Eudravigilance C-19 - Pfizer / Biontech

Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)

PT

Décès

10590 (%)

Mise en jeu du pronostic vital

13810 (%)

Invalidité ou incapacité

25725 (%)

Anomalies congénitales

288 (%)

Hospitalisation

53479 (%)

Médicalement significatif

188737 (%)

Cas Graves

292629 (%)
Abdominal discomfort 5 (0.05) 25 (0.18) 127 (0.49) 0 129 (0.24) 584 (0.31) 888 (0.30)
Abdominal distension 8 (0.08) 28 (0.20) 99 (0.38) 0 80 (0.15) 414 (0.22) 642 (0.22)
Abdominal pain 62 (0.59) 136 (0.98) 411 (1.60) 5 (1.74) 853 (1.60) 1704 (0.90) 3248 (1.11)
Abdominal pain lower 2 (0.02) 6 (0.04) 41 (0.16) 0 97 (0.18) 170 (0.09) 320 (0.11)
Abdominal pain upper 33 (0.31) 81 (0.59) 369 (1.43) 0 402 (0.75) 2059 (1.09) 2981 (1.02)
Abnormal behaviour 3 (0.03) 4 (0.03) 9 (0.03) 0 20 (0.04) 26 (0.01) 68 (0.02)
Abnormal dreams 0 1 (0.01) 16 (0.06) 0 3 (0.01) 102 (0.05) 123 (0.04)
Abnormal faeces 1 (0.01) 1 (0.01) 6 (0.02) 0 41 (0.08) 19 (0.01) 68 (0.02)
Abnormal loss of weight 1 (0.01) 6 (0.04) 16 (0.06) 0 11 (0.02) 18 (0.01) 57 (0.02)
Abortion 0 0 0 4 (1.39) 16 (0.03) 39 (0.02) 63 (0.02)
Abortion missed 1 (0.01) 3 (0.02) 1 (0.00) 4 (1.39) 19 (0.04) 72 (0.04) 100 (0.03)
Abortion spontaneous 10 (0.09) 34 (0.25) 38 (0.15) 93 (32.29) 153 (0.29) 1159 (0.61) 1491 (0.51)
Abscess 1 (0.01) 2 (0.01) 6 (0.02) 0 35 (0.07) 34 (0.02) 81 (0.03)
Acne 0 3 (0.02) 19 (0.07) 0 9 (0.02) 109 (0.06) 140 (0.05)
Acute coronary syndrome 33 (0.31) 54 (0.39) 3 (0.01) 0 138 (0.26) 20 (0.01) 259 (0.09)
Acute disseminated encephalomyelitis 5 (0.05) 6 (0.04) 15 (0.06) 0 60 (0.11) 13 (0.01) 108 (0.04)
Acute kidney injury 92 (0.87) 74 (0.54) 7 (0.03) 0 170 (0.32) 65 (0.03) 450 (0.15)
Acute myocardial infarction 180 (1.70) 234 (1.69) 9 (0.03) 0 282 (0.53) 51 (0.03) 773 (0.26)
Acute pulmonary oedema 24 (0.23) 17 (0.12) 0 0 41 (0.08) 4 (0.00) 89 (0.03)
Acute respiratory distress syndrome 48 (0.45) 18 (0.13) 0 0 15 (0.03) 5 (0.00) 101 (0.03)
Acute respiratory failure 76 (0.72) 29 (0.21) 1 (0.00) 0 43 (0.08) 11 (0.01) 170 (0.06)
Administration site pain 1 (0.01) 31 (0.22) 30 (0.12) 0 3 (0.01) 35 (0.02) 100 (0.03)
Adnexa uteri pain 0 0 27 (0.10) 1 (0.35) 6 (0.01) 86 (0.05) 120 (0.04)
Ageusia 2 (0.02) 19 (0.14) 162 (0.63) 0 66 (0.12) 452 (0.24) 711 (0.24)
Aggression 2 (0.02) 3 (0.02) 12 (0.05) 0 18 (0.03) 24 (0.01) 59 (0.02)
Agitation 11 (0.10) 26 (0.19) 23 (0.09) 0 60 (0.11) 116 (0.06) 244 (0.08)
Alanine aminotransferase increased 0 6 (0.04) 10 (0.04) 0 42 (0.08) 57 (0.03) 129 (0.04)
Allergy to vaccine 1 (0.01) 15 (0.11) 7 (0.03) 0 47 (0.09) 139 (0.07) 217 (0.07)
Alopecia 0 9 (0.07) 102 (0.40) 0 38 (0.07) 307 (0.16) 466 (0.16)
Alopecia areata 0 0 16 (0.06) 0 6 (0.01) 60 (0.03) 83 (0.03)
Altered state of consciousness 47 (0.44) 39 (0.28) 21 (0.08) 0 201 (0.38) 196 (0.10) 595 (0.20)
Amenorrhoea 0 18 (0.13) 184 (0.72) 6 (2.08) 34 (0.06) 600 (0.32) 848 (0.29)
Amnesia 3 (0.03) 41 (0.30) 112 (0.44) 0 130 (0.24) 231 (0.12) 534 (0.18)
Anaemia 20 (0.19) 65 (0.47) 47 (0.18) 0 168 (0.31) 141 (0.07) 472 (0.16)
Anal incontinence 1 (0.01) 2 (0.01) 10 (0.04) 0 19 (0.04) 22 (0.01) 61 (0.02)
Anaphylactic reaction 31 (0.29) 973 (7.05) 49 (0.19) 1 (0.35) 1603 (3.00) 3523 (1.87) 6267 (2.14)
Anaphylactic shock 12 (0.11) 313 (2.27) 10 (0.04) 0 270 (0.50) 353 (0.19) 981 (0.34)
Anaphylactoid reaction 1 (0.01) 16 (0.12) 2 (0.01) 0 25 (0.05) 112 (0.06) 157 (0.05)
Anger 1 (0.01) 4 (0.03) 10 (0.04) 0 5 (0.01) 34 (0.02) 56 (0.02)
Angina pectoris 13 (0.12) 100 (0.72) 105 (0.41) 1 (0.35) 349 (0.65) 1192 (0.63) 1812 (0.62)
Angioedema 3 (0.03) 143 (1.04) 23 (0.09) 1 (0.35) 194 (0.36) 1098 (0.58) 1496 (0.51)
Ankylosing spondylitis 0 0 10 (0.04) 0 10 (0.02) 81 (0.04) 104 (0.04)
Anosmia 0 17 (0.12) 136 (0.53) 0 38 (0.07) 330 (0.17) 527 (0.18)
Anovulatory cycle 0 0 14 (0.05) 0 1 (0.00) 35 (0.02) 51 (0.02)
Anxiety 16 (0.15) 98 (0.71) 289 (1.12) 1 (0.35) 279 (0.52) 1031 (0.55) 1746 (0.60)
Aortic dissection 59 (0.56) 28 (0.20) 1 (0.00) 0 13 (0.02) 4 (0.00) 108 (0.04)
Apathy 5 (0.05) 10 (0.07) 24 (0.09) 0 34 (0.06) 62 (0.03) 143 (0.05)
Aphasia 25 (0.24) 94 (0.68) 77 (0.30) 0 293 (0.55) 139 (0.07) 674 (0.23)
Aphonia 1 (0.01) 14 (0.10) 31 (0.12) 0 34 (0.06) 144 (0.08) 229 (0.08)
Aphthous ulcer 3 (0.03) 3 (0.02) 16 (0.06) 0 15 (0.03) 74 (0.04) 112 (0.04)
Apnoea 24 (0.23) 10 (0.07) 3 (0.01) 0 12 (0.02) 47 (0.02) 107 (0.04)
Appendicitis 0 66 (0.48) 13 (0.05) 0 281 (0.53) 103 (0.05) 466 (0.16)
Areflexia 2 (0.02) 6 (0.04) 11 (0.04) 0 27 (0.05) 7 (0.00) 58 (0.02)
Arrhythmia 104 (0.98) 146 (1.06) 132 (0.51) 0 862 (1.61) 1682 (0.89) 3004 (1.03)
Arterial occlusive disease 5 (0.05) 9 (0.07) 5 (0.02) 0 38 (0.07) 13 (0.01) 72 (0.02)
Arterial thrombosis 6 (0.06) 12 (0.09) 4 (0.02) 0 19 (0.04) 10 (0.01) 53 (0.02)
Arteriosclerosis 20 (0.19) 4 (0.03) 1 (0.00) 0 21 (0.04) 2 (0.00) 54 (0.02)
Arthralgia 35 (0.33) 269 (1.95) 4146 (16.12) 3 (1.04) 1184 (2.21) 8914 (4.72) 14665 (5.01)
Arthritis 0 14 (0.10) 220 (0.86) 0 96 (0.18) 430 (0.23) 770 (0.26)
Arthritis reactive 0 3 (0.02) 36 (0.14) 0 22 (0.04) 114 (0.06) 179 (0.06)
Arthropathy 0 2 (0.01) 37 (0.14) 0 15 (0.03) 61 (0.03) 115 (0.04)
Ascites 8 (0.08) 7 (0.05) 2 (0.01) 2 (0.69) 19 (0.04) 15 (0.01) 68 (0.02)
Aspartate aminotransferase increased 0 4 (0.03) 1 (0.00) 0 33 (0.06) 37 (0.02) 85 (0.03)
Asphyxia 24 (0.23) 13 (0.09) 2 (0.01) 0 9 (0.02) 45 (0.02) 101 (0.03)
Aspiration 26 (0.25) 2 (0.01) 3 (0.01) 0 6 (0.01) 7 (0.00) 54 (0.02)
Asthenia 212 (2.00) 342 (2.48) 1362 (5.29) 2 (0.69) 1724 (3.22) 4604 (2.44) 8455 (2.89)
Asthenopia 0 2 (0.01) 33 (0.13) 0 7 (0.01) 146 (0.08) 188 (0.06)
Asthma 9 (0.08) 101 (0.73) 107 (0.42) 0 257 (0.48) 695 (0.37) 1183 (0.40)
Asthmatic crisis 0 12 (0.09) 4 (0.02) 0 16 (0.03) 62 (0.03) 94 (0.03)
Asymptomatic COVID-19 7 (0.07) 2 (0.01) 0 0 164 (0.31) 641 (0.34) 819 (0.28)
Ataxia 3 (0.03) 12 (0.09) 31 (0.12) 0 60 (0.11) 23 (0.01) 140 (0.05)
Atrial fibrillation 68 (0.64) 223 (1.61) 89 (0.35) 0 793 (1.48) 862 (0.46) 2126 (0.73)
Atrial flutter 4 (0.04) 19 (0.14) 15 (0.06) 0 77 (0.14) 47 (0.02) 165 (0.06)
Atrioventricular block 5 (0.05) 20 (0.14) 5 (0.02) 0 39 (0.07) 18 (0.01) 88 (0.03)
Atrioventricular block complete 4 (0.04) 43 (0.31) 2 (0.01) 0 31 (0.06) 7 (0.00) 94 (0.03)
Auditory disorder 0 2 (0.01) 12 (0.05) 0 12 (0.02) 24 (0.01) 52 (0.02)
Autoimmune disorder 5 (0.05) 15 (0.11) 47 (0.18) 0 34 (0.06) 185 (0.10) 312 (0.11)
Autoimmune haemolytic anaemia 5 (0.05) 18 (0.13) 4 (0.02) 0 41 (0.08) 19 (0.01) 87 (0.03)
Autoimmune hepatitis 1 (0.01) 6 (0.04) 2 (0.01) 0 46 (0.09) 29 (0.02) 85 (0.03)
Autoimmune thyroiditis 0 1 (0.01) 7 (0.03) 0 14 (0.03) 125 (0.07) 150 (0.05)
Autonomic nervous system imbalance 1 (0.01) 10 (0.07) 29 (0.11) 0 12 (0.02) 25 (0.01) 80 (0.03)
Axillary mass 0 3 (0.02) 55 (0.21) 0 8 (0.01) 249 (0.13) 318 (0.11)
Axillary pain 1 (0.01) 17 (0.12) 304 (1.18) 0 56 (0.10) 2471 (1.31) 2853 (0.97)
Back pain 27 (0.25) 113 (0.82) 750 (2.92) 1 (0.35) 548 (1.02) 2457 (1.30) 3962 (1.35)
Bacterial infection 6 (0.06) 4 (0.03) 7 (0.03) 0 18 (0.03) 24 (0.01) 63 (0.02)
Balance disorder 12 (0.11) 67 (0.49) 345 (1.34) 1 (0.35) 288 (0.54) 655 (0.35) 1415 (0.48)
Basedow's disease 0 5 (0.04) 17 (0.07) 0 37 (0.07) 149 (0.08) 210 (0.07)
Bedridden 12 (0.11) 15 (0.11) 75 (0.29) 0 26 (0.05) 93 (0.05) 237 (0.08)
Bell's palsy 1 (0.01) 12 (0.09) 258 (1.00) 3 (1.04) 299 (0.56) 2004 (1.06) 2612 (0.89)
Blepharospasm 0 3 (0.02) 28 (0.11) 0 16 (0.03) 85 (0.05) 133 (0.05)
Blindness 2 (0.02) 26 (0.19) 124 (0.48) 0 84 (0.16) 344 (0.18) 615 (0.21)
Blindness transient 0 8 (0.06) 10 (0.04) 0 22 (0.04) 119 (0.06) 162 (0.06)
Blindness unilateral 0 5 (0.04) 61 (0.24) 0 26 (0.05) 81 (0.04) 191 (0.07)
Blister 2 (0.02) 11 (0.08) 66 (0.26) 0 72 (0.13) 406 (0.22) 570 (0.19)
Blood creatine phosphokinase increased 3 (0.03) 10 (0.07) 9 (0.03) 0 121 (0.23) 41 (0.02) 211 (0.07)
Blood creatinine increased 3 (0.03) 5 (0.04) 7 (0.03) 0 23 (0.04) 17 (0.01) 59 (0.02)
Blood glucose decreased 2 (0.02) 14 (0.10) 9 (0.03) 0 13 (0.02) 51 (0.03) 95 (0.03)
Blood glucose increased 6 (0.06) 24 (0.17) 23 (0.09) 0 55 (0.10) 156 (0.08) 290 (0.10)
Blood lactate dehydrogenase increased 2 (0.02) 5 (0.04) 1 (0.00) 0 30 (0.06) 11 (0.01) 60 (0.02)
Blood potassium decreased 0 8 (0.06) 1 (0.00) 0 33 (0.06) 9 (0.00) 58 (0.02)
Blood pressure abnormal 4 (0.04) 12 (0.09) 21 (0.08) 0 33 (0.06) 85 (0.05) 160 (0.05)
Blood pressure decreased 45 (0.42) 136 (0.98) 64 (0.25) 1 (0.35) 305 (0.57) 692 (0.37) 1315 (0.45)
Blood pressure fluctuation 1 (0.01) 21 (0.15) 38 (0.15) 1 (0.35) 57 (0.11) 91 (0.05) 225 (0.08)
Blood pressure increased 17 (0.16) 163 (1.18) 174 (0.68) 0 793 (1.48) 2791 (1.48) 4042 (1.38)
Blood pressure systolic increased 0 7 (0.05) 4 (0.02) 0 30 (0.06) 103 (0.05) 155 (0.05)
Blood test abnormal 1 (0.01) 3 (0.02) 7 (0.03) 0 24 (0.04) 41 (0.02) 77 (0.03)
Blood urine present 2 (0.02) 11 (0.08) 13 (0.05) 0 24 (0.04) 92 (0.05) 143 (0.05)
Body temperature 0 2 (0.01) 8 (0.03) 0 2 (0.00) 55 (0.03) 68 (0.02)
Body temperature abnormal 0 6 (0.04) 27 (0.10) 0 4 (0.01) 137 (0.07) 176 (0.06)
Body temperature decreased 5 (0.05) 9 (0.07) 20 (0.08) 0 12 (0.02) 77 (0.04) 126 (0.04)
Body temperature fluctuation 1 (0.01) 0 17 (0.07) 0 12 (0.02) 76 (0.04) 106 (0.04)
Body temperature increased 17 (0.16) 10 (0.07) 74 (0.29) 0 117 (0.22) 456 (0.24) 686 (0.23)
Bone pain 3 (0.03) 28 (0.20) 152 (0.59) 0 53 (0.10) 512 (0.27) 757 (0.26)
Bradycardia 20 (0.19) 56 (0.41) 20 (0.08) 0 127 (0.24) 518 (0.27) 783 (0.27)
Bradykinesia 1 (0.01) 7 (0.05) 7 (0.03) 0 6 (0.01) 33 (0.02) 57 (0.02)
Bradyphrenia 1 (0.01) 3 (0.02) 15 (0.06) 0 7 (0.01) 46 (0.02) 73 (0.02)
Brain injury 25 (0.24) 8 (0.06) 4 (0.02) 0 10 (0.02) 22 (0.01) 81 (0.03)
Brain oedema 27 (0.25) 17 (0.12) 5 (0.02) 0 17 (0.03) 29 (0.02) 122 (0.04)
Brain stem infarction 7 (0.07) 20 (0.14) 7 (0.03) 0 36 (0.07) 8 (0.00) 81 (0.03)
