Eudravigilance C-19 - Astrazeneca

Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)

PT

Décès

4877 (%)

Mise en jeu du pronostic vital

9211 (%)

Invalidité ou incapacité

24244 (%)

Anomalies congénitales

157 (%)

Hospitalisation

24779 (%)

Médicalement significatif

160991 (%)

Cas Graves

224259 (%)

Abdominal discomfort 12 (0.25) 18 (0.20) 163 (0.67) 0 59 (0.24) 1075 (0.67) 1335 (0.60)
Abdominal distension 11 (0.23) 13 (0.14) 96 (0.40) 1 (0.64) 39 (0.16) 410 (0.25) 574 (0.26)
Abdominal pain 99 (2.03) 170 (1.85) 616 (2.54) 2 (1.27) 494 (1.99) 3079 (1.91) 4520 (2.02)
Abdominal pain lower 0 7 (0.08) 28 (0.12) 0 53 (0.21) 185 (0.11) 275 (0.12)
Abdominal pain upper 24 (0.49) 71 (0.77) 562 (2.32) 2 (1.27) 249 (1.00) 3668 (2.28) 4595 (2.05)
Abdominal rigidity 2 (0.04) 1 (0.01) 11 (0.05) 0 4 (0.02) 39 (0.02) 57 (0.03)
Abnormal dreams 1 (0.02) 3 (0.03) 29 (0.12) 0 4 (0.02) 237 (0.15) 274 (0.12)
Abnormal loss of weight 2 (0.04) 6 (0.07) 25 (0.10) 0 7 (0.03) 40 (0.02) 81 (0.04)
Abortion spontaneous 3 (0.06) 14 (0.15) 23 (0.09) 69 (43.95) 37 (0.15) 171 (0.11) 321 (0.14)
Abscess 0 1 (0.01) 7 (0.03) 0 15 (0.06) 28 (0.02) 54 (0.02)
Acne 1 (0.02) 3 (0.03) 8 (0.03) 0 4 (0.02) 81 (0.05) 98 (0.04)
Activated partial thromboplastin time prolonged 3 (0.06) 46 (0.50) 6 (0.02) 0 28 (0.11) 46 (0.03) 131 (0.06)
Acute coronary syndrome 29 (0.59) 23 (0.25) 0 0 61 (0.25) 6 (0.00) 120 (0.05)
Acute disseminated encephalomyelitis 3 (0.06) 10 (0.11) 8 (0.03) 0 23 (0.09) 8 (0.00) 55 (0.02)
Acute kidney injury 26 (0.53) 39 (0.42) 11 (0.05) 0 74 (0.30) 29 (0.02) 194 (0.09)
Acute myocardial infarction 109 (2.23) 129 (1.40) 3 (0.01) 0 146 (0.59) 25 (0.02) 427 (0.19)
Acute respiratory distress syndrome 44 (0.90) 13 (0.14) 0 0 65 (0.26) 59 (0.04) 187 (0.08)
Acute respiratory failure 29 (0.59) 10 (0.11) 0 0 26 (0.10) 1 (0.00) 68 (0.03)
Administration site pain 0 20 (0.22) 19 (0.08) 1 (0.64) 6 (0.02) 29 (0.02) 76 (0.03)
Adverse drug reaction 0 2 (0.02) 18 (0.07) 1 (0.64) 5 (0.02) 80 (0.05) 107 (0.05)
Adverse event following immunisation 110 (2.26) 0 1 (0.00) 0 1 (0.00) 0 112 (0.05)
Ageusia 15 (0.31) 14 (0.15) 160 (0.66) 0 79 (0.32) 671 (0.42) 943 (0.42)
Agitation 14 (0.29) 22 (0.24) 35 (0.14) 0 25 (0.10) 123 (0.08) 229 (0.10)
Allergy to vaccine 0 6 (0.07) 5 (0.02) 0 3 (0.01) 40 (0.02) 54 (0.02)
Alopecia 0 12 (0.13) 56 (0.23) 1 (0.64) 12 (0.05) 270 (0.17) 353 (0.16)
Altered state of consciousness 15 (0.31) 7 (0.08) 5 (0.02) 0 27 (0.11) 21 (0.01) 85 (0.04)
Amenorrhoea 0 9 (0.10) 47 (0.19) 2 (1.27) 10 (0.04) 271 (0.17) 339 (0.15)
Amnesia 2 (0.04) 52 (0.56) 132 (0.54) 0 93 (0.38) 241 (0.15) 527 (0.23)
Anaemia 12 (0.25) 30 (0.33) 35 (0.14) 0 65 (0.26) 107 (0.07) 260 (0.12)
Anal incontinence 2 (0.04) 6 (0.07) 12 (0.05) 0 14 (0.06) 19 (0.01) 55 (0.02)
Anaphylactic reaction 10 (0.21) 357 (3.88) 23 (0.09) 0 263 (1.06) 555 (0.34) 1225 (0.55)
Anaphylactic shock 8 (0.16) 66 (0.72) 13 (0.05) 0 61 (0.25) 100 (0.06) 255 (0.11)
Anaphylactoid reaction 0 6 (0.07) 2 (0.01) 0 7 (0.03) 60 (0.04) 75 (0.03)
Anger 1 (0.02) 6 (0.07) 10 (0.04) 0 1 (0.00) 51 (0.03) 71 (0.03)
Angina pectoris 5 (0.10) 48 (0.52) 51 (0.21) 1 (0.64) 90 (0.36) 177 (0.11) 383 (0.17)
Angioedema 0 64 (0.69) 28 (0.12) 0 61 (0.25) 486 (0.30) 653 (0.29)
Anosmia 16 (0.33) 8 (0.09) 66 (0.27) 0 54 (0.22) 215 (0.13) 365 (0.16)
Anxiety 3 (0.06) 47 (0.51) 245 (1.01) 0 152 (0.61) 836 (0.52) 1292 (0.58)
Aortic thrombosis 11 (0.23) 15 (0.16) 1 (0.00) 0 19 (0.08) 5 (0.00) 59 (0.03)
Apathy 0 1 (0.01) 25 (0.10) 0 11 (0.04) 47 (0.03) 86 (0.04)
Aphasia 26 (0.53) 67 (0.73) 56 (0.23) 0 107 (0.43) 172 (0.11) 472 (0.21)
Aphonia 1 (0.02) 8 (0.09) 18 (0.07) 0 11 (0.04) 73 (0.05) 113 (0.05)
Aphthous ulcer 1 (0.02) 1 (0.01) 5 (0.02) 0 5 (0.02) 49 (0.03) 62 (0.03)
Appendicitis 2 (0.04) 16 (0.17) 4 (0.02) 0 42 (0.17) 20 (0.01) 84 (0.04)
Application site pain 3 (0.06) 7 (0.08) 5 (0.02) 0 11 (0.04) 70 (0.04) 99 (0.04)
Areflexia 1 (0.02) 11 (0.12) 16 (0.07) 0 23 (0.09) 1 (0.00) 57 (0.03)
Arrhythmia 11 (0.23) 36 (0.39) 43 (0.18) 0 200 (0.81) 365 (0.23) 670 (0.30)
Arterial thrombosis 11 (0.23) 33 (0.36) 7 (0.03) 0 26 (0.10) 24 (0.01) 108 (0.05)
Arthralgia 40 (0.82) 195 (2.12) 4247 (17.52) 3 (1.91) 643 (2.59) 16442 (10.21) 21629 (9.64)
Arthritis 0 6 (0.07) 167 (0.69) 0 34 (0.14) 370 (0.23) 582 (0.26)
Arthritis reactive 0 1 (0.01) 27 (0.11) 0 9 (0.04) 32 (0.02) 69 (0.03)
Asthenia 127 (2.60) 198 (2.15) 1091 (4.50) 1 (0.64) 830 (3.35) 3983 (2.47) 6318 (2.82)
Asthenopia 0 3 (0.03) 46 (0.19) 0 10 (0.04) 220 (0.14) 280 (0.12)
Asthma 3 (0.06) 38 (0.41) 105 (0.43) 0 53 (0.21) 428 (0.27) 630 (0.28)
Ataxia 2 (0.04) 12 (0.13) 22 (0.09) 0 48 (0.19) 19 (0.01) 111 (0.05)
Atrial fibrillation 19 (0.39) 94 (1.02) 41 (0.17) 0 217 (0.88) 266 (0.17) 659 (0.29)
Atrial flutter 0 6 (0.07) 8 (0.03) 0 21 (0.08) 26 (0.02) 64 (0.03)
Autoimmune disorder 2 (0.04) 12 (0.13) 27 (0.11) 0 21 (0.08) 47 (0.03) 113 (0.05)
Axillary mass 0 1 (0.01) 8 (0.03) 0 3 (0.01) 40 (0.02) 53 (0.02)
Axillary pain 0 1 (0.01) 60 (0.25) 0 15 (0.06) 463 (0.29) 541 (0.24)
Back pain 34 (0.70) 103 (1.12) 808 (3.33) 2 (1.27) 331 (1.34) 3939 (2.45) 5238 (2.34)
Balance disorder 7 (0.14) 55 (0.60) 292 (1.20) 0 143 (0.58) 592 (0.37) 1108 (0.49)
Bedridden 3 (0.06) 5 (0.05) 55 (0.23) 0 9 (0.04) 95 (0.06) 173 (0.08)
Bell's palsy 1 (0.02) 18 (0.20) 142 (0.59) 0 146 (0.59) 395 (0.25) 707 (0.32)
Bladder pain 0 1 (0.01) 9 (0.04) 0 5 (0.02) 43 (0.03) 59 (0.03)
Blepharospasm 0 1 (0.01) 22 (0.09) 0 6 (0.02) 58 (0.04) 87 (0.04)
Blindness 2 (0.04) 35 (0.38) 140 (0.58) 0 56 (0.23) 215 (0.13) 467 (0.21)
Blindness transient 0 4 (0.04) 9 (0.04) 0 10 (0.04) 47 (0.03) 74 (0.03)
Blindness unilateral 1 (0.02) 10 (0.11) 44 (0.18) 0 17 (0.07) 40 (0.02) 115 (0.05)
Blister 1 (0.02) 16 (0.17) 52 (0.21) 0 27 (0.11) 339 (0.21) 442 (0.20)
Blood blister 0 2 (0.02) 10 (0.04) 0 6 (0.02) 53 (0.03) 73 (0.03)
Blood fibrinogen increased 2 (0.04) 6 (0.07) 2 (0.01) 0 14 (0.06) 17 (0.01) 52 (0.02)
Blood glucose increased 1 (0.02) 7 (0.08) 17 (0.07) 0 17 (0.07) 130 (0.08) 178 (0.08)
Blood pressure decreased 7 (0.14) 25 (0.27) 38 (0.16) 0 54 (0.22) 110 (0.07) 239 (0.11)
Blood pressure fluctuation 1 (0.02) 16 (0.17) 16 (0.07) 0 20 (0.08) 40 (0.02) 101 (0.05)
Blood pressure increased 10 (0.21) 85 (0.92) 95 (0.39) 0 216 (0.87) 355 (0.22) 775 (0.35)
Blood pressure measurement 0 10 (0.11) 12 (0.05) 0 17 (0.07) 65 (0.04) 104 (0.05)
Blood test abnormal 0 5 (0.05) 24 (0.10) 0 29 (0.12) 40 (0.02) 99 (0.04)
Blood urine present 1 (0.02) 7 (0.08) 5 (0.02) 0 9 (0.04) 63 (0.04) 89 (0.04)
Body temperature 0 1 (0.01) 72 (0.30) 0 11 (0.04) 676 (0.42) 763 (0.34)
Body temperature abnormal 0 1 (0.01) 9 (0.04) 0 3 (0.01) 52 (0.03) 65 (0.03)
Body temperature decreased 1 (0.02) 3 (0.03) 17 (0.07) 0 5 (0.02) 101 (0.06) 128 (0.06)
Body temperature fluctuation 0 3 (0.03) 29 (0.12) 0 1 (0.00) 127 (0.08) 160 (0.07)
