Eudravigilance C-19 - Moderna
Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)
PT |
Décès 4605 (%) |
Mise en jeu du pronostic vital 5112 (%) |
Invalidité ou incapacité 5983 (%) |
Anomalies congénitales 112 (%) |
Hospitalisation 18686 (%) |
Médicalement significatif 36001 (%) |
Cas Graves 70499 (%) |
|---|---|---|---|---|---|---|---|
| Abdominal discomfort | 12 (0.26) | 16 (0.31) | 21 (0.35) | 1 (0.89) | 67 (0.36) | 59 (0.16) | 183 (0.26) |
| Abdominal distension | 7 (0.15) | 13 (0.25) | 7 (0.12) | 0 | 50 (0.27) | 29 (0.08) | 108 (0.15) |
| Abdominal pain | 28 (0.61) | 77 (1.51) | 77 (1.29) | 5 (4.46) | 371 (1.99) | 212 (0.59) | 794 (1.13) |
| Abdominal pain lower | 2 (0.04) | 17 (0.33) | 10 (0.17) | 0 | 54 (0.29) | 18 (0.05) | 103 (0.15) |
| Abdominal pain upper | 27 (0.59) | 48 (0.94) | 59 (0.99) | 0 | 199 (1.06) | 269 (0.75) | 608 (0.86) |
| Abnormal behaviour | 4 (0.09) | 6 (0.12) | 4 (0.07) | 0 | 31 (0.17) | 5 (0.01) | 54 (0.08) |
| Abortion spontaneous | 0 | 8 (0.16) | 14 (0.23) | 34 (30.36) | 29 (0.16) | 310 (0.86) | 399 (0.57) |
| Acute kidney injury | 75 (1.63) | 60 (1.17) | 8 (0.13) | 0 | 234 (1.25) | 27 (0.07) | 442 (0.63) |
| Acute myocardial infarction | 51 (1.11) | 113 (2.21) | 6 (0.10) | 0 | 197 (1.05) | 9 (0.02) | 389 (0.55) |
| Acute respiratory distress syndrome | 27 (0.59) | 13 (0.25) | 1 (0.02) | 0 | 18 (0.10) | 4 (0.01) | 70 (0.10) |
| Acute respiratory failure | 107 (2.32) | 43 (0.84) | 3 (0.05) | 0 | 211 (1.13) | 3 (0.01) | 378 (0.54) |
| Ageusia | 6 (0.13) | 11 (0.22) | 39 (0.65) | 1 (0.89) | 68 (0.36) | 45 (0.12) | 174 (0.25) |
| Agitation | 7 (0.15) | 7 (0.14) | 4 (0.07) | 0 | 23 (0.12) | 13 (0.04) | 59 (0.08) |
| Alopecia | 0 | 4 (0.08) | 24 (0.40) | 1 (0.89) | 13 (0.07) | 36 (0.10) | 79 (0.11) |
| Altered state of consciousness | 19 (0.41) | 11 (0.22) | 6 (0.10) | 0 | 61 (0.33) | 73 (0.20) | 183 (0.26) |
| Amenorrhoea | 0 | 1 (0.02) | 39 (0.65) | 0 | 4 (0.02) | 58 (0.16) | 102 (0.14) |
| Amnesia | 6 (0.13) | 27 (0.53) | 45 (0.75) | 0 | 67 (0.36) | 32 (0.09) | 183 (0.26) |
| Anaemia | 15 (0.33) | 29 (0.57) | 11 (0.18) | 0 | 96 (0.51) | 12 (0.03) | 177 (0.25) |
| Anaphylactic reaction | 2 (0.04) | 209 (4.09) | 9 (0.15) | 0 | 289 (1.55) | 811 (2.25) | 1338 (1.90) |
| Anaphylactic shock | 3 (0.07) | 47 (0.92) | 1 (0.02) | 0 | 46 (0.25) | 54 (0.15) | 155 (0.22) |
| Anaphylactoid reaction | 0 | 1 (0.02) | 0 | 0 | 16 (0.09) | 35 (0.10) | 54 (0.08) |
| Angina pectoris | 4 (0.09) | 13 (0.25) | 17 (0.28) | 0 | 72 (0.39) | 182 (0.51) | 294 (0.42) |
| Angioedema | 0 | 34 (0.67) | 5 (0.08) | 0 | 52 (0.28) | 403 (1.12) | 503 (0.71) |
| Anosmia | 6 (0.13) | 8 (0.16) | 30 (0.50) | 0 | 50 (0.27) | 30 (0.08) | 128 (0.18) |
| Anticoagulant therapy | 1 (0.02) | 29 (0.57) | 0 | 0 | 28 (0.15) | 0 | 59 (0.08) |
| Anxiety | 4 (0.09) | 24 (0.47) | 81 (1.35) | 1 (0.89) | 100 (0.54) | 82 (0.23) | 301 (0.43) |
| Aphasia | 15 (0.33) | 75 (1.47) | 62 (1.04) | 0 | 175 (0.94) | 15 (0.04) | 359 (0.51) |
| Appendicitis | 0 | 51 (1.00) | 1 (0.02) | 0 | 121 (0.65) | 35 (0.10) | 210 (0.30) |
| Arrhythmia | 20 (0.43) | 42 (0.82) | 29 (0.48) | 0 | 149 (0.80) | 347 (0.96) | 597 (0.85) |
| Arthralgia | 21 (0.46) | 108 (2.11) | 941 (15.73) | 1 (0.89) | 403 (2.16) | 1049 (2.91) | 2546 (3.61) |
| Arthritis | 2 (0.04) | 3 (0.06) | 45 (0.75) | 0 | 24 (0.13) | 33 (0.09) | 107 (0.15) |
| Asthenia | 168 (3.65) | 268 (5.24) | 335 (5.60) | 1 (0.89) | 1109 (5.93) | 516 (1.43) | 2511 (3.56) |
| Asthma | 6 (0.13) | 35 (0.68) | 14 (0.23) | 0 | 76 (0.41) | 56 (0.16) | 189 (0.27) |
| Asymptomatic COVID-19 | 4 (0.09) | 0 | 0 | 0 | 62 (0.33) | 5 (0.01) | 71 (0.10) |
| Atelectasis | 11 (0.24) | 13 (0.25) | 2 (0.03) | 0 | 77 (0.41) | 0 | 106 (0.15) |
| Atrial fibrillation | 40 (0.87) | 139 (2.72) | 32 (0.53) | 0 | 390 (2.09) | 479 (1.33) | 1114 (1.58) |
| Atrial flutter | 1 (0.02) | 14 (0.27) | 1 (0.02) | 0 | 33 (0.18) | 12 (0.03) | 66 (0.09) |
| Autoimmune disorder | 2 (0.04) | 5 (0.10) | 17 (0.28) | 0 | 20 (0.11) | 72 (0.20) | 125 (0.18) |
| Axillary pain | 1 (0.02) | 9 (0.18) | 59 (0.99) | 0 | 22 (0.12) | 224 (0.62) | 317 (0.45) |
| Back pain | 29 (0.63) | 75 (1.47) | 167 (2.79) | 4 (3.57) | 234 (1.25) | 324 (0.90) | 856 (1.21) |
| Balance disorder | 9 (0.20) | 30 (0.59) | 95 (1.59) | 0 | 123 (0.66) | 64 (0.18) | 332 (0.47) |
| Bedridden | 5 (0.11) | 8 (0.16) | 7 (0.12) | 0 | 9 (0.05) | 23 (0.06) | 53 (0.08) |
| Bell's palsy | 0 | 6 (0.12) | 107 (1.79) | 1 (0.89) | 93 (0.50) | 1211 (3.36) | 1425 (2.02) |
| Blindness | 3 (0.07) | 13 (0.25) | 59 (0.99) | 0 | 38 (0.20) | 190 (0.53) | 311 (0.44) |
| Blindness transient | 0 | 0 | 3 (0.05) | 0 | 9 (0.05) | 42 (0.12) | 57 (0.08) |
| Blindness unilateral | 1 (0.02) | 7 (0.14) | 60 (1.00) | 0 | 21 (0.11) | 41 (0.11) | 136 (0.19) |
| Blister | 2 (0.04) | 9 (0.18) | 27 (0.45) | 0 | 32 (0.17) | 42 (0.12) | 114 (0.16) |
| Blood glucose increased | 5 (0.11) | 3 (0.06) | 4 (0.07) | 0 | 31 (0.17) | 9 (0.02) | 56 (0.08) |
| Blood pressure decreased | 4 (0.09) | 14 (0.27) | 11 (0.18) | 0 | 49 (0.26) | 34 (0.09) | 115 (0.16) |
| Blood pressure increased | 3 (0.07) | 37 (0.72) | 25 (0.42) | 1 (0.89) | 133 (0.71) | 68 (0.19) | 278 (0.39) |
| Body temperature increased | 8 (0.17) | 6 (0.12) | 7 (0.12) | 0 | 45 (0.24) | 26 (0.07) | 96 (0.14) |
| Bone pain | 2 (0.04) | 11 (0.22) | 29 (0.48) | 0 | 18 (0.10) | 50 (0.14) | 111 (0.16) |
| Bradycardia | 16 (0.35) | 33 (0.65) | 3 (0.05) | 1 (0.89) | 63 (0.34) | 206 (0.57) | 332 (0.47) |