Breast cancer 0 14 (0.10) 5 (0.02) 0 7 (0.01) 73 (0.04) 100 (0.03)
Breast discomfort 0 0 6 (0.02) 0 10 (0.02) 36 (0.02) 52 (0.02)
Breast enlargement 0 4 (0.03) 5 (0.02) 0 3 (0.01) 41 (0.02) 53 (0.02)
Breast mass 0 5 (0.04) 14 (0.05) 1 (0.35) 8 (0.01) 106 (0.06) 137 (0.05)
Breast pain 0 13 (0.09) 93 (0.36) 1 (0.35) 99 (0.19) 761 (0.40) 975 (0.33)
Breast swelling 0 5 (0.04) 32 (0.12) 0 14 (0.03) 197 (0.10) 249 (0.09)
Breast tenderness 0 0 13 (0.05) 0 3 (0.01) 88 (0.05) 105 (0.04)
Bronchitis 10 (0.09) 5 (0.04) 16 (0.06) 0 31 (0.06) 78 (0.04) 149 (0.05)
Bronchospasm 5 (0.05) 61 (0.44) 5 (0.02) 0 102 (0.19) 196 (0.10) 389 (0.13)
Burning sensation 4 (0.04) 54 (0.39) 238 (0.93) 0 198 (0.37) 741 (0.39) 1266 (0.43)
Bursitis 0 3 (0.02) 50 (0.19) 0 16 (0.03) 100 (0.05) 172 (0.06)
C-reactive protein increased 27 (0.25) 29 (0.21) 35 (0.14) 0 312 (0.58) 133 (0.07) 583 (0.20)
COVID-19 860 (8.12) 176 (1.27) 168 (0.65) 2 (0.69) 1732 (3.24) 26555 (14.07) 29726 (10.16)
COVID-19 immunisation 11 (0.10) 38 (0.28) 187 (0.73) 0 81 (0.15) 65 (0.03) 383 (0.13)
COVID-19 pneumonia 245 (2.31) 85 (0.62) 9 (0.03) 0 425 (0.79) 83 (0.04) 866 (0.30)
Cardiac arrest 636 (6.01) 212 (1.54) 2 (0.01) 0 65 (0.12) 46 (0.02) 1035 (0.35)
Cardiac death 54 (0.51) 0 0 0 1 (0.00) 0 55 (0.02)
Cardiac discomfort 3 (0.03) 14 (0.10) 29 (0.11) 0 59 (0.11) 79 (0.04) 188 (0.06)
Cardiac disorder 52 (0.49) 63 (0.46) 34 (0.13) 0 132 (0.25) 161 (0.09) 459 (0.16)
Cardiac dysfunction 5 (0.05) 8 (0.06) 2 (0.01) 0 13 (0.02) 14 (0.01) 52 (0.02)
Cardiac failure 303 (2.86) 177 (1.28) 37 (0.14) 0 382 (0.71) 159 (0.08) 1114 (0.38)
Cardiac failure acute 109 (1.03) 24 (0.17) 0 0 43 (0.08) 8 (0.00) 187 (0.06)
Cardiac failure congestive 49 (0.46) 14 (0.10) 4 (0.02) 0 51 (0.10) 27 (0.01) 153 (0.05)
Cardiac fibrillation 1 (0.01) 13 (0.09) 8 (0.03) 0 34 (0.06) 45 (0.02) 107 (0.04)
Cardiac flutter 2 (0.02) 15 (0.11) 46 (0.18) 1 (0.35) 69 (0.13) 871 (0.46) 1014 (0.35)
Cardiac infection 0 5 (0.04) 5 (0.02) 0 13 (0.02) 36 (0.02) 67 (0.02)
Cardiac murmur 0 4 (0.03) 5 (0.02) 1 (0.35) 14 (0.03) 33 (0.02) 59 (0.02)
Cardiac tamponade 23 (0.22) 13 (0.09) 0 0 21 (0.04) 6 (0.00) 68 (0.02)
Cardio-respiratory arrest 416 (3.93) 70 (0.51) 0 0 16 (0.03) 2 (0.00) 550 (0.19)
Cardiogenic shock 65 (0.61) 38 (0.28) 1 (0.00) 0 16 (0.03) 8 (0.00) 134 (0.05)
Cardiomegaly 23 (0.22) 15 (0.11) 9 (0.03) 1 (0.35) 37 (0.07) 33 (0.02) 128 (0.04)
Cardiomyopathy 13 (0.12) 27 (0.20) 8 (0.03) 0 53 (0.10) 52 (0.03) 168 (0.06)
Cardiovascular disorder 39 (0.37) 34 (0.25) 55 (0.21) 0 128 (0.24) 101 (0.05) 364 (0.12)
Carditis 1 (0.01) 6 (0.04) 14 (0.05) 0 19 (0.04) 68 (0.04) 110 (0.04)
Carpal tunnel syndrome 0 1 (0.01) 12 (0.05) 0 5 (0.01) 48 (0.03) 67 (0.02)
Cataract 0 0 7 (0.03) 0 7 (0.01) 60 (0.03) 75 (0.03)
Cellulitis 8 (0.08) 10 (0.07) 17 (0.07) 0 82 (0.15) 473 (0.25) 608 (0.21)
Cerebellar haemorrhage 9 (0.08) 12 (0.09) 5 (0.02) 0 16 (0.03) 5 (0.00) 51 (0.02)
Cerebellar infarction 7 (0.07) 17 (0.12) 10 (0.04) 0 56 (0.10) 12 (0.01) 105 (0.04)
Cerebral artery embolism 11 (0.10) 16 (0.12) 5 (0.02) 0 14 (0.03) 9 (0.00) 56 (0.02)
Cerebral haemorrhage 269 (2.54) 178 (1.29) 53 (0.21) 0 268 (0.50) 60 (0.03) 862 (0.29)
Cerebral infarction 117 (1.10) 253 (1.83) 154 (0.60) 0 716 (1.34) 128 (0.07) 1419 (0.48)
Cerebral ischaemia 14 (0.13) 23 (0.17) 17 (0.07) 0 65 (0.12) 33 (0.02) 162 (0.06)
Cerebral thrombosis 26 (0.25) 62 (0.45) 15 (0.06) 0 103 (0.19) 37 (0.02) 254 (0.09)
Cerebral venous sinus thrombosis 30 (0.28) 117 (0.85) 7 (0.03) 0 150 (0.28) 51 (0.03) 363 (0.12)
Cerebral venous thrombosis 11 (0.10) 49 (0.35) 9 (0.03) 0 90 (0.17) 17 (0.01) 183 (0.06)
Cerebrovascular accident 296 (2.80) 563 (4.08) 272 (1.06) 1 (0.35) 1331 (2.49) 634 (0.34) 3210 (1.10)
Cerebrovascular disorder 14 (0.13) 6 (0.04) 5 (0.02) 0 17 (0.03) 10 (0.01) 53 (0.02)
Chest discomfort 40 (0.38) 267 (1.93) 443 (1.72) 3 (1.04) 1594 (2.98) 2532 (1.34) 4970 (1.70)
Chest pain 138 (1.30) 761 (5.51) 1107 (4.30) 1 (0.35) 3501 (6.55) 5583 (2.96) 11328 (3.87)
Chillblains 0 1 (0.01) 3 (0.01) 0 2 (0.00) 47 (0.02) 53 (0.02)
Chills 69 (0.65) 329 (2.38) 2949 (11.46) 4 (1.39) 1298 (2.43) 7911 (4.19) 12678 (4.33)
Choking 9 (0.08) 20 (0.14) 4 (0.02) 0 16 (0.03) 81 (0.04) 146 (0.05)
Choking sensation 0 14 (0.10) 7 (0.03) 0 20 (0.04) 42 (0.02) 88 (0.03)
Cholecystitis 4 (0.04) 5 (0.04) 4 (0.02) 0 29 (0.05) 13 (0.01) 60 (0.02)
Chromaturia 0 9 (0.07) 13 (0.05) 0 29 (0.05) 56 (0.03) 111 (0.04)
Chronic fatigue syndrome 0 1 (0.01) 57 (0.22) 0 19 (0.04) 79 (0.04) 159 (0.05)
Chronic kidney disease 9 (0.08) 2 (0.01) 2 (0.01) 0 21 (0.04) 13 (0.01) 52 (0.02)
Chronic obstructive pulmonary disease 33 (0.31) 16 (0.12) 6 (0.02) 0 58 (0.11) 36 (0.02) 161 (0.06)
Circulatory collapse 99 (0.93) 67 (0.49) 12 (0.05) 0 169 (0.32) 305 (0.16) 703 (0.24)
Cluster headache 0 4 (0.03) 43 (0.17) 0 19 (0.04) 170 (0.09) 236 (0.08)
Coagulopathy 21 (0.20) 37 (0.27) 28 (0.11) 0 59 (0.11) 62 (0.03) 216 (0.07)
Cognitive disorder 15 (0.14) 17 (0.12) 94 (0.37) 0 56 (0.10) 140 (0.07) 341 (0.12)
Cold sweat 13 (0.12) 71 (0.51) 108 (0.42) 0 244 (0.46) 789 (0.42) 1251 (0.43)
Colitis 3 (0.03) 12 (0.09) 14 (0.05) 0 68 (0.13) 66 (0.03) 164 (0.06)
Colitis ischaemic 3 (0.03) 4 (0.03) 0 0 43 (0.08) 28 (0.01) 79 (0.03)
Colitis ulcerative 0 9 (0.07) 31 (0.12) 0 59 (0.11) 210 (0.11) 312 (0.11)
Coma 54 (0.51) 52 (0.38) 6 (0.02) 0 38 (0.07) 14 (0.01) 197 (0.07)
Concomitant disease aggravated 12 (0.11) 1 (0.01) 15 (0.06) 0 11 (0.02) 22 (0.01) 63 (0.02)
Condition aggravated 98 (0.93) 100 (0.72) 420 (1.63) 0 388 (0.73) 1593 (0.84) 2679 (0.92)
Confusional state 61 (0.58) 173 (1.25) 295 (1.15) 0 511 (0.96) 829 (0.44) 1931 (0.66)
Congestive cardiomyopathy 6 (0.06) 15 (0.11) 3 (0.01) 0 34 (0.06) 7 (0.00) 70 (0.02)
Conjunctival haemorrhage 2 (0.02) 2 (0.01) 1 (0.00) 0 10 (0.02) 177 (0.09) 196 (0.07)
Conjunctival hyperaemia 0 2 (0.01) 2 (0.01) 0 24 (0.04) 37 (0.02) 66 (0.02)
Conjunctivitis 1 (0.01) 5 (0.04) 17 (0.07) 0 28 (0.05) 80 (0.04) 131 (0.04)
Constipation 5 (0.05) 9 (0.07) 66 (0.26) 0 59 (0.11) 186 (0.10) 341 (0.12)
Contusion 15 (0.14) 64 (0.46) 138 (0.54) 1 (0.35) 162 (0.30) 784 (0.42) 1193 (0.41)
Conversion disorder 0 0 17 (0.07) 0 25 (0.05) 16 (0.01) 60 (0.02)
Coordination abnormal 5 (0.05) 12 (0.09) 48 (0.19) 1 (0.35) 54 (0.10) 65 (0.03) 192 (0.07)
Coronary artery disease 22 (0.21) 21 (0.15) 2 (0.01) 0 38 (0.07) 6 (0.00) 93 (0.03)
Coronary artery thrombosis 15 (0.14) 25 (0.18) 0 0 15 (0.03) 3 (0.00) 66 (0.02)
Costochondritis 0 3 (0.02) 33 (0.13) 0 34 (0.06) 83 (0.04) 156 (0.05)
Cough 123 (1.16) 241 (1.75) 507 (1.97) 2 (0.69) 1125 (2.10) 2970 (1.57) 5079 (1.74)
Crohn's disease 0 3 (0.02) 17 (0.07) 0 32 (0.06) 116 (0.06) 172 (0.06)
Crying 0 8 (0.06) 35 (0.14) 0 23 (0.04) 145 (0.08) 214 (0.07)
Cutaneous vasculitis 1 (0.01) 4 (0.03) 1 (0.00) 0 64 (0.12) 71 (0.04) 145 (0.05)
Cyanosis 39 (0.37) 53 (0.38) 22 (0.09) 0 100 (0.19) 109 (0.06) 361 (0.12)
Cyst 0 1 (0.01) 7 (0.03) 0 9 (0.02) 35 (0.02) 53 (0.02)
Cystitis 1 (0.01) 6 (0.04) 15 (0.06) 0 29 (0.05) 91 (0.05) 148 (0.05)
Deafness 0 18 (0.13) 169 (0.66) 0 68 (0.13) 632 (0.33) 920 (0.31)
Deafness neurosensory 0 1 (0.01) 44 (0.17) 0 13 (0.02) 86 (0.05) 146 (0.05)
Deafness unilateral 0 1 (0.01) 113 (0.44) 0 32 (0.06) 269 (0.14) 427 (0.15)
Death 1999 (18.88) 0 0 0 1 (0.00) 4 (0.00) 2005 (0.69)
Decreased appetite 99 (0.93) 87 (0.63) 486 (1.89) 1 (0.35) 517 (0.97) 1672 (0.89) 2957 (1.01)
Deep vein thrombosis 62 (0.59) 536 (3.88) 74 (0.29) 1 (0.35) 954 (1.78) 1810 (0.96) 3520 (1.20)
Dehydration 45 (0.42) 37 (0.27) 42 (0.16) 0 184 (0.34) 256 (0.14) 605 (0.21)
Delirium 18 (0.17) 33 (0.24) 29 (0.11) 0 85 (0.16) 226 (0.12) 429 (0.15)
Dementia 14 (0.13) 3 (0.02) 21 (0.08) 0 27 (0.05) 69 (0.04) 161 (0.06)
Demyelination 2 (0.02) 3 (0.02) 19 (0.07) 0 43 (0.08) 33 (0.02) 113 (0.04)
Depressed level of consciousness 85 (0.80) 92 (0.67) 30 (0.12) 0 278 (0.52) 510 (0.27) 1126 (0.38)
Depressed mood 1 (0.01) 11 (0.08) 85 (0.33) 0 30 (0.06) 348 (0.18) 479 (0.16)
Depression 2 (0.02) 39 (0.28) 141 (0.55) 1 (0.35) 64 (0.12) 348 (0.18) 605 (0.21)
Dermatitis 1 (0.01) 7 (0.05) 22 (0.09) 0 23 (0.04) 151 (0.08) 206 (0.07)
Dermatitis allergic 0 11 (0.08) 28 (0.11) 0 45 (0.08) 224 (0.12) 311 (0.11)
Dermatitis atopic 0 0 17 (0.07) 1 (0.35) 10 (0.02) 48 (0.03) 76 (0.03)
Dermatitis bullous 2 (0.02) 0 10 (0.04) 0 20 (0.04) 81 (0.04) 114 (0.04)
Diabetes mellitus 9 (0.08) 13 (0.09) 16 (0.06) 0 44 (0.08) 157 (0.08) 258 (0.09)
Diabetes mellitus inadequate control 4 (0.04) 2 (0.01) 4 (0.02) 0 10 (0.02) 75 (0.04) 99 (0.03)
Diabetic ketoacidosis 7 (0.07) 15 (0.11) 2 (0.01) 0 17 (0.03) 18 (0.01) 65 (0.02)
Diarrhoea 105 (0.99) 184 (1.33) 950 (3.69) 3 (1.04) 1076 (2.01) 4667 (2.47) 7116 (2.43)
Diarrhoea haemorrhagic 0 10 (0.07) 3 (0.01) 0 30 (0.06) 92 (0.05) 139 (0.05)
Diplegia 3 (0.03) 7 (0.05) 28 (0.11) 0 23 (0.04) 50 (0.03) 118 (0.04)
Diplopia 2 (0.02) 20 (0.14) 127 (0.49) 0 217 (0.41) 242 (0.13) 626 (0.21)
Discomfort 13 (0.12) 31 (0.22) 152 (0.59) 0 171 (0.32) 701 (0.37) 1087 (0.37)
Disease recurrence 22 (0.21) 73 (0.53) 143 (0.56) 0 197 (0.37) 986 (0.52) 1456 (0.50)
Disorientation 14 (0.13) 35 (0.25) 84 (0.33) 0 141 (0.26) 331 (0.18) 622 (0.21)
Disseminated intravascular coagulation 26 (0.25) 19 (0.14) 0 0 11 (0.02) 5 (0.00) 79 (0.03)
Disturbance in attention 11 (0.10) 32 (0.23) 291 (1.13) 1 (0.35) 201 (0.38) 611 (0.32) 1175 (0.40)
Diverticulitis 2 (0.02) 3 (0.02) 5 (0.02) 0 48 (0.09) 84 (0.04) 148 (0.05)
Dizziness 75 (0.71) 674 (4.88) 2216 (8.61) 6 (2.08) 3617 (6.76) 9251 (4.90) 16086 (5.50)
Dizziness exertional 0 0 12 (0.05) 0 5 (0.01) 49 (0.03) 68 (0.02)
Dizziness postural 0 6 (0.04) 88 (0.34) 0 42 (0.08) 563 (0.30) 701 (0.24)
Drug eruption 0 2 (0.01) 2 (0.01) 0 32 (0.06) 84 (0.04) 121 (0.04)
Drug hypersensitivity 1 (0.01) 11 (0.08) 9 (0.03) 0 26 (0.05) 91 (0.05) 144 (0.05)