Body temperature increased 5 (0.10) 14 (0.15) 99 (0.41) 1 (0.64) 86 (0.35) 821 (0.51) 1028 (0.46)
Bone pain 2 (0.04) 28 (0.30) 231 (0.95) 0 32 (0.13) 782 (0.49) 1078 (0.48)
Bradycardia 12 (0.25) 21 (0.23) 17 (0.07) 0 38 (0.15) 55 (0.03) 158 (0.07)
Bradyphrenia 0 2 (0.02) 19 (0.08) 0 6 (0.02) 64 (0.04) 91 (0.04)
Brain injury 16 (0.33) 18 (0.20) 5 (0.02) 0 6 (0.02) 9 (0.01) 64 (0.03)
Brain oedema 39 (0.80) 15 (0.16) 3 (0.01) 0 13 (0.05) 14 (0.01) 88 (0.04)
Breast cancer 0 7 (0.08) 5 (0.02) 0 6 (0.02) 33 (0.02) 52 (0.02)
Breast mass 0 2 (0.02) 6 (0.02) 0 7 (0.03) 40 (0.02) 56 (0.02)
Breast pain 0 0 44 (0.18) 1 (0.64) 30 (0.12) 277 (0.17) 353 (0.16)
Breast swelling 0 0 8 (0.03) 0 4 (0.02) 40 (0.02) 52 (0.02)
Bronchospasm 0 7 (0.08) 3 (0.01) 0 16 (0.06) 26 (0.02) 53 (0.02)
Burning sensation 0 31 (0.34) 168 (0.69) 2 (1.27) 70 (0.28) 626 (0.39) 904 (0.40)
Bursitis 0 2 (0.02) 80 (0.33) 0 9 (0.04) 122 (0.08) 213 (0.09)
C-reactive protein increased 7 (0.14) 11 (0.12) 17 (0.07) 0 64 (0.26) 44 (0.03) 156 (0.07)
COVID-19 278 (5.70) 163 (1.77) 215 (0.89) 2 (1.27) 689 (2.78) 10453 (6.49) 11824 (5.27)
COVID-19 immunisation 4 (0.08) 12 (0.13) 62 (0.26) 0 34 (0.14) 138 (0.09) 251 (0.11)
COVID-19 pneumonia 66 (1.35) 32 (0.35) 13 (0.05) 0 168 (0.68) 26 (0.02) 305 (0.14)
Candida infection 1 (0.02) 1 (0.01) 6 (0.02) 0 2 (0.01) 46 (0.03) 56 (0.02)
Cardiac arrest 247 (5.06) 92 (1.00) 4 (0.02) 0 15 (0.06) 41 (0.03) 419 (0.19)
Cardiac disorder 4 (0.08) 27 (0.29) 10 (0.04) 0 46 (0.19) 41 (0.03) 136 (0.06)
Cardiac failure 63 (1.29) 61 (0.66) 21 (0.09) 0 76 (0.31) 26 (0.02) 259 (0.12)
Cardiac flutter 0 8 (0.09) 30 (0.12) 0 14 (0.06) 169 (0.10) 222 (0.10)
Cardio-respiratory arrest 68 (1.39) 18 (0.20) 0 0 5 (0.02) 4 (0.00) 98 (0.04)
Cardiovascular disorder 16 (0.33) 8 (0.09) 49 (0.20) 0 45 (0.18) 32 (0.02) 154 (0.07)
Cellulitis 3 (0.06) 13 (0.14) 39 (0.16) 0 56 (0.23) 287 (0.18) 402 (0.18)
Cerebral artery thrombosis 11 (0.23) 17 (0.18) 3 (0.01) 0 10 (0.04) 8 (0.00) 52 (0.02)
Cerebral haemorrhage 197 (4.04) 146 (1.59) 27 (0.11) 0 116 (0.47) 47 (0.03) 559 (0.25)
Cerebral infarction 42 (0.86) 110 (1.19) 34 (0.14) 0 176 (0.71) 53 (0.03) 432 (0.19)
Cerebral ischaemia 7 (0.14) 13 (0.14) 5 (0.02) 0 27 (0.11) 10 (0.01) 67 (0.03)
Cerebral thrombosis 54 (1.11) 38 (0.41) 4 (0.02) 0 70 (0.28) 41 (0.03) 221 (0.10)
Cerebral venous sinus thrombosis 103 (2.11) 234 (2.54) 20 (0.08) 0 252 (1.02) 75 (0.05) 704 (0.31)
Cerebral venous thrombosis 44 (0.90) 53 (0.58) 5 (0.02) 0 81 (0.33) 36 (0.02) 229 (0.10)
Cerebrovascular accident 191 (3.92) 539 (5.85) 252 (1.04) 3 (1.91) 767 (3.10) 581 (0.36) 2399 (1.07)
Chest discomfort 16 (0.33) 91 (0.99) 297 (1.23) 0 326 (1.32) 1393 (0.87) 2155 (0.96)
Chest pain 107 (2.19) 487 (5.29) 871 (3.59) 1 (0.64) 1119 (4.52) 3538 (2.20) 6226 (2.78)
Chills 65 (1.33) 380 (4.13) 5692 (23.48) 7 (4.46) 1285 (5.19) 31777 (19.74) 39264 (17.51)
Chromaturia 3 (0.06) 5 (0.05) 13 (0.05) 0 7 (0.03) 75 (0.05) 105 (0.05)
Chronic fatigue syndrome 0 1 (0.01) 85 (0.35) 0 9 (0.04) 64 (0.04) 160 (0.07)
Chronic obstructive pulmonary disease 20 (0.41) 10 (0.11) 6 (0.02) 0 19 (0.08) 23 (0.01) 79 (0.04)
Circulatory collapse 62 (1.27) 47 (0.51) 15 (0.06) 0 77 (0.31) 123 (0.08) 348 (0.16)
Clumsiness 0 1 (0.01) 19 (0.08) 0 6 (0.02) 27 (0.02) 54 (0.02)
Cluster headache 2 (0.04) 12 (0.13) 96 (0.40) 0 24 (0.10) 494 (0.31) 629 (0.28)
Coagulopathy 21 (0.43) 43 (0.47) 34 (0.14) 1 (0.64) 52 (0.21) 72 (0.04) 231 (0.10)
Cognitive disorder 3 (0.06) 9 (0.10) 98 (0.40) 0 23 (0.09) 106 (0.07) 250 (0.11)
Cold sweat 12 (0.25) 32 (0.35) 181 (0.75) 1 (0.64) 69 (0.28) 1148 (0.71) 1452 (0.65)
Cold-stimulus headache 0 3 (0.03) 15 (0.06) 0 3 (0.01) 54 (0.03) 75 (0.03)
Colitis 1 (0.02) 3 (0.03) 7 (0.03) 0 27 (0.11) 41 (0.03) 79 (0.04)
Colitis ulcerative 0 3 (0.03) 20 (0.08) 0 17 (0.07) 73 (0.05) 113 (0.05)
Coma 27 (0.55) 31 (0.34) 3 (0.01) 0 12 (0.05) 3 (0.00) 98 (0.04)
Condition aggravated 15 (0.31) 20 (0.22) 148 (0.61) 0 66 (0.27) 302 (0.19) 558 (0.25)
Confusional state 52 (1.07) 149 (1.62) 429 (1.77) 1 (0.64) 284 (1.15) 1320 (0.82) 2274 (1.01)
Conjunctival haemorrhage 0 4 (0.04) 8 (0.03) 0 7 (0.03) 86 (0.05) 106 (0.05)
Conjunctivitis 1 (0.02) 0 7 (0.03) 0 7 (0.03) 53 (0.03) 68 (0.03)
Constipation 3 (0.06) 15 (0.16) 91 (0.38) 0 36 (0.15) 272 (0.17) 420 (0.19)
Contusion 17 (0.35) 83 (0.90) 225 (0.93) 0 180 (0.73) 1597 (0.99) 2128 (0.95)
Coordination abnormal 5 (0.10) 6 (0.07) 32 (0.13) 0 21 (0.08) 82 (0.05) 152 (0.07)
Coronary artery thrombosis 18 (0.37) 24 (0.26) 0 0 11 (0.04) 9 (0.01) 66 (0.03)
Costochondritis 0 1 (0.01) 21 (0.09) 0 10 (0.04) 54 (0.03) 86 (0.04)
Cough 237 (4.86) 143 (1.55) 489 (2.02) 2 (1.27) 649 (2.62) 2537 (1.58) 4105 (1.83)
Crohn's disease 0 1 (0.01) 25 (0.10) 0 12 (0.05) 56 (0.03) 94 (0.04)
Crying 1 (0.02) 7 (0.08) 48 (0.20) 0 11 (0.04) 199 (0.12) 266 (0.12)
Cutaneous vasculitis 0 0 2 (0.01) 0 24 (0.10) 51 (0.03) 79 (0.04)
Cyanosis 25 (0.51) 18 (0.20) 18 (0.07) 0 94 (0.38) 88 (0.05) 251 (0.11)
Cystitis 1 (0.02) 1 (0.01) 11 (0.05) 0 12 (0.05) 81 (0.05) 106 (0.05)
Deafness 1 (0.02) 9 (0.10) 158 (0.65) 0 32 (0.13) 289 (0.18) 491 (0.22)
Deafness neurosensory 1 (0.02) 1 (0.01) 34 (0.14) 0 1 (0.00) 20 (0.01) 60 (0.03)
Deafness unilateral 0 2 (0.02) 41 (0.17) 0 8 (0.03) 58 (0.04) 110 (0.05)
Death 746 (15.30) 1 (0.01) 0 0 0 2 (0.00) 752 (0.34)
Decreased appetite 76 (1.56) 78 (0.85) 850 (3.51) 2 (1.27) 278 (1.12) 4740 (2.94) 6061 (2.70)
Deep vein thrombosis 79 (1.62) 546 (5.93) 115 (0.47) 0 1120 (4.52) 1955 (1.21) 3939 (1.76)
Dehydration 6 (0.12) 18 (0.20) 75 (0.31) 0 88 (0.36) 416 (0.26) 610 (0.27)
Delirium 9 (0.18) 16 (0.17) 81 (0.33) 0 47 (0.19) 326 (0.20) 487 (0.22)
Delusion 1 (0.02) 2 (0.02) 14 (0.06) 0 8 (0.03) 35 (0.02) 63 (0.03)
Demyelination 1 (0.02) 5 (0.05) 17 (0.07) 0 16 (0.06) 21 (0.01) 62 (0.03)
Depressed level of consciousness 29 (0.59) 19 (0.21) 13 (0.05) 0 50 (0.20) 60 (0.04) 184 (0.08)
Depressed mood 1 (0.02) 9 (0.10) 106 (0.44) 0 11 (0.04) 471 (0.29) 599 (0.27)
Depression 4 (0.08) 31 (0.34) 146 (0.60) 0 25 (0.10) 434 (0.27) 645 (0.29)
Dermatitis 0 5 (0.05) 13 (0.05) 0 8 (0.03) 107 (0.07) 134 (0.06)
Dermatitis allergic 0 10 (0.11) 18 (0.07) 0 11 (0.04) 182 (0.11) 223 (0.10)
Dermatitis bullous 1 (0.02) 4 (0.04) 5 (0.02) 0 4 (0.02) 46 (0.03) 60 (0.03)
Diabetes mellitus 7 (0.14) 15 (0.16) 19 (0.08) 0 25 (0.10) 79 (0.05) 147 (0.07)
Diabetic ketoacidosis 5 (0.10) 14 (0.15) 1 (0.00) 0 17 (0.07) 13 (0.01) 54 (0.02)
Diarrhoea 97 (1.99) 137 (1.49) 1009 (4.16) 0 529 (2.13) 6138 (3.81) 7952 (3.55)
Diplegia 5 (0.10) 8 (0.09) 25 (0.10) 0 17 (0.07) 41 (0.03) 100 (0.04)
Diplopia 1 (0.02) 26 (0.28) 105 (0.43) 0 112 (0.45) 219 (0.14) 469 (0.21)
Discomfort 5 (0.10) 15 (0.16) 89 (0.37) 1 (0.64) 52 (0.21) 380 (0.24) 550 (0.25)
Disorientation 13 (0.27) 19 (0.21) 113 (0.47) 0 91 (0.37) 507 (0.31) 756 (0.34)
Disseminated intravascular coagulation 30 (0.62) 26 (0.28) 1 (0.00) 0 15 (0.06) 2 (0.00) 78 (0.03)