| Brain oedema | 5 (0.11) | 15 (0.29) | 5 (0.08) | 0 | 14 (0.07) | 13 (0.04) | 55 (0.08) |
| Breast pain | 1 (0.02) | 9 (0.18) | 17 (0.28) | 0 | 26 (0.14) | 38 (0.11) | 91 (0.13) |
| Bronchitis | 3 (0.07) | 5 (0.10) | 2 (0.03) | 0 | 33 (0.18) | 16 (0.04) | 60 (0.09) |
| Burning sensation | 2 (0.04) | 27 (0.53) | 84 (1.40) | 2 (1.79) | 40 (0.21) | 75 (0.21) | 235 (0.33) |
| C-reactive protein increased | 1 (0.02) | 4 (0.08) | 1 (0.02) | 0 | 45 (0.24) | 11 (0.03) | 64 (0.09) |
| COVID-19 | 477 (10.36) | 93 (1.82) | 26 (0.43) | 1 (0.89) | 2119 (11.34) | 842 (2.34) | 3632 (5.15) |
| COVID-19 immunisation | 0 | 9 (0.18) | 23 (0.38) | 0 | 38 (0.20) | 23 (0.06) | 93 (0.13) |
| COVID-19 pneumonia | 141 (3.06) | 18 (0.35) | 3 (0.05) | 0 | 396 (2.12) | 48 (0.13) | 628 (0.89) |
| Cardiac arrest | 326 (7.08) | 93 (1.82) | 2 (0.03) | 0 | 30 (0.16) | 10 (0.03) | 481 (0.68) |
| Cardiac disorder | 16 (0.35) | 21 (0.41) | 13 (0.22) | 0 | 45 (0.24) | 10 (0.03) | 114 (0.16) |
| Cardiac failure | 63 (1.37) | 41 (0.80) | 10 (0.17) | 0 | 96 (0.51) | 28 (0.08) | 252 (0.36) |
| Cardiac failure acute | 17 (0.37) | 6 (0.12) | 0 | 0 | 29 (0.16) | 0 | 54 (0.08) |
| Cardiac failure congestive | 35 (0.76) | 40 (0.78) | 10 (0.17) | 0 | 109 (0.58) | 26 (0.07) | 230 (0.33) |
| Cardiac flutter | 1 (0.02) | 11 (0.22) | 7 (0.12) | 0 | 21 (0.11) | 322 (0.89) | 365 (0.52) |
| Cardio-respiratory arrest | 101 (2.19) | 27 (0.53) | 0 | 0 | 9 (0.05) | 8 (0.02) | 154 (0.22) |
| Cardiogenic shock | 29 (0.63) | 15 (0.29) | 0 | 0 | 8 (0.04) | 3 (0.01) | 58 (0.08) |
| Cardiomegaly | 12 (0.26) | 20 (0.39) | 5 (0.08) | 1 (0.89) | 60 (0.32) | 6 (0.02) | 109 (0.15) |
| Cardiomyopathy | 6 (0.13) | 21 (0.41) | 4 (0.07) | 0 | 24 (0.13) | 13 (0.04) | 70 (0.10) |
| Cardiovascular disorder | 9 (0.20) | 4 (0.08) | 8 (0.13) | 0 | 15 (0.08) | 19 (0.05) | 58 (0.08) |
| Cellulitis | 5 (0.11) | 10 (0.20) | 8 (0.13) | 0 | 100 (0.54) | 883 (2.45) | 1021 (1.45) |
| Cerebral haemorrhage | 66 (1.43) | 52 (1.02) | 14 (0.23) | 0 | 62 (0.33) | 16 (0.04) | 220 (0.31) |
| Cerebral infarction | 8 (0.17) | 41 (0.80) | 27 (0.45) | 0 | 102 (0.55) | 12 (0.03) | 194 (0.28) |
| Cerebral thrombosis | 11 (0.24) | 30 (0.59) | 8 (0.13) | 0 | 40 (0.21) | 3 (0.01) | 94 (0.13) |
| Cerebral venous sinus thrombosis | 4 (0.09) | 39 (0.76) | 5 (0.08) | 0 | 41 (0.22) | 4 (0.01) | 93 (0.13) |
| Cerebrovascular accident | 116 (2.52) | 332 (6.49) | 167 (2.79) | 0 | 515 (2.76) | 209 (0.58) | 1383 (1.96) |
| Chest discomfort | 24 (0.52) | 179 (3.50) | 74 (1.24) | 0 | 464 (2.48) | 270 (0.75) | 1034 (1.47) |
| Chest pain | 75 (1.63) | 414 (8.10) | 172 (2.87) | 1 (0.89) | 1441 (7.71) | 589 (1.64) | 2755 (3.91) |
| Chills | 63 (1.37) | 196 (3.83) | 891 (14.89) | 5 (4.46) | 908 (4.86) | 1696 (4.71) | 3814 (5.41) |
| Choking | 4 (0.09) | 5 (0.10) | 1 (0.02) | 0 | 6 (0.03) | 45 (0.12) | 62 (0.09) |
| Chromaturia | 1 (0.02) | 12 (0.23) | 5 (0.08) | 0 | 29 (0.16) | 11 (0.03) | 60 (0.09) |
| Chronic obstructive pulmonary disease | 20 (0.43) | 7 (0.14) | 2 (0.03) | 0 | 67 (0.36) | 6 (0.02) | 107 (0.15) |
| Circulatory collapse | 10 (0.22) | 7 (0.14) | 1 (0.02) | 0 | 18 (0.10) | 55 (0.15) | 99 (0.14) |
| Cognitive disorder | 7 (0.15) | 10 (0.20) | 50 (0.84) | 0 | 24 (0.13) | 15 (0.04) | 109 (0.15) |
| Cold sweat | 10 (0.22) | 21 (0.41) | 23 (0.38) | 0 | 65 (0.35) | 101 (0.28) | 229 (0.32) |
| Colitis | 3 (0.07) | 10 (0.20) | 3 (0.05) | 0 | 37 (0.20) | 8 (0.02) | 62 (0.09) |
| Colitis ulcerative | 0 | 0 | 5 (0.08) | 0 | 15 (0.08) | 49 (0.14) | 71 (0.10) |
| Coma | 11 (0.24) | 17 (0.33) | 1 (0.02) | 0 | 15 (0.08) | 6 (0.02) | 58 (0.08) |
| Condition aggravated | 110 (2.39) | 152 (2.97) | 283 (4.73) | 1 (0.89) | 519 (2.78) | 115 (0.32) | 1219 (1.73) |
| Confusional state | 50 (1.09) | 80 (1.56) | 96 (1.60) | 0 | 364 (1.95) | 106 (0.29) | 742 (1.05) |
| Conjunctival haemorrhage | 0 | 1 (0.02) | 3 (0.05) | 0 | 3 (0.02) | 48 (0.13) | 55 (0.08) |
| Constipation | 2 (0.04) | 7 (0.14) | 17 (0.28) | 0 | 56 (0.30) | 28 (0.08) | 112 (0.16) |
| Contusion | 2 (0.04) | 38 (0.74) | 38 (0.64) | 0 | 84 (0.45) | 98 (0.27) | 268 (0.38) |
| Coordination abnormal | 2 (0.04) | 6 (0.12) | 15 (0.25) | 0 | 21 (0.11) | 8 (0.02) | 53 (0.08) |
| Coronary artery disease | 15 (0.33) | 15 (0.29) | 3 (0.05) | 0 | 32 (0.17) | 1 (0.00) | 70 (0.10) |
| Coronary artery occlusion | 6 (0.13) | 29 (0.57) | 1 (0.02) | 0 | 24 (0.13) | 3 (0.01) | 66 (0.09) |
| Cough | 122 (2.65) | 131 (2.56) | 85 (1.42) | 1 (0.89) | 783 (4.19) | 267 (0.74) | 1435 (2.04) |
| Cyanosis | 27 (0.59) | 12 (0.23) | 11 (0.18) | 0 | 22 (0.12) | 10 (0.03) | 87 (0.12) |
| Deafness | 1 (0.02) | 2 (0.04) | 83 (1.39) | 0 | 11 (0.06) | 310 (0.86) | 412 (0.58) |
| Deafness neurosensory | 0 | 2 (0.04) | 52 (0.87) | 0 | 2 (0.01) | 52 (0.14) | 110 (0.16) |
| Deafness unilateral | 0 | 2 (0.04) | 132 (2.21) | 0 | 12 (0.06) | 201 (0.56) | 353 (0.50) |
| Death | 2282 (49.55) | 1 (0.02) | 0 | 0 | 0 | 0 | 2283 (3.24) |
| Decreased appetite | 86 (1.87) | 63 (1.23) | 105 (1.75) | 1 (0.89) | 312 (1.67) | 213 (0.59) | 820 (1.16) |
| Deep vein thrombosis | 18 (0.39) | 288 (5.63) | 15 (0.25) | 1 (0.89) | 309 (1.65) | 488 (1.36) | 1146 (1.63) |
| Dehydration | 15 (0.33) | 42 (0.82) | 21 (0.35) | 0 | 200 (1.07) | 34 (0.09) | 325 (0.46) |
| Delirium | 9 (0.20) | 18 (0.35) | 11 (0.18) | 0 | 33 (0.18) | 131 (0.36) | 213 (0.30) |
| Dementia | 13 (0.28) | 6 (0.12) | 9 (0.15) | 0 | 14 (0.07) | 29 (0.08) | 81 (0.11) |