Drug ineffective 253 (2.39) 118 (0.85) 128 (0.50) 2 (0.69) 610 (1.14) 7885 (4.18) 9250 (3.16)
Drug interaction 5 (0.05) 6 (0.04) 7 (0.03) 0 34 (0.06) 54 (0.03) 107 (0.04)
Dry eye 0 3 (0.02) 46 (0.18) 0 14 (0.03) 129 (0.07) 196 (0.07)
Dry mouth 1 (0.01) 37 (0.27) 76 (0.30) 0 89 (0.17) 344 (0.18) 558 (0.19)
Dry skin 0 6 (0.04) 32 (0.12) 0 7 (0.01) 150 (0.08) 199 (0.07)
Dry throat 0 4 (0.03) 26 (0.10) 0 20 (0.04) 114 (0.06) 166 (0.06)
Dysaesthesia 0 9 (0.07) 25 (0.10) 0 70 (0.13) 114 (0.06) 223 (0.08)
Dysarthria 30 (0.28) 69 (0.50) 104 (0.40) 1 (0.35) 327 (0.61) 180 (0.10) 755 (0.26)
Dysentery 1 (0.01) 2 (0.01) 18 (0.07) 0 9 (0.02) 99 (0.05) 129 (0.04)
Dysgeusia 2 (0.02) 29 (0.21) 113 (0.44) 0 114 (0.21) 585 (0.31) 853 (0.29)
Dyskinesia 4 (0.04) 12 (0.09) 48 (0.19) 1 (0.35) 91 (0.17) 120 (0.06) 286 (0.10)
Dyslalia 0 3 (0.02) 9 (0.03) 0 46 (0.09) 6 (0.00) 78 (0.03)
Dysmenorrhoea 0 8 (0.06) 357 (1.39) 2 (0.69) 67 (0.13) 2815 (1.49) 3259 (1.11)
Dyspepsia 2 (0.02) 27 (0.20) 100 (0.39) 0 58 (0.11) 357 (0.19) 555 (0.19)
Dysphagia 40 (0.38) 131 (0.95) 123 (0.48) 1 (0.35) 301 (0.56) 556 (0.29) 1206 (0.41)
Dysphemia 0 4 (0.03) 10 (0.04) 0 19 (0.04) 19 (0.01) 55 (0.02)
Dysphonia 2 (0.02) 63 (0.46) 64 (0.25) 0 176 (0.33) 356 (0.19) 693 (0.24)
Dysphoria 3 (0.03) 6 (0.04) 0 0 61 (0.11) 116 (0.06) 193 (0.07)
Dyspnoea 622 (5.87) 1572 (11.38) 1553 (6.04) 6 (2.08) 4885 (9.13) 7431 (3.94) 16633 (5.68)
Dyspnoea at rest 1 (0.01) 9 (0.07) 6 (0.02) 0 27 (0.05) 74 (0.04) 125 (0.04)
Dyspnoea exertional 16 (0.15) 68 (0.49) 69 (0.27) 0 217 (0.41) 276 (0.15) 686 (0.23)
Dysstasia 6 (0.06) 28 (0.20) 98 (0.38) 0 143 (0.27) 222 (0.12) 527 (0.18)
Dystonia 0 1 (0.01) 7 (0.03) 0 8 (0.01) 34 (0.02) 53 (0.02)
Dysuria 6 (0.06) 9 (0.07) 23 (0.09) 0 59 (0.11) 98 (0.05) 199 (0.07)
Ear discomfort 0 7 (0.05) 100 (0.39) 0 53 (0.10) 211 (0.11) 384 (0.13)
Ear disorder 0 2 (0.01) 22 (0.09) 1 (0.35) 7 (0.01) 32 (0.02) 66 (0.02)
Ear infection 0 3 (0.02) 23 (0.09) 0 11 (0.02) 109 (0.06) 150 (0.05)
Ear pain 2 (0.02) 15 (0.11) 217 (0.84) 0 92 (0.17) 863 (0.46) 1208 (0.41)
Ear swelling 0 3 (0.02) 8 (0.03) 0 15 (0.03) 49 (0.03) 77 (0.03)
Eating disorder 6 (0.06) 9 (0.07) 19 (0.07) 0 37 (0.07) 56 (0.03) 136 (0.05)
Ecchymosis 2 (0.02) 9 (0.07) 5 (0.02) 1 (0.35) 51 (0.10) 51 (0.03) 126 (0.04)
Eczema 1 (0.01) 2 (0.01) 58 (0.23) 0 56 (0.10) 313 (0.17) 436 (0.15)
Ejection fraction decreased 1 (0.01) 8 (0.06) 6 (0.02) 0 27 (0.05) 9 (0.00) 63 (0.02)
Electric shock sensation 0 15 (0.11) 52 (0.20) 0 19 (0.04) 61 (0.03) 148 (0.05)
Electrocardiogram ST segment elevation 0 5 (0.04) 1 (0.00) 0 87 (0.16) 105 (0.06) 220 (0.08)
Electrocardiogram abnormal 0 13 (0.09) 4 (0.02) 0 63 (0.12) 45 (0.02) 134 (0.05)
Embolic stroke 5 (0.05) 16 (0.12) 9 (0.03) 0 49 (0.09) 12 (0.01) 95 (0.03)
Embolism 28 (0.26) 42 (0.30) 25 (0.10) 0 75 (0.14) 70 (0.04) 256 (0.09)
Emotional disorder 0 1 (0.01) 22 (0.09) 0 6 (0.01) 71 (0.04) 100 (0.03)
Emotional distress 1 (0.01) 11 (0.08) 32 (0.12) 0 16 (0.03) 72 (0.04) 135 (0.05)
Encephalitis 12 (0.11) 44 (0.32) 17 (0.07) 0 127 (0.24) 30 (0.02) 242 (0.08)
Encephalopathy 10 (0.09) 9 (0.07) 7 (0.03) 0 38 (0.07) 21 (0.01) 101 (0.03)
Endocarditis 10 (0.09) 11 (0.08) 1 (0.00) 0 31 (0.06) 14 (0.01) 71 (0.02)
Endometriosis 0 0 26 (0.10) 0 18 (0.03) 103 (0.05) 148 (0.05)
Eosinophilia 0 5 (0.04) 6 (0.02) 0 29 (0.05) 21 (0.01) 65 (0.02)
Epilepsy 25 (0.24) 98 (0.71) 48 (0.19) 0 407 (0.76) 494 (0.26) 1097 (0.37)
Epistaxis 9 (0.08) 53 (0.38) 81 (0.31) 1 (0.35) 179 (0.33) 580 (0.31) 916 (0.31)
Epstein-Barr virus infection reactivation 0 2 (0.01) 4 (0.02) 0 11 (0.02) 38 (0.02) 56 (0.02)
Erectile dysfunction 0 3 (0.02) 45 (0.17) 0 8 (0.01) 180 (0.10) 242 (0.08)
Eructation 0 3 (0.02) 14 (0.05) 0 18 (0.03) 44 (0.02) 84 (0.03)
Erysipelas 5 (0.05) 3 (0.02) 5 (0.02) 0 61 (0.11) 79 (0.04) 157 (0.05)
Erythema 11 (0.10) 143 (1.04) 215 (0.84) 0 724 (1.35) 2561 (1.36) 3726 (1.27)
Erythema multiforme 1 (0.01) 2 (0.01) 5 (0.02) 0 65 (0.12) 190 (0.10) 270 (0.09)
Erythema nodosum 0 2 (0.01) 7 (0.03) 0 27 (0.05) 61 (0.03) 98 (0.03)
Erythema of eyelid 0 1 (0.01) 4 (0.02) 0 10 (0.02) 41 (0.02) 56 (0.02)
Exercise tolerance decreased 1 (0.01) 13 (0.09) 104 (0.40) 0 61 (0.11) 71 (0.04) 262 (0.09)
Exposure during pregnancy 2 (0.02) 11 (0.08) 2 (0.01) 3 (1.04) 29 (0.05) 96 (0.05) 147 (0.05)
Exposure via breast milk 2 (0.02) 2 (0.01) 4 (0.02) 2 (0.69) 19 (0.04) 175 (0.09) 205 (0.07)
Extensive swelling of vaccinated limb 2 (0.02) 10 (0.07) 332 (1.29) 0 14 (0.03) 86 (0.05) 444 (0.15)
Extrasystoles 2 (0.02) 33 (0.24) 73 (0.28) 0 122 (0.23) 291 (0.15) 527 (0.18)
Eye disorder 1 (0.01) 4 (0.03) 34 (0.13) 0 51 (0.10) 112 (0.06) 203 (0.07)
Eye haemorrhage 1 (0.01) 4 (0.03) 18 (0.07) 0 14 (0.03) 252 (0.13) 297 (0.10)
Eye inflammation 0 0 22 (0.09) 0 13 (0.02) 49 (0.03) 86 (0.03)
Eye irritation 0 8 (0.06) 34 (0.13) 0 11 (0.02) 142 (0.08) 198 (0.07)
Eye movement disorder 1 (0.01) 15 (0.11) 26 (0.10) 0 46 (0.09) 59 (0.03) 156 (0.05)
Eye oedema 0 4 (0.03) 11 (0.04) 0 9 (0.02) 36 (0.02) 61 (0.02)
Eye pain 1 (0.01) 37 (0.27) 260 (1.01) 0 147 (0.27) 1058 (0.56) 1525 (0.52)
Eye pruritus 0 14 (0.10) 33 (0.13) 0 33 (0.06) 239 (0.13) 328 (0.11)
Eye swelling 0 38 (0.28) 58 (0.23) 1 (0.35) 63 (0.12) 537 (0.28) 708 (0.24)
Eyelid oedema 0 11 (0.08) 8 (0.03) 0 54 (0.10) 152 (0.08) 231 (0.08)
Eyelid ptosis 1 (0.01) 7 (0.05) 21 (0.08) 0 50 (0.09) 79 (0.04) 167 (0.06)
Face oedema 2 (0.02) 40 (0.29) 26 (0.10) 0 116 (0.22) 277 (0.15) 472 (0.16)
Facial asymmetry 0 1 (0.01) 4 (0.02) 0 25 (0.05) 22 (0.01) 53 (0.02)
Facial pain 0 4 (0.03) 68 (0.26) 0 50 (0.09) 269 (0.14) 397 (0.14)
Facial paralysis 5 (0.05) 54 (0.39) 234 (0.91) 2 (0.69) 743 (1.39) 2189 (1.16) 3290 (1.12)
Facial paresis 1 (0.01) 29 (0.21) 93 (0.36) 0 318 (0.59) 333 (0.18) 790 (0.27)
Facial spasm 0 5 (0.04) 17 (0.07) 0 5 (0.01) 33 (0.02) 60 (0.02)
Faeces discoloured 4 (0.04) 5 (0.04) 10 (0.04) 0 17 (0.03) 39 (0.02) 81 (0.03)
Fall 99 (0.93) 99 (0.72) 124 (0.48) 0 459 (0.86) 611 (0.32) 1530 (0.52)
Fatigue 212 (2.00) 720 (5.21) 6691 (26.01) 10 (3.47) 2833 (5.30) 17547 (9.30) 28270 (9.66)
Fear 1 (0.01) 7 (0.05) 17 (0.07) 0 12 (0.02) 66 (0.03) 105 (0.04)
Febrile convulsion 1 (0.01) 4 (0.03) 5 (0.02) 1 (0.35) 35 (0.07) 39 (0.02) 85 (0.03)
Feeding disorder 6 (0.06) 16 (0.12) 59 (0.23) 0 52 (0.10) 147 (0.08) 303 (0.10)
Feeling abnormal 16 (0.15) 120 (0.87) 598 (2.32) 1 (0.35) 539 (1.01) 2356 (1.25) 3722 (1.27)
Feeling cold 6 (0.06) 48 (0.35) 252 (0.98) 0 181 (0.34) 1367 (0.72) 1875 (0.64)
Feeling drunk 1 (0.01) 3 (0.02) 15 (0.06) 1 (0.35) 9 (0.02) 88 (0.05) 118 (0.04)
Feeling hot 4 (0.04) 92 (0.67) 218 (0.85) 1 (0.35) 390 (0.73) 1562 (0.83) 2303 (0.79)
Feeling jittery 1 (0.01) 2 (0.01) 5 (0.02) 0 22 (0.04) 42 (0.02) 76 (0.03)
Feeling of body temperature change 1 (0.01) 13 (0.09) 96 (0.37) 0 63 (0.12) 451 (0.24) 625 (0.21)
Fibrin D dimer increased 14 (0.13) 43 (0.31) 20 (0.08) 0 210 (0.39) 205 (0.11) 525 (0.18)
Fibromyalgia 1 (0.01) 6 (0.04) 87 (0.34) 0 14 (0.03) 135 (0.07) 246 (0.08)
Fine motor skill dysfunction 1 (0.01) 2 (0.01) 17 (0.07) 0 14 (0.03) 16 (0.01) 52 (0.02)
Flank pain 2 (0.02) 4 (0.03) 22 (0.09) 0 38 (0.07) 73 (0.04) 142 (0.05)
Flatulence 1 (0.01) 7 (0.05) 33 (0.13) 0 18 (0.03) 138 (0.07) 200 (0.07)
Fluid retention 6 (0.06) 9 (0.07) 14 (0.05) 1 (0.35) 21 (0.04) 48 (0.03) 104 (0.04)
Flushing 1 (0.01) 57 (0.41) 40 (0.16) 0 183 (0.34) 544 (0.29) 841 (0.29)
Foetal death 22 (0.21) 4 (0.03) 2 (0.01) 6 (2.08) 29 (0.05) 46 (0.02) 112 (0.04)
Foetal exposure during pregnancy 16 (0.15) 7 (0.05) 1 (0.00) 13 (4.51) 5 (0.01) 7 (0.00) 53 (0.02)
Foetal growth restriction 16 (0.15) 3 (0.02) 1 (0.00) 10 (3.47) 3 (0.01) 25 (0.01) 62 (0.02)
Food allergy 0 20 (0.14) 14 (0.05) 0 9 (0.02) 38 (0.02) 84 (0.03)
Formication 0 4 (0.03) 26 (0.10) 1 (0.35) 12 (0.02) 122 (0.06) 169 (0.06)
Fracture 1 (0.01) 2 (0.01) 3 (0.01) 0 20 (0.04) 24 (0.01) 53 (0.02)
Gait disturbance 20 (0.19) 100 (0.72) 530 (2.06) 0 528 (0.99) 835 (0.44) 2118 (0.72)
Gait inability 8 (0.08) 33 (0.24) 212 (0.82) 0 156 (0.29) 247 (0.13) 705 (0.24)
Gamma-glutamyltransferase increased 0 2 (0.01) 3 (0.01) 0 20 (0.04) 20 (0.01) 51 (0.02)
Gastric disorder 2 (0.02) 2 (0.01) 9 (0.03) 0 7 (0.01) 31 (0.02) 53 (0.02)
Gastritis 1 (0.01) 2 (0.01) 24 (0.09) 0 36 (0.07) 56 (0.03) 123 (0.04)
Gastroenteritis 2 (0.02) 4 (0.03) 3 (0.01) 0 51 (0.10) 38 (0.02) 101 (0.03)
Gastrointestinal disorder 4 (0.04) 8 (0.06) 42 (0.16) 0 58 (0.11) 113 (0.06) 234 (0.08)
Gastrointestinal haemorrhage 34 (0.32) 19 (0.14) 1 (0.00) 0 37 (0.07) 30 (0.02) 131 (0.04)
Gastrointestinal pain 0 10 (0.07) 44 (0.17) 0 45 (0.08) 132 (0.07) 236 (0.08)
Gastrooesophageal reflux disease 2 (0.02) 11 (0.08) 52 (0.20) 0 35 (0.07) 133 (0.07) 235 (0.08)
Gaze palsy 4 (0.04) 5 (0.04) 4 (0.02) 0 18 (0.03) 26 (0.01) 63 (0.02)
General physical health deterioration 222 (2.10) 51 (0.37) 67 (0.26) 0 260 (0.49) 85 (0.05) 754 (0.26)
Generalised oedema 8 (0.08) 7 (0.05) 7 (0.03) 0 26 (0.05) 36 (0.02) 92 (0.03)
Generalised tonic-clonic seizure 8 (0.08) 47 (0.34) 10 (0.04) 0 171 (0.32) 200 (0.11) 447 (0.15)
Genital haemorrhage 0 1 (0.01) 1 (0.00) 0 9 (0.02) 69 (0.04) 81 (0.03)
Genital herpes 0 0 17 (0.07) 0 14 (0.03) 79 (0.04) 110 (0.04)
Giant cell arteritis 2 (0.02) 10 (0.07) 15 (0.06) 0 70 (0.13) 43 (0.02) 141 (0.05)
Gingival bleeding 0 13 (0.09) 11 (0.04) 0 31 (0.06) 66 (0.03) 122 (0.04)
Gingival pain 0 2 (0.01) 16 (0.06) 0 4 (0.01) 88 (0.05) 111 (0.04)
Gingival swelling 1 (0.01) 3 (0.02) 12 (0.05) 0 2 (0.00) 45 (0.02) 64 (0.02)
Glaucoma 0 1 (0.01) 6 (0.02) 0 9 (0.02) 40 (0.02) 59 (0.02)
Glossodynia 0 4 (0.03) 31 (0.12) 0 14 (0.03) 131 (0.07) 180 (0.06)
Goitre 1 (0.01) 1 (0.01) 9 (0.03) 0 12 (0.02) 30 (0.02) 56 (0.02)
Gout 0 3 (0.02) 31 (0.12) 0 22 (0.04) 80 (0.04) 138 (0.05)