Dissociation 0 2 (0.02) 11 (0.05) 0 3 (0.01) 45 (0.03) 61 (0.03)
Disturbance in attention 1 (0.02) 26 (0.28) 218 (0.90) 0 112 (0.45) 517 (0.32) 884 (0.39)
Diverticulitis 3 (0.06) 4 (0.04) 6 (0.02) 0 23 (0.09) 25 (0.02) 61 (0.03)
Dizziness 71 (1.46) 430 (4.67) 2780 (11.47) 5 (3.18) 1613 (6.51) 15413 (9.57) 20419 (9.11)
Dizziness exertional 0 1 (0.01) 17 (0.07) 0 1 (0.00) 76 (0.05) 95 (0.04)
Dizziness postural 2 (0.04) 7 (0.08) 228 (0.94) 0 55 (0.22) 1481 (0.92) 1775 (0.79)
Drug hypersensitivity 0 8 (0.09) 5 (0.02) 0 6 (0.02) 38 (0.02) 57 (0.03)
Drug ineffective 16 (0.33) 14 (0.15) 21 (0.09) 0 54 (0.22) 167 (0.10) 276 (0.12)
Dry eye 0 3 (0.03) 42 (0.17) 0 16 (0.06) 192 (0.12) 253 (0.11)
Dry mouth 1 (0.02) 11 (0.12) 118 (0.49) 0 44 (0.18) 729 (0.45) 906 (0.40)
Dry skin 0 2 (0.02) 38 (0.16) 0 13 (0.05) 230 (0.14) 283 (0.13)
Dry throat 1 (0.02) 4 (0.04) 24 (0.10) 0 7 (0.03) 153 (0.10) 189 (0.08)
Dysaesthesia 0 3 (0.03) 7 (0.03) 0 24 (0.10) 44 (0.03) 82 (0.04)
Dysarthria 28 (0.57) 69 (0.75) 100 (0.41) 0 172 (0.69) 234 (0.15) 623 (0.28)
Dysgeusia 3 (0.06) 13 (0.14) 153 (0.63) 1 (0.64) 30 (0.12) 1046 (0.65) 1254 (0.56)
Dyskinesia 4 (0.08) 4 (0.04) 29 (0.12) 0 19 (0.08) 78 (0.05) 141 (0.06)
Dysmenorrhoea 0 2 (0.02) 115 (0.47) 1 (0.64) 25 (0.10) 882 (0.55) 1028 (0.46)
Dyspepsia 4 (0.08) 21 (0.23) 94 (0.39) 0 33 (0.13) 551 (0.34) 707 (0.32)
Dysphagia 17 (0.35) 42 (0.46) 50 (0.21) 1 (0.64) 78 (0.31) 174 (0.11) 381 (0.17)
Dysphonia 1 (0.02) 20 (0.22) 42 (0.17) 0 31 (0.13) 106 (0.07) 202 (0.09)
Dyspnoea 515 (10.56) 911 (9.89) 1284 (5.30) 1 (0.64) 2202 (8.89) 4905 (3.05) 10057 (4.48)
Dyspnoea exertional 8 (0.16) 22 (0.24) 31 (0.13) 0 73 (0.29) 72 (0.04) 219 (0.10)
Dysstasia 1 (0.02) 13 (0.14) 48 (0.20) 0 19 (0.08) 81 (0.05) 169 (0.08)
Dysuria 2 (0.04) 5 (0.05) 15 (0.06) 0 25 (0.10) 67 (0.04) 117 (0.05)
Ear discomfort 0 2 (0.02) 26 (0.11) 0 18 (0.07) 80 (0.05) 129 (0.06)
Ear infection 1 (0.02) 5 (0.05) 21 (0.09) 0 8 (0.03) 104 (0.06) 142 (0.06)
Ear pain 0 16 (0.17) 266 (1.10) 0 66 (0.27) 1404 (0.87) 1756 (0.78)
Ear swelling 0 1 (0.01) 2 (0.01) 0 8 (0.03) 50 (0.03) 61 (0.03)
Ecchymosis 0 9 (0.10) 7 (0.03) 0 38 (0.15) 53 (0.03) 114 (0.05)
Eczema 1 (0.02) 7 (0.08) 32 (0.13) 0 17 (0.07) 198 (0.12) 255 (0.11)
Electric shock sensation 1 (0.02) 3 (0.03) 25 (0.10) 0 8 (0.03) 73 (0.05) 110 (0.05)
Embolism 32 (0.66) 100 (1.09) 30 (0.12) 0 80 (0.32) 112 (0.07) 360 (0.16)
Emotional disorder 0 0 16 (0.07) 0 2 (0.01) 66 (0.04) 85 (0.04)
Emotional distress 0 6 (0.07) 21 (0.09) 0 5 (0.02) 57 (0.04) 91 (0.04)
Encephalitis 5 (0.10) 36 (0.39) 13 (0.05) 0 66 (0.27) 19 (0.01) 141 (0.06)
Endometriosis 0 0 8 (0.03) 0 7 (0.03) 54 (0.03) 69 (0.03)
Enuresis 0 2 (0.02) 8 (0.03) 0 2 (0.01) 42 (0.03) 54 (0.02)
Epilepsy 6 (0.12) 55 (0.60) 52 (0.21) 0 137 (0.55) 201 (0.12) 459 (0.20)
Epistaxis 12 (0.25) 82 (0.89) 149 (0.61) 1 (0.64) 191 (0.77) 1177 (0.73) 1626 (0.73)
Erectile dysfunction 1 (0.02) 7 (0.08) 30 (0.12) 0 5 (0.02) 43 (0.03) 86 (0.04)
Eructation 1 (0.02) 5 (0.05) 18 (0.07) 0 3 (0.01) 66 (0.04) 93 (0.04)
Erythema 7 (0.14) 69 (0.75) 169 (0.70) 2 (1.27) 168 (0.68) 1656 (1.03) 2090 (0.93)
Erythema multiforme 0 5 (0.05) 1 (0.00) 0 11 (0.04) 49 (0.03) 67 (0.03)
Exercise tolerance decreased 0 8 (0.09) 21 (0.09) 0 23 (0.09) 39 (0.02) 100 (0.04)
Exposure during pregnancy 5 (0.10) 7 (0.08) 3 (0.01) 4 (2.55) 20 (0.08) 40 (0.02) 91 (0.04)
Exposure via breast milk 0 1 (0.01) 4 (0.02) 0 0 52 (0.03) 57 (0.03)
Extensive swelling of vaccinated limb 0 4 (0.04) 182 (0.75) 0 6 (0.02) 40 (0.02) 233 (0.10)
Extrasystoles 1 (0.02) 7 (0.08) 28 (0.12) 1 (0.64) 20 (0.08) 127 (0.08) 186 (0.08)
Eye disorder 0 2 (0.02) 9 (0.04) 0 9 (0.04) 30 (0.02) 52 (0.02)
Eye haemorrhage 0 2 (0.02) 24 (0.10) 0 15 (0.06) 91 (0.06) 136 (0.06)
Eye injury 0 5 (0.05) 20 (0.08) 0 4 (0.02) 25 (0.02) 55 (0.02)
Eye irritation 0 6 (0.07) 35 (0.14) 0 10 (0.04) 142 (0.09) 194 (0.09)
Eye movement disorder 0 6 (0.07) 12 (0.05) 0 9 (0.04) 32 (0.02) 61 (0.03)
Eye pain 2 (0.04) 43 (0.47) 453 (1.87) 0 107 (0.43) 2213 (1.37) 2825 (1.26)
Eye pruritus 0 10 (0.11) 25 (0.10) 0 12 (0.05) 167 (0.10) 215 (0.10)
Eye swelling 0 16 (0.17) 48 (0.20) 0 28 (0.11) 356 (0.22) 449 (0.20)
Eyelid oedema 1 (0.02) 2 (0.02) 7 (0.03) 0 14 (0.06) 35 (0.02) 60 (0.03)
Eyelid ptosis 1 (0.02) 5 (0.05) 16 (0.07) 0 19 (0.08) 40 (0.02) 85 (0.04)
Face oedema 1 (0.02) 21 (0.23) 10 (0.04) 0 29 (0.12) 72 (0.04) 134 (0.06)
Facial pain 0 5 (0.05) 60 (0.25) 0 16 (0.06) 191 (0.12) 274 (0.12)
Facial paralysis 13 (0.27) 49 (0.53) 126 (0.52) 0 210 (0.85) 321 (0.20) 754 (0.34)
Facial paresis 5 (0.10) 27 (0.29) 49 (0.20) 0 106 (0.43) 101 (0.06) 297 (0.13)
Faeces discoloured 0 2 (0.02) 8 (0.03) 0 8 (0.03) 30 (0.02) 51 (0.02)
Fall 27 (0.55) 46 (0.50) 58 (0.24) 0 110 (0.44) 188 (0.12) 452 (0.20)
Fatigue 146 (2.99) 506 (5.49) 7870 (32.46) 5 (3.18) 1594 (6.43) 35059 (21.78) 45307 (20.20)
Fear 0 6 (0.07) 18 (0.07) 0 5 (0.02) 38 (0.02) 68 (0.03)
Febrile convulsion 2 (0.04) 4 (0.04) 17 (0.07) 0 22 (0.09) 103 (0.06) 151 (0.07)
Feeding disorder 3 (0.06) 9 (0.10) 53 (0.22) 0 11 (0.04) 147 (0.09) 226 (0.10)
Feeling abnormal 15 (0.31) 55 (0.60) 429 (1.77) 0 116 (0.47) 2073 (1.29) 2709 (1.21)
Feeling cold 7 (0.14) 43 (0.47) 464 (1.91) 0 125 (0.50) 3710 (2.30) 4353 (1.94)
Feeling drunk 0 1 (0.01) 17 (0.07) 0 2 (0.01) 82 (0.05) 102 (0.05)
Feeling hot 5 (0.10) 42 (0.46) 201 (0.83) 0 114 (0.46) 1552 (0.96) 1929 (0.86)
Feeling of body temperature change 4 (0.08) 3 (0.03) 118 (0.49) 0 26 (0.10) 655 (0.41) 807 (0.36)
Fibrin D dimer increased 40 (0.82) 74 (0.80) 16 (0.07) 0 308 (1.24) 165 (0.10) 759 (0.34)
Fibromyalgia 0 3 (0.03) 102 (0.42) 0 15 (0.06) 189 (0.12) 312 (0.14)
Flank pain 2 (0.04) 3 (0.03) 19 (0.08) 0 19 (0.08) 59 (0.04) 108 (0.05)
Flatulence 0 5 (0.05) 38 (0.16) 0 10 (0.04) 277 (0.17) 332 (0.15)
Fluid retention 2 (0.04) 5 (0.05) 18 (0.07) 0 10 (0.04) 51 (0.03) 86 (0.04)
Flushing 1 (0.02) 20 (0.22) 67 (0.28) 0 46 (0.19) 450 (0.28) 587 (0.26)
Food aversion 0 1 (0.01) 9 (0.04) 0 3 (0.01) 41 (0.03) 54 (0.02)
Formication 0 1 (0.01) 12 (0.05) 0 6 (0.02) 67 (0.04) 86 (0.04)
Freezing phenomenon 0 2 (0.02) 12 (0.05) 0 5 (0.02) 114 (0.07) 133 (0.06)
Gait disturbance 12 (0.25) 47 (0.51) 251 (1.04) 1 (0.64) 173 (0.70) 329 (0.20) 841 (0.38)
Gait inability 5 (0.10) 17 (0.18) 104 (0.43) 0 44 (0.18) 110 (0.07) 297 (0.13)
Gastritis 2 (0.04) 3 (0.03) 31 (0.13) 0 16 (0.06) 71 (0.04) 124 (0.06)
Gastroenteritis viral 1 (0.02) 0 4 (0.02) 0 3 (0.01) 49 (0.03) 58 (0.03)
Gastrointestinal disorder 0 1 (0.01) 30 (0.12) 0 8 (0.03) 44 (0.03) 85 (0.04)
Gastrointestinal haemorrhage 16 (0.33) 11 (0.12) 7 (0.03) 0 12 (0.05) 15 (0.01) 66 (0.03)
Gastrointestinal pain 0 0 54 (0.22) 0 35 (0.14) 232 (0.14) 322 (0.14)
Gastrooesophageal reflux disease 1 (0.02) 1 (0.01) 40 (0.16) 0 10 (0.04) 147 (0.09) 201 (0.09)
General physical health deterioration 24 (0.49) 13 (0.14) 15 (0.06) 0 56 (0.23) 21 (0.01) 139 (0.06)