| Depressed level of consciousness | 11 (0.24) | 19 (0.37) | 5 (0.08) | 0 | 48 (0.26) | 162 (0.45) | 261 (0.37) |
| Depressed mood | 1 (0.02) | 5 (0.10) | 11 (0.18) | 1 (0.89) | 2 (0.01) | 45 (0.12) | 66 (0.09) |
| Depression | 2 (0.04) | 15 (0.29) | 31 (0.52) | 1 (0.89) | 26 (0.14) | 42 (0.12) | 122 (0.17) |
| Diabetes mellitus | 13 (0.28) | 13 (0.25) | 7 (0.12) | 0 | 21 (0.11) | 30 (0.08) | 87 (0.12) |
| Diabetic ketoacidosis | 3 (0.07) | 21 (0.41) | 3 (0.05) | 0 | 28 (0.15) | 2 (0.01) | 59 (0.08) |
| Diarrhoea | 55 (1.19) | 119 (2.33) | 151 (2.52) | 1 (0.89) | 571 (3.06) | 520 (1.44) | 1457 (2.07) |
| Diarrhoea haemorrhagic | 2 (0.04) | 5 (0.10) | 0 | 0 | 10 (0.05) | 46 (0.13) | 65 (0.09) |
| Diplopia | 0 | 23 (0.45) | 53 (0.89) | 0 | 76 (0.41) | 26 (0.07) | 182 (0.26) |
| Discomfort | 14 (0.30) | 16 (0.31) | 39 (0.65) | 0 | 63 (0.34) | 64 (0.18) | 203 (0.29) |
| Disorientation | 8 (0.17) | 32 (0.63) | 32 (0.53) | 0 | 81 (0.43) | 34 (0.09) | 193 (0.27) |
| Disturbance in attention | 0 | 15 (0.29) | 48 (0.80) | 0 | 51 (0.27) | 84 (0.23) | 200 (0.28) |
| Diverticulitis | 0 | 1 (0.02) | 1 (0.02) | 0 | 35 (0.19) | 36 (0.10) | 74 (0.10) |
| Dizziness | 53 (1.15) | 302 (5.91) | 493 (8.24) | 3 (2.68) | 1114 (5.96) | 1224 (3.40) | 3257 (4.62) |
| Dizziness postural | 0 | 2 (0.04) | 13 (0.22) | 0 | 18 (0.10) | 57 (0.16) | 91 (0.13) |
| Drug ineffective | 12 (0.26) | 4 (0.08) | 2 (0.03) | 0 | 49 (0.26) | 25 (0.07) | 94 (0.13) |
| Dry mouth | 0 | 10 (0.20) | 11 (0.18) | 0 | 28 (0.15) | 46 (0.13) | 95 (0.13) |
| Dysarthria | 7 (0.15) | 56 (1.10) | 47 (0.79) | 0 | 153 (0.82) | 32 (0.09) | 306 (0.43) |
| Dysgeusia | 1 (0.02) | 10 (0.20) | 13 (0.22) | 0 | 14 (0.07) | 73 (0.20) | 112 (0.16) |
| Dyskinesia | 1 (0.02) | 9 (0.18) | 18 (0.30) | 0 | 40 (0.21) | 14 (0.04) | 84 (0.12) |
| Dysmenorrhoea | 0 | 3 (0.06) | 53 (0.89) | 0 | 14 (0.07) | 209 (0.58) | 280 (0.40) |
| Dyspepsia | 6 (0.13) | 14 (0.27) | 18 (0.30) | 0 | 28 (0.15) | 51 (0.14) | 119 (0.17) |
| Dysphagia | 19 (0.41) | 68 (1.33) | 47 (0.79) | 0 | 119 (0.64) | 44 (0.12) | 317 (0.45) |
| Dysphonia | 5 (0.11) | 20 (0.39) | 14 (0.23) | 0 | 40 (0.21) | 17 (0.05) | 100 (0.14) |
| Dyspnoea | 392 (8.51) | 816 (15.96) | 326 (5.45) | 2 (1.79) | 2319 (12.41) | 804 (2.23) | 4865 (6.90) |
| Dyspnoea exertional | 12 (0.26) | 52 (1.02) | 19 (0.32) | 0 | 141 (0.75) | 41 (0.11) | 277 (0.39) |
| Dysstasia | 6 (0.13) | 27 (0.53) | 73 (1.22) | 0 | 86 (0.46) | 16 (0.04) | 216 (0.31) |
| Dysuria | 1 (0.02) | 8 (0.16) | 9 (0.15) | 0 | 26 (0.14) | 14 (0.04) | 59 (0.08) |
| Ear discomfort | 0 | 7 (0.14) | 62 (1.04) | 0 | 15 (0.08) | 16 (0.04) | 101 (0.14) |
| Ear pain | 0 | 9 (0.18) | 60 (1.00) | 1 (0.89) | 33 (0.18) | 85 (0.24) | 188 (0.27) |
| Encephalitis | 2 (0.04) | 16 (0.31) | 4 (0.07) | 0 | 34 (0.18) | 8 (0.02) | 68 (0.10) |
| Encephalopathy | 13 (0.28) | 19 (0.37) | 7 (0.12) | 0 | 74 (0.40) | 9 (0.02) | 129 (0.18) |
| Endotracheal intubation | 17 (0.37) | 20 (0.39) | 1 (0.02) | 0 | 16 (0.09) | 0 | 58 (0.08) |
| Epilepsy | 3 (0.07) | 17 (0.33) | 5 (0.08) | 0 | 62 (0.33) | 74 (0.21) | 163 (0.23) |
| Epistaxis | 12 (0.26) | 33 (0.65) | 11 (0.18) | 1 (0.89) | 54 (0.29) | 67 (0.19) | 184 (0.26) |
| Erectile dysfunction | 0 | 0 | 5 (0.08) | 0 | 1 (0.01) | 49 (0.14) | 55 (0.08) |
| Erysipelas | 0 | 2 (0.04) | 3 (0.05) | 0 | 10 (0.05) | 78 (0.22) | 94 (0.13) |
| Erythema | 9 (0.20) | 65 (1.27) | 80 (1.34) | 2 (1.79) | 217 (1.16) | 340 (0.94) | 724 (1.03) |
| Erythema multiforme | 0 | 1 (0.02) | 1 (0.02) | 0 | 11 (0.06) | 171 (0.47) | 184 (0.26) |
| Exposure during pregnancy | 0 | 8 (0.16) | 4 (0.07) | 15 (13.39) | 65 (0.35) | 27 (0.07) | 122 (0.17) |
| Exposure to SARS-CoV-2 | 9 (0.20) | 1 (0.02) | 2 (0.03) | 0 | 47 (0.25) | 3 (0.01) | 65 (0.09) |
| Extensive swelling of vaccinated limb | 0 | 5 (0.10) | 152 (2.54) | 0 | 6 (0.03) | 31 (0.09) | 194 (0.28) |
| Extrasystoles | 1 (0.02) | 16 (0.31) | 15 (0.25) | 0 | 16 (0.09) | 23 (0.06) | 71 (0.10) |
| Eye haemorrhage | 1 (0.02) | 3 (0.06) | 6 (0.10) | 0 | 5 (0.03) | 92 (0.26) | 114 (0.16) |
| Eye pain | 0 | 8 (0.16) | 75 (1.25) | 0 | 40 (0.21) | 113 (0.31) | 239 (0.34) |
| Eye swelling | 0 | 15 (0.29) | 18 (0.30) | 0 | 15 (0.08) | 29 (0.08) | 79 (0.11) |
| Face oedema | 0 | 6 (0.12) | 2 (0.03) | 0 | 17 (0.09) | 32 (0.09) | 57 (0.08) |
| Facial pain | 0 | 3 (0.06) | 23 (0.38) | 0 | 12 (0.06) | 20 (0.06) | 59 (0.08) |
| Facial paralysis | 1 (0.02) | 38 (0.74) | 95 (1.59) | 1 (0.89) | 207 (1.11) | 755 (2.10) | 1117 (1.58) |
| Facial paresis | 1 (0.02) | 6 (0.12) | 22 (0.37) | 0 | 57 (0.31) | 36 (0.10) | 123 (0.17) |
| Fall | 77 (1.67) | 84 (1.64) | 87 (1.45) | 0 | 453 (2.42) | 63 (0.17) | 813 (1.15) |
| Fatigue | 144 (3.13) | 353 (6.91) | 1456 (24.34) | 9 (8.04) | 1220 (6.53) | 2370 (6.58) | 5656 (8.02) |
| Feeding disorder | 8 (0.17) | 15 (0.29) | 17 (0.28) | 0 | 42 (0.22) | 19 (0.05) | 107 (0.15) |
| Feeling abnormal | 34 (0.74) | 93 (1.82) | 194 (3.24) | 2 (1.79) | 272 (1.46) | 183 (0.51) | 807 (1.14) |
| Feeling cold | 4 (0.09) | 24 (0.47) | 48 (0.80) | 0 | 47 (0.25) | 108 (0.30) | 234 (0.33) |
| Feeling hot | 8 (0.17) | 25 (0.49) | 55 (0.92) | 0 | 125 (0.67) | 149 (0.41) | 366 (0.52) |
| Feeling of body temperature change | 2 (0.04) | 3 (0.06) | 16 (0.27) | 0 | 21 (0.11) | 57 (0.16) | 100 (0.14) |
| Fibrin D dimer increased | 3 (0.07) | 8 (0.16) | 5 (0.08) | 0 | 46 (0.25) | 20 (0.06) | 86 (0.12) |
| Flank pain | 2 (0.04) | 18 (0.35) | 14 (0.23) | 0 | 34 (0.18) | 8 (0.02) | 76 (0.11) |