Grip strength decreased 1 (0.01) 1 (0.01) 37 (0.14) 0 21 (0.04) 69 (0.04) 131 (0.04)
Groin pain 4 (0.04) 6 (0.04) 50 (0.19) 0 30 (0.06) 128 (0.07) 225 (0.08)
Guillain-Barre syndrome 22 (0.21) 99 (0.72) 104 (0.40) 0 571 (1.07) 280 (0.15) 1120 (0.38)
Haematemesis 38 (0.36) 17 (0.12) 12 (0.05) 0 47 (0.09) 86 (0.05) 216 (0.07)
Haematochezia 7 (0.07) 8 (0.06) 22 (0.09) 1 (0.35) 75 (0.14) 351 (0.19) 478 (0.16)
Haematoma 13 (0.12) 41 (0.30) 61 (0.24) 1 (0.35) 117 (0.22) 203 (0.11) 448 (0.15)
Haematuria 4 (0.04) 18 (0.13) 11 (0.04) 0 82 (0.15) 143 (0.08) 268 (0.09)
Haemoglobin decreased 7 (0.07) 17 (0.12) 8 (0.03) 0 58 (0.11) 35 (0.02) 137 (0.05)
Haemolytic anaemia 5 (0.05) 13 (0.09) 2 (0.01) 0 28 (0.05) 11 (0.01) 62 (0.02)
Haemophagocytic lymphohistiocytosis 8 (0.08) 14 (0.10) 0 0 19 (0.04) 7 (0.00) 51 (0.02)
Haemoptysis 16 (0.15) 34 (0.25) 20 (0.08) 0 66 (0.12) 85 (0.05) 237 (0.08)
Haemorrhage 25 (0.24) 66 (0.48) 80 (0.31) 8 (2.78) 149 (0.28) 1567 (0.83) 1945 (0.66)
Haemorrhage intracranial 20 (0.19) 17 (0.12) 1 (0.00) 0 20 (0.04) 5 (0.00) 70 (0.02)
Haemorrhage subcutaneous 3 (0.03) 1 (0.01) 2 (0.01) 0 13 (0.02) 170 (0.09) 206 (0.07)
Haemorrhage urinary tract 1 (0.01) 2 (0.01) 3 (0.01) 0 4 (0.01) 57 (0.03) 70 (0.02)
Haemorrhagic diathesis 1 (0.01) 4 (0.03) 1 (0.00) 0 13 (0.02) 27 (0.01) 55 (0.02)
Haemorrhagic stroke 64 (0.60) 31 (0.22) 8 (0.03) 0 31 (0.06) 11 (0.01) 147 (0.05)
Haemorrhoids 1 (0.01) 0 9 (0.03) 0 7 (0.01) 44 (0.02) 62 (0.02)
Hallucination 7 (0.07) 29 (0.21) 57 (0.22) 0 55 (0.10) 455 (0.24) 625 (0.21)
Hallucination, auditory 0 3 (0.02) 6 (0.02) 0 13 (0.02) 46 (0.02) 70 (0.02)
Hallucination, visual 1 (0.01) 6 (0.04) 10 (0.04) 0 19 (0.04) 90 (0.05) 129 (0.04)
Hangover 0 0 20 (0.08) 0 3 (0.01) 60 (0.03) 83 (0.03)
Head discomfort 0 36 (0.26) 152 (0.59) 1 (0.35) 156 (0.29) 441 (0.23) 805 (0.28)
Head injury 4 (0.04) 18 (0.13) 10 (0.04) 0 62 (0.12) 130 (0.07) 242 (0.08)
Headache 135 (1.27) 863 (6.25) 6468 (25.14) 8 (2.78) 4598 (8.60) 21739 (11.52) 34173 (11.68)
Heart rate 0 2 (0.01) 17 (0.07) 0 18 (0.03) 78 (0.04) 115 (0.04)
Heart rate abnormal 0 16 (0.12) 29 (0.11) 0 42 (0.08) 149 (0.08) 239 (0.08)
Heart rate decreased 6 (0.06) 43 (0.31) 33 (0.13) 1 (0.35) 96 (0.18) 276 (0.15) 482 (0.16)
Heart rate increased 21 (0.20) 226 (1.64) 379 (1.47) 0 668 (1.25) 1663 (0.88) 3038 (1.04)
Heart rate irregular 1 (0.01) 41 (0.30) 83 (0.32) 1 (0.35) 127 (0.24) 319 (0.17) 581 (0.20)
Heavy menstrual bleeding 0 47 (0.34) 529 (2.06) 7 (2.43) 205 (0.38) 4485 (2.38) 5296 (1.81)
Hemianaesthesia 0 9 (0.07) 24 (0.09) 0 55 (0.10) 54 (0.03) 144 (0.05)
Hemiparaesthesia 1 (0.01) 1 (0.01) 12 (0.05) 0 47 (0.09) 117 (0.06) 181 (0.06)
Hemiparesis 45 (0.42) 89 (0.64) 104 (0.40) 0 356 (0.67) 248 (0.13) 908 (0.31)
Hemiplegia 21 (0.20) 45 (0.33) 55 (0.21) 0 146 (0.27) 87 (0.05) 413 (0.14)
Henoch-Schonlein purpura 1 (0.01) 1 (0.01) 5 (0.02) 0 38 (0.07) 23 (0.01) 69 (0.02)
Hepatic cytolysis 1 (0.01) 2 (0.01) 0 0 44 (0.08) 48 (0.03) 97 (0.03)
Hepatic enzyme increased 4 (0.04) 9 (0.07) 5 (0.02) 0 58 (0.11) 36 (0.02) 119 (0.04)
Hepatic failure 22 (0.21) 9 (0.07) 1 (0.00) 0 15 (0.03) 7 (0.00) 61 (0.02)
Hepatic function abnormal 6 (0.06) 11 (0.08) 4 (0.02) 0 89 (0.17) 39 (0.02) 156 (0.05)
Hepatitis 4 (0.04) 4 (0.03) 4 (0.02) 0 59 (0.11) 67 (0.04) 146 (0.05)
Hepatitis acute 4 (0.04) 5 (0.04) 1 (0.00) 0 46 (0.09) 22 (0.01) 81 (0.03)
Herpes ophthalmic 0 0 3 (0.01) 0 6 (0.01) 69 (0.04) 79 (0.03)
Herpes simplex 0 1 (0.01) 7 (0.03) 0 16 (0.03) 54 (0.03) 78 (0.03)
Herpes virus infection 0 1 (0.01) 14 (0.05) 0 8 (0.01) 44 (0.02) 69 (0.02)
Herpes zoster 15 (0.14) 36 (0.26) 317 (1.23) 1 (0.35) 543 (1.02) 2572 (1.36) 3506 (1.20)
Herpes zoster oticus 0 3 (0.02) 11 (0.04) 0 40 (0.07) 67 (0.04) 124 (0.04)
Hormone level abnormal 1 (0.01) 2 (0.01) 24 (0.09) 0 7 (0.01) 90 (0.05) 124 (0.04)
Hospitalisation 2 (0.02) 5 (0.04) 1 (0.00) 0 93 (0.17) 1 (0.00) 127 (0.04)
Hot flush 1 (0.01) 20 (0.14) 156 (0.61) 0 126 (0.24) 871 (0.46) 1185 (0.40)
Hyperacusis 0 4 (0.03) 64 (0.25) 1 (0.35) 32 (0.06) 95 (0.05) 199 (0.07)
Hyperaesthesia 0 2 (0.01) 59 (0.23) 0 21 (0.04) 162 (0.09) 247 (0.08)
Hyperglycaemia 7 (0.07) 17 (0.12) 12 (0.05) 0 38 (0.07) 106 (0.06) 188 (0.06)
Hyperhidrosis 24 (0.23) 180 (1.30) 481 (1.87) 2 (0.69) 518 (0.97) 2422 (1.28) 3682 (1.26)
Hyperpyrexia 24 (0.23) 15 (0.11) 11 (0.04) 0 82 (0.15) 643 (0.34) 782 (0.27)
Hypersensitivity 10 (0.09) 326 (2.36) 181 (0.70) 2 (0.69) 694 (1.30) 1765 (0.94) 3043 (1.04)
Hypersomnia 3 (0.03) 14 (0.10) 87 (0.34) 0 27 (0.05) 270 (0.14) 412 (0.14)
Hypertension 49 (0.46) 323 (2.34) 248 (0.96) 2 (0.69) 1128 (2.11) 2825 (1.50) 4715 (1.61)
Hypertensive crisis 10 (0.09) 49 (0.35) 11 (0.04) 0 203 (0.38) 477 (0.25) 766 (0.26)
Hyperthermia 9 (0.08) 8 (0.06) 13 (0.05) 0 39 (0.07) 72 (0.04) 147 (0.05)
Hyperthyroidism 1 (0.01) 9 (0.07) 26 (0.10) 0 35 (0.07) 194 (0.10) 269 (0.09)
Hyperventilation 1 (0.01) 22 (0.16) 16 (0.06) 0 149 (0.28) 196 (0.10) 396 (0.14)
Hypoacusis 1 (0.01) 12 (0.09) 180 (0.70) 0 68 (0.13) 316 (0.17) 583 (0.20)
Hypoaesthesia 11 (0.10) 292 (2.11) 1199 (4.66) 4 (1.39) 1446 (2.70) 3332 (1.77) 6415 (2.19)
Hypoaesthesia oral 2 (0.02) 64 (0.46) 85 (0.33) 1 (0.35) 165 (0.31) 527 (0.28) 865 (0.30)
Hypoglycaemia 7 (0.07) 27 (0.20) 11 (0.04) 1 (0.35) 35 (0.07) 131 (0.07) 215 (0.07)
Hypokalaemia 5 (0.05) 15 (0.11) 4 (0.02) 0 47 (0.09) 30 (0.02) 125 (0.04)
Hypokinesia 3 (0.03) 13 (0.09) 127 (0.49) 1 (0.35) 56 (0.10) 259 (0.14) 473 (0.16)
Hypomenorrhoea 0 0 40 (0.16) 1 (0.35) 6 (0.01) 284 (0.15) 331 (0.11)
Hyponatraemia 6 (0.06) 22 (0.16) 6 (0.02) 0 49 (0.09) 2 (0.00) 93 (0.03)
Hypophagia 19 (0.18) 3 (0.02) 7 (0.03) 0 39 (0.07) 34 (0.02) 114 (0.04)
Hypopnoea 5 (0.05) 17 (0.12) 19 (0.07) 0 21 (0.04) 110 (0.06) 185 (0.06)
Hypotension 84 (0.79) 209 (1.51) 110 (0.43) 1 (0.35) 447 (0.84) 897 (0.48) 1843 (0.63)
Hypothermia 10 (0.09) 14 (0.10) 9 (0.03) 0 17 (0.03) 144 (0.08) 205 (0.07)
Hypothyroidism 0 3 (0.02) 26 (0.10) 0 16 (0.03) 133 (0.07) 187 (0.06)
Hypotonia 7 (0.07) 11 (0.08) 21 (0.08) 0 77 (0.14) 71 (0.04) 194 (0.07)
Hypotonic-hyporesponsive episode 6 (0.06) 1 (0.01) 0 0 15 (0.03) 46 (0.02) 69 (0.02)
Hypovolaemic shock 8 (0.08) 3 (0.02) 0 0 8 (0.01) 61 (0.03) 85 (0.03)
Hypoxia 55 (0.52) 45 (0.33) 4 (0.02) 0 100 (0.19) 86 (0.05) 352 (0.12)
IIIrd nerve paralysis 0 2 (0.01) 3 (0.01) 0 24 (0.04) 27 (0.01) 59 (0.02)
Illness 13 (0.12) 66 (0.48) 267 (1.04) 3 (1.04) 210 (0.39) 1578 (0.84) 2168 (0.74)
Immobile 3 (0.03) 5 (0.04) 23 (0.09) 0 9 (0.02) 49 (0.03) 98 (0.03)
Immune system disorder 4 (0.04) 4 (0.03) 28 (0.11) 0 24 (0.04) 80 (0.04) 153 (0.05)
Immune thrombocytopenia 13 (0.12) 134 (0.97) 4 (0.02) 0 299 (0.56) 213 (0.11) 674 (0.23)
Immunisation 120 (1.13) 329 (2.38) 1113 (4.33) 7 (2.43) 779 (1.46) 12489 (6.62) 14936 (5.10)
Immunisation reaction 0 0 5 (0.02) 0 36 (0.07) 149 (0.08) 200 (0.07)
Immunodeficiency 0 1 (0.01) 8 (0.03) 0 4 (0.01) 66 (0.03) 88 (0.03)
Impaired driving ability 0 5 (0.04) 40 (0.16) 0 9 (0.02) 42 (0.02) 101 (0.03)
Impaired quality of life 0 7 (0.05) 38 (0.15) 0 5 (0.01) 50 (0.03) 104 (0.04)
Impaired work ability 0 23 (0.17) 286 (1.11) 0 71 (0.13) 282 (0.15) 696 (0.24)
Inappropriate schedule of product administration 4 (0.04) 8 (0.06) 58 (0.23) 3 (1.04) 39 (0.07) 410 (0.22) 544 (0.19)
Incontinence 5 (0.05) 16 (0.12) 21 (0.08) 0 27 (0.05) 30 (0.02) 109 (0.04)
Increased tendency to bruise 0 3 (0.02) 13 (0.05) 0 7 (0.01) 37 (0.02) 60 (0.02)
Induration 0 0 4 (0.02) 0 23 (0.04) 52 (0.03) 80 (0.03)
Infarction 20 (0.19) 31 (0.22) 8 (0.03) 0 32 (0.06) 13 (0.01) 110 (0.04)
Infection 30 (0.28) 22 (0.16) 43 (0.17) 1 (0.35) 123 (0.23) 227 (0.12) 469 (0.16)
Infectious mononucleosis 0 5 (0.04) 11 (0.04) 0 17 (0.03) 32 (0.02) 65 (0.02)
Inflammation 10 (0.09) 46 (0.33) 187 (0.73) 0 270 (0.50) 543 (0.29) 1104 (0.38)
Inflammatory marker increased 4 (0.04) 7 (0.05) 7 (0.03) 0 57 (0.11) 21 (0.01) 105 (0.04)
Influenza 1 (0.01) 21 (0.15) 176 (0.68) 0 216 (0.40) 1170 (0.62) 1593 (0.54)
Influenza like illness 23 (0.22) 40 (0.29) 584 (2.27) 1 (0.35) 413 (0.77) 2846 (1.51) 3954 (1.35)
Initial insomnia 0 2 (0.01) 12 (0.05) 0 11 (0.02) 39 (0.02) 65 (0.02)
Injected limb mobility decreased 0 3 (0.02) 66 (0.26) 0 4 (0.01) 133 (0.07) 206 (0.07)
Injection site erythema 3 (0.03) 2 (0.01) 35 (0.14) 0 31 (0.06) 100 (0.05) 173 (0.06)
Injection site pain 4 (0.04) 18 (0.13) 294 (1.14) 0 215 (0.40) 503 (0.27) 1036 (0.35)
Injection site reaction 2 (0.02) 22 (0.16) 1392 (5.41) 0 59 (0.11) 84 (0.04) 1560 (0.53)
Injection site swelling 3 (0.03) 1 (0.01) 41 (0.16) 0 45 (0.08) 55 (0.03) 145 (0.05)
Injury 2 (0.02) 4 (0.03) 9 (0.03) 0 23 (0.04) 39 (0.02) 79 (0.03)
Insomnia 11 (0.10) 99 (0.72) 659 (2.56) 1 (0.35) 241 (0.45) 2190 (1.16) 3234 (1.11)
Interchange of vaccine products 58 (0.55) 190 (1.38) 716 (2.78) 2 (0.69) 415 (0.78) 7882 (4.18) 9319 (3.18)
Intermenstrual bleeding 0 5 (0.04) 96 (0.37) 1 (0.35) 51 (0.10) 863 (0.46) 1024 (0.35)
Internal haemorrhage 8 (0.08) 9 (0.07) 3 (0.01) 0 17 (0.03) 144 (0.08) 192 (0.07)
International normalised ratio increased 6 (0.06) 9 (0.07) 3 (0.01) 0 23 (0.04) 54 (0.03) 104 (0.04)
Interstitial lung disease 47 (0.44) 24 (0.17) 9 (0.03) 0 81 (0.15) 36 (0.02) 214 (0.07)
Intestinal haemorrhage 4 (0.04) 4 (0.03) 0 0 24 (0.04) 19 (0.01) 53 (0.02)
Intestinal ischaemia 40 (0.38) 12 (0.09) 1 (0.00) 0 23 (0.04) 9 (0.00) 90 (0.03)
Intestinal obstruction 13 (0.12) 6 (0.04) 0 0 23 (0.04) 20 (0.01) 63 (0.02)
Intracardiac thrombus 17 (0.16) 11 (0.08) 1 (0.00) 0 21 (0.04) 7 (0.00) 62 (0.02)
Intracranial aneurysm 13 (0.12) 12 (0.09) 1 (0.00) 0 12 (0.02) 7 (0.00) 52 (0.02)
Intracranial pressure increased 4 (0.04) 7 (0.05) 9 (0.03) 0 16 (0.03) 31 (0.02) 74 (0.03)
Iridocyclitis 0 0 7 (0.03) 0 9 (0.02) 73 (0.04) 92 (0.03)
Irritability 4 (0.04) 4 (0.03) 33 (0.13) 0 36 (0.07) 211 (0.11) 290 (0.10)