Generalised tonic-clonic seizure 4 (0.08) 33 (0.36) 11 (0.05) 0 57 (0.23) 55 (0.03) 166 (0.07)
Genital herpes 0 0 9 (0.04) 0 1 (0.00) 52 (0.03) 62 (0.03)
Giant cell arteritis 2 (0.04) 9 (0.10) 9 (0.04) 0 20 (0.08) 42 (0.03) 83 (0.04)
Gingival bleeding 0 14 (0.15) 14 (0.06) 0 23 (0.09) 108 (0.07) 164 (0.07)
Gingival pain 0 1 (0.01) 21 (0.09) 1 (0.64) 2 (0.01) 143 (0.09) 168 (0.07)
Glossodynia 0 2 (0.02) 23 (0.09) 0 3 (0.01) 137 (0.09) 165 (0.07)
Gout 1 (0.02) 2 (0.02) 26 (0.11) 0 7 (0.03) 117 (0.07) 153 (0.07)
Groin pain 2 (0.04) 8 (0.09) 43 (0.18) 0 18 (0.07) 138 (0.09) 211 (0.09)
Guillain-Barre syndrome 22 (0.45) 205 (2.23) 212 (0.87) 3 (1.91) 661 (2.67) 236 (0.15) 1375 (0.61)
Haematemesis 15 (0.31) 17 (0.18) 8 (0.03) 0 43 (0.17) 74 (0.05) 164 (0.07)
Haematochezia 3 (0.06) 7 (0.08) 9 (0.04) 0 33 (0.13) 93 (0.06) 147 (0.07)
Haematoma 6 (0.12) 42 (0.46) 41 (0.17) 1 (0.64) 103 (0.42) 192 (0.12) 396 (0.18)
Haematuria 2 (0.04) 9 (0.10) 7 (0.03) 0 26 (0.10) 63 (0.04) 114 (0.05)
Haemoglobin decreased 5 (0.10) 9 (0.10) 6 (0.02) 0 13 (0.05) 16 (0.01) 56 (0.02)
Haemoptysis 14 (0.29) 35 (0.38) 9 (0.04) 0 50 (0.20) 80 (0.05) 196 (0.09)
Haemorrhage 27 (0.55) 102 (1.11) 83 (0.34) 6 (3.82) 110 (0.44) 758 (0.47) 1103 (0.49)
Haemorrhage intracranial 48 (0.98) 29 (0.31) 6 (0.02) 0 13 (0.05) 14 (0.01) 120 (0.05)
Haemorrhage urinary tract 1 (0.02) 10 (0.11) 4 (0.02) 0 8 (0.03) 34 (0.02) 58 (0.03)
Haemorrhagic stroke 35 (0.72) 34 (0.37) 6 (0.02) 0 25 (0.10) 15 (0.01) 119 (0.05)
Haemorrhoids 1 (0.02) 1 (0.01) 8 (0.03) 0 2 (0.01) 47 (0.03) 60 (0.03)
Hallucination 1 (0.02) 19 (0.21) 145 (0.60) 0 39 (0.16) 653 (0.41) 864 (0.39)
Hallucination, visual 0 4 (0.04) 8 (0.03) 0 5 (0.02) 44 (0.03) 62 (0.03)
Hangover 0 0 23 (0.09) 0 2 (0.01) 121 (0.08) 148 (0.07)
Head discomfort 2 (0.04) 22 (0.24) 174 (0.72) 0 75 (0.30) 499 (0.31) 782 (0.35)
Head injury 3 (0.06) 17 (0.18) 11 (0.05) 0 14 (0.06) 22 (0.01) 71 (0.03)
Headache 292 (5.99) 1055 (11.45) 9443 (38.95) 17 (10.83) 3970 (16.02) 56135 (34.87) 71181 (31.74)
Heart rate 0 19 (0.21) 79 (0.33) 0 66 (0.27) 746 (0.46) 910 (0.41)
Heart rate abnormal 1 (0.02) 2 (0.02) 10 (0.04) 0 13 (0.05) 47 (0.03) 76 (0.03)
Heart rate decreased 2 (0.04) 14 (0.15) 16 (0.07) 0 29 (0.12) 81 (0.05) 142 (0.06)
Heart rate increased 3 (0.06) 77 (0.84) 245 (1.01) 3 (1.91) 186 (0.75) 1523 (0.95) 2054 (0.92)
Heart rate irregular 1 (0.02) 17 (0.18) 45 (0.19) 1 (0.64) 36 (0.15) 159 (0.10) 259 (0.12)
Heavy menstrual bleeding 0 23 (0.25) 256 (1.06) 2 (1.27) 102 (0.41) 2562 (1.59) 2950 (1.32)
Hemiparaesthesia 1 (0.02) 2 (0.02) 4 (0.02) 0 17 (0.07) 32 (0.02) 59 (0.03)
Hemiparesis 34 (0.70) 68 (0.74) 46 (0.19) 0 111 (0.45) 120 (0.07) 422 (0.19)
Hemiplegia 8 (0.16) 33 (0.36) 23 (0.09) 0 40 (0.16) 58 (0.04) 187 (0.08)
Hemiplegic migraine 0 3 (0.03) 21 (0.09) 0 8 (0.03) 22 (0.01) 55 (0.02)
Heparin-induced thrombocytopenia test positive 7 (0.14) 8 (0.09) 0 0 29 (0.12) 2 (0.00) 51 (0.02)
Hepatic pain 0 3 (0.03) 22 (0.09) 0 3 (0.01) 50 (0.03) 78 (0.03)
Hepatitis 1 (0.02) 6 (0.07) 2 (0.01) 0 21 (0.08) 28 (0.02) 59 (0.03)
Herpes zoster 0 17 (0.18) 161 (0.66) 0 115 (0.46) 1246 (0.77) 1539 (0.69)
Hospitalisation 2 (0.04) 3 (0.03) 4 (0.02) 0 61 (0.25) 0 76 (0.03)
Hot flush 2 (0.04) 12 (0.13) 188 (0.78) 0 55 (0.22) 1392 (0.86) 1654 (0.74)
Hunger 0 2 (0.02) 3 (0.01) 0 1 (0.00) 46 (0.03) 52 (0.02)
Hyperacusis 0 8 (0.09) 56 (0.23) 0 23 (0.09) 86 (0.05) 173 (0.08)
Hyperaesthesia 0 4 (0.04) 34 (0.14) 1 (0.64) 25 (0.10) 185 (0.11) 250 (0.11)
Hyperglycaemia 5 (0.10) 16 (0.17) 15 (0.06) 0 26 (0.10) 95 (0.06) 161 (0.07)
Hyperhidrosis 22 (0.45) 87 (0.94) 1028 (4.24) 1 (0.64) 300 (1.21) 6605 (4.10) 8071 (3.60)
Hyperpyrexia 5 (0.10) 13 (0.14) 16 (0.07) 0 43 (0.17) 738 (0.46) 816 (0.36)
Hypersensitivity 10 (0.21) 98 (1.06) 187 (0.77) 0 242 (0.98) 969 (0.60) 1521 (0.68)
Hypersomnia 1 (0.02) 7 (0.08) 33 (0.14) 0 14 (0.06) 148 (0.09) 206 (0.09)
Hypertension 51 (1.05) 168 (1.82) 187 (0.77) 1 (0.64) 449 (1.81) 876 (0.54) 1779 (0.79)
Hypertensive crisis 4 (0.08) 13 (0.14) 2 (0.01) 0 66 (0.27) 110 (0.07) 201 (0.09)
Hyperthyroidism 0 11 (0.12) 13 (0.05) 1 (0.64) 12 (0.05) 49 (0.03) 87 (0.04)
Hyperventilation 1 (0.02) 4 (0.04) 13 (0.05) 0 26 (0.10) 72 (0.04) 118 (0.05)
Hypoacusis 1 (0.02) 6 (0.07) 77 (0.32) 0 21 (0.08) 170 (0.11) 277 (0.12)
Hypoaesthesia 20 (0.41) 163 (1.77) 851 (3.51) 1 (0.64) 582 (2.35) 3369 (2.09) 5033 (2.24)
Hypoaesthesia oral 1 (0.02) 17 (0.18) 50 (0.21) 0 56 (0.23) 349 (0.22) 479 (0.21)
Hypoglycaemia 7 (0.14) 9 (0.10) 8 (0.03) 0 20 (0.08) 67 (0.04) 114 (0.05)
Hypokinesia 2 (0.04) 6 (0.07) 38 (0.16) 0 28 (0.11) 54 (0.03) 144 (0.06)
Hypomenorrhoea 0 0 23 (0.09) 0 2 (0.01) 144 (0.09) 169 (0.08)
Hypopnoea 3 (0.06) 15 (0.16) 30 (0.12) 0 9 (0.04) 148 (0.09) 208 (0.09)
Hypotension 48 (0.98) 78 (0.85) 100 (0.41) 0 164 (0.66) 415 (0.26) 839 (0.37)
Hypothermia 8 (0.16) 8 (0.09) 10 (0.04) 0 6 (0.02) 71 (0.04) 107 (0.05)
Hypothyroidism 1 (0.02) 4 (0.04) 11 (0.05) 0 6 (0.02) 45 (0.03) 69 (0.03)
Hypotonia 2 (0.04) 10 (0.11) 13 (0.05) 0 89 (0.36) 32 (0.02) 150 (0.07)
Hypovolaemic shock 4 (0.08) 3 (0.03) 0 0 3 (0.01) 62 (0.04) 75 (0.03)
Hypoxia 17 (0.35) 32 (0.35) 6 (0.02) 0 47 (0.19) 26 (0.02) 144 (0.06)
Illness 12 (0.25) 56 (0.61) 467 (1.93) 1 (0.64) 166 (0.67) 3424 (2.13) 4132 (1.84)
Immobile 2 (0.04) 6 (0.07) 20 (0.08) 0 11 (0.04) 26 (0.02) 67 (0.03)
Immune system disorder 2 (0.04) 3 (0.03) 15 (0.06) 0 9 (0.04) 26 (0.02) 57 (0.03)
Immune thrombocytopenia 38 (0.78) 143 (1.55) 13 (0.05) 0 309 (1.25) 149 (0.09) 693 (0.31)
Immunisation 4 (0.08) 6 (0.07) 20 (0.08) 0 9 (0.04) 137 (0.09) 176 (0.08)
Impaired work ability 0 7 (0.08) 119 (0.49) 0 25 (0.10) 141 (0.09) 305 (0.14)
Incontinence 3 (0.06) 11 (0.12) 24 (0.10) 0 15 (0.06) 40 (0.02) 97 (0.04)
Increased tendency to bruise 0 5 (0.05) 29 (0.12) 0 10 (0.04) 65 (0.04) 111 (0.05)
Infarction 22 (0.45) 17 (0.18) 2 (0.01) 0 29 (0.12) 9 (0.01) 81 (0.04)
Infection 8 (0.16) 23 (0.25) 52 (0.21) 0 59 (0.24) 292 (0.18) 444 (0.20)
Infectious mononucleosis 0 0 19 (0.08) 0 4 (0.02) 34 (0.02) 57 (0.03)
Inflammation 6 (0.12) 34 (0.37) 160 (0.66) 1 (0.64) 77 (0.31) 477 (0.30) 764 (0.34)
Influenza 5 (0.10) 28 (0.30) 565 (2.33) 0 326 (1.32) 4794 (2.98) 5721 (2.55)
Influenza like illness 24 (0.49) 60 (0.65) 1012 (4.17) 0 501 (2.02) 8167 (5.07) 9785 (4.36)
Initial insomnia 0 1 (0.01) 5 (0.02) 0 0 49 (0.03) 55 (0.02)
Injected limb mobility decreased 1 (0.02) 1 (0.01) 54 (0.22) 0 2 (0.01) 71 (0.04) 129 (0.06)
Injection related reaction 0 1 (0.01) 36 (0.15) 0 5 (0.02) 448 (0.28) 491 (0.22)
Injection site bruising 0 1 (0.01) 11 (0.05) 0 1 (0.00) 80 (0.05) 94 (0.04)
Injection site erythema 0 7 (0.08) 62 (0.26) 0 44 (0.18) 353 (0.22) 469 (0.21)
Injection site mass 0 2 (0.02) 54 (0.22) 0 8 (0.03) 779 (0.48) 844 (0.38)
Injection site pain 9 (0.18) 30 (0.33) 550 (2.27) 0 232 (0.94) 3169 (1.97) 4001 (1.78)
