.03) |
| Yawning | 0 | 1 (0.01) | 7 (0.03) | 0 | 0 | 45 (0.03) | 54 (0.02) |