Irritable bowel syndrome 0 3 (0.02) 32 (0.12) 0 5 (0.01) 79 (0.04) 120 (0.04)
Ischaemia 8 (0.08) 19 (0.14) 16 (0.06) 0 35 (0.07) 20 (0.01) 100 (0.03)
Ischaemic cerebral infarction 12 (0.11) 32 (0.23) 10 (0.04) 0 49 (0.09) 11 (0.01) 116 (0.04)
Ischaemic stroke 85 (0.80) 185 (1.34) 92 (0.36) 0 671 (1.25) 59 (0.03) 1100 (0.38)
Jaundice 12 (0.11) 11 (0.08) 5 (0.02) 1 (0.35) 72 (0.13) 36 (0.02) 144 (0.05)
Joint effusion 0 0 16 (0.06) 0 8 (0.01) 33 (0.02) 58 (0.02)
Joint range of motion decreased 1 (0.01) 5 (0.04) 118 (0.46) 1 (0.35) 26 (0.05) 374 (0.20) 537 (0.18)
Joint stiffness 0 6 (0.04) 103 (0.40) 0 26 (0.05) 264 (0.14) 403 (0.14)
Joint swelling 2 (0.02) 25 (0.18) 249 (0.97) 0 124 (0.23) 612 (0.32) 1030 (0.35)
Jugular vein thrombosis 1 (0.01) 12 (0.09) 0 0 25 (0.05) 17 (0.01) 55 (0.02)
Kidney infection 1 (0.01) 8 (0.06) 9 (0.03) 0 20 (0.04) 81 (0.04) 125 (0.04)
Labyrinthitis 0 1 (0.01) 32 (0.12) 0 14 (0.03) 91 (0.05) 139 (0.05)
Lacrimation increased 0 11 (0.08) 41 (0.16) 0 39 (0.07) 183 (0.10) 282 (0.10)
Lacunar infarction 1 (0.01) 7 (0.05) 0 0 37 (0.07) 15 (0.01) 67 (0.02)
Language disorder 1 (0.01) 5 (0.04) 12 (0.05) 0 79 (0.15) 15 (0.01) 121 (0.04)
Laryngeal oedema 3 (0.03) 63 (0.46) 0 0 56 (0.10) 196 (0.10) 331 (0.11)
Laryngospasm 1 (0.01) 12 (0.09) 1 (0.00) 0 20 (0.04) 37 (0.02) 71 (0.02)
Left ventricular dysfunction 4 (0.04) 12 (0.09) 3 (0.01) 0 24 (0.04) 4 (0.00) 54 (0.02)
Lethargy 33 (0.31) 62 (0.45) 292 (1.14) 0 268 (0.50) 1545 (0.82) 2221 (0.76)
Leukocytosis 5 (0.05) 11 (0.08) 1 (0.00) 0 34 (0.06) 12 (0.01) 69 (0.02)
Leukopenia 6 (0.06) 6 (0.04) 4 (0.02) 0 27 (0.05) 65 (0.03) 114 (0.04)
Limb discomfort 2 (0.02) 34 (0.25) 283 (1.10) 0 426 (0.80) 1220 (0.65) 1996 (0.68)
Limb injury 1 (0.01) 2 (0.01) 62 (0.24) 1 (0.35) 12 (0.02) 102 (0.05) 183 (0.06)
Limb mass 0 1 (0.01) 14 (0.05) 0 3 (0.01) 61 (0.03) 80 (0.03)
Lip oedema 1 (0.01) 9 (0.07) 6 (0.02) 0 48 (0.09) 148 (0.08) 216 (0.07)
Lip pain 0 1 (0.01) 8 (0.03) 0 4 (0.01) 61 (0.03) 76 (0.03)
Lip pruritus 0 7 (0.05) 1 (0.00) 0 11 (0.02) 53 (0.03) 73 (0.02)
Lip swelling 1 (0.01) 124 (0.90) 53 (0.21) 0 173 (0.32) 742 (0.39) 1109 (0.38)
Livedo reticularis 5 (0.05) 4 (0.03) 6 (0.02) 0 7 (0.01) 31 (0.02) 56 (0.02)
Liver disorder 6 (0.06) 13 (0.09) 15 (0.06) 0 53 (0.10) 32 (0.02) 126 (0.04)
Liver function test abnormal 3 (0.03) 4 (0.03) 7 (0.03) 0 32 (0.06) 35 (0.02) 86 (0.03)
Liver function test increased 0 2 (0.01) 5 (0.02) 0 22 (0.04) 28 (0.01) 59 (0.02)
Liver injury 0 3 (0.02) 3 (0.01) 0 26 (0.05) 35 (0.02) 74 (0.03)
Local reaction 5 (0.05) 12 (0.09) 52 (0.20) 0 37 (0.07) 70 (0.04) 176 (0.06)
Localised infection 1 (0.01) 4 (0.03) 9 (0.03) 0 12 (0.02) 34 (0.02) 63 (0.02)
Localised oedema 0 17 (0.12) 21 (0.08) 0 31 (0.06) 83 (0.04) 154 (0.05)
Loss of consciousness 178 (1.68) 371 (2.69) 147 (0.57) 2 (0.69) 829 (1.55) 3154 (1.67) 4978 (1.70)
Loss of control of legs 0 3 (0.02) 9 (0.03) 0 18 (0.03) 35 (0.02) 71 (0.02)
Loss of personal independence in daily activities 3 (0.03) 40 (0.29) 352 (1.37) 0 77 (0.14) 443 (0.23) 959 (0.33)
Lower respiratory tract infection 21 (0.20) 21 (0.15) 41 (0.16) 0 40 (0.07) 274 (0.15) 413 (0.14)
Lung disorder 23 (0.22) 21 (0.15) 19 (0.07) 0 75 (0.14) 58 (0.03) 211 (0.07)
Lung infiltration 7 (0.07) 5 (0.04) 0 0 29 (0.05) 11 (0.01) 58 (0.02)
Lyme disease 0 2 (0.01) 7 (0.03) 0 5 (0.01) 48 (0.03) 66 (0.02)
Lymph node pain 1 (0.01) 8 (0.06) 154 (0.60) 0 50 (0.09) 1505 (0.80) 1728 (0.59)
Lymphadenitis 1 (0.01) 13 (0.09) 30 (0.12) 0 50 (0.09) 245 (0.13) 343 (0.12)
Lymphadenopathy 16 (0.15) 124 (0.90) 1065 (4.14) 8 (2.78) 592 (1.11) 7369 (3.90) 9228 (3.15)
Lymphangitis 0 0 2 (0.01) 0 13 (0.02) 43 (0.02) 58 (0.02)
Lymphoedema 0 6 (0.04) 22 (0.09) 0 10 (0.02) 133 (0.07) 173 (0.06)
Lymphoma 7 (0.07) 15 (0.11) 2 (0.01) 0 13 (0.02) 79 (0.04) 122 (0.04)
Lymphopenia 3 (0.03) 6 (0.04) 2 (0.01) 0 23 (0.04) 22 (0.01) 56 (0.02)
Macular oedema 0 0 16 (0.06) 0 6 (0.01) 32 (0.02) 60 (0.02)
Malaise 289 (2.73) 517 (3.74) 2688 (10.45) 3 (1.04) 2144 (4.01) 6232 (3.30) 12120 (4.14)
Mass 0 4 (0.03) 18 (0.07) 0 10 (0.02) 119 (0.06) 158 (0.05)
Mastitis 0 0 9 (0.03) 0 11 (0.02) 181 (0.10) 202 (0.07)
Maternal exposure during breast feeding 0 2 (0.01) 21 (0.08) 2 (0.69) 16 (0.03) 190 (0.10) 233 (0.08)
Maternal exposure during pregnancy 46 (0.43) 40 (0.29) 31 (0.12) 37 (12.85) 87 (0.16) 422 (0.22) 683 (0.23)
Melaena 10 (0.09) 7 (0.05) 0 0 30 (0.06) 36 (0.02) 90 (0.03)
Memory impairment 4 (0.04) 26 (0.19) 171 (0.66) 0 128 (0.24) 251 (0.13) 610 (0.21)
Meniere's disease 0 2 (0.01) 26 (0.10) 0 21 (0.04) 58 (0.03) 108 (0.04)
Meningitis 2 (0.02) 12 (0.09) 7 (0.03) 0 71 (0.13) 38 (0.02) 138 (0.05)
Meningitis aseptic 0 6 (0.04) 1 (0.00) 0 65 (0.12) 13 (0.01) 87 (0.03)
Menometrorrhagia 0 4 (0.03) 14 (0.05) 0 14 (0.03) 51 (0.03) 84 (0.03)
Menstrual disorder 0 22 (0.16) 285 (1.11) 1 (0.35) 99 (0.19) 1415 (0.75) 1833 (0.63)
Menstruation delayed 0 8 (0.06) 199 (0.77) 4 (1.39) 21 (0.04) 1858 (0.98) 2094 (0.72)
Menstruation irregular 0 17 (0.12) 257 (1.00) 5 (1.74) 74 (0.14) 1950 (1.03) 2312 (0.79)
Mental disorder 1 (0.01) 7 (0.05) 26 (0.10) 0 23 (0.04) 41 (0.02) 102 (0.03)
Mental fatigue 1 (0.01) 8 (0.06) 81 (0.31) 0 11 (0.02) 143 (0.08) 245 (0.08)
Mental impairment 4 (0.04) 18 (0.13) 39 (0.15) 0 23 (0.04) 274 (0.15) 384 (0.13)
Mesenteric vein thrombosis 9 (0.08) 22 (0.16) 2 (0.01) 0 50 (0.09) 13 (0.01) 97 (0.03)
Micturition urgency 1 (0.01) 0 10 (0.04) 0 16 (0.03) 57 (0.03) 90 (0.03)
Middle insomnia 0 4 (0.03) 27 (0.10) 0 12 (0.02) 74 (0.04) 118 (0.04)
Migraine 5 (0.05) 82 (0.59) 754 (2.93) 1 (0.35) 328 (0.61) 2563 (1.36) 3762 (1.29)
Migraine with aura 0 1 (0.01) 49 (0.19) 0 33 (0.06) 190 (0.10) 276 (0.09)
Miliaria 0 0 6 (0.02) 0 3 (0.01) 58 (0.03) 67 (0.02)
Mitral valve incompetence 3 (0.03) 5 (0.04) 2 (0.01) 0 23 (0.04) 16 (0.01) 65 (0.02)
Mobility decreased 11 (0.10) 30 (0.22) 262 (1.02) 0 135 (0.25) 382 (0.20) 857 (0.29)
Monoparesis 2 (0.02) 16 (0.12) 32 (0.12) 0 76 (0.14) 104 (0.06) 242 (0.08)
Monoplegia 6 (0.06) 17 (0.12) 79 (0.31) 0 80 (0.15) 249 (0.13) 449 (0.15)
Mood altered 0 5 (0.04) 13 (0.05) 0 7 (0.01) 62 (0.03) 88 (0.03)
Mood swings 0 1 (0.01) 25 (0.10) 0 6 (0.01) 103 (0.05) 136 (0.05)
Motion sickness 0 2 (0.01) 16 (0.06) 0 2 (0.00) 57 (0.03) 78 (0.03)
Motor dysfunction 6 (0.06) 7 (0.05) 39 (0.15) 0 92 (0.17) 51 (0.03) 200 (0.07)
Mouth haemorrhage 4 (0.04) 12 (0.09) 3 (0.01) 0 27 (0.05) 21 (0.01) 78 (0.03)
Mouth swelling 3 (0.03) 27 (0.20) 11 (0.04) 0 32 (0.06) 117 (0.06) 192 (0.07)
Mouth ulceration 1 (0.01) 4 (0.03) 26 (0.10) 0 12 (0.02) 213 (0.11) 257 (0.09)
Movement disorder 10 (0.09) 27 (0.20) 135 (0.52) 1 (0.35) 204 (0.38) 299 (0.16) 718 (0.25)
Multiple organ dysfunction syndrome 125 (1.18) 21 (0.15) 0 0 13 (0.02) 12 (0.01) 195 (0.07)
Multiple sclerosis 1 (0.01) 3 (0.02) 56 (0.22) 0 81 (0.15) 170 (0.09) 327 (0.11)
Multiple sclerosis relapse 1 (0.01) 4 (0.03) 39 (0.15) 0 71 (0.13) 159 (0.08) 276 (0.09)
Multisystem inflammatory syndrome in children 0 21 (0.15) 0 0 24 (0.04) 5 (0.00) 51 (0.02)
Muscle atrophy 1 (0.01) 7 (0.05) 23 (0.09) 0 10 (0.02) 23 (0.01) 68 (0.02)
Muscle contractions involuntary 1 (0.01) 10 (0.07) 35 (0.14) 0 38 (0.07) 54 (0.03) 139 (0.05)
Muscle fatigue 0 3 (0.02) 71 (0.28) 0 13 (0.02) 261 (0.14) 351 (0.12)
Muscle injury 0 3 (0.02) 11 (0.04) 0 6 (0.01) 32 (0.02) 52 (0.02)
Muscle rigidity 3 (0.03) 9 (0.07) 37 (0.14) 0 25 (0.05) 47 (0.02) 126 (0.04)
Muscle spasms 8 (0.08) 92 (0.67) 451 (1.75) 0 355 (0.66) 1602 (0.85) 2559 (0.87)
Muscle spasticity 1 (0.01) 2 (0.01) 16 (0.06) 0 14 (0.03) 20 (0.01) 54 (0.02)
Muscle strain 0 1 (0.01) 18 (0.07) 0 11 (0.02) 50 (0.03) 81 (0.03)
Muscle swelling 0 0 6 (0.02) 0 7 (0.01) 41 (0.02) 55 (0.02)
Muscle tightness 0 7 (0.05) 48 (0.19) 0 56 (0.10) 154 (0.08) 271 (0.09)
Muscle twitching 4 (0.04) 32 (0.23) 145 (0.56) 0 126 (0.24) 366 (0.19) 682 (0.23)
Muscular weakness 27 (0.25) 122 (0.88) 786 (3.06) 0 777 (1.45) 1301 (0.69) 3104 (1.06)
Musculoskeletal chest pain 1 (0.01) 19 (0.14) 64 (0.25) 0 70 (0.13) 314 (0.17) 476 (0.16)
Musculoskeletal discomfort 1 (0.01) 7 (0.05) 42 (0.16) 0 41 (0.08) 140 (0.07) 239 (0.08)
Musculoskeletal disorder 1 (0.01) 7 (0.05) 45 (0.17) 0 21 (0.04) 52 (0.03) 132 (0.05)
Musculoskeletal pain 1 (0.01) 19 (0.14) 109 (0.42) 0 134 (0.25) 383 (0.20) 658 (0.22)
Musculoskeletal stiffness 5 (0.05) 39 (0.28) 430 (1.67) 0 171 (0.32) 1217 (0.64) 1891 (0.65)
Myalgia 64 (0.60) 319 (2.31) 4757 (18.49) 4 (1.39) 1471 (2.75) 8951 (4.74) 15686 (5.36)
Myasthenia gravis 2 (0.02) 3 (0.02) 16 (0.06) 0 44 (0.08) 41 (0.02) 109 (0.04)
Mydriasis 3 (0.03) 8 (0.06) 2 (0.01) 0 17 (0.03) 32 (0.02) 67 (0.02)
Myelitis 4 (0.04) 4 (0.03) 40 (0.16) 1 (0.35) 146 (0.27) 42 (0.02) 242 (0.08)
Myelitis transverse 1 (0.01) 9 (0.07) 44 (0.17) 0 74 (0.14) 39 (0.02) 175 (0.06)
Myocardial infarction 456 (4.31) 406 (2.94) 46 (0.18) 0 584 (1.09) 343 (0.18) 1911 (0.65)
Myocardial injury 0 15 (0.11) 2 (0.01) 0 21 (0.04) 18 (0.01) 67 (0.02)
Myocardial ischaemia 73 (0.69) 7 (0.05) 3 (0.01) 0 20 (0.04) 21 (0.01) 131 (0.04)
Myocardial necrosis marker increased 1 (0.01) 3 (0.02) 2 (0.01) 0 44 (0.08) 12 (0.01) 75 (0.03)
Myocarditis 101 (0.95) 693 (5.02) 299 (1.16) 3 (1.04) 3758 (7.03) 3582 (1.90) 8563 (2.93)
Myoclonus 2 (0.02) 11 (0.08) 22 (0.09) 0 40 (0.07) 49 (0.03) 130 (0.04)
Myositis 4 (0.04) 8 (0.06) 30 (0.12) 0 60 (0.11) 62 (0.03) 166 (0.06)
Nasal congestion 1 (0.01) 12 (0.09) 83 (0.32) 0 47 (0.09) 418 (0.22) 563 (0.19)
Nasal discomfort 0 2 (0.01) 11 (0.04) 0 8 (0.01) 50 (0.03) 71 (0.02)
Nasopharyngitis 26 (0.25) 25 (0.18) 150 (0.58) 2 (0.69) 131 (0.24) 910 (0.48) 1258 (0.43)
Nausea 118 (1.11) 496 (3.59) 3397 (13.21) 4 (1.39) 2695 (5.04) 11794 (6.25) 18722 (6.40)
Near death experience 0 31 (0.22) 4 (0.02) 0 7 (0.01) 104 (0.06) 164 (0.06)
Neck mass 0 4 (0.03) 10 (0.04) 0 4 (0.01) 49 (0.03) 68 (0.02)