| Flushing | 2 (0.04) | 30 (0.59) | 12 (0.20) | 0 | 57 (0.31) | 37 (0.10) | 139 (0.20) |
| Foetal death | 3 (0.07) | 2 (0.04) | 1 (0.02) | 6 (5.36) | 15 (0.08) | 24 (0.07) | 53 (0.08) |
| Gait disturbance | 10 (0.22) | 69 (1.35) | 181 (3.03) | 0 | 275 (1.47) | 76 (0.21) | 641 (0.91) |
| Gait inability | 14 (0.30) | 39 (0.76) | 102 (1.70) | 1 (0.89) | 143 (0.77) | 13 (0.04) | 323 (0.46) |
| Gastrointestinal haemorrhage | 17 (0.37) | 20 (0.39) | 1 (0.02) | 0 | 42 (0.22) | 16 (0.04) | 101 (0.14) |
| Gastrooesophageal reflux disease | 2 (0.04) | 9 (0.18) | 5 (0.08) | 0 | 23 (0.12) | 15 (0.04) | 54 (0.08) |
| Gaze palsy | 2 (0.04) | 7 (0.14) | 3 (0.05) | 0 | 11 (0.06) | 66 (0.18) | 92 (0.13) |
| General physical health deterioration | 100 (2.17) | 19 (0.37) | 20 (0.33) | 0 | 60 (0.32) | 15 (0.04) | 240 (0.34) |
| Generalised tonic-clonic seizure | 3 (0.07) | 15 (0.29) | 5 (0.08) | 0 | 42 (0.22) | 101 (0.28) | 169 (0.24) |
| Guillain-Barre syndrome | 4 (0.09) | 52 (1.02) | 63 (1.05) | 0 | 149 (0.80) | 66 (0.18) | 339 (0.48) |
| Haematemesis | 12 (0.26) | 8 (0.16) | 0 | 0 | 12 (0.06) | 43 (0.12) | 78 (0.11) |
| Haematochezia | 3 (0.07) | 4 (0.08) | 5 (0.08) | 0 | 30 (0.16) | 138 (0.38) | 187 (0.27) |
| Haematoma | 5 (0.11) | 13 (0.25) | 11 (0.18) | 0 | 28 (0.15) | 25 (0.07) | 84 (0.12) |
| Haematuria | 3 (0.07) | 8 (0.16) | 2 (0.03) | 0 | 29 (0.16) | 22 (0.06) | 71 (0.10) |
| Haemoptysis | 9 (0.20) | 23 (0.45) | 3 (0.05) | 0 | 31 (0.17) | 3 (0.01) | 75 (0.11) |
| Haemorrhage | 20 (0.43) | 23 (0.45) | 12 (0.20) | 1 (0.89) | 42 (0.22) | 267 (0.74) | 379 (0.54) |
| Haemorrhagic stroke | 21 (0.46) | 11 (0.22) | 2 (0.03) | 0 | 11 (0.06) | 6 (0.02) | 54 (0.08) |
| Hallucination | 5 (0.11) | 6 (0.12) | 15 (0.25) | 0 | 48 (0.26) | 318 (0.88) | 403 (0.57) |
| Hallucination, visual | 0 | 0 | 2 (0.03) | 0 | 5 (0.03) | 43 (0.12) | 52 (0.07) |
| Head discomfort | 1 (0.02) | 7 (0.14) | 36 (0.60) | 0 | 29 (0.16) | 37 (0.10) | 113 (0.16) |
| Head injury | 11 (0.24) | 18 (0.35) | 5 (0.08) | 0 | 69 (0.37) | 21 (0.06) | 130 (0.18) |
| Headache | 74 (1.61) | 375 (7.34) | 1413 (23.62) | 9 (8.04) | 1436 (7.68) | 3221 (8.95) | 6620 (9.39) |
| Heart rate increased | 9 (0.20) | 57 (1.12) | 63 (1.05) | 1 (0.89) | 164 (0.88) | 112 (0.31) | 421 (0.60) |
| Heart rate irregular | 4 (0.09) | 8 (0.16) | 16 (0.27) | 0 | 30 (0.16) | 23 (0.06) | 84 (0.12) |
| Heavy menstrual bleeding | 0 | 11 (0.22) | 68 (1.14) | 0 | 38 (0.20) | 365 (1.01) | 482 (0.68) |
| Hemiparesis | 6 (0.13) | 46 (0.90) | 67 (1.12) | 0 | 130 (0.70) | 99 (0.27) | 366 (0.52) |
| Hemiplegia | 4 (0.09) | 28 (0.55) | 31 (0.52) | 0 | 36 (0.19) | 39 (0.11) | 150 (0.21) |
| Herpes zoster | 6 (0.13) | 14 (0.27) | 56 (0.94) | 0 | 112 (0.60) | 269 (0.75) | 463 (0.66) |
| Hospitalisation | 10 (0.22) | 2 (0.04) | 0 | 0 | 213 (1.14) | 0 | 239 (0.34) |
| Hot flush | 0 | 14 (0.27) | 32 (0.53) | 1 (0.89) | 26 (0.14) | 103 (0.29) | 177 (0.25) |
| Hyperglycaemia | 3 (0.07) | 11 (0.22) | 1 (0.02) | 0 | 36 (0.19) | 7 (0.02) | 63 (0.09) |
| Hyperhidrosis | 21 (0.46) | 95 (1.86) | 116 (1.94) | 0 | 234 (1.25) | 409 (1.14) | 891 (1.26) |
| Hyperkalaemia | 11 (0.24) | 2 (0.04) | 0 | 0 | 23 (0.12) | 5 (0.01) | 51 (0.07) |
| Hyperpyrexia | 9 (0.20) | 8 (0.16) | 2 (0.03) | 0 | 15 (0.08) | 160 (0.44) | 196 (0.28) |
| Hypersensitivity | 4 (0.09) | 60 (1.17) | 28 (0.47) | 0 | 154 (0.82) | 254 (0.71) | 506 (0.72) |
| Hypersomnia | 3 (0.07) | 17 (0.33) | 18 (0.30) | 1 (0.89) | 25 (0.13) | 21 (0.06) | 90 (0.13) |
| Hypertension | 35 (0.76) | 109 (2.13) | 68 (1.14) | 0 | 361 (1.93) | 194 (0.54) | 792 (1.12) |
| Hypertensive crisis | 1 (0.02) | 15 (0.29) | 0 | 0 | 35 (0.19) | 60 (0.17) | 113 (0.16) |
| Hyperthyroidism | 0 | 4 (0.08) | 5 (0.08) | 0 | 5 (0.03) | 43 (0.12) | 57 (0.08) |
| Hyperventilation | 4 (0.09) | 7 (0.14) | 1 (0.02) | 0 | 42 (0.22) | 6 (0.02) | 63 (0.09) |
| Hypoacusis | 0 | 3 (0.06) | 65 (1.09) | 0 | 24 (0.13) | 31 (0.09) | 125 (0.18) |
| Hypoaesthesia | 4 (0.09) | 125 (2.45) | 371 (6.20) | 0 | 504 (2.70) | 328 (0.91) | 1361 (1.93) |
| Hypoaesthesia oral | 1 (0.02) | 12 (0.23) | 29 (0.48) | 0 | 55 (0.29) | 38 (0.11) | 138 (0.20) |
| Hypokalaemia | 7 (0.15) | 7 (0.14) | 2 (0.03) | 0 | 42 (0.22) | 23 (0.06) | 88 (0.12) |
| Hypokinesia | 3 (0.07) | 3 (0.06) | 7 (0.12) | 0 | 31 (0.17) | 15 (0.04) | 63 (0.09) |
| Hyponatraemia | 10 (0.22) | 12 (0.23) | 3 (0.05) | 0 | 66 (0.35) | 1 (0.00) | 103 (0.15) |
| Hypophagia | 14 (0.30) | 9 (0.18) | 3 (0.05) | 0 | 67 (0.36) | 2 (0.01) | 102 (0.14) |
| Hypotension | 73 (1.59) | 78 (1.53) | 28 (0.47) | 0 | 247 (1.32) | 114 (0.32) | 571 (0.81) |
| Hypothyroidism | 1 (0.02) | 1 (0.02) | 7 (0.12) | 0 | 12 (0.06) | 26 (0.07) | 51 (0.07) |
| Hypoxia | 98 (2.13) | 63 (1.23) | 3 (0.05) | 0 | 339 (1.81) | 53 (0.15) | 595 (0.84) |
| Illness | 27 (0.59) | 19 (0.37) | 39 (0.65) | 1 (0.89) | 64 (0.34) | 186 (0.52) | 349 (0.50) |
| Immediate post-injection reaction | 5 (0.11) | 26 (0.51) | 51 (0.85) | 0 | 39 (0.21) | 3 (0.01) | 124 (0.18) |
| Immune thrombocytopenia | 4 (0.09) | 63 (1.23) | 3 (0.05) | 0 | 108 (0.58) | 46 (0.13) | 226 (0.32) |
| Impaired driving ability | 2 (0.04) | 17 (0.33) | 42 (0.70) | 0 | 28 (0.15) | 10 (0.03) | 103 (0.15) |
| Impaired work ability | 4 (0.09) | 47 (0.92) | 168 (2.81) | 2 (1.79) | 69 (0.37) | 44 (0.12) | 346 (0.49) |
| Inappropriate schedule of product administration | 6 (0.13) | 4 (0.08) | 4 (0.07) | 1 (0.89) | 31 (0.17) | 11 (0.03) | 58 (0.08) |