Injection site pruritus 0 1 (0.01) 20 (0.08) 0 3 (0.01) 170 (0.11) 195 (0.09)
Injection site rash 0 0 10 (0.04) 1 (0.64) 2 (0.01) 151 (0.09) 165 (0.07)
Injection site reaction 3 (0.06) 5 (0.05) 1273 (5.25) 0 38 (0.15) 102 (0.06) 1426 (0.64)
Injection site swelling 1 (0.02) 8 (0.09) 65 (0.27) 0 43 (0.17) 180 (0.11) 300 (0.13)
Injection site warmth 0 2 (0.02) 39 (0.16) 0 6 (0.02) 210 (0.13) 258 (0.12)
Insomnia 6 (0.12) 43 (0.47) 482 (1.99) 0 92 (0.37) 2143 (1.33) 2776 (1.24)
Interchange of vaccine products 7 (0.14) 9 (0.10) 21 (0.09) 0 13 (0.05) 134 (0.08) 189 (0.08)
Intermenstrual bleeding 0 3 (0.03) 19 (0.08) 0 19 (0.08) 338 (0.21) 380 (0.17)
International normalised ratio increased 2 (0.04) 10 (0.11) 6 (0.02) 0 5 (0.02) 46 (0.03) 71 (0.03)
Interstitial lung disease 8 (0.16) 9 (0.10) 7 (0.03) 0 12 (0.05) 20 (0.01) 57 (0.03)
Intestinal ischaemia 21 (0.43) 28 (0.30) 3 (0.01) 0 14 (0.06) 10 (0.01) 77 (0.03)
Intracranial pressure increased 19 (0.39) 12 (0.13) 7 (0.03) 0 14 (0.06) 15 (0.01) 75 (0.03)
Irritability 4 (0.08) 10 (0.11) 29 (0.12) 0 24 (0.10) 216 (0.13) 286 (0.13)
Irritable bowel syndrome 0 3 (0.03) 20 (0.08) 0 11 (0.04) 95 (0.06) 130 (0.06)
Ischaemia 5 (0.10) 15 (0.16) 9 (0.04) 0 20 (0.08) 6 (0.00) 56 (0.02)
Ischaemic cerebral infarction 4 (0.08) 24 (0.26) 4 (0.02) 0 16 (0.06) 4 (0.00) 53 (0.02)
Ischaemic stroke 43 (0.88) 161 (1.75) 71 (0.29) 0 295 (1.19) 77 (0.05) 659 (0.29)
Jaundice 7 (0.14) 7 (0.08) 1 (0.00) 1 (0.64) 27 (0.11) 29 (0.02) 74 (0.03)
Joint lock 1 (0.02) 1 (0.01) 11 (0.05) 0 4 (0.02) 43 (0.03) 60 (0.03)
Joint stiffness 0 3 (0.03) 87 (0.36) 0 16 (0.06) 288 (0.18) 394 (0.18)
Joint swelling 4 (0.08) 22 (0.24) 186 (0.77) 0 68 (0.27) 635 (0.39) 922 (0.41)
Jugular vein thrombosis 7 (0.14) 24 (0.26) 2 (0.01) 0 30 (0.12) 20 (0.01) 87 (0.04)
Kidney infection 1 (0.02) 6 (0.07) 12 (0.05) 0 11 (0.04) 41 (0.03) 72 (0.03)
Labyrinthitis 1 (0.02) 2 (0.02) 27 (0.11) 0 20 (0.08) 117 (0.07) 168 (0.07)
Lacrimation increased 0 3 (0.03) 35 (0.14) 0 21 (0.08) 173 (0.11) 232 (0.10)
Laryngeal oedema 1 (0.02) 24 (0.26) 0 0 22 (0.09) 46 (0.03) 95 (0.04)
Lethargy 31 (0.64) 61 (0.66) 415 (1.71) 0 121 (0.49) 3200 (1.99) 3855 (1.72)
Limb discomfort 2 (0.04) 33 (0.36) 234 (0.97) 0 431 (1.74) 1393 (0.87) 2105 (0.94)
Limb injury 2 (0.04) 3 (0.03) 92 (0.38) 0 5 (0.02) 199 (0.12) 302 (0.13)
Lip dry 0 2 (0.02) 4 (0.02) 0 2 (0.01) 48 (0.03) 56 (0.02)
Lip oedema 2 (0.04) 9 (0.10) 4 (0.02) 0 12 (0.05) 39 (0.02) 68 (0.03)
Lip swelling 2 (0.04) 44 (0.48) 44 (0.18) 0 65 (0.26) 535 (0.33) 691 (0.31)
Listless 4 (0.08) 0 16 (0.07) 0 2 (0.01) 84 (0.05) 106 (0.05)
Livedo reticularis 1 (0.02) 4 (0.04) 5 (0.02) 0 10 (0.04) 46 (0.03) 70 (0.03)
Liver function test abnormal 2 (0.04) 6 (0.07) 8 (0.03) 0 16 (0.06) 21 (0.01) 62 (0.03)
Local reaction 4 (0.08) 1 (0.01) 11 (0.05) 0 30 (0.12) 31 (0.02) 78 (0.03)
Localised infection 0 1 (0.01) 5 (0.02) 0 11 (0.04) 73 (0.05) 91 (0.04)
Loss of consciousness 84 (1.72) 173 (1.88) 117 (0.48) 0 352 (1.42) 954 (0.59) 1721 (0.77)
Loss of control of legs 0 4 (0.04) 10 (0.04) 0 10 (0.04) 36 (0.02) 61 (0.03)
Loss of personal independence in daily activities 0 6 (0.07) 75 (0.31) 0 7 (0.03) 44 (0.03) 138 (0.06)
Lower respiratory tract infection 19 (0.39) 25 (0.27) 45 (0.19) 0 36 (0.15) 161 (0.10) 294 (0.13)
Lung disorder 3 (0.06) 7 (0.08) 7 (0.03) 0 23 (0.09) 8 (0.00) 55 (0.02)
Lymph node pain 1 (0.02) 2 (0.02) 50 (0.21) 0 14 (0.06) 384 (0.24) 451 (0.20)
Lymphadenopathy 3 (0.06) 42 (0.46) 459 (1.89) 3 (1.91) 150 (0.61) 3098 (1.92) 3768 (1.68)
Lymphoedema 0 4 (0.04) 11 (0.05) 0 2 (0.01) 49 (0.03) 67 (0.03)
Malaise 179 (3.67) 326 (3.54) 2801 (11.55) 2 (1.27) 912 (3.68) 8671 (5.39) 12987 (5.79)
Mass 0 2 (0.02) 7 (0.03) 0 4 (0.02) 38 (0.02) 54 (0.02)
Maternal exposure during breast feeding 1 (0.02) 12 (0.13) 62 (0.26) 7 (4.46) 12 (0.05) 799 (0.50) 896 (0.40)
Maternal exposure during pregnancy 4 (0.08) 21 (0.23) 31 (0.13) 56 (35.67) 38 (0.15) 184 (0.11) 344 (0.15)
Memory impairment 3 (0.06) 18 (0.20) 134 (0.55) 0 49 (0.20) 243 (0.15) 460 (0.21)
Meningitis 3 (0.06) 6 (0.07) 3 (0.01) 0 27 (0.11) 23 (0.01) 66 (0.03)
Menstrual disorder 1 (0.02) 7 (0.08) 82 (0.34) 5 (3.18) 22 (0.09) 694 (0.43) 812 (0.36)
Menstruation delayed 0 5 (0.05) 111 (0.46) 1 (0.64) 19 (0.08) 1054 (0.65) 1190 (0.53)
Menstruation irregular 0 5 (0.05) 112 (0.46) 4 (2.55) 22 (0.09) 880 (0.55) 1025 (0.46)
Mental fatigue 0 10 (0.11) 95 (0.39) 0 12 (0.05) 325 (0.20) 443 (0.20)
Mental impairment 2 (0.04) 5 (0.05) 44 (0.18) 0 8 (0.03) 84 (0.05) 146 (0.07)
Mesenteric vein thrombosis 12 (0.25) 32 (0.35) 2 (0.01) 0 41 (0.17) 10 (0.01) 107 (0.05)
Micturition urgency 1 (0.02) 2 (0.02) 13 (0.05) 0 9 (0.04) 52 (0.03) 77 (0.03)
Middle insomnia 0 2 (0.02) 6 (0.02) 0 3 (0.01) 53 (0.03) 65 (0.03)
Migraine 4 (0.08) 87 (0.94) 1189 (4.90) 0 303 (1.22) 5341 (3.32) 6939 (3.09)
Migraine with aura 0 3 (0.03) 73 (0.30) 0 23 (0.09) 258 (0.16) 359 (0.16)
Miliaria 0 1 (0.01) 18 (0.07) 0 3 (0.01) 104 (0.06) 127 (0.06)
Mobility decreased 6 (0.12) 12 (0.13) 111 (0.46) 0 83 (0.33) 84 (0.05) 311 (0.14)
Monoparesis 3 (0.06) 6 (0.07) 31 (0.13) 0 28 (0.11) 103 (0.06) 177 (0.08)
Monoplegia 2 (0.04) 10 (0.11) 52 (0.21) 0 39 (0.16) 151 (0.09) 262 (0.12)
Mood altered 1 (0.02) 2 (0.02) 9 (0.04) 0 5 (0.02) 61 (0.04) 81 (0.04)
Mood swings 1 (0.02) 4 (0.04) 23 (0.09) 0 2 (0.01) 81 (0.05) 111 (0.05)
Motion sickness 0 2 (0.02) 22 (0.09) 0 4 (0.02) 86 (0.05) 115 (0.05)
Motor dysfunction 3 (0.06) 8 (0.09) 17 (0.07) 0 27 (0.11) 18 (0.01) 80 (0.04)
Mouth haemorrhage 1 (0.02) 6 (0.07) 4 (0.02) 0 9 (0.04) 40 (0.02) 64 (0.03)
Mouth swelling 0 13 (0.14) 8 (0.03) 0 10 (0.04) 82 (0.05) 113 (0.05)
Mouth ulceration 0 2 (0.02) 56 (0.23) 0 11 (0.04) 374 (0.23) 444 (0.20)
Movement disorder 0 13 (0.14) 41 (0.17) 0 61 (0.25) 62 (0.04) 184 (0.08)
Multiple organ dysfunction syndrome 57 (1.17) 10 (0.11) 0 0 6 (0.02) 2 (0.00) 82 (0.04)
Multiple sclerosis 1 (0.02) 0 25 (0.10) 1 (0.64) 14 (0.06) 52 (0.03) 95 (0.04)
Multiple sclerosis relapse 0 0 24 (0.10) 0 14 (0.06) 58 (0.04) 97 (0.04)
Muscle contractions involuntary 0 1 (0.01) 16 (0.07) 0 2 (0.01) 39 (0.02) 58 (0.03)
Muscle fatigue 2 (0.04) 8 (0.09) 160 (0.66) 0 16 (0.06) 697 (0.43) 885 (0.39)
Muscle injury 0 2 (0.02) 9 (0.04) 0 2 (0.01) 41 (0.03) 54 (0.02)
Muscle rigidity 1 (0.02) 2 (0.02) 14 (0.06) 0 10 (0.04) 48 (0.03) 75 (0.03)
Muscle spasms 3 (0.06) 64 (0.69) 547 (2.26) 3 (1.91) 180 (0.73) 2211 (1.37) 3021 (1.35)
Muscle tightness 0 6 (0.07) 31 (0.13) 1 (0.64) 19 (0.08) 140 (0.09) 199 (0.09)
Muscle twitching 1 (0.02) 11 (0.12) 96 (0.40) 0 47 (0.19) 287 (0.18) 447 (0.20)
Muscular weakness 22 (0.45) 107 (1.16) 618 (2.55) 1 (0.64) 319 (1.29) 1352 (0.84) 2463 (1.10)
Musculoskeletal chest pain 1 (0.02) 13 (0.14) 66 (0.27) 0 33 (0.13) 280 (0.17) 396 (0.18)
Musculoskeletal discomfort 0 4 (0.04) 17 (0.07) 0 11 (0.04) 89 (0.06) 122 (0.05)