Neck pain 6 (0.06) 72 (0.52) 525 (2.04) 1 (0.35) 363 (0.68) 1925 (1.02) 2933 (1.00)
Neoplasm malignant 14 (0.13) 12 (0.09) 1 (0.00) 0 15 (0.03) 70 (0.04) 120 (0.04)
Nephritis 1 (0.01) 4 (0.03) 1 (0.00) 0 20 (0.04) 33 (0.02) 61 (0.02)
Nephrolithiasis 0 3 (0.02) 3 (0.01) 0 27 (0.05) 68 (0.04) 109 (0.04)
Nephrotic syndrome 2 (0.02) 7 (0.05) 6 (0.02) 0 106 (0.20) 74 (0.04) 201 (0.07)
Nerve compression 1 (0.01) 1 (0.01) 9 (0.03) 0 3 (0.01) 46 (0.02) 62 (0.02)
Nerve injury 2 (0.02) 8 (0.06) 74 (0.29) 0 16 (0.03) 81 (0.04) 187 (0.06)
Nervous system disorder 25 (0.24) 30 (0.22) 100 (0.39) 0 100 (0.19) 84 (0.04) 357 (0.12)
Nervousness 0 16 (0.12) 41 (0.16) 0 26 (0.05) 204 (0.11) 289 (0.10)
Neuralgia 2 (0.02) 21 (0.15) 317 (1.23) 0 219 (0.41) 619 (0.33) 1201 (0.41)
Neuralgic amyotrophy 0 0 52 (0.20) 0 30 (0.06) 68 (0.04) 150 (0.05)
Neuritis 0 1 (0.01) 17 (0.07) 0 37 (0.07) 37 (0.02) 94 (0.03)
Neurological symptom 2 (0.02) 10 (0.07) 51 (0.20) 1 (0.35) 57 (0.11) 69 (0.04) 194 (0.07)
Neuropathy peripheral 0 10 (0.07) 145 (0.56) 0 100 (0.19) 814 (0.43) 1113 (0.38)
Neutropenia 2 (0.02) 14 (0.10) 2 (0.01) 0 31 (0.06) 82 (0.04) 138 (0.05)
Night sweats 3 (0.03) 15 (0.11) 112 (0.44) 1 (0.35) 75 (0.14) 578 (0.31) 793 (0.27)
Nightmare 0 7 (0.05) 33 (0.13) 0 8 (0.01) 133 (0.07) 184 (0.06)
Nodule 1 (0.01) 10 (0.07) 21 (0.08) 0 31 (0.06) 73 (0.04) 140 (0.05)
Nuchal rigidity 0 1 (0.01) 11 (0.04) 0 13 (0.02) 35 (0.02) 61 (0.02)
Nystagmus 1 (0.01) 4 (0.03) 10 (0.04) 0 50 (0.09) 28 (0.01) 101 (0.03)
Obstructive airways disorder 5 (0.05) 20 (0.14) 2 (0.01) 0 32 (0.06) 37 (0.02) 99 (0.03)
Ocular discomfort 0 8 (0.06) 24 (0.09) 0 43 (0.08) 98 (0.05) 173 (0.06)
Ocular hyperaemia 0 15 (0.11) 34 (0.13) 0 61 (0.11) 299 (0.16) 422 (0.14)
Odynophagia 0 1 (0.01) 22 (0.09) 0 37 (0.07) 140 (0.07) 203 (0.07)
Oedema 10 (0.09) 37 (0.27) 43 (0.17) 1 (0.35) 154 (0.29) 286 (0.15) 551 (0.19)
Oedema peripheral 32 (0.30) 61 (0.44) 109 (0.42) 0 239 (0.45) 423 (0.22) 901 (0.31)
Off label use 67 (0.63) 216 (1.56) 805 (3.13) 2 (0.69) 512 (0.96) 8902 (4.72) 10579 (3.62)
Oligomenorrhoea 0 1 (0.01) 48 (0.19) 0 14 (0.03) 174 (0.09) 237 (0.08)
Ophthalmic herpes zoster 0 3 (0.02) 23 (0.09) 0 58 (0.11) 290 (0.15) 379 (0.13)
Ophthalmic vein thrombosis 1 (0.01) 1 (0.01) 9 (0.03) 0 33 (0.06) 51 (0.03) 95 (0.03)
Optic ischaemic neuropathy 0 0 24 (0.09) 0 32 (0.06) 30 (0.02) 88 (0.03)
Optic neuritis 0 0 49 (0.19) 0 126 (0.24) 108 (0.06) 289 (0.10)
Oral discomfort 0 11 (0.08) 24 (0.09) 0 28 (0.05) 96 (0.05) 160 (0.05)
Oral herpes 0 6 (0.04) 32 (0.12) 0 18 (0.03) 236 (0.13) 295 (0.10)
Oral mucosal blistering 0 1 (0.01) 14 (0.05) 0 11 (0.02) 33 (0.02) 62 (0.02)
Oral pain 1 (0.01) 2 (0.01) 31 (0.12) 0 18 (0.03) 122 (0.06) 178 (0.06)
Oral pruritus 0 10 (0.07) 7 (0.03) 0 29 (0.05) 60 (0.03) 108 (0.04)
Organising pneumonia 7 (0.07) 3 (0.02) 4 (0.02) 0 26 (0.05) 15 (0.01) 58 (0.02)
Oropharyngeal discomfort 0 27 (0.20) 25 (0.10) 0 249 (0.47) 547 (0.29) 867 (0.30)
Oropharyngeal pain 16 (0.15) 71 (0.51) 377 (1.47) 3 (1.04) 346 (0.65) 2082 (1.10) 2920 (1.00)
Orthostatic hypotension 0 4 (0.03) 7 (0.03) 0 25 (0.05) 41 (0.02) 82 (0.03)
Osteoarthritis 0 1 (0.01) 37 (0.14) 0 8 (0.01) 65 (0.03) 115 (0.04)
Ovarian cyst 0 0 12 (0.05) 0 23 (0.04) 25 (0.01) 61 (0.02)
Overdose 0 2 (0.01) 4 (0.02) 0 20 (0.04) 44 (0.02) 72 (0.02)
Ovulation pain 0 0 10 (0.04) 0 2 (0.00) 61 (0.03) 74 (0.03)
Oxygen saturation decreased 154 (1.45) 122 (0.88) 42 (0.16) 0 407 (0.76) 541 (0.29) 1388 (0.47)
Pain 52 (0.49) 266 (1.93) 2047 (7.96) 3 (1.04) 1240 (2.32) 8236 (4.36) 12000 (4.10)
Pain in extremity 44 (0.42) 327 (2.37) 2602 (10.11) 3 (1.04) 1304 (2.44) 10656 (5.65) 15119 (5.17)
Pain in jaw 2 (0.02) 16 (0.12) 78 (0.30) 0 73 (0.14) 335 (0.18) 514 (0.18)
Pain of skin 2 (0.02) 7 (0.05) 86 (0.33) 0 29 (0.05) 317 (0.17) 446 (0.15)
Painful respiration 1 (0.01) 7 (0.05) 23 (0.09) 0 41 (0.08) 84 (0.04) 163 (0.06)
Palatal oedema 0 14 (0.10) 2 (0.01) 0 16 (0.03) 51 (0.03) 84 (0.03)
Pallor 16 (0.15) 86 (0.62) 40 (0.16) 0 219 (0.41) 549 (0.29) 944 (0.32)
Palpitations 20 (0.19) 405 (2.93) 1006 (3.91) 3 (1.04) 1715 (3.21) 4572 (2.42) 7830 (2.68)
Pancreatitis 2 (0.02) 11 (0.08) 5 (0.02) 0 96 (0.18) 64 (0.03) 187 (0.06)
Pancreatitis acute 7 (0.07) 23 (0.17) 0 0 194 (0.36) 47 (0.02) 277 (0.09)
Pancytopenia 10 (0.09) 18 (0.13) 0 0 42 (0.08) 21 (0.01) 104 (0.04)
Panic attack 2 (0.02) 25 (0.18) 73 (0.28) 0 104 (0.19) 199 (0.11) 416 (0.14)
Panic reaction 0 9 (0.07) 9 (0.03) 0 11 (0.02) 60 (0.03) 92 (0.03)
Papilloedema 0 1 (0.01) 9 (0.03) 0 17 (0.03) 27 (0.01) 61 (0.02)
Papule 0 1 (0.01) 6 (0.02) 0 9 (0.02) 70 (0.04) 88 (0.03)
Paraesthesia 7 (0.07) 270 (1.96) 1176 (4.57) 1 (0.35) 1855 (3.47) 4669 (2.47) 8111 (2.77)
Paraesthesia oral 1 (0.01) 83 (0.60) 90 (0.35) 0 210 (0.39) 826 (0.44) 1225 (0.42)
Paralysis 14 (0.13) 50 (0.36) 119 (0.46) 0 164 (0.31) 418 (0.22) 827 (0.28)
Paranasal sinus discomfort 0 1 (0.01) 11 (0.04) 0 2 (0.00) 38 (0.02) 52 (0.02)
Paraparesis 1 (0.01) 4 (0.03) 11 (0.04) 0 25 (0.05) 20 (0.01) 64 (0.02)
Paresis 2 (0.02) 13 (0.09) 30 (0.12) 0 84 (0.16) 41 (0.02) 183 (0.06)
Parkinson's disease 4 (0.04) 2 (0.01) 7 (0.03) 0 7 (0.01) 38 (0.02) 61 (0.02)
Parosmia 0 6 (0.04) 112 (0.44) 0 23 (0.04) 167 (0.09) 308 (0.11)
Partial seizures 1 (0.01) 7 (0.05) 6 (0.02) 0 28 (0.05) 48 (0.03) 93 (0.03)
Pelvic pain 0 4 (0.03) 39 (0.15) 0 20 (0.04) 138 (0.07) 203 (0.07)
Pelvic venous thrombosis 2 (0.02) 12 (0.09) 2 (0.01) 0 36 (0.07) 17 (0.01) 72 (0.02)
Pemphigoid 6 (0.06) 9 (0.07) 15 (0.06) 0 29 (0.05) 80 (0.04) 142 (0.05)
Performance status decreased 0 5 (0.04) 7 (0.03) 0 19 (0.04) 16 (0.01) 53 (0.02)
Periarthritis 0 0 127 (0.49) 0 7 (0.01) 157 (0.08) 295 (0.10)
Pericardial effusion 20 (0.19) 77 (0.56) 21 (0.08) 0 361 (0.68) 358 (0.19) 881 (0.30)
Pericarditis 18 (0.17) 275 (1.99) 242 (0.94) 1 (0.35) 1722 (3.22) 4631 (2.45) 6961 (2.38)
Periorbital oedema 0 4 (0.03) 4 (0.02) 0 21 (0.04) 50 (0.03) 82 (0.03)
Periorbital swelling 0 7 (0.05) 13 (0.05) 0 35 (0.07) 132 (0.07) 187 (0.06)
Peripheral artery thrombosis 2 (0.02) 17 (0.12) 6 (0.02) 0 46 (0.09) 24 (0.01) 97 (0.03)
Peripheral coldness 5 (0.05) 26 (0.19) 94 (0.37) 0 121 (0.23) 397 (0.21) 658 (0.22)
Peripheral ischaemia 14 (0.13) 10 (0.07) 6 (0.02) 0 40 (0.07) 15 (0.01) 88 (0.03)
Peripheral swelling 18 (0.17) 147 (1.06) 526 (2.04) 2 (0.69) 415 (0.78) 2708 (1.43) 3874 (1.32)
Peripheral vascular disorder 7 (0.07) 5 (0.04) 5 (0.02) 0 34 (0.06) 16 (0.01) 72 (0.02)
Petechiae 15 (0.14) 46 (0.33) 25 (0.10) 0 184 (0.34) 196 (0.10) 487 (0.17)
Petit mal epilepsy 1 (0.01) 7 (0.05) 1 (0.00) 0 21 (0.04) 68 (0.04) 102 (0.03)
Pharyngeal hypoaesthesia 0 6 (0.04) 7 (0.03) 0 16 (0.03) 43 (0.02) 76 (0.03)
Pharyngeal oedema 1 (0.01) 32 (0.23) 10 (0.04) 0 48 (0.09) 82 (0.04) 177 (0.06)
Pharyngeal paraesthesia 0 17 (0.12) 6 (0.02) 0 35 (0.07) 76 (0.04) 136 (0.05)
Pharyngeal swelling 3 (0.03) 158 (1.14) 50 (0.19) 0 152 (0.28) 466 (0.25) 852 (0.29)
Pharyngitis 0 6 (0.04) 12 (0.05) 0 22 (0.04) 52 (0.03) 95 (0.03)
Phlebitis 0 14 (0.10) 16 (0.06) 0 45 (0.08) 129 (0.07) 207 (0.07)
Photophobia 0 23 (0.17) 170 (0.66) 0 119 (0.22) 460 (0.24) 780 (0.27)
Photopsia 0 11 (0.08) 33 (0.13) 0 39 (0.07) 144 (0.08) 231 (0.08)
Photosensitivity reaction 0 5 (0.04) 32 (0.12) 0 14 (0.03) 76 (0.04) 131 (0.04)
Physical deconditioning 7 (0.07) 3 (0.02) 8 (0.03) 0 54 (0.10) 41 (0.02) 128 (0.04)
Pityriasis rosea 0 0 4 (0.02) 0 5 (0.01) 72 (0.04) 81 (0.03)
Platelet count decreased 21 (0.20) 71 (0.51) 15 (0.06) 0 122 (0.23) 145 (0.08) 411 (0.14)
Platelet count increased 2 (0.02) 3 (0.02) 4 (0.02) 0 14 (0.03) 24 (0.01) 51 (0.02)
Pleural effusion 27 (0.25) 63 (0.46) 8 (0.03) 1 (0.35) 217 (0.41) 65 (0.03) 432 (0.15)
Pleurisy 2 (0.02) 17 (0.12) 12 (0.05) 0 112 (0.21) 54 (0.03) 206 (0.07)
Pleuritic pain 1 (0.01) 9 (0.07) 11 (0.04) 0 50 (0.09) 22 (0.01) 94 (0.03)
Pneumonia 337 (3.18) 193 (1.40) 30 (0.12) 0 622 (1.16) 485 (0.26) 1812 (0.62)
Pneumonia aspiration 98 (0.93) 16 (0.12) 1 (0.00) 0 36 (0.07) 14 (0.01) 184 (0.06)
Pneumonia bacterial 16 (0.15) 2 (0.01) 0 0 21 (0.04) 9 (0.00) 56 (0.02)
Pneumonitis 22 (0.21) 26 (0.19) 7 (0.03) 0 79 (0.15) 34 (0.02) 181 (0.06)
Pneumothorax 2 (0.02) 13 (0.09) 2 (0.01) 0 52 (0.10) 30 (0.02) 112 (0.04)
Pollakiuria 3 (0.03) 5 (0.04) 34 (0.13) 0 24 (0.04) 122 (0.06) 200 (0.07)
Polyarthritis 0 2 (0.01) 20 (0.08) 0 42 (0.08) 100 (0.05) 167 (0.06)
Polymenorrhoea 1 (0.01) 4 (0.03) 114 (0.44) 0 26 (0.05) 543 (0.29) 689 (0.24)
Polymyalgia rheumatica 0 5 (0.04) 91 (0.35) 0 76 (0.14) 323 (0.17) 504 (0.17)
Polyneuropathy 1 (0.01) 5 (0.04) 38 (0.15) 0 75 (0.14) 124 (0.07) 259 (0.09)
Poor peripheral circulation 0 8 (0.06) 9 (0.03) 0 19 (0.04) 24 (0.01) 64 (0.02)
Poor quality sleep 2 (0.02) 1 (0.01) 61 (0.24) 0 22 (0.04) 228 (0.12) 316 (0.11)
Portal vein thrombosis 14 (0.13) 23 (0.17) 2 (0.01) 0 76 (0.14) 16 (0.01) 136 (0.05)
Post herpetic neuralgia 0 0 20 (0.08) 0 14 (0.03) 34 (0.02) 70 (0.02)
Post viral fatigue syndrome 0 0 56 (0.22) 0 3 (0.01) 65 (0.03) 127 (0.04)
Post-acute COVID-19 syndrome 0 3 (0.02) 16 (0.06) 0 5 (0.01) 31 (0.02) 63 (0.02)
Postmenopausal haemorrhage 0 6 (0.04) 24 (0.09) 0 27 (0.05) 1126 (0.60) 1183 (0.40)
Postural orthostatic tachycardia syndrome 0 3 (0.02) 45 (0.17) 0 26 (0.05) 33 (0.02) 112 (0.04)
Premature baby 4 (0.04) 13 (0.09) 0 2 (0.69) 34 (0.06) 15 (0.01) 75 (0.03)
Premenstrual pain 0 0 16 (0.06) 0 1 (0.00) 109 (0.06) 126 (0.04)
Premenstrual syndrome 0 2 (0.01) 29 (0.11) 0 4 (0.01) 157 (0.08) 194 (0.07)
Presyncope 7 (0.07) 91 (0.66) 144 (0.56) 0 449 (0.84) 1292 (0.68) 2022 (0.69)
Product administered at inappropriate site 0 3 (0.02) 25 (0.10) 0 2 (0.00) 23 (0.01) 56 (0.02)
Product use issue 8 (0.08) 9 (0.07) 27 (0.10) 1 (0.35) 26 (0.05) 366 (0.19) 443 (0.15)
Productive cough 13 (0.12) 13 (0.09) 47 (0.18) 0 79 (0.15) 204 (0.11) 372 (0.13)