| Infection | 6 (0.13) | 13 (0.25) | 16 (0.27) | 0 | 85 (0.45) | 34 (0.09) | 156 (0.22) |
| Inflammation | 3 (0.07) | 25 (0.49) | 74 (1.24) | 0 | 93 (0.50) | 47 (0.13) | 247 (0.35) |
| Influenza | 2 (0.04) | 12 (0.23) | 25 (0.42) | 0 | 73 (0.39) | 193 (0.54) | 307 (0.44) |
| Influenza like illness | 12 (0.26) | 31 (0.61) | 158 (2.64) | 0 | 183 (0.98) | 444 (1.23) | 836 (1.19) |
| Injected limb mobility decreased | 1 (0.02) | 6 (0.12) | 83 (1.39) | 0 | 5 (0.03) | 26 (0.07) | 122 (0.17) |
| Injection site erythema | 3 (0.07) | 11 (0.22) | 61 (1.02) | 0 | 69 (0.37) | 126 (0.35) | 270 (0.38) |
| Injection site pain | 12 (0.26) | 31 (0.61) | 162 (2.71) | 1 (0.89) | 157 (0.84) | 392 (1.09) | 761 (1.08) |
| Injection site pruritus | 3 (0.07) | 6 (0.12) | 24 (0.40) | 0 | 18 (0.10) | 42 (0.12) | 93 (0.13) |
| Injection site rash | 0 | 6 (0.12) | 15 (0.25) | 0 | 16 (0.09) | 60 (0.17) | 97 (0.14) |
| Injection site reaction | 1 (0.02) | 6 (0.12) | 492 (8.22) | 0 | 23 (0.12) | 124 (0.34) | 647 (0.92) |
| Injection site swelling | 3 (0.07) | 15 (0.29) | 48 (0.80) | 0 | 71 (0.38) | 88 (0.24) | 228 (0.32) |
| Injection site warmth | 1 (0.02) | 6 (0.12) | 23 (0.38) | 0 | 8 (0.04) | 36 (0.10) | 74 (0.10) |
| Insomnia | 8 (0.17) | 23 (0.45) | 104 (1.74) | 2 (1.79) | 56 (0.30) | 196 (0.54) | 397 (0.56) |
| Intensive care | 11 (0.24) | 31 (0.61) | 1 (0.02) | 0 | 34 (0.18) | 0 | 77 (0.11) |
| Intermenstrual bleeding | 0 | 2 (0.04) | 18 (0.30) | 2 (1.79) | 8 (0.04) | 107 (0.30) | 137 (0.19) |
| Interstitial lung disease | 9 (0.20) | 8 (0.16) | 3 (0.05) | 0 | 33 (0.18) | 8 (0.02) | 66 (0.09) |
| Ischaemic stroke | 19 (0.41) | 59 (1.15) | 29 (0.48) | 0 | 148 (0.79) | 16 (0.04) | 274 (0.39) |
| Joint range of motion decreased | 1 (0.02) | 5 (0.10) | 51 (0.85) | 0 | 12 (0.06) | 2 (0.01) | 71 (0.10) |
| Joint stiffness | 1 (0.02) | 3 (0.06) | 34 (0.57) | 0 | 11 (0.06) | 26 (0.07) | 77 (0.11) |
| Joint swelling | 2 (0.04) | 16 (0.31) | 71 (1.19) | 0 | 45 (0.24) | 32 (0.09) | 170 (0.24) |
| Lactic acidosis | 12 (0.26) | 8 (0.16) | 1 (0.02) | 0 | 29 (0.16) | 2 (0.01) | 55 (0.08) |
| Lethargy | 37 (0.80) | 42 (0.82) | 36 (0.60) | 1 (0.89) | 133 (0.71) | 154 (0.43) | 417 (0.59) |
| Leukocytosis | 8 (0.17) | 9 (0.18) | 1 (0.02) | 0 | 59 (0.32) | 3 (0.01) | 88 (0.12) |
| Leukopenia | 4 (0.09) | 6 (0.12) | 1 (0.02) | 0 | 23 (0.12) | 15 (0.04) | 52 (0.07) |
| Limb discomfort | 3 (0.07) | 24 (0.47) | 58 (0.97) | 0 | 118 (0.63) | 125 (0.35) | 333 (0.47) |
| Lip swelling | 1 (0.02) | 34 (0.67) | 14 (0.23) | 1 (0.89) | 73 (0.39) | 59 (0.16) | 187 (0.27) |
| Loss of consciousness | 78 (1.69) | 152 (2.97) | 53 (0.89) | 1 (0.89) | 405 (2.17) | 2752 (7.64) | 3544 (5.03) |
| Loss of personal independence in daily activities | 3 (0.07) | 44 (0.86) | 148 (2.47) | 0 | 69 (0.37) | 16 (0.04) | 297 (0.42) |
| Lower respiratory tract infection | 1 (0.02) | 2 (0.04) | 4 (0.07) | 0 | 6 (0.03) | 45 (0.12) | 59 (0.08) |
| Lung disorder | 12 (0.26) | 6 (0.12) | 4 (0.07) | 0 | 41 (0.22) | 7 (0.02) | 74 (0.10) |
| Lung infiltration | 24 (0.52) | 20 (0.39) | 0 | 0 | 101 (0.54) | 0 | 158 (0.22) |
| Lung opacity | 22 (0.48) | 40 (0.78) | 3 (0.05) | 0 | 150 (0.80) | 1 (0.00) | 222 (0.31) |
| Lymph node pain | 1 (0.02) | 3 (0.06) | 18 (0.30) | 0 | 12 (0.06) | 69 (0.19) | 104 (0.15) |
| Lymphadenopathy | 10 (0.22) | 43 (0.84) | 142 (2.37) | 0 | 172 (0.92) | 663 (1.84) | 1040 (1.48) |
| Malaise | 149 (3.24) | 158 (3.09) | 657 (10.98) | 5 (4.46) | 635 (3.40) | 547 (1.52) | 2211 (3.14) |
| Maternal exposure during breast feeding | 0 | 0 | 5 (0.08) | 0 | 1 (0.01) | 112 (0.31) | 118 (0.17) |
| Maternal exposure during pregnancy | 1 (0.02) | 12 (0.23) | 7 (0.12) | 16 (14.29) | 61 (0.33) | 122 (0.34) | 222 (0.31) |
| Memory impairment | 6 (0.13) | 22 (0.43) | 55 (0.92) | 0 | 89 (0.48) | 30 (0.08) | 209 (0.30) |
| Menstrual disorder | 0 | 2 (0.04) | 42 (0.70) | 0 | 16 (0.09) | 126 (0.35) | 188 (0.27) |
| Menstruation delayed | 0 | 1 (0.02) | 27 (0.45) | 0 | 3 (0.02) | 161 (0.45) | 192 (0.27) |
| Menstruation irregular | 0 | 1 (0.02) | 39 (0.65) | 2 (1.79) | 16 (0.09) | 146 (0.41) | 206 (0.29) |
| Mental impairment | 2 (0.04) | 3 (0.06) | 23 (0.38) | 0 | 18 (0.10) | 159 (0.44) | 212 (0.30) |
| Mental status changes | 33 (0.72) | 39 (0.76) | 7 (0.12) | 0 | 164 (0.88) | 2 (0.01) | 258 (0.37) |
| Migraine | 2 (0.04) | 27 (0.53) | 135 (2.26) | 0 | 105 (0.56) | 314 (0.87) | 589 (0.84) |
| Mobility decreased | 17 (0.37) | 68 (1.33) | 181 (3.03) | 2 (1.79) | 176 (0.94) | 30 (0.08) | 490 (0.70) |
| Monoplegia | 0 | 4 (0.08) | 17 (0.28) | 0 | 22 (0.12) | 95 (0.26) | 141 (0.20) |
| Movement disorder | 6 (0.13) | 9 (0.18) | 41 (0.69) | 0 | 35 (0.19) | 17 (0.05) | 114 (0.16) |
| Multiple organ dysfunction syndrome | 40 (0.87) | 6 (0.12) | 0 | 0 | 4 (0.02) | 1 (0.00) | 63 (0.09) |
| Multiple sclerosis | 0 | 3 (0.06) | 22 (0.37) | 0 | 15 (0.08) | 59 (0.16) | 100 (0.14) |
| Multiple sclerosis relapse | 0 | 1 (0.02) | 5 (0.08) | 0 | 18 (0.10) | 32 (0.09) | 56 (0.08) |
| Muscle spasms | 4 (0.09) | 39 (0.76) | 88 (1.47) | 3 (2.68) | 118 (0.63) | 184 (0.51) | 444 (0.63) |
| Muscle tightness | 1 (0.02) | 12 (0.23) | 14 (0.23) | 1 (0.89) | 23 (0.12) | 14 (0.04) | 68 (0.10) |
| Muscle twitching | 2 (0.04) | 7 (0.14) | 41 (0.69) | 1 (0.89) | 26 (0.14) | 32 (0.09) | 111 (0.16) |
| Muscular weakness | 17 (0.37) | 68 (1.33) | 231 (3.86) | 1 (0.89) | 352 (1.88) | 137 (0.38) | 833 (1.18) |
| Musculoskeletal chest pain | 1 (0.02) | 14 (0.27) | 13 (0.22) | 0 | 33 (0.18) | 23 (0.06) | 86 (0.12) |