Musculoskeletal pain 2 (0.04) 9 (0.10) 40 (0.16) 0 43 (0.17) 164 (0.10) 260 (0.12)
Musculoskeletal stiffness 6 (0.12) 19 (0.21) 447 (1.84) 0 88 (0.36) 1482 (0.92) 2051 (0.91)
Myalgia 66 (1.35) 246 (2.67) 5136 (21.18) 4 (2.55) 939 (3.79) 19526 (12.13) 25995 (11.59)
Myelitis 0 4 (0.04) 16 (0.07) 0 49 (0.20) 15 (0.01) 87 (0.04)
Myelitis transverse 1 (0.02) 10 (0.11) 64 (0.26) 0 58 (0.23) 40 (0.02) 176 (0.08)
Myocardial infarction 197 (4.04) 352 (3.82) 42 (0.17) 0 235 (0.95) 149 (0.09) 1001 (0.45)
Myocardial ischaemia 30 (0.62) 5 (0.05) 2 (0.01) 0 8 (0.03) 5 (0.00) 57 (0.03)
Myocarditis 17 (0.35) 86 (0.93) 77 (0.32) 0 188 (0.76) 270 (0.17) 663 (0.30)
Myositis 1 (0.02) 8 (0.09) 24 (0.10) 0 10 (0.04) 37 (0.02) 83 (0.04)
Nasal congestion 4 (0.08) 7 (0.08) 61 (0.25) 0 20 (0.08) 305 (0.19) 398 (0.18)
Nasal discomfort 0 0 8 (0.03) 0 3 (0.01) 75 (0.05) 86 (0.04)
Nasopharyngitis 26 (0.53) 12 (0.13) 160 (0.66) 0 162 (0.65) 1110 (0.69) 1478 (0.66)
Nausea 111 (2.28) 319 (3.46) 4602 (18.98) 5 (3.18) 1336 (5.39) 24502 (15.22) 30967 (13.81)
Neck pain 9 (0.18) 54 (0.59) 464 (1.91) 0 191 (0.77) 2044 (1.27) 2774 (1.24)
Nerve injury 0 11 (0.12) 67 (0.28) 0 15 (0.06) 89 (0.06) 184 (0.08)
Nervous system disorder 7 (0.14) 16 (0.17) 59 (0.24) 1 (0.64) 42 (0.17) 58 (0.04) 192 (0.09)
Nervousness 0 7 (0.08) 84 (0.35) 0 20 (0.08) 407 (0.25) 519 (0.23)
Neuralgia 2 (0.04) 17 (0.18) 328 (1.35) 0 109 (0.44) 906 (0.56) 1365 (0.61)
Neurological symptom 6 (0.12) 11 (0.12) 43 (0.18) 0 29 (0.12) 68 (0.04) 160 (0.07)
Neuropathy peripheral 0 9 (0.10) 78 (0.32) 0 33 (0.13) 171 (0.11) 293 (0.13)
Neutropenia 0 9 (0.10) 3 (0.01) 0 17 (0.07) 58 (0.04) 89 (0.04)
Night sweats 2 (0.04) 15 (0.16) 159 (0.66) 0 42 (0.17) 1294 (0.80) 1516 (0.68)
Nightmare 1 (0.02) 6 (0.07) 46 (0.19) 0 5 (0.02) 295 (0.18) 353 (0.16)
Ocular discomfort 2 (0.04) 2 (0.02) 19 (0.08) 1 (0.64) 20 (0.08) 58 (0.04) 103 (0.05)
Ocular hyperaemia 1 (0.02) 7 (0.08) 34 (0.14) 0 24 (0.10) 231 (0.14) 300 (0.13)
Odynophagia 4 (0.08) 2 (0.02) 1 (0.00) 1 (0.64) 7 (0.03) 42 (0.03) 59 (0.03)
Oedema 11 (0.23) 33 (0.36) 19 (0.08) 0 75 (0.30) 67 (0.04) 214 (0.10)
Oedema peripheral 15 (0.31) 63 (0.68) 63 (0.26) 0 102 (0.41) 208 (0.13) 465 (0.21)
Off label use 8 (0.16) 12 (0.13) 22 (0.09) 0 18 (0.07) 127 (0.08) 193 (0.09)
Oligomenorrhoea 0 0 14 (0.06) 0 2 (0.01) 48 (0.03) 64 (0.03)
Ophthalmic herpes zoster 0 1 (0.01) 5 (0.02) 0 11 (0.04) 45 (0.03) 62 (0.03)
Ophthalmic vein thrombosis 1 (0.02) 7 (0.08) 9 (0.04) 0 18 (0.07) 26 (0.02) 64 (0.03)
Optic neuritis 0 4 (0.04) 45 (0.19) 0 44 (0.18) 39 (0.02) 136 (0.06)
Oral candidiasis 3 (0.06) 0 4 (0.02) 0 5 (0.02) 39 (0.02) 52 (0.02)
Oral discomfort 0 3 (0.03) 9 (0.04) 0 5 (0.02) 81 (0.05) 98 (0.04)
Oral herpes 1 (0.02) 4 (0.04) 45 (0.19) 0 14 (0.06) 399 (0.25) 464 (0.21)
Oral pain 1 (0.02) 1 (0.01) 26 (0.11) 1 (0.64) 8 (0.03) 207 (0.13) 248 (0.11)
Oropharyngeal pain 22 (0.45) 44 (0.48) 389 (1.60) 2 (1.27) 175 (0.71) 2831 (1.76) 3468 (1.55)
Orthostatic hypotension 1 (0.02) 4 (0.04) 17 (0.07) 0 9 (0.04) 24 (0.01) 55 (0.02)
Osteoarthritis 0 2 (0.02) 36 (0.15) 0 6 (0.02) 56 (0.03) 103 (0.05)
Oxygen saturation 13 (0.27) 1 (0.01) 1 (0.00) 0 30 (0.12) 17 (0.01) 62 (0.03)
Oxygen saturation decreased 52 (1.07) 30 (0.33) 26 (0.11) 0 164 (0.66) 109 (0.07) 401 (0.18)
Pain 62 (1.27) 228 (2.48) 2156 (8.89) 4 (2.55) 677 (2.73) 11448 (7.11) 14648 (6.53)
Pain in extremity 61 (1.25) 317 (3.44) 2414 (9.96) 4 (2.55) 852 (3.44) 13752 (8.54) 17485 (7.80)
Pain in jaw 1 (0.02) 16 (0.17) 94 (0.39) 0 31 (0.13) 400 (0.25) 545 (0.24)
Pain of skin 0 3 (0.03) 121 (0.50) 0 21 (0.08) 640 (0.40) 786 (0.35)
Pallor 16 (0.33) 35 (0.38) 61 (0.25) 0 40 (0.16) 243 (0.15) 409 (0.18)
Palpitations 8 (0.16) 216 (2.35) 816 (3.37) 1 (0.64) 573 (2.31) 3658 (2.27) 5305 (2.37)
Pancreatitis 7 (0.14) 11 (0.12) 3 (0.01) 0 36 (0.15) 35 (0.02) 93 (0.04)
Pancreatitis acute 3 (0.06) 9 (0.10) 2 (0.01) 0 23 (0.09) 13 (0.01) 51 (0.02)
Panic attack 1 (0.02) 11 (0.12) 51 (0.21) 0 34 (0.14) 223 (0.14) 322 (0.14)
Papule 0 0 8 (0.03) 1 (0.64) 3 (0.01) 61 (0.04) 73 (0.03)
Paraesthesia 17 (0.35) 258 (2.80) 1057 (4.36) 3 (1.91) 914 (3.69) 5426 (3.37) 7739 (3.45)
Paraesthesia oral 0 19 (0.21) 58 (0.24) 0 67 (0.27) 462 (0.29) 608 (0.27)
Paralysis 12 (0.25) 42 (0.46) 96 (0.40) 0 111 (0.45) 197 (0.12) 490 (0.22)
Paranasal sinus discomfort 0 1 (0.01) 8 (0.03) 0 3 (0.01) 50 (0.03) 62 (0.03)
Paresis 2 (0.04) 9 (0.10) 16 (0.07) 0 37 (0.15) 21 (0.01) 87 (0.04)
Parosmia 0 2 (0.02) 38 (0.16) 0 11 (0.04) 202 (0.13) 254 (0.11)
Partial seizures 5 (0.10) 9 (0.10) 5 (0.02) 0 18 (0.07) 34 (0.02) 74 (0.03)
Pelvic pain 0 4 (0.04) 37 (0.15) 0 17 (0.07) 123 (0.08) 182 (0.08)
Pelvic venous thrombosis 2 (0.04) 14 (0.15) 3 (0.01) 0 19 (0.08) 16 (0.01) 61 (0.03)
Periarthritis 0 3 (0.03) 153 (0.63) 0 5 (0.02) 314 (0.20) 475 (0.21)
Pericardial effusion 4 (0.08) 19 (0.21) 8 (0.03) 0 50 (0.20) 39 (0.02) 134 (0.06)
Pericarditis 2 (0.04) 40 (0.43) 39 (0.16) 0 225 (0.91) 182 (0.11) 499 (0.22)
Periorbital swelling 0 2 (0.02) 16 (0.07) 0 8 (0.03) 76 (0.05) 103 (0.05)
Peripheral artery thrombosis 9 (0.18) 37 (0.40) 6 (0.02) 0 51 (0.21) 41 (0.03) 150 (0.07)
Peripheral coldness 4 (0.08) 24 (0.26) 163 (0.67) 0 43 (0.17) 850 (0.53) 1092 (0.49)
Peripheral ischaemia 11 (0.23) 12 (0.13) 6 (0.02) 0 32 (0.13) 14 (0.01) 79 (0.04)
Peripheral swelling 24 (0.49) 162 (1.76) 615 (2.54) 2 (1.27) 256 (1.03) 3361 (2.09) 4461 (1.99)
Petechiae 11 (0.23) 54 (0.59) 33 (0.14) 0 188 (0.76) 254 (0.16) 562 (0.25)
Petit mal epilepsy 0 6 (0.07) 8 (0.03) 0 6 (0.02) 34 (0.02) 55 (0.02)
Pharyngeal swelling 2 (0.04) 39 (0.42) 38 (0.16) 0 46 (0.19) 170 (0.11) 300 (0.13)
Phlebitis 0 10 (0.11) 10 (0.04) 0 31 (0.13) 107 (0.07) 158 (0.07)
Photophobia 6 (0.12) 26 (0.28) 216 (0.89) 0 85 (0.34) 687 (0.43) 1026 (0.46)
Photopsia 1 (0.02) 11 (0.12) 36 (0.15) 0 20 (0.08) 223 (0.14) 292 (0.13)
Photosensitivity reaction 0 4 (0.04) 31 (0.13) 0 14 (0.06) 100 (0.06) 150 (0.07)
Piloerection 0 0 8 (0.03) 0 3 (0.01) 71 (0.04) 83 (0.04)
Platelet count decreased 34 (0.70) 78 (0.85) 32 (0.13) 1 (0.64) 138 (0.56) 198 (0.12) 516 (0.23)
Pleural effusion 10 (0.21) 36 (0.39) 6 (0.02) 0 53 (0.21) 19 (0.01) 138 (0.06)
Pleurisy 0 2 (0.02) 8 (0.03) 0 33 (0.13) 20 (0.01) 65 (0.03)
Pleuritic pain 0 19 (0.21) 6 (0.02) 0 17 (0.07) 12 (0.01) 56 (0.02)
Pneumonia 103 (2.11) 102 (1.11) 32 (0.13) 0 229 (0.92) 102 (0.06) 606 (0.27)
Pneumonia aspiration 23 (0.47) 8 (0.09) 3 (0.01) 0 8 (0.03) 5 (0.00) 52 (0.02)
Pneumonitis 8 (0.16) 10 (0.11) 7 (0.03) 0 25 (0.10) 26 (0.02) 78 (0.03)
Pollakiuria 2 (0.04) 11 (0.12) 32 (0.13) 0 20 (0.08) 176 (0.11) 241 (0.11)
Polymenorrhoea 0 1 (0.01) 35 (0.14) 1 (0.64) 9 (0.04) 283 (0.18) 329 (0.15)
Polymyalgia rheumatica 0 4 (0.04) 42 (0.17) 0 15 (0.06) 95 (0.06) 157 (0.07)
Polyneuropathy 2 (0.04) 8 (0.09) 12 (0.05) 0 40 (0.16) 51 (0.03) 118 (0.05)
Poor peripheral circulation 3 (0.06) 1 (0.01) 12 (0.05) 0 2 (0.01) 36 (0.02) 55 (0.02)