Proteinuria 0 5 (0.04) 5 (0.02) 0 29 (0.05) 29 (0.02) 72 (0.02)
Pruritus 8 (0.08) 197 (1.43) 424 (1.65) 2 (0.69) 846 (1.58) 4560 (2.42) 6125 (2.09)
Psoriasis 1 (0.01) 2 (0.01) 40 (0.16) 0 35 (0.07) 208 (0.11) 287 (0.10)
Psoriatic arthropathy 0 0 17 (0.07) 0 3 (0.01) 71 (0.04) 92 (0.03)
Psychomotor hyperactivity 4 (0.04) 5 (0.04) 5 (0.02) 0 5 (0.01) 31 (0.02) 52 (0.02)
Psychotic disorder 0 9 (0.07) 12 (0.05) 0 31 (0.06) 18 (0.01) 73 (0.02)
Pulmonary congestion 13 (0.12) 3 (0.02) 2 (0.01) 0 22 (0.04) 69 (0.04) 125 (0.04)
Pulmonary embolism 402 (3.80) 1465 (10.61) 63 (0.24) 0 2638 (4.93) 1007 (0.53) 5654 (1.93)
Pulmonary fibrosis 10 (0.09) 7 (0.05) 5 (0.02) 0 10 (0.02) 18 (0.01) 55 (0.02)
Pulmonary hypertension 6 (0.06) 7 (0.05) 1 (0.00) 0 20 (0.04) 11 (0.01) 53 (0.02)
Pulmonary infarction 8 (0.08) 37 (0.27) 2 (0.01) 0 70 (0.13) 24 (0.01) 149 (0.05)
Pulmonary oedema 83 (0.78) 52 (0.38) 9 (0.03) 0 80 (0.15) 45 (0.02) 313 (0.11)
Pulmonary pain 1 (0.01) 11 (0.08) 53 (0.21) 0 46 (0.09) 111 (0.06) 225 (0.08)
Pulmonary thrombosis 16 (0.15) 80 (0.58) 7 (0.03) 0 98 (0.18) 51 (0.03) 270 (0.09)
Pulse abnormal 3 (0.03) 14 (0.10) 7 (0.03) 0 29 (0.05) 48 (0.03) 105 (0.04)
Purpura 7 (0.07) 11 (0.08) 9 (0.03) 0 74 (0.14) 99 (0.05) 208 (0.07)
Pyelonephritis 5 (0.05) 6 (0.04) 3 (0.01) 0 45 (0.08) 43 (0.02) 106 (0.04)
Pyrexia 503 (4.75) 791 (5.73) 4264 (16.58) 15 (5.21) 4438 (8.30) 13788 (7.31) 24210 (8.27)
Quadriparesis 2 (0.02) 7 (0.05) 8 (0.03) 0 29 (0.05) 2 (0.00) 51 (0.02)
Radiculopathy 1 (0.01) 0 13 (0.05) 0 28 (0.05) 16 (0.01) 59 (0.02)
Rales 11 (0.10) 1 (0.01) 5 (0.02) 0 10 (0.02) 20 (0.01) 51 (0.02)
Rash 19 (0.18) 237 (1.72) 446 (1.73) 2 (0.69) 1276 (2.39) 4345 (2.30) 6414 (2.19)
Rash erythematous 2 (0.02) 31 (0.22) 68 (0.26) 0 122 (0.23) 831 (0.44) 1063 (0.36)
Rash macular 3 (0.03) 23 (0.17) 55 (0.21) 0 51 (0.10) 390 (0.21) 530 (0.18)
Rash maculo-papular 0 8 (0.06) 2 (0.01) 0 77 (0.14) 103 (0.05) 192 (0.07)
Rash morbilliform 0 0 6 (0.02) 0 7 (0.01) 34 (0.02) 51 (0.02)
Rash papular 0 4 (0.03) 17 (0.07) 0 35 (0.07) 207 (0.11) 265 (0.09)
Rash pruritic 4 (0.04) 22 (0.16) 68 (0.26) 0 104 (0.19) 859 (0.46) 1074 (0.37)
Rash vesicular 0 4 (0.03) 14 (0.05) 0 22 (0.04) 95 (0.05) 138 (0.05)
Raynaud's phenomenon 0 3 (0.02) 10 (0.04) 0 11 (0.02) 79 (0.04) 105 (0.04)
Rectal haemorrhage 10 (0.09) 7 (0.05) 13 (0.05) 1 (0.35) 54 (0.10) 185 (0.10) 280 (0.10)
Red blood cell sedimentation rate increased 2 (0.02) 3 (0.02) 13 (0.05) 0 25 (0.05) 28 (0.01) 76 (0.03)
Renal disorder 7 (0.07) 16 (0.12) 7 (0.03) 0 32 (0.06) 24 (0.01) 93 (0.03)
Renal failure 93 (0.88) 63 (0.46) 5 (0.02) 0 98 (0.18) 58 (0.03) 364 (0.12)
Renal impairment 16 (0.15) 22 (0.16) 7 (0.03) 0 55 (0.10) 85 (0.05) 214 (0.07)
Renal infarct 1 (0.01) 10 (0.07) 6 (0.02) 0 26 (0.05) 5 (0.00) 53 (0.02)
Renal pain 1 (0.01) 11 (0.08) 72 (0.28) 1 (0.35) 46 (0.09) 284 (0.15) 419 (0.14)
Respiration abnormal 7 (0.07) 16 (0.12) 12 (0.05) 0 61 (0.11) 106 (0.06) 208 (0.07)
Respiratory arrest 141 (1.33) 47 (0.34) 4 (0.02) 0 22 (0.04) 37 (0.02) 287 (0.10)
Respiratory disorder 31 (0.29) 43 (0.31) 77 (0.30) 0 88 (0.16) 120 (0.06) 379 (0.13)
Respiratory distress 67 (0.63) 62 (0.45) 19 (0.07) 0 312 (0.58) 1050 (0.56) 1596 (0.55)
Respiratory failure 200 (1.89) 78 (0.56) 5 (0.02) 0 139 (0.26) 42 (0.02) 510 (0.17)
Respiratory rate increased 7 (0.07) 17 (0.12) 11 (0.04) 0 51 (0.10) 74 (0.04) 168 (0.06)
Respiratory symptom 0 1 (0.01) 5 (0.02) 0 16 (0.03) 34 (0.02) 56 (0.02)
Respiratory tract infection 10 (0.09) 3 (0.02) 1 (0.00) 0 14 (0.03) 50 (0.03) 90 (0.03)
Respiratory tract oedema 0 16 (0.12) 2 (0.01) 0 10 (0.02) 27 (0.01) 60 (0.02)
Restless legs syndrome 1 (0.01) 1 (0.01) 33 (0.13) 0 17 (0.03) 93 (0.05) 146 (0.05)
Restlessness 15 (0.14) 14 (0.10) 43 (0.17) 0 103 (0.19) 188 (0.10) 376 (0.13)
Resuscitation 26 (0.25) 20 (0.14) 1 (0.00) 0 15 (0.03) 3 (0.00) 69 (0.02)
Retching 3 (0.03) 13 (0.09) 33 (0.13) 0 52 (0.10) 122 (0.06) 231 (0.08)
Retinal artery occlusion 0 2 (0.01) 51 (0.20) 0 35 (0.07) 53 (0.03) 142 (0.05)
Retinal detachment 0 1 (0.01) 17 (0.07) 0 56 (0.10) 51 (0.03) 129 (0.04)
Retinal haemorrhage 0 1 (0.01) 15 (0.06) 0 13 (0.02) 58 (0.03) 88 (0.03)
Retinal tear 0 0 9 (0.03) 0 8 (0.01) 30 (0.02) 53 (0.02)
Retinal vascular thrombosis 0 2 (0.01) 23 (0.09) 0 11 (0.02) 21 (0.01) 58 (0.02)
Retinal vein occlusion 0 1 (0.01) 80 (0.31) 0 30 (0.06) 187 (0.10) 302 (0.10)
Retinal vein thrombosis 0 3 (0.02) 28 (0.11) 0 5 (0.01) 48 (0.03) 87 (0.03)
Rhabdomyolysis 8 (0.08) 20 (0.14) 6 (0.02) 0 101 (0.19) 50 (0.03) 191 (0.07)
Rheumatic disorder 0 1 (0.01) 16 (0.06) 0 22 (0.04) 32 (0.02) 75 (0.03)
Rheumatoid arthritis 2 (0.02) 9 (0.07) 134 (0.52) 0 61 (0.11) 541 (0.29) 760 (0.26)
Rhinitis 0 6 (0.04) 35 (0.14) 0 14 (0.03) 80 (0.04) 135 (0.05)
Rhinorrhoea 3 (0.03) 24 (0.17) 111 (0.43) 0 106 (0.20) 788 (0.42) 1042 (0.36)
Road traffic accident 4 (0.04) 2 (0.01) 2 (0.01) 0 22 (0.04) 32 (0.02) 70 (0.02)
Rotator cuff syndrome 0 1 (0.01) 29 (0.11) 0 4 (0.01) 61 (0.03) 96 (0.03)
SARS-CoV-2 test negative 6 (0.06) 12 (0.09) 36 (0.14) 0 25 (0.05) 15 (0.01) 94 (0.03)
SARS-CoV-2 test positive 77 (0.73) 10 (0.07) 10 (0.04) 0 148 (0.28) 523 (0.28) 798 (0.27)
Salivary hypersecretion 2 (0.02) 5 (0.04) 9 (0.03) 0 15 (0.03) 44 (0.02) 78 (0.03)
Sarcoidosis 0 1 (0.01) 13 (0.05) 0 29 (0.05) 60 (0.03) 107 (0.04)
Scar 0 1 (0.01) 15 (0.06) 0 5 (0.01) 34 (0.02) 56 (0.02)
Sciatica 0 4 (0.03) 82 (0.32) 0 27 (0.05) 121 (0.06) 242 (0.08)
Seasonal allergy 0 2 (0.01) 10 (0.04) 0 2 (0.00) 80 (0.04) 94 (0.03)
Secretion discharge 5 (0.05) 5 (0.04) 10 (0.04) 0 9 (0.02) 28 (0.01) 59 (0.02)
Seizure 66 (0.62) 244 (1.77) 128 (0.50) 0 891 (1.67) 1763 (0.93) 3199 (1.09)
Sensation of foreign body 0 46 (0.33) 17 (0.07) 0 119 (0.22) 207 (0.11) 392 (0.13)
Sense of oppression 2 (0.02) 5 (0.04) 18 (0.07) 0 19 (0.04) 25 (0.01) 69 (0.02)
Sensitive skin 0 1 (0.01) 35 (0.14) 0 110 (0.21) 353 (0.19) 503 (0.17)
Sensory disturbance 1 (0.01) 13 (0.09) 75 (0.29) 0 199 (0.37) 190 (0.10) 500 (0.17)
Sensory loss 1 (0.01) 17 (0.12) 73 (0.28) 0 74 (0.14) 113 (0.06) 289 (0.10)
Sepsis 128 (1.21) 61 (0.44) 11 (0.04) 0 120 (0.22) 42 (0.02) 395 (0.13)
Septic shock 77 (0.73) 24 (0.17) 0 0 23 (0.04) 5 (0.00) 142 (0.05)
Shock 39 (0.37) 50 (0.36) 9 (0.03) 0 44 (0.08) 143 (0.08) 333 (0.11)
Shoulder injury related to vaccine administration 0 0 45 (0.17) 0 0 61 (0.03) 107 (0.04)
Sinus bradycardia 0 4 (0.03) 4 (0.02) 0 23 (0.04) 16 (0.01) 52 (0.02)
Sinus congestion 0 3 (0.02) 12 (0.05) 0 2 (0.00) 56 (0.03) 74 (0.03)
Sinus headache 0 1 (0.01) 29 (0.11) 0 6 (0.01) 203 (0.11) 239 (0.08)
Sinus pain 0 4 (0.03) 31 (0.12) 0 11 (0.02) 168 (0.09) 216 (0.07)
Sinus tachycardia 1 (0.01) 19 (0.14) 23 (0.09) 0 114 (0.21) 112 (0.06) 274 (0.09)
Sinusitis 2 (0.02) 4 (0.03) 49 (0.19) 0 31 (0.06) 179 (0.09) 271 (0.09)
Sjogren's syndrome 0 1 (0.01) 6 (0.02) 0 6 (0.01) 50 (0.03) 69 (0.02)
Skin burning sensation 1 (0.01) 17 (0.12) 61 (0.24) 0 42 (0.08) 232 (0.12) 359 (0.12)
Skin discolouration 3 (0.03) 14 (0.10) 33 (0.13) 0 65 (0.12) 184 (0.10) 312 (0.11)
Skin disorder 3 (0.03) 21 (0.15) 241 (0.94) 1 (0.35) 39 (0.07) 122 (0.06) 437 (0.15)
Skin exfoliation 0 3 (0.02) 30 (0.12) 1 (0.35) 23 (0.04) 135 (0.07) 199 (0.07)
Skin haemorrhage 2 (0.02) 6 (0.04) 5 (0.02) 0 15 (0.03) 23 (0.01) 55 (0.02)
Skin irritation 0 5 (0.04) 16 (0.06) 0 3 (0.01) 93 (0.05) 117 (0.04)
Skin laceration 0 1 (0.01) 3 (0.01) 0 10 (0.02) 32 (0.02) 51 (0.02)
Skin lesion 3 (0.03) 3 (0.02) 11 (0.04) 0 13 (0.02) 63 (0.03) 96 (0.03)
Skin mass 0 0 3 (0.01) 0 7 (0.01) 46 (0.02) 57 (0.02)
Skin reaction 1 (0.01) 13 (0.09) 12 (0.05) 0 21 (0.04) 127 (0.07) 174 (0.06)
Skin swelling 0 1 (0.01) 8 (0.03) 0 8 (0.01) 65 (0.03) 83 (0.03)
Skin ulcer 3 (0.03) 3 (0.02) 9 (0.03) 0 17 (0.03) 33 (0.02) 67 (0.02)
Skin warm 1 (0.01) 3 (0.02) 15 (0.06) 0 14 (0.03) 208 (0.11) 244 (0.08)
Sleep disorder 1 (0.01) 19 (0.14) 223 (0.87) 1 (0.35) 79 (0.15) 542 (0.29) 875 (0.30)
Slow speech 2 (0.02) 5 (0.04) 12 (0.05) 0 12 (0.02) 19 (0.01) 51 (0.02)
Sneezing 2 (0.02) 7 (0.05) 47 (0.18) 0 16 (0.03) 280 (0.15) 353 (0.12)
Somnolence 50 (0.47) 104 (0.75) 304 (1.18) 1 (0.35) 283 (0.53) 1294 (0.69) 2079 (0.71)
Speech disorder 14 (0.13) 81 (0.59) 98 (0.38) 0 250 (0.47) 229 (0.12) 717 (0.25)
Spinal pain 2 (0.02) 6 (0.04) 50 (0.19) 0 37 (0.07) 143 (0.08) 244 (0.08)
Splenomegaly 2 (0.02) 6 (0.04) 2 (0.01) 0 33 (0.06) 16 (0.01) 66 (0.02)
Status epilepticus 10 (0.09) 34 (0.25) 7 (0.03) 0 47 (0.09) 70 (0.04) 171 (0.06)
Stevens-Johnson syndrome 4 (0.04) 1 (0.01) 0 0 18 (0.03) 33 (0.02) 60 (0.02)
Stomatitis 0 8 (0.06) 9 (0.03) 0 16 (0.03) 82 (0.04) 120 (0.04)
Stress 0 11 (0.08) 48 (0.19) 0 24 (0.04) 124 (0.07) 214 (0.07)
Stress cardiomyopathy 4 (0.04) 17 (0.12) 1 (0.00) 0 45 (0.08) 5 (0.00) 75 (0.03)
Stridor 2 (0.02) 40 (0.29) 1 (0.00) 0 58 (0.11) 63 (0.03) 168 (0.06)
Subarachnoid haemorrhage 90 (0.85) 78 (0.56) 6 (0.02) 0 95 (0.18) 12 (0.01) 289 (0.10)
Subclavian vein thrombosis 3 (0.03) 13 (0.09) 2 (0.01) 0 19 (0.04) 29 (0.02) 67 (0.02)
Subdural haematoma 9 (0.08) 29 (0.21) 1 (0.00) 0 48 (0.09) 7 (0.00) 99 (0.03)
Sudden cardiac death 78 (0.74) 0 0 0 0 0 78 (0.03)
Sudden death 650 (6.14) 0 0 0 0 0 650 (0.22)
Sudden hearing loss 0 1 (0.01) 82 (0.32) 0 56 (0.10) 318 (0.17) 462 (0.16)
Suffocation feeling 0 20 (0.14) 10 (0.04) 0 17 (0.03) 27 (0.01) 75 (0.03)
Suicidal ideation 2 (0.02) 32 (0.23) 26 (0.10) 0 11 (0.02) 175 (0.09) 263 (0.09)
Superficial vein thrombosis 0 29 (0.21) 8 (0.03) 0 71 (0.13) 359 (0.19) 472 (0.16)
Suppressed lactation 0 1 (0.01) 8 (0.03) 0 3 (0.01) 44 (0.02) 56 (0.02)
Supraventricular extrasystoles 0 7 (0.05) 9 (0.03) 0 17 (0.03) 57 (0.03) 94 (0.03)
Supraventricular tachycardia 1 (0.01) 28 (0.20) 11 (0.04) 1 (0.35) 85 (0.16) 82 (0.04) 215 (0.07)
Suspected COVID-19 29 (0.27) 15 (0.11) 75 (0.29) 0 84 (0.16) 1459 (0.77) 1725 (0.59)