| Musculoskeletal pain | 2 (0.04) | 2 (0.04) | 12 (0.20) | 1 (0.89) | 25 (0.13) | 97 (0.27) | 140 (0.20) |
| Musculoskeletal stiffness | 1 (0.02) | 12 (0.23) | 126 (2.11) | 0 | 75 (0.40) | 173 (0.48) | 392 (0.56) |
| Myalgia | 34 (0.74) | 130 (2.54) | 1041 (17.40) | 3 (2.68) | 578 (3.09) | 1560 (4.33) | 3381 (4.80) |
| Myasthenia gravis | 1 (0.02) | 7 (0.14) | 17 (0.28) | 0 | 16 (0.09) | 28 (0.08) | 71 (0.10) |
| Myelitis transverse | 0 | 4 (0.08) | 32 (0.53) | 0 | 31 (0.17) | 13 (0.04) | 84 (0.12) |
| Myocardial infarction | 154 (3.34) | 193 (3.78) | 4 (0.07) | 0 | 191 (1.02) | 80 (0.22) | 649 (0.92) |
| Myocarditis | 24 (0.52) | 231 (4.52) | 35 (0.58) | 1 (0.89) | 1293 (6.92) | 348 (0.97) | 1963 (2.78) |
| Nasal congestion | 2 (0.04) | 6 (0.12) | 16 (0.27) | 0 | 40 (0.21) | 30 (0.08) | 96 (0.14) |
| Nasopharyngitis | 6 (0.13) | 4 (0.08) | 16 (0.27) | 0 | 47 (0.25) | 98 (0.27) | 172 (0.24) |
| Nausea | 84 (1.82) | 264 (5.16) | 834 (13.94) | 3 (2.68) | 1089 (5.83) | 1798 (4.99) | 4143 (5.88) |
| Neck pain | 6 (0.13) | 39 (0.76) | 118 (1.97) | 2 (1.79) | 134 (0.72) | 164 (0.46) | 471 (0.67) |
| Nephrolithiasis | 0 | 4 (0.08) | 2 (0.03) | 0 | 27 (0.14) | 52 (0.14) | 86 (0.12) |
| Nervous system disorder | 3 (0.07) | 2 (0.04) | 18 (0.30) | 0 | 21 (0.11) | 13 (0.04) | 61 (0.09) |
| Neuralgia | 1 (0.02) | 9 (0.18) | 70 (1.17) | 1 (0.89) | 42 (0.22) | 70 (0.19) | 196 (0.28) |
| Neurological symptom | 6 (0.13) | 26 (0.51) | 31 (0.52) | 0 | 66 (0.35) | 8 (0.02) | 141 (0.20) |
| Neuropathy peripheral | 0 | 5 (0.10) | 49 (0.82) | 0 | 31 (0.17) | 314 (0.87) | 409 (0.58) |
| Night sweats | 1 (0.02) | 12 (0.23) | 23 (0.38) | 0 | 37 (0.20) | 79 (0.22) | 156 (0.22) |
| Oedema | 11 (0.24) | 11 (0.22) | 12 (0.20) | 0 | 52 (0.28) | 26 (0.07) | 117 (0.17) |
| Oedema peripheral | 9 (0.20) | 19 (0.37) | 32 (0.53) | 0 | 84 (0.45) | 65 (0.18) | 214 (0.30) |
| Ophthalmic herpes zoster | 0 | 1 (0.02) | 5 (0.08) | 0 | 7 (0.04) | 54 (0.15) | 67 (0.10) |
| Optic neuritis | 0 | 0 | 16 (0.27) | 0 | 21 (0.11) | 29 (0.08) | 67 (0.10) |
| Oral herpes | 1 (0.02) | 2 (0.04) | 8 (0.13) | 0 | 8 (0.04) | 37 (0.10) | 56 (0.08) |
| Oropharyngeal discomfort | 0 | 10 (0.20) | 3 (0.05) | 0 | 21 (0.11) | 15 (0.04) | 52 (0.07) |
| Oropharyngeal pain | 13 (0.28) | 31 (0.61) | 62 (1.04) | 0 | 128 (0.69) | 205 (0.57) | 445 (0.63) |
| Oxygen saturation decreased | 19 (0.41) | 23 (0.45) | 4 (0.07) | 0 | 70 (0.37) | 19 (0.05) | 153 (0.22) |
| Pain | 64 (1.39) | 222 (4.34) | 572 (9.56) | 5 (4.46) | 711 (3.80) | 946 (2.63) | 2575 (3.65) |
| Pain in extremity | 38 (0.83) | 248 (4.85) | 639 (10.68) | 5 (4.46) | 534 (2.86) | 1446 (4.02) | 2950 (4.18) |
| Pain in jaw | 2 (0.04) | 11 (0.22) | 19 (0.32) | 0 | 35 (0.19) | 23 (0.06) | 93 (0.13) |
| Pain of skin | 0 | 5 (0.10) | 20 (0.33) | 0 | 5 (0.03) | 45 (0.12) | 76 (0.11) |
| Painful respiration | 3 (0.07) | 15 (0.29) | 5 (0.08) | 0 | 45 (0.24) | 7 (0.02) | 78 (0.11) |
| Pallor | 12 (0.26) | 15 (0.29) | 7 (0.12) | 1 (0.89) | 44 (0.24) | 36 (0.10) | 122 (0.17) |
| Palpitations | 9 (0.20) | 135 (2.64) | 161 (2.69) | 1 (0.89) | 413 (2.21) | 446 (1.24) | 1184 (1.68) |
| Pancreatitis | 2 (0.04) | 13 (0.25) | 3 (0.05) | 0 | 48 (0.26) | 29 (0.08) | 96 (0.14) |
| Pancreatitis acute | 0 | 11 (0.22) | 0 | 0 | 56 (0.30) | 7 (0.02) | 77 (0.11) |
| Panic attack | 1 (0.02) | 4 (0.08) | 24 (0.40) | 0 | 12 (0.06) | 22 (0.06) | 66 (0.09) |
| Paraesthesia | 2 (0.04) | 106 (2.07) | 292 (4.88) | 0 | 414 (2.22) | 507 (1.41) | 1340 (1.90) |
| Paraesthesia oral | 0 | 26 (0.51) | 18 (0.30) | 0 | 46 (0.25) | 62 (0.17) | 154 (0.22) |
| Paralysis | 6 (0.13) | 27 (0.53) | 54 (0.90) | 1 (0.89) | 55 (0.29) | 132 (0.37) | 288 (0.41) |
| Parosmia | 1 (0.02) | 3 (0.06) | 27 (0.45) | 0 | 10 (0.05) | 12 (0.03) | 53 (0.08) |
| Periarthritis | 0 | 0 | 28 (0.47) | 0 | 4 (0.02) | 20 (0.06) | 52 (0.07) |
| Pericardial effusion | 5 (0.11) | 51 (1.00) | 5 (0.08) | 0 | 101 (0.54) | 63 (0.17) | 239 (0.34) |
| Pericarditis | 5 (0.11) | 105 (2.05) | 17 (0.28) | 0 | 465 (2.49) | 409 (1.14) | 1009 (1.43) |
| Peripheral coldness | 11 (0.24) | 17 (0.33) | 17 (0.28) | 0 | 26 (0.14) | 37 (0.10) | 111 (0.16) |
| Peripheral swelling | 16 (0.35) | 134 (2.62) | 206 (3.44) | 1 (0.89) | 243 (1.30) | 562 (1.56) | 1191 (1.69) |
| Petechiae | 3 (0.07) | 31 (0.61) | 7 (0.12) | 0 | 78 (0.42) | 22 (0.06) | 145 (0.21) |
| Pharyngeal swelling | 0 | 84 (1.64) | 12 (0.20) | 0 | 52 (0.28) | 60 (0.17) | 214 (0.30) |
| Photophobia | 1 (0.02) | 9 (0.18) | 42 (0.70) | 0 | 33 (0.18) | 68 (0.19) | 156 (0.22) |
| Platelet count decreased | 7 (0.15) | 24 (0.47) | 2 (0.03) | 1 (0.89) | 41 (0.22) | 10 (0.03) | 90 (0.13) |
| Pleural effusion | 22 (0.48) | 39 (0.76) | 9 (0.15) | 0 | 134 (0.72) | 4 (0.01) | 226 (0.32) |
| Pleuritic pain | 0 | 14 (0.27) | 0 | 0 | 31 (0.17) | 2 (0.01) | 51 (0.07) |
| Pneumonia | 145 (3.15) | 102 (2.00) | 14 (0.23) | 0 | 515 (2.76) | 231 (0.64) | 1074 (1.52) |
| Pneumonia aspiration | 19 (0.41) | 9 (0.18) | 1 (0.02) | 0 | 17 (0.09) | 2 (0.01) | 52 (0.07) |
| Pneumonitis | 4 (0.09) | 11 (0.22) | 1 (0.02) | 0 | 25 (0.13) | 8 (0.02) | 51 (0.07) |
| Pollakiuria | 4 (0.09) | 5 (0.10) | 13 (0.22) | 0 | 17 (0.09) | 17 (0.05) | 57 (0.08) |
| Polymenorrhoea | 0 | 0 | 22 (0.37) | 1 (0.89) | 7 (0.04) | 59 (0.16) | 89 (0.13) |
| Polymyalgia rheumatica | 0 | 1 (0.02) | 18 (0.30) | 0 | 6 (0.03) | 95 (0.26) | 120 (0.17) |