Poor quality sleep 0 5 (0.05) 78 (0.32) 0 3 (0.01) 434 (0.27) 521 (0.23)
Portal vein thrombosis 33 (0.68) 69 (0.75) 2 (0.01) 0 102 (0.41) 32 (0.02) 259 (0.12)
Post viral fatigue syndrome 0 0 60 (0.25) 0 4 (0.02) 78 (0.05) 142 (0.06)
Postmenopausal haemorrhage 0 0 6 (0.02) 0 12 (0.05) 221 (0.14) 240 (0.11)
Premenstrual pain 0 0 10 (0.04) 0 0 55 (0.03) 65 (0.03)
Presyncope 6 (0.12) 15 (0.16) 93 (0.38) 0 84 (0.34) 440 (0.27) 647 (0.29)
Productive cough 9 (0.18) 9 (0.10) 29 (0.12) 0 31 (0.13) 120 (0.07) 201 (0.09)
Pruritus 5 (0.10) 116 (1.26) 461 (1.90) 0 236 (0.95) 4014 (2.49) 4853 (2.16)
Psoriasis 0 7 (0.08) 41 (0.17) 0 10 (0.04) 141 (0.09) 201 (0.09)
Psychotic disorder 0 6 (0.07) 7 (0.03) 0 13 (0.05) 27 (0.02) 54 (0.02)
Pulmonary embolism 330 (6.77) 1318 (14.31) 89 (0.37) 0 2088 (8.43) 990 (0.61) 4955 (2.21)
Pulmonary infarction 4 (0.08) 28 (0.30) 1 (0.00) 0 31 (0.13) 13 (0.01) 87 (0.04)
Pulmonary oedema 21 (0.43) 24 (0.26) 2 (0.01) 0 19 (0.08) 23 (0.01) 102 (0.05)
Pulmonary pain 0 18 (0.20) 44 (0.18) 0 22 (0.09) 152 (0.09) 239 (0.11)
Pulmonary thrombosis 22 (0.45) 23 (0.25) 3 (0.01) 0 62 (0.25) 25 (0.02) 143 (0.06)
Purpura 5 (0.10) 13 (0.14) 11 (0.05) 0 62 (0.25) 90 (0.06) 186 (0.08)
Pyrexia 356 (7.30) 824 (8.95) 7464 (30.79) 11 (7.01) 2996 (12.09) 41388 (25.71) 53214 (23.73)
Q fever 0 1 (0.01) 13 (0.05) 0 2 (0.01) 82 (0.05) 99 (0.04)
Rash 15 (0.31) 135 (1.47) 517 (2.13) 3 (1.91) 442 (1.78) 4099 (2.55) 5234 (2.33)
Rash erythematous 2 (0.04) 9 (0.10) 99 (0.41) 0 39 (0.16) 892 (0.55) 1041 (0.46)
Rash macular 1 (0.02) 22 (0.24) 36 (0.15) 0 47 (0.19) 385 (0.24) 491 (0.22)
Rash maculo-papular 0 3 (0.03) 3 (0.01) 0 5 (0.02) 51 (0.03) 65 (0.03)
Rash papular 1 (0.02) 4 (0.04) 19 (0.08) 0 12 (0.05) 243 (0.15) 282 (0.13)
Rash pruritic 1 (0.02) 11 (0.12) 59 (0.24) 0 45 (0.18) 906 (0.56) 1022 (0.46)
Rash vesicular 0 4 (0.04) 7 (0.03) 0 12 (0.05) 49 (0.03) 73 (0.03)
Raynaud's phenomenon 1 (0.02) 0 20 (0.08) 0 7 (0.03) 98 (0.06) 126 (0.06)
Rectal haemorrhage 6 (0.12) 14 (0.15) 11 (0.05) 0 31 (0.13) 100 (0.06) 165 (0.07)
Renal failure 26 (0.53) 30 (0.33) 6 (0.02) 0 28 (0.11) 25 (0.02) 125 (0.06)
Renal pain 2 (0.04) 18 (0.20) 120 (0.49) 0 49 (0.20) 654 (0.41) 844 (0.38)
Respiration abnormal 6 (0.12) 7 (0.08) 9 (0.04) 0 25 (0.10) 60 (0.04) 114 (0.05)
Respiratory arrest 10 (0.21) 16 (0.17) 1 (0.00) 0 11 (0.04) 13 (0.01) 55 (0.02)
Respiratory disorder 11 (0.23) 16 (0.17) 113 (0.47) 0 31 (0.13) 29 (0.02) 204 (0.09)
Respiratory distress 17 (0.35) 27 (0.29) 13 (0.05) 1 (0.64) 143 (0.58) 80 (0.05) 304 (0.14)
Respiratory failure 42 (0.86) 41 (0.45) 0 0 37 (0.15) 16 (0.01) 151 (0.07)
Respiratory rate increased 5 (0.10) 7 (0.08) 6 (0.02) 0 7 (0.03) 65 (0.04) 92 (0.04)
Restless legs syndrome 0 7 (0.08) 48 (0.20) 0 10 (0.04) 258 (0.16) 324 (0.14)
Restlessness 5 (0.10) 6 (0.07) 50 (0.21) 0 32 (0.13) 336 (0.21) 432 (0.19)
Retching 4 (0.08) 6 (0.07) 33 (0.14) 0 24 (0.10) 190 (0.12) 260 (0.12)
Retinal artery occlusion 0 3 (0.03) 30 (0.12) 0 19 (0.08) 31 (0.02) 86 (0.04)
Retinal detachment 0 0 20 (0.08) 0 38 (0.15) 33 (0.02) 92 (0.04)
Retinal migraine 0 0 7 (0.03) 0 2 (0.01) 67 (0.04) 76 (0.03)
Retinal vein occlusion 0 3 (0.03) 63 (0.26) 0 17 (0.07) 156 (0.10) 240 (0.11)
Retinal vein thrombosis 1 (0.02) 0 14 (0.06) 0 6 (0.02) 49 (0.03) 71 (0.03)
Rheumatoid arthritis 1 (0.02) 3 (0.03) 77 (0.32) 0 13 (0.05) 156 (0.10) 253 (0.11)
Rhinitis 11 (0.23) 7 (0.08) 8 (0.03) 0 33 (0.13) 39 (0.02) 101 (0.05)
Rhinorrhoea 7 (0.14) 8 (0.09) 136 (0.56) 0 40 (0.16) 1052 (0.65) 1248 (0.56)
Rotator cuff syndrome 0 1 (0.01) 27 (0.11) 0 3 (0.01) 73 (0.05) 106 (0.05)
SARS-CoV-2 test negative 1 (0.02) 3 (0.03) 13 (0.05) 0 21 (0.08) 12 (0.01) 51 (0.02)
SARS-CoV-2 test positive 17 (0.35) 6 (0.07) 5 (0.02) 0 66 (0.27) 43 (0.03) 145 (0.06)
Salivary hypersecretion 0 6 (0.07) 13 (0.05) 0 12 (0.05) 46 (0.03) 77 (0.03)
Sciatica 0 3 (0.03) 63 (0.26) 0 11 (0.04) 142 (0.09) 219 (0.10)
Seasonal allergy 1 (0.02) 0 11 (0.05) 0 3 (0.01) 69 (0.04) 84 (0.04)
Seizure 63 (1.29) 230 (2.50) 194 (0.80) 1 (0.64) 483 (1.95) 1074 (0.67) 2109 (0.94)
Sensation of foreign body 0 7 (0.08) 8 (0.03) 0 21 (0.08) 44 (0.03) 86 (0.04)
Sensitive skin 0 3 (0.03) 60 (0.25) 0 5 (0.02) 403 (0.25) 473 (0.21)
Sensory disturbance 0 11 (0.12) 55 (0.23) 0 135 (0.54) 107 (0.07) 316 (0.14)
Sensory loss 0 23 (0.25) 70 (0.29) 0 46 (0.19) 98 (0.06) 243 (0.11)
Sepsis 61 (1.25) 43 (0.47) 9 (0.04) 0 47 (0.19) 43 (0.03) 231 (0.10)
Severe acute respiratory syndrome 22 (0.45) 1 (0.01) 0 0 125 (0.50) 29 (0.02) 177 (0.08)
Shock 10 (0.21) 13 (0.14) 5 (0.02) 0 6 (0.02) 41 (0.03) 78 (0.03)
Shoulder injury related to vaccine administration 0 0 47 (0.19) 0 2 (0.01) 60 (0.04) 109 (0.05)
Sinus congestion 0 4 (0.04) 8 (0.03) 0 4 (0.02) 63 (0.04) 79 (0.04)
Sinus headache 0 2 (0.02) 79 (0.33) 0 11 (0.04) 658 (0.41) 751 (0.33)
Sinus pain 0 6 (0.07) 70 (0.29) 0 5 (0.02) 439 (0.27) 521 (0.23)
Sinus tachycardia 4 (0.08) 9 (0.10) 8 (0.03) 0 36 (0.15) 45 (0.03) 104 (0.05)
Sinusitis 1 (0.02) 6 (0.07) 48 (0.20) 0 15 (0.06) 263 (0.16) 334 (0.15)
Skin burning sensation 0 10 (0.11) 81 (0.33) 0 33 (0.13) 365 (0.23) 490 (0.22)
Skin discolouration 7 (0.14) 16 (0.17) 24 (0.10) 0 26 (0.10) 121 (0.08) 198 (0.09)
Skin disorder 2 (0.04) 5 (0.05) 124 (0.51) 0 20 (0.08) 37 (0.02) 188 (0.08)
Skin erosion 0 0 5 (0.02) 0 3 (0.01) 42 (0.03) 51 (0.02)
Skin exfoliation 0 7 (0.08) 23 (0.09) 0 11 (0.04) 88 (0.05) 131 (0.06)
Skin haemorrhage 2 (0.04) 3 (0.03) 9 (0.04) 0 17 (0.07) 31 (0.02) 64 (0.03)
Skin irritation 0 0 9 (0.04) 0 8 (0.03) 74 (0.05) 91 (0.04)
Skin lesion 1 (0.02) 7 (0.08) 5 (0.02) 0 9 (0.04) 32 (0.02) 55 (0.02)
Skin reaction 0 5 (0.05) 20 (0.08) 0 13 (0.05) 128 (0.08) 166 (0.07)
Skin sensitisation 0 0 16 (0.07) 0 0 69 (0.04) 85 (0.04)
Skin swelling 0 0 5 (0.02) 0 6 (0.02) 46 (0.03) 58 (0.03)
Skin temperature 0 0 10 (0.04) 0 0 135 (0.08) 145 (0.06)
Skin warm 0 4 (0.04) 30 (0.12) 0 9 (0.04) 304 (0.19) 347 (0.15)
Sleep disorder 3 (0.06) 10 (0.11) 109 (0.45) 0 22 (0.09) 309 (0.19) 457 (0.20)
Sneezing 1 (0.02) 7 (0.08) 32 (0.13) 0 10 (0.04) 314 (0.20) 364 (0.16)
Somnolence 28 (0.57) 93 (1.01) 239 (0.99) 1 (0.64) 219 (0.88) 1412 (0.88) 2020 (0.90)
Speech disorder 11 (0.23) 26 (0.28) 52 (0.21) 0 81 (0.33) 86 (0.05) 279 (0.12)
Spinal pain 1 (0.02) 9 (0.10) 50 (0.21) 0 21 (0.08) 178 (0.11) 265 (0.12)
Splenic infarction 7 (0.14) 9 (0.10) 1 (0.00) 0 23 (0.09) 12 (0.01) 58 (0.03)
Splenic vein thrombosis 9 (0.18) 16 (0.17) 3 (0.01) 0 11 (0.04) 8 (0.00) 53 (0.02)
Stomatitis 0 0 10 (0.04) 0 5 (0.02) 57 (0.04) 72 (0.03)
Stress 0 2 (0.02) 34 (0.14) 0 5 (0.02) 84 (0.05) 126 (0.06)
Subarachnoid haemorrhage 52 (1.07) 71 (0.77) 3 (0.01) 0 49 (0.20) 20 (0.01) 209 (0.09)
Subdural haematoma 7 (0.14) 19 (0.21) 2 (0.01) 0 16 (0.06) 12 (0.01) 62 (0.03)
Sudden death 202 (4.14) 0 0 0 0 0 203 (0.09)
Sudden hearing loss 0 1 (0.01) 43 (0.18) 0 20 (0.08) 103 (0.06) 169 (0.08)