Sweating fever 0 1 (0.01) 11 (0.04) 0 2 (0.00) 114 (0.06) 128 (0.04)
Swelling 7 (0.07) 104 (0.75) 275 (1.07) 1 (0.35) 287 (0.54) 2264 (1.20) 2971 (1.02)
Swelling face 5 (0.05) 123 (0.89) 124 (0.48) 0 262 (0.49) 1054 (0.56) 1600 (0.55)
Swelling of eyelid 0 7 (0.05) 14 (0.05) 2 (0.69) 25 (0.05) 164 (0.09) 213 (0.07)
Swollen tongue 3 (0.03) 168 (1.22) 55 (0.21) 0 212 (0.40) 553 (0.29) 1010 (0.35)
Syncope 88 (0.83) 391 (2.83) 305 (1.19) 3 (1.04) 1241 (2.32) 6444 (3.41) 8688 (2.97)
Systemic inflammatory response syndrome 8 (0.08) 17 (0.12) 0 0 27 (0.05) 18 (0.01) 75 (0.03)
Systemic lupus erythematosus 1 (0.01) 8 (0.06) 11 (0.04) 0 43 (0.08) 116 (0.06) 186 (0.06)
Tachyarrhythmia 2 (0.02) 14 (0.10) 5 (0.02) 0 11 (0.02) 25 (0.01) 59 (0.02)
Tachycardia 61 (0.58) 444 (3.22) 466 (1.81) 5 (1.74) 1729 (3.23) 2925 (1.55) 5749 (1.96)
Tachypnoea 33 (0.31) 37 (0.27) 5 (0.02) 0 134 (0.25) 129 (0.07) 384 (0.13)
Taste disorder 2 (0.02) 11 (0.08) 112 (0.44) 0 50 (0.09) 205 (0.11) 385 (0.13)
Tearfulness 0 3 (0.02) 2 (0.01) 0 2 (0.00) 50 (0.03) 57 (0.02)
Temperature intolerance 0 2 (0.01) 10 (0.04) 0 8 (0.01) 41 (0.02) 62 (0.02)
Temperature regulation disorder 0 1 (0.01) 11 (0.04) 0 4 (0.01) 42 (0.02) 60 (0.02)
Tenderness 2 (0.02) 3 (0.02) 44 (0.17) 0 30 (0.06) 337 (0.18) 421 (0.14)
Tendon pain 0 2 (0.01) 25 (0.10) 0 7 (0.01) 43 (0.02) 79 (0.03)
Tendonitis 0 2 (0.01) 39 (0.15) 0 10 (0.02) 82 (0.04) 136 (0.05)
Tension 0 0 16 (0.06) 0 7 (0.01) 49 (0.03) 73 (0.02)
Tension headache 0 5 (0.04) 78 (0.30) 0 40 (0.07) 347 (0.18) 473 (0.16)
Testicular pain 1 (0.01) 1 (0.01) 13 (0.05) 0 10 (0.02) 64 (0.03) 92 (0.03)
Thalamic infarction 1 (0.01) 12 (0.09) 5 (0.02) 0 36 (0.07) 6 (0.00) 63 (0.02)
Thinking abnormal 0 3 (0.02) 18 (0.07) 0 9 (0.02) 35 (0.02) 69 (0.02)
Thirst 1 (0.01) 14 (0.10) 60 (0.23) 0 38 (0.07) 264 (0.14) 382 (0.13)
Throat irritation 2 (0.02) 52 (0.38) 38 (0.15) 0 135 (0.25) 474 (0.25) 712 (0.24)
Throat tightness 1 (0.01) 168 (1.22) 44 (0.17) 1 (0.35) 299 (0.56) 780 (0.41) 1331 (0.45)
Thrombocytopenia 84 (0.79) 211 (1.53) 23 (0.09) 0 467 (0.87) 561 (0.30) 1412 (0.48)
Thrombocytopenic purpura 4 (0.04) 13 (0.09) 1 (0.00) 0 47 (0.09) 13 (0.01) 83 (0.03)
Thrombophlebitis 3 (0.03) 28 (0.20) 18 (0.07) 0 79 (0.15) 274 (0.15) 409 (0.14)
Thrombosis 130 (1.23) 453 (3.28) 135 (0.52) 1 (0.35) 672 (1.26) 1778 (0.94) 3317 (1.13)
Thrombosis with thrombocytopenia syndrome 13 (0.12) 5 (0.04) 1 (0.00) 0 18 (0.03) 8 (0.00) 51 (0.02)
Thrombotic thrombocytopenic purpura 11 (0.10) 31 (0.22) 0 0 22 (0.04) 9 (0.00) 74 (0.03)
Thyroiditis 0 1 (0.01) 13 (0.05) 0 12 (0.02) 55 (0.03) 83 (0.03)
Thyroiditis subacute 0 0 7 (0.03) 0 20 (0.04) 65 (0.03) 92 (0.03)
Tinnitus 2 (0.02) 61 (0.44) 914 (3.55) 4 (1.39) 269 (0.50) 1855 (0.98) 3143 (1.07)
Tongue discomfort 0 7 (0.05) 14 (0.05) 0 9 (0.02) 50 (0.03) 81 (0.03)
Tongue disorder 0 3 (0.02) 5 (0.02) 0 16 (0.03) 66 (0.03) 94 (0.03)
Tongue oedema 1 (0.01) 35 (0.25) 8 (0.03) 0 40 (0.07) 120 (0.06) 205 (0.07)
Tongue pruritus 0 6 (0.04) 4 (0.02) 0 18 (0.03) 38 (0.02) 67 (0.02)
Tonic clonic movements 0 7 (0.05) 2 (0.01) 0 15 (0.03) 39 (0.02) 65 (0.02)
Tonic convulsion 1 (0.01) 11 (0.08) 0 0 26 (0.05) 40 (0.02) 80 (0.03)
Tonsillar hypertrophy 0 5 (0.04) 11 (0.04) 0 6 (0.01) 68 (0.04) 91 (0.03)
Tonsillitis 0 6 (0.04) 14 (0.05) 0 25 (0.05) 104 (0.06) 151 (0.05)
Toothache 0 11 (0.08) 34 (0.13) 0 23 (0.04) 174 (0.09) 244 (0.08)
Toxic skin eruption 1 (0.01) 0 1 (0.00) 0 11 (0.02) 81 (0.04) 95 (0.03)
Transaminases increased 2 (0.02) 4 (0.03) 4 (0.02) 0 19 (0.04) 26 (0.01) 58 (0.02)
Transient ischaemic attack 10 (0.09) 119 (0.86) 40 (0.16) 1 (0.35) 551 (1.03) 353 (0.19) 1110 (0.38)
Tremor 19 (0.18) 160 (1.16) 512 (1.99) 0 668 (1.25) 1964 (1.04) 3389 (1.16)
Trigeminal neuralgia 0 3 (0.02) 38 (0.15) 0 35 (0.07) 144 (0.08) 220 (0.08)
Trismus 1 (0.01) 4 (0.03) 10 (0.04) 0 14 (0.03) 50 (0.03) 82 (0.03)
Troponin I increased 0 7 (0.05) 0 0 42 (0.08) 10 (0.01) 66 (0.02)
Troponin T increased 2 (0.02) 7 (0.05) 1 (0.00) 0 53 (0.10) 4 (0.00) 77 (0.03)
Troponin increased 5 (0.05) 40 (0.29) 8 (0.03) 0 258 (0.48) 55 (0.03) 395 (0.13)
Tunnel vision 0 0 4 (0.02) 0 11 (0.02) 83 (0.04) 101 (0.03)
Type 1 diabetes mellitus 1 (0.01) 21 (0.15) 20 (0.08) 0 40 (0.07) 45 (0.02) 130 (0.04)
Type I hypersensitivity 0 5 (0.04) 0 0 10 (0.02) 118 (0.06) 137 (0.05)
Unresponsive to stimuli 50 (0.47) 35 (0.25) 7 (0.03) 0 52 (0.10) 132 (0.07) 319 (0.11)
Urinary incontinence 6 (0.06) 20 (0.14) 28 (0.11) 0 58 (0.11) 98 (0.05) 229 (0.08)
Urinary retention 6 (0.06) 12 (0.09) 24 (0.09) 0 63 (0.12) 108 (0.06) 229 (0.08)
Urinary tract infection 30 (0.28) 34 (0.25) 48 (0.19) 0 144 (0.27) 257 (0.14) 550 (0.19)
Urosepsis 22 (0.21) 9 (0.07) 0 0 16 (0.03) 3 (0.00) 53 (0.02)
Urticaria 5 (0.05) 201 (1.46) 212 (0.82) 2 (0.69) 708 (1.32) 2910 (1.54) 4094 (1.40)
Urticaria chronic 0 10 (0.07) 14 (0.05) 0 5 (0.01) 60 (0.03) 90 (0.03)
Uterine haemorrhage 0 8 (0.06) 4 (0.02) 0 16 (0.03) 88 (0.05) 117 (0.04)
Uveitis 0 1 (0.01) 27 (0.10) 0 21 (0.04) 141 (0.07) 195 (0.07)
VIth nerve paralysis 0 1 (0.01) 17 (0.07) 0 27 (0.05) 37 (0.02) 82 (0.03)
Vaccination complication 11 (0.10) 5 (0.04) 10 (0.04) 0 38 (0.07) 90 (0.05) 159 (0.05)
Vaccination failure 702 (6.63) 161 (1.17) 14 (0.05) 0 1642 (3.07) 20452 (10.84) 23167 (7.92)
Vaccination site bruising 0 0 21 (0.08) 1 (0.35) 8 (0.01) 181 (0.10) 212 (0.07)
Vaccination site cellulitis 0 1 (0.01) 4 (0.02) 0 5 (0.01) 80 (0.04) 90 (0.03)
Vaccination site discomfort 0 1 (0.01) 11 (0.04) 0 9 (0.02) 84 (0.04) 106 (0.04)
Vaccination site erythema 4 (0.04) 15 (0.11) 126 (0.49) 0 67 (0.13) 973 (0.52) 1193 (0.41)
Vaccination site haematoma 0 1 (0.01) 11 (0.04) 0 8 (0.01) 36 (0.02) 56 (0.02)
Vaccination site haemorrhage 0 1 (0.01) 8 (0.03) 0 9 (0.02) 78 (0.04) 99 (0.03)
Vaccination site hypoaesthesia 0 4 (0.03) 14 (0.05) 0 12 (0.02) 70 (0.04) 101 (0.03)
Vaccination site induration 0 0 18 (0.07) 0 12 (0.02) 107 (0.06) 138 (0.05)
Vaccination site inflammation 1 (0.01) 0 18 (0.07) 0 4 (0.01) 160 (0.08) 183 (0.06)
Vaccination site joint movement impairment 0 0 19 (0.07) 0 2 (0.00) 42 (0.02) 63 (0.02)
Vaccination site joint pain 0 1 (0.01) 18 (0.07) 0 4 (0.01) 33 (0.02) 56 (0.02)
Vaccination site lymphadenopathy 0 0 5 (0.02) 1 (0.35) 4 (0.01) 94 (0.05) 104 (0.04)
Vaccination site mass 0 5 (0.04) 45 (0.17) 0 12 (0.02) 457 (0.24) 523 (0.18)
Vaccination site movement impairment 0 6 (0.04) 124 (0.48) 0 23 (0.04) 172 (0.09) 328 (0.11)
Vaccination site oedema 0 2 (0.01) 55 (0.21) 0 23 (0.04) 118 (0.06) 200 (0.07)
Vaccination site pain 21 (0.20) 118 (0.85) 1050 (4.08) 1 (0.35) 474 (0.89) 4842 (2.57) 6555 (2.24)
Vaccination site paraesthesia 0 4 (0.03) 15 (0.06) 0 5 (0.01) 69 (0.04) 93 (0.03)
Vaccination site pruritus 0 13 (0.09) 72 (0.28) 0 38 (0.07) 423 (0.22) 550 (0.19)
Vaccination site rash 1 (0.01) 7 (0.05) 17 (0.07) 0 22 (0.04) 258 (0.14) 306 (0.10)
Vaccination site reaction 2 (0.02) 4 (0.03) 31 (0.12) 0 46 (0.09) 209 (0.11) 292 (0.10)
Vaccination site swelling 2 (0.02) 13 (0.09) 157 (0.61) 1 (0.35) 82 (0.15) 1078 (0.57) 1342 (0.46)
Vaccination site urticaria 0 5 (0.04) 3 (0.01) 0 16 (0.03) 63 (0.03) 90 (0.03)
Vaccination site warmth 0 1 (0.01) 51 (0.20) 0 23 (0.04) 495 (0.26) 572 (0.20)
Vaginal discharge 0 0 6 (0.02) 1 (0.35) 4 (0.01) 53 (0.03) 64 (0.02)
Vaginal haemorrhage 0 28 (0.20) 72 (0.28) 5 (1.74) 102 (0.19) 885 (0.47) 1100 (0.38)
Varicose vein 0 6 (0.04) 13 (0.05) 0 6 (0.01) 63 (0.03) 89 (0.03)
Vascular pain 1 (0.01) 4 (0.03) 10 (0.04) 0 13 (0.02) 48 (0.03) 78 (0.03)
Vasculitis 10 (0.09) 25 (0.18) 19 (0.07) 0 115 (0.22) 108 (0.06) 286 (0.10)
Vasodilatation 1 (0.01) 2 (0.01) 20 (0.08) 0 9 (0.02) 45 (0.02) 79 (0.03)
Venous thrombosis 1 (0.01) 45 (0.33) 15 (0.06) 0 82 (0.15) 140 (0.07) 287 (0.10)
Venous thrombosis limb 1 (0.01) 45 (0.33) 11 (0.04) 0 135 (0.25) 266 (0.14) 467 (0.16)
Ventricular extrasystoles 1 (0.01) 16 (0.12) 23 (0.09) 0 69 (0.13) 153 (0.08) 269 (0.09)
Ventricular fibrillation 71 (0.67) 61 (0.44) 3 (0.01) 0 29 (0.05) 8 (0.00) 190 (0.06)
Ventricular tachycardia 15 (0.14) 46 (0.33) 2 (0.01) 0 53 (0.10) 24 (0.01) 157 (0.05)
Vertigo 9 (0.08) 89 (0.64) 610 (2.37) 2 (0.69) 559 (1.05) 1803 (0.96) 3124 (1.07)
Vertigo positional 0 2 (0.01) 33 (0.13) 0 34 (0.06) 96 (0.05) 167 (0.06)
Vestibular disorder 0 0 15 (0.06) 0 14 (0.03) 25 (0.01) 56 (0.02)
Vestibular neuronitis 0 3 (0.02) 32 (0.12) 1 (0.35) 124 (0.23) 139 (0.07) 302 (0.10)
Viral infection 1 (0.01) 6 (0.04) 15 (0.06) 0 44 (0.08) 62 (0.03) 132 (0.05)
Vision blurred 3 (0.03) 93 (0.67) 422 (1.64) 3 (1.04) 393 (0.73) 1278 (0.68) 2224 (0.76)
Visual acuity reduced 1 (0.01) 5 (0.04) 37 (0.14) 0 34 (0.06) 93 (0.05) 175 (0.06)
Visual field defect 0 6 (0.04) 39 (0.15) 0 61 (0.11) 93 (0.05) 212 (0.07)
Visual impairment 11 (0.10) 66 (0.48) 353 (1.37) 3 (1.04) 465 (0.87) 756 (0.40) 1705 (0.58)
Vitreous detachment 0 1 (0.01) 23 (0.09) 0 12 (0.02) 100 (0.05) 139 (0.05)
Vitreous floaters 0 0 37 (0.14) 0 12 (0.02) 101 (0.05) 153 (0.05)
Vomiting 241 (2.28) 375 (2.72) 950 (3.69) 1 (0.35) 2000 (3.74) 4605 (2.44) 8392 (2.87)
Vomiting projectile 0 2 (0.01) 11 (0.04) 0 5 (0.01) 67 (0.04) 85 (0.03)
Walking disability 2 (0.02) 5 (0.04) 18 (0.07) 0 12 (0.02) 16 (0.01) 57 (0.02)
Weight bearing difficulty 0 1 (0.01) 11 (0.04) 0 30 (0.06) 23 (0.01) 67 (0.02)
Weight decreased 9 (0.08) 35 (0.25) 149 (0.58) 0 174 (0.33) 287 (0.15) 705 (0.24)
Weight increased 2 (0.02) 12 (0.09) 18 (0.07) 1 (0.35) 22 (0.04) 45 (0.02) 109 (0.04)
Wheezing 14 (0.13) 92 (0.67) 63 (0.24) 0 231 (0.43) 517 (0.27) 948 (0.32)
White blood cell count decreased 0 9 (0.07) 6 (0.02) 0 32 (0.06) 45 (0.02) 102 (0.03)
White blood cell count increased 2 (0.02) 17 (0.12) 13 (0.05) 0 92 (0.17) 50 (0.03) 205 (0.07)
Wound 0 0 4 (0.02) 0 11 (0.02) 42 (0.02) 61 (0.02)