| Postmenopausal haemorrhage | 0 | 0 | 5 (0.08) | 0 | 1 (0.01) | 139 (0.39) | 145 (0.21) |
| Presyncope | 1 (0.02) | 22 (0.43) | 36 (0.60) | 1 (0.89) | 160 (0.86) | 145 (0.40) | 375 (0.53) |
| Productive cough | 16 (0.35) | 10 (0.20) | 10 (0.17) | 0 | 79 (0.42) | 13 (0.04) | 134 (0.19) |
| Pruritus | 6 (0.13) | 93 (1.82) | 101 (1.69) | 3 (2.68) | 198 (1.06) | 563 (1.56) | 974 (1.38) |
| Pulmonary congestion | 4 (0.09) | 7 (0.14) | 2 (0.03) | 0 | 30 (0.16) | 91 (0.25) | 141 (0.20) |
| Pulmonary embolism | 100 (2.17) | 644 (12.60) | 20 (0.33) | 0 | 774 (4.14) | 226 (0.63) | 1786 (2.53) |
| Pulmonary infarction | 3 (0.07) | 28 (0.55) | 1 (0.02) | 0 | 22 (0.12) | 9 (0.02) | 65 (0.09) |
| Pulmonary mass | 9 (0.20) | 11 (0.22) | 6 (0.10) | 0 | 33 (0.18) | 4 (0.01) | 67 (0.10) |
| Pulmonary oedema | 32 (0.69) | 37 (0.72) | 5 (0.08) | 1 (0.89) | 82 (0.44) | 20 (0.06) | 196 (0.28) |
| Pulmonary pain | 0 | 11 (0.22) | 11 (0.18) | 0 | 16 (0.09) | 14 (0.04) | 52 (0.07) |
| Pulmonary thrombosis | 10 (0.22) | 92 (1.80) | 7 (0.12) | 0 | 89 (0.48) | 19 (0.05) | 220 (0.31) |
| Pyrexia | 222 (4.82) | 435 (8.51) | 1325 (22.15) | 13 (11.61) | 2296 (12.29) | 3316 (9.21) | 7760 (11.01) |
| Rash | 9 (0.20) | 112 (2.19) | 170 (2.84) | 1 (0.89) | 372 (1.99) | 717 (1.99) | 1396 (1.98) |
| Rash erythematous | 1 (0.02) | 20 (0.39) | 25 (0.42) | 0 | 47 (0.25) | 185 (0.51) | 282 (0.40) |
| Rash macular | 1 (0.02) | 6 (0.12) | 26 (0.43) | 0 | 19 (0.10) | 54 (0.15) | 107 (0.15) |
| Rash papular | 0 | 5 (0.10) | 4 (0.07) | 0 | 8 (0.04) | 53 (0.15) | 71 (0.10) |
| Rash pruritic | 1 (0.02) | 10 (0.20) | 21 (0.35) | 0 | 46 (0.25) | 130 (0.36) | 208 (0.30) |
| Rectal haemorrhage | 2 (0.04) | 1 (0.02) | 3 (0.05) | 0 | 30 (0.16) | 57 (0.16) | 98 (0.14) |
| Renal failure | 52 (1.13) | 31 (0.61) | 6 (0.10) | 0 | 45 (0.24) | 16 (0.04) | 171 (0.24) |
| Renal impairment | 10 (0.22) | 5 (0.10) | 6 (0.10) | 0 | 32 (0.17) | 37 (0.10) | 99 (0.14) |
| Renal pain | 1 (0.02) | 1 (0.02) | 19 (0.32) | 0 | 10 (0.05) | 44 (0.12) | 75 (0.11) |
| Respiratory arrest | 73 (1.59) | 23 (0.45) | 1 (0.02) | 0 | 15 (0.08) | 15 (0.04) | 140 (0.20) |
| Respiratory disorder | 13 (0.28) | 9 (0.18) | 11 (0.18) | 0 | 18 (0.10) | 7 (0.02) | 61 (0.09) |
| Respiratory distress | 31 (0.67) | 31 (0.61) | 3 (0.05) | 0 | 58 (0.31) | 55 (0.15) | 191 (0.27) |
| Respiratory failure | 102 (2.21) | 46 (0.90) | 4 (0.07) | 0 | 90 (0.48) | 6 (0.02) | 258 (0.37) |
| Respiratory tract congestion | 14 (0.30) | 3 (0.06) | 10 (0.17) | 0 | 80 (0.43) | 2 (0.01) | 115 (0.16) |
| Restlessness | 4 (0.09) | 7 (0.14) | 7 (0.12) | 0 | 17 (0.09) | 33 (0.09) | 69 (0.10) |
| Retching | 0 | 10 (0.20) | 8 (0.13) | 0 | 27 (0.14) | 19 (0.05) | 65 (0.09) |
| Retinal vein occlusion | 0 | 2 (0.04) | 19 (0.32) | 0 | 5 (0.03) | 28 (0.08) | 54 (0.08) |
| Rhabdomyolysis | 4 (0.09) | 16 (0.31) | 5 (0.08) | 0 | 57 (0.31) | 23 (0.06) | 109 (0.15) |
| Rheumatoid arthritis | 5 (0.11) | 1 (0.02) | 30 (0.50) | 0 | 12 (0.06) | 187 (0.52) | 238 (0.34) |
| Rhinorrhoea | 12 (0.26) | 4 (0.08) | 11 (0.18) | 0 | 59 (0.32) | 55 (0.15) | 144 (0.20) |
| SARS-CoV-2 test positive | 39 (0.85) | 9 (0.18) | 2 (0.03) | 0 | 180 (0.96) | 36 (0.10) | 269 (0.38) |
| Seizure | 37 (0.80) | 99 (1.94) | 52 (0.87) | 2 (1.79) | 326 (1.74) | 1174 (3.26) | 1735 (2.46) |
| Seizure like phenomena | 5 (0.11) | 6 (0.12) | 5 (0.08) | 0 | 24 (0.13) | 64 (0.18) | 106 (0.15) |
| Sensitive skin | 0 | 1 (0.02) | 12 (0.20) | 0 | 4 (0.02) | 53 (0.15) | 72 (0.10) |
| Sensory disturbance | 0 | 4 (0.08) | 19 (0.32) | 0 | 32 (0.17) | 17 (0.05) | 74 (0.10) |
| Sensory loss | 0 | 9 (0.18) | 20 (0.33) | 0 | 23 (0.12) | 10 (0.03) | 64 (0.09) |
| Sepsis | 85 (1.85) | 47 (0.92) | 6 (0.10) | 0 | 182 (0.97) | 14 (0.04) | 346 (0.49) |
| Septic shock | 51 (1.11) | 19 (0.37) | 0 | 0 | 25 (0.13) | 2 (0.01) | 100 (0.14) |
| Shock | 19 (0.41) | 14 (0.27) | 1 (0.02) | 0 | 12 (0.06) | 18 (0.05) | 71 (0.10) |
| Sinus tachycardia | 4 (0.09) | 10 (0.20) | 7 (0.12) | 0 | 54 (0.29) | 5 (0.01) | 83 (0.12) |
| Skin burning sensation | 0 | 6 (0.12) | 11 (0.18) | 0 | 17 (0.09) | 23 (0.06) | 59 (0.08) |
| Skin discolouration | 5 (0.11) | 25 (0.49) | 25 (0.42) | 1 (0.89) | 25 (0.13) | 13 (0.04) | 103 (0.15) |
| Skin disorder | 0 | 1 (0.02) | 77 (1.29) | 0 | 6 (0.03) | 12 (0.03) | 96 (0.14) |
| Skin reaction | 1 (0.02) | 4 (0.08) | 6 (0.10) | 0 | 12 (0.06) | 61 (0.17) | 84 (0.12) |
| Skin warm | 2 (0.04) | 21 (0.41) | 18 (0.30) | 0 | 39 (0.21) | 53 (0.15) | 133 (0.19) |
| Sleep disorder | 2 (0.04) | 37 (0.72) | 87 (1.45) | 0 | 73 (0.39) | 53 (0.15) | 261 (0.37) |
| Somnolence | 27 (0.59) | 28 (0.55) | 54 (0.90) | 1 (0.89) | 103 (0.55) | 143 (0.40) | 380 (0.54) |
| Speech disorder | 7 (0.15) | 40 (0.78) | 55 (0.92) | 1 (0.89) | 113 (0.60) | 27 (0.07) | 253 (0.36) |
| Status epilepticus | 1 (0.02) | 8 (0.16) | 2 (0.03) | 0 | 13 (0.07) | 27 (0.07) | 52 (0.07) |
| Subarachnoid haemorrhage | 14 (0.30) | 33 (0.65) | 1 (0.02) | 0 | 35 (0.19) | 0 | 84 (0.12) |
| Sudden death | 105 (2.28) | 0 | 0 | 0 | 0 | 0 | 105 (0.15) |
| Sudden hearing loss | 0 | 2 (0.04) | 59 (0.99) | 0 | 13 (0.07) | 80 (0.22) | 154 (0.22) |
| Suicidal ideation | 1 (0.02) | 12 (0.23) | 8 (0.13) | 0 | 11 (0.06) | 69 (0.19) | 105 (0.15) |
| Superficial vein thrombosis | 1 (0.02) | 9 (0.18) | 2 (0.03) | 0 | 15 (0.08) | 42 (0.12) | 70 (0.10) |
| Supraventricular tachycardia | 5 (0.11) | 22 (0.43) | 10 (0.17) | 0 | 40 (0.21) | 9 (0.02) | 89 (0.13) |
| Swelling | 8 (0.17) | 30 (0.59) | 72 (1.20) | 0 | 107 (0.57) | 289 (0.80) | 510 (0.72) |