Suicidal ideation 1 (0.02) 17 (0.18) 16 (0.07) 0 5 (0.02) 93 (0.06) 138 (0.06)
Superficial vein thrombosis 1 (0.02) 30 (0.33) 14 (0.06) 0 86 (0.35) 275 (0.17) 416 (0.19)
Superior sagittal sinus thrombosis 16 (0.33) 25 (0.27) 3 (0.01) 0 24 (0.10) 11 (0.01) 85 (0.04)
Supraventricular tachycardia 0 5 (0.05) 9 (0.04) 0 28 (0.11) 23 (0.01) 66 (0.03)
Suspected COVID-19 2 (0.04) 2 (0.02) 5 (0.02) 0 13 (0.05) 38 (0.02) 60 (0.03)
Sweating fever 0 2 (0.02) 77 (0.32) 0 7 (0.03) 536 (0.33) 622 (0.28)
Swelling 3 (0.06) 60 (0.65) 206 (0.85) 1 (0.64) 116 (0.47) 1408 (0.87) 1800 (0.80)
Swelling face 1 (0.02) 36 (0.39) 82 (0.34) 0 117 (0.47) 664 (0.41) 908 (0.40)
Swelling of eyelid 0 3 (0.03) 8 (0.03) 0 13 (0.05) 65 (0.04) 89 (0.04)
Swollen tongue 1 (0.02) 61 (0.66) 43 (0.18) 0 63 (0.25) 343 (0.21) 514 (0.23)
Syncope 53 (1.09) 237 (2.57) 267 (1.10) 3 (1.91) 574 (2.32) 2114 (1.31) 3304 (1.47)
Systemic lupus erythematosus 0 6 (0.07) 8 (0.03) 0 8 (0.03) 31 (0.02) 53 (0.02)
Tachycardia 30 (0.62) 230 (2.50) 297 (1.23) 0 553 (2.23) 1210 (0.75) 2367 (1.06)
Tachypnoea 10 (0.21) 9 (0.10) 10 (0.04) 0 17 (0.07) 22 (0.01) 70 (0.03)
Taste disorder 0 6 (0.07) 61 (0.25) 0 28 (0.11) 308 (0.19) 406 (0.18)
Tearfulness 0 1 (0.01) 18 (0.07) 0 0 70 (0.04) 89 (0.04)
Temperature intolerance 0 0 9 (0.04) 0 2 (0.01) 65 (0.04) 76 (0.03)
Tenderness 4 (0.08) 6 (0.07) 94 (0.39) 0 52 (0.21) 1076 (0.67) 1250 (0.56)
Tendonitis 0 1 (0.01) 41 (0.17) 0 0 65 (0.04) 108 (0.05)
Tension 1 (0.02) 4 (0.04) 5 (0.02) 0 2 (0.01) 40 (0.02) 54 (0.02)
Tension headache 1 (0.02) 10 (0.11) 146 (0.60) 0 56 (0.23) 988 (0.61) 1202 (0.54)
Testicular pain 0 0 8 (0.03) 0 3 (0.01) 61 (0.04) 72 (0.03)
Therapeutic response unexpected 0 0 10 (0.04) 0 3 (0.01) 57 (0.04) 71 (0.03)
Thirst 1 (0.02) 18 (0.20) 121 (0.50) 1 (0.64) 22 (0.09) 900 (0.56) 1065 (0.47)
Throat irritation 1 (0.02) 14 (0.15) 21 (0.09) 0 35 (0.14) 140 (0.09) 212 (0.09)
Throat tightness 0 29 (0.31) 26 (0.11) 0 44 (0.18) 142 (0.09) 242 (0.11)
Thrombocytopenia 262 (5.37) 591 (6.42) 61 (0.25) 0 1038 (4.19) 753 (0.47) 2989 (1.33)
Thrombophlebitis 4 (0.08) 42 (0.46) 28 (0.12) 0 48 (0.19) 248 (0.15) 377 (0.17)
Thrombosis 200 (4.10) 575 (6.24) 201 (0.83) 1 (0.64) 736 (2.97) 1286 (0.80) 3117 (1.39)
Thrombosis in device 2 (0.04) 24 (0.26) 1 (0.00) 0 17 (0.07) 17 (0.01) 62 (0.03)
Thrombosis with thrombocytopenia syndrome 23 (0.47) 17 (0.18) 0 0 38 (0.15) 21 (0.01) 121 (0.05)
Thunderclap headache 1 (0.02) 2 (0.02) 9 (0.04) 0 18 (0.07) 30 (0.02) 60 (0.03)
Tinnitus 1 (0.02) 41 (0.45) 647 (2.67) 1 (0.64) 161 (0.65) 2301 (1.43) 3163 (1.41)
Tongue oedema 2 (0.04) 12 (0.13) 3 (0.01) 0 20 (0.08) 39 (0.02) 79 (0.04)
Tonsillitis 0 2 (0.02) 9 (0.04) 0 6 (0.02) 57 (0.04) 74 (0.03)
Toothache 1 (0.02) 2 (0.02) 36 (0.15) 0 10 (0.04) 224 (0.14) 273 (0.12)
Transient ischaemic attack 7 (0.14) 135 (1.47) 57 (0.24) 0 350 (1.41) 353 (0.22) 910 (0.41)
Tremor 20 (0.41) 123 (1.34) 1080 (4.45) 1 (0.64) 353 (1.42) 7243 (4.50) 8839 (3.94)
Trigeminal neuralgia 0 1 (0.01) 39 (0.16) 0 27 (0.11) 100 (0.06) 168 (0.07)
Troponin increased 4 (0.08) 9 (0.10) 3 (0.01) 0 37 (0.15) 12 (0.01) 93 (0.04)
Unresponsive to stimuli 27 (0.55) 18 (0.20) 7 (0.03) 0 28 (0.11) 63 (0.04) 158 (0.07)
Urinary incontinence 4 (0.08) 10 (0.11) 35 (0.14) 0 32 (0.13) 74 (0.05) 162 (0.07)
Urinary retention 2 (0.04) 14 (0.15) 27 (0.11) 0 32 (0.13) 53 (0.03) 136 (0.06)
Urinary tract infection 11 (0.23) 12 (0.13) 26 (0.11) 0 47 (0.19) 176 (0.11) 287 (0.13)
Urticaria 1 (0.02) 95 (1.03) 149 (0.61) 0 172 (0.69) 1415 (0.88) 1834 (0.82)
Uterine haemorrhage 0 2 (0.02) 3 (0.01) 0 8 (0.03) 43 (0.03) 57 (0.03)
Uveitis 0 0 12 (0.05) 0 7 (0.03) 35 (0.02) 54 (0.02)
Vaccination complication 2 (0.04) 2 (0.02) 17 (0.07) 0 9 (0.04) 83 (0.05) 115 (0.05)
Vaccination failure 100 (2.05) 53 (0.58) 1 (0.00) 0 342 (1.38) 9932 (6.17) 10437 (4.65)
Vaccination site bruising 0 2 (0.02) 15 (0.06) 0 4 (0.02) 76 (0.05) 98 (0.04)
Vaccination site erythema 1 (0.02) 7 (0.08) 78 (0.32) 0 30 (0.12) 400 (0.25) 516 (0.23)
Vaccination site induration 0 0 13 (0.05) 0 2 (0.01) 55 (0.03) 70 (0.03)
Vaccination site inflammation 0 2 (0.02) 8 (0.03) 0 7 (0.03) 59 (0.04) 76 (0.03)
Vaccination site mass 0 2 (0.02) 33 (0.14) 0 7 (0.03) 266 (0.17) 310 (0.14)
Vaccination site movement impairment 0 2 (0.02) 56 (0.23) 0 18 (0.07) 74 (0.05) 150 (0.07)
Vaccination site oedema 0 2 (0.02) 25 (0.10) 0 3 (0.01) 49 (0.03) 79 (0.04)
Vaccination site pain 12 (0.25) 23 (0.25) 404 (1.67) 0 142 (0.57) 1825 (1.13) 2416 (1.08)
Vaccination site pruritus 0 1 (0.01) 24 (0.10) 0 10 (0.04) 89 (0.06) 124 (0.06)
Vaccination site rash 1 (0.02) 0 9 (0.04) 0 4 (0.02) 100 (0.06) 114 (0.05)
Vaccination site reaction 1 (0.02) 2 (0.02) 32 (0.13) 0 19 (0.08) 94 (0.06) 150 (0.07)
Vaccination site swelling 0 4 (0.04) 89 (0.37) 0 32 (0.13) 312 (0.19) 439 (0.20)
Vaccination site warmth 0 1 (0.01) 41 (0.17) 0 5 (0.02) 229 (0.14) 277 (0.12)
Vaginal discharge 0 1 (0.01) 6 (0.02) 0 5 (0.02) 43 (0.03) 55 (0.02)
Vaginal haemorrhage 0 20 (0.22) 51 (0.21) 6 (3.82) 59 (0.24) 673 (0.42) 812 (0.36)
Varicose vein 0 10 (0.11) 12 (0.05) 0 9 (0.04) 97 (0.06) 129 (0.06)
Vascular headache 0 4 (0.04) 21 (0.09) 0 3 (0.01) 50 (0.03) 79 (0.04)
Vascular pain 0 7 (0.08) 15 (0.06) 0 9 (0.04) 106 (0.07) 138 (0.06)
Vasculitis 9 (0.18) 29 (0.31) 18 (0.07) 0 42 (0.17) 103 (0.06) 210 (0.09)
Vasodilatation 0 5 (0.05) 18 (0.07) 1 (0.64) 10 (0.04) 88 (0.05) 123 (0.05)
Venous thrombosis 8 (0.16) 68 (0.74) 19 (0.08) 0 88 (0.36) 118 (0.07) 311 (0.14)
Venous thrombosis limb 5 (0.10) 41 (0.45) 10 (0.04) 0 66 (0.27) 129 (0.08) 253 (0.11)
Vertigo 4 (0.08) 60 (0.65) 509 (2.10) 0 288 (1.16) 1596 (0.99) 2479 (1.11)
Vertigo positional 0 1 (0.01) 27 (0.11) 0 27 (0.11) 98 (0.06) 154 (0.07)
Vestibular neuronitis 0 1 (0.01) 20 (0.08) 0 38 (0.15) 30 (0.02) 89 (0.04)
Viral infection 3 (0.06) 3 (0.03) 23 (0.09) 0 14 (0.06) 40 (0.02) 85 (0.04)
Vision blurred 11 (0.23) 97 (1.05) 530 (2.19) 0 304 (1.23) 1952 (1.21) 2924 (1.30)
Visual acuity reduced 0 3 (0.03) 22 (0.09) 0 11 (0.04) 47 (0.03) 85 (0.04)
Visual field defect 1 (0.02) 5 (0.05) 18 (0.07) 0 21 (0.08) 41 (0.03) 88 (0.04)
Visual impairment 10 (0.21) 48 (0.52) 258 (1.06) 0 225 (0.91) 568 (0.35) 1139 (0.51)
Vitreous detachment 0 0 9 (0.04) 0 3 (0.01) 60 (0.04) 73 (0.03)
Vitreous floaters 1 (0.02) 0 33 (0.14) 0 12 (0.05) 133 (0.08) 179 (0.08)
Vomiting 185 (3.79) 292 (3.17) 1413 (5.83) 0 1045 (4.22) 8310 (5.16) 11336 (5.05)
Vomiting projectile 2 (0.04) 2 (0.02) 33 (0.14) 0 8 (0.03) 96 (0.06) 141 (0.06)
Weight decreased 4 (0.08) 13 (0.14) 75 (0.31) 0 54 (0.22) 150 (0.09) 302 (0.13)
Weight increased 0 3 (0.03) 15 (0.06) 0 7 (0.03) 43 (0.03) 68 (0.03)
Wheezing 4 (0.08) 42 (0.46) 69 (0.28) 0 44 (0.18) 387 (0.24) 556 (0.25)
Withdrawal syndrome 0 1 (0.01) 5 (0.02) 0 2 (0.01) 56 (0.03) 64 (0.03)
Yawning 0 1 (0.01) 7 (0.03) 0 0 45 (0.03) 54 (0.02)