| Swelling face | 3 (0.07) | 55 (1.08) | 40 (0.67) | 0 | 102 (0.55) | 90 (0.25) | 301 (0.43) |
| Swollen tongue | 2 (0.04) | 80 (1.56) | 14 (0.23) | 0 | 90 (0.48) | 54 (0.15) | 246 (0.35) |
| Syncope | 72 (1.56) | 153 (2.99) | 92 (1.54) | 3 (2.68) | 519 (2.78) | 3771 (10.47) | 4691 (6.65) |
| Systemic inflammatory response syndrome | 5 (0.11) | 12 (0.23) | 1 (0.02) | 0 | 36 (0.19) | 18 (0.05) | 75 (0.11) |
| Systemic lupus erythematosus | 0 | 9 (0.18) | 8 (0.13) | 0 | 10 (0.05) | 53 (0.15) | 81 (0.11) |
| Tachycardia | 19 (0.41) | 112 (2.19) | 65 (1.09) | 1 (0.89) | 390 (2.09) | 249 (0.69) | 849 (1.20) |
| Tachypnoea | 9 (0.20) | 9 (0.18) | 1 (0.02) | 0 | 72 (0.39) | 5 (0.01) | 100 (0.14) |
| Taste disorder | 2 (0.04) | 7 (0.14) | 26 (0.43) | 0 | 22 (0.12) | 19 (0.05) | 80 (0.11) |
| Tenderness | 2 (0.04) | 7 (0.14) | 22 (0.37) | 0 | 26 (0.14) | 49 (0.14) | 108 (0.15) |
| Tension headache | 0 | 2 (0.04) | 7 (0.12) | 0 | 6 (0.03) | 52 (0.14) | 67 (0.10) |
| Thirst | 0 | 5 (0.10) | 9 (0.15) | 0 | 17 (0.09) | 32 (0.09) | 66 (0.09) |
| Throat irritation | 0 | 24 (0.47) | 6 (0.10) | 0 | 41 (0.22) | 39 (0.11) | 111 (0.16) |
| Throat tightness | 2 (0.04) | 89 (1.74) | 15 (0.25) | 0 | 76 (0.41) | 65 (0.18) | 253 (0.36) |
| Thrombocytopenia | 25 (0.54) | 75 (1.47) | 5 (0.08) | 0 | 201 (1.08) | 127 (0.35) | 456 (0.65) |
| Thrombosis | 52 (1.13) | 198 (3.87) | 41 (0.69) | 1 (0.89) | 247 (1.32) | 662 (1.84) | 1238 (1.76) |
| Tinnitus | 0 | 26 (0.51) | 408 (6.82) | 1 (0.89) | 64 (0.34) | 159 (0.44) | 668 (0.95) |
| Transient ischaemic attack | 7 (0.15) | 46 (0.90) | 18 (0.30) | 0 | 144 (0.77) | 107 (0.30) | 332 (0.47) |
| Tremor | 15 (0.33) | 85 (1.66) | 148 (2.47) | 0 | 237 (1.27) | 239 (0.66) | 744 (1.06) |
| Troponin increased | 3 (0.07) | 16 (0.31) | 1 (0.02) | 0 | 57 (0.31) | 3 (0.01) | 85 (0.12) |
| Tunnel vision | 0 | 1 (0.02) | 4 (0.07) | 0 | 1 (0.01) | 86 (0.24) | 93 (0.13) |
| Unevaluable event | 4 (0.09) | 12 (0.23) | 7 (0.12) | 1 (0.89) | 431 (2.31) | 1 (0.00) | 457 (0.65) |
| Unresponsive to stimuli | 163 (3.54) | 58 (1.13) | 7 (0.12) | 0 | 112 (0.60) | 523 (1.45) | 934 (1.32) |
| Urinary incontinence | 2 (0.04) | 12 (0.23) | 15 (0.25) | 0 | 34 (0.18) | 13 (0.04) | 81 (0.11) |
| Urinary retention | 4 (0.09) | 8 (0.16) | 4 (0.07) | 0 | 34 (0.18) | 36 (0.10) | 88 (0.12) |
| Urinary tract infection | 32 (0.69) | 23 (0.45) | 11 (0.18) | 0 | 173 (0.93) | 40 (0.11) | 300 (0.43) |
| Urticaria | 0 | 86 (1.68) | 63 (1.05) | 1 (0.89) | 182 (0.97) | 307 (0.85) | 650 (0.92) |
| Uveitis | 0 | 0 | 7 (0.12) | 0 | 2 (0.01) | 44 (0.12) | 54 (0.08) |
| Vaccination complication | 17 (0.37) | 32 (0.63) | 34 (0.57) | 0 | 97 (0.52) | 38 (0.11) | 229 (0.32) |
| Vaccination failure | 12 (0.26) | 6 (0.12) | 0 | 0 | 61 (0.33) | 694 (1.93) | 781 (1.11) |
| Vaccination site erythema | 0 | 6 (0.12) | 77 (1.29) | 0 | 59 (0.32) | 193 (0.54) | 337 (0.48) |
| Vaccination site inflammation | 0 | 0 | 8 (0.13) | 0 | 6 (0.03) | 43 (0.12) | 57 (0.08) |
| Vaccination site movement impairment | 0 | 1 (0.02) | 25 (0.42) | 0 | 7 (0.04) | 17 (0.05) | 51 (0.07) |
| Vaccination site oedema | 0 | 1 (0.02) | 34 (0.57) | 0 | 9 (0.05) | 61 (0.17) | 105 (0.15) |
| Vaccination site pain | 8 (0.17) | 21 (0.41) | 193 (3.23) | 0 | 105 (0.56) | 332 (0.92) | 668 (0.95) |
| Vaccination site pruritus | 0 | 4 (0.08) | 38 (0.64) | 0 | 15 (0.08) | 97 (0.27) | 154 (0.22) |
| Vaccination site rash | 0 | 0 | 9 (0.15) | 0 | 10 (0.05) | 73 (0.20) | 92 (0.13) |
| Vaccination site reaction | 0 | 4 (0.08) | 11 (0.18) | 0 | 27 (0.14) | 59 (0.16) | 102 (0.14) |
| Vaccination site swelling | 2 (0.04) | 7 (0.14) | 46 (0.77) | 0 | 51 (0.27) | 129 (0.36) | 239 (0.34) |
| Vaccination site warmth | 0 | 2 (0.04) | 26 (0.43) | 0 | 18 (0.10) | 85 (0.24) | 131 (0.19) |
| Vaccine breakthrough infection | 24 (0.52) | 1 (0.02) | 0 | 0 | 149 (0.80) | 73 (0.20) | 262 (0.37) |
| Vaginal haemorrhage | 1 (0.02) | 12 (0.23) | 9 (0.15) | 5 (4.46) | 32 (0.17) | 92 (0.26) | 151 (0.21) |
| Vasculitis | 3 (0.07) | 6 (0.12) | 1 (0.02) | 0 | 28 (0.15) | 14 (0.04) | 57 (0.08) |
| Venous thrombosis | 1 (0.02) | 15 (0.29) | 3 (0.05) | 0 | 15 (0.08) | 15 (0.04) | 53 (0.08) |
| Venous thrombosis limb | 0 | 8 (0.16) | 5 (0.08) | 0 | 16 (0.09) | 31 (0.09) | 61 (0.09) |
| Ventricular extrasystoles | 0 | 6 (0.12) | 11 (0.18) | 0 | 31 (0.17) | 20 (0.06) | 71 (0.10) |
| Ventricular fibrillation | 20 (0.43) | 23 (0.45) | 1 (0.02) | 0 | 12 (0.06) | 0 | 64 (0.09) |
| Ventricular tachycardia | 14 (0.30) | 31 (0.61) | 2 (0.03) | 0 | 39 (0.21) | 19 (0.05) | 110 (0.16) |
| Vertigo | 2 (0.04) | 30 (0.59) | 167 (2.79) | 0 | 160 (0.86) | 198 (0.55) | 565 (0.80) |
| Vestibular neuronitis | 0 | 2 (0.04) | 9 (0.15) | 0 | 35 (0.19) | 12 (0.03) | 59 (0.08) |
| Vision blurred | 6 (0.13) | 33 (0.65) | 122 (2.04) | 2 (1.79) | 135 (0.72) | 160 (0.44) | 463 (0.66) |
| Visual field defect | 0 | 5 (0.10) | 19 (0.32) | 0 | 22 (0.12) | 4 (0.01) | 53 (0.08) |
| Visual impairment | 2 (0.04) | 29 (0.57) | 106 (1.77) | 0 | 121 (0.65) | 80 (0.22) | 348 (0.49) |
| Vomiting | 102 (2.21) | 221 (4.32) | 277 (4.63) | 2 (1.79) | 902 (4.83) | 786 (2.18) | 2372 (3.36) |
| Walking aid user | 6 (0.13) | 9 (0.18) | 30 (0.50) | 0 | 20 (0.11) | 0 | 68 (0.10) |
| Weight decreased | 7 (0.15) | 17 (0.33) | 28 (0.47) | 0 | 55 (0.29) | 26 (0.07) | 138 (0.20) |
| Wheezing | 9 (0.20) | 36 (0.70) | 9 (0.15) | 0 | 84 (0.45) | 45 (0.12) | 193 (0.27) |