Eudravigilance C-19 - Pfizer / Biontech

Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)

PT

Décès

8849 (%)

Mise en jeu du pronostic vital

10980 (%)

Invalidité ou incapacité

19300 (%)

Anomalies congénitales

210 (%)

Hospitalisation

42625 (%)

Médicalement significatif

143734 (%)

Cas Graves

225698 (%)

Abdominal discomfort 4 (0.05) 21 (0.19) 95 (0.49) 0 100 (0.23) 477 (0.33) 713 (0.32)
Abdominal distension 8 (0.09) 23 (0.21) 83 (0.43) 0 63 (0.15) 352 (0.24) 538 (0.24)
Abdominal pain 50 (0.57) 107 (0.97) 304 (1.58) 5 (2.38) 654 (1.53) 1404 (0.98) 2585 (1.15)
Abdominal pain lower 2 (0.02) 4 (0.04) 34 (0.18) 0 79 (0.19) 141 (0.10) 263 (0.12)
Abdominal pain upper 28 (0.32) 59 (0.54) 265 (1.37) 0 308 (0.72) 1646 (1.15) 2330 (1.03)
Abnormal behaviour 2 (0.02) 3 (0.03) 6 (0.03) 0 15 (0.04) 21 (0.01) 51 (0.02)
Abnormal dreams 0 1 (0.01) 13 (0.07) 0 3 (0.01) 81 (0.06) 99 (0.04)
Abnormal faeces 0 1 (0.01) 3 (0.02) 0 39 (0.09) 15 (0.01) 58 (0.03)
Abortion missed 1 (0.01) 3 (0.03) 0 4 (1.90) 14 (0.03) 49 (0.03) 71 (0.03)
Abortion spontaneous 5 (0.06) 23 (0.21) 28 (0.15) 77 (36.67) 119 (0.28) 877 (0.61) 1132 (0.50)
Abscess 0 1 (0.01) 6 (0.03) 0 28 (0.07) 26 (0.02) 64 (0.03)
Acne 0 2 (0.02) 10 (0.05) 0 7 (0.02) 92 (0.06) 111 (0.05)
Acute coronary syndrome 26 (0.29) 41 (0.37) 2 (0.01) 0 109 (0.26) 14 (0.01) 201 (0.09)
Acute disseminated encephalomyelitis 2 (0.02) 3 (0.03) 15 (0.08) 0 50 (0.12) 14 (0.01) 91 (0.04)
Acute kidney injury 78 (0.88) 58 (0.53) 7 (0.04) 0 145 (0.34) 51 (0.04) 374 (0.17)
Acute myocardial infarction 161 (1.82) 188 (1.71) 6 (0.03) 0 225 (0.53) 36 (0.03) 633 (0.28)
Acute pulmonary oedema 21 (0.24) 14 (0.13) 0 0 36 (0.08) 4 (0.00) 77 (0.03)
Acute respiratory distress syndrome 41 (0.46) 12 (0.11) 0 0 10 (0.02) 4 (0.00) 79 (0.04)
Acute respiratory failure 63 (0.71) 22 (0.20) 1 (0.01) 0 34 (0.08) 10 (0.01) 136 (0.06)
Administration site pain 1 (0.01) 28 (0.26) 24 (0.12) 0 3 (0.01) 33 (0.02) 89 (0.04)
Adnexa uteri pain 0 0 16 (0.08) 1 (0.48) 5 (0.01) 63 (0.04) 85 (0.04)
Ageusia 1 (0.01) 14 (0.13) 122 (0.63) 0 55 (0.13) 380 (0.26) 580 (0.26)
Aggression 2 (0.02) 3 (0.03) 10 (0.05) 0 16 (0.04) 21 (0.01) 52 (0.02)
Agitation 11 (0.12) 18 (0.16) 18 (0.09) 0 53 (0.12) 96 (0.07) 202 (0.09)
Alanine aminotransferase increased 0 5 (0.05) 9 (0.05) 0 34 (0.08) 50 (0.03) 109 (0.05)
Allergy to vaccine 1 (0.01) 13 (0.12) 7 (0.04) 0 43 (0.10) 125 (0.09) 196 (0.09)
Alopecia 0 6 (0.05) 57 (0.30) 0 22 (0.05) 191 (0.13) 280 (0.12)
Altered state of consciousness 41 (0.46) 27 (0.25) 20 (0.10) 0 173 (0.41) 180 (0.13) 508 (0.23)
Amenorrhoea 0 13 (0.12) 111 (0.58) 3 (1.43) 20 (0.05) 436 (0.30) 588 (0.26)
Amnesia 3 (0.03) 33 (0.30) 86 (0.45) 0 108 (0.25) 186 (0.13) 428 (0.19)
Anaemia 15 (0.17) 48 (0.44) 31 (0.16) 0 130 (0.30) 115 (0.08) 362 (0.16)
Anal incontinence 1 (0.01) 2 (0.02) 8 (0.04) 0 16 (0.04) 21 (0.01) 55 (0.02)
Anaphylactic reaction 26 (0.29) 850 (7.74) 40 (0.21) 1 (0.48) 1492 (3.50) 3266 (2.27) 5747 (2.55)
Anaphylactic shock 7 (0.08) 268 (2.44) 7 (0.04) 0 245 (0.57) 314 (0.22) 860 (0.38)
Anaphylactoid reaction 1 (0.01) 11 (0.10) 1 (0.01) 0 20 (0.05) 97 (0.07) 131 (0.06)
Angina pectoris 8 (0.09) 63 (0.57) 64 (0.33) 0 252 (0.59) 743 (0.52) 1166 (0.52)
Angioedema 2 (0.02) 110 (1.00) 15 (0.08) 0 160 (0.38) 916 (0.64) 1225 (0.54)
Ankylosing spondylitis 0 0 8 (0.04) 0 5 (0.01) 51 (0.04) 65 (0.03)
Anosmia 0 11 (0.10) 101 (0.52) 0 28 (0.07) 276 (0.19) 421 (0.19)
Anxiety 13 (0.15) 69 (0.63) 187 (0.97) 2 (0.95) 215 (0.50) 818 (0.57) 1328 (0.59)
Aortic dissection 52 (0.59) 21 (0.19) 0 0 9 (0.02) 5 (0.00) 89 (0.04)
Apathy 3 (0.03) 8 (0.07) 19 (0.10) 0 32 (0.08) 50 (0.03) 119 (0.05)
Aphasia 24 (0.27) 73 (0.66) 62 (0.32) 0 245 (0.57) 113 (0.08) 556 (0.25)
Aphonia 1 (0.01) 10 (0.09) 18 (0.09) 0 27 (0.06) 119 (0.08) 180 (0.08)
Aphthous ulcer 2 (0.02) 3 (0.03) 9 (0.05) 0 14 (0.03) 60 (0.04) 89 (0.04)
Apnoea 24 (0.27) 7 (0.06) 2 (0.01) 0 10 (0.02) 33 (0.02) 87 (0.04)
Appendicitis 0 57 (0.52) 10 (0.05) 0 223 (0.52) 71 (0.05) 364 (0.16)
Arrhythmia 79 (0.89) 104 (0.95) 73 (0.38) 0 615 (1.44) 1159 (0.81) 2088 (0.93)
Arterial occlusive disease 4 (0.05) 8 (0.07) 4 (0.02) 0 28 (0.07) 9 (0.01) 55 (0.02)
Arthralgia 31 (0.35) 206 (1.88) 3075 (15.93) 3 (1.43) 944 (2.21) 7034 (4.89) 11378 (5.04)
Arthritis 0 9 (0.08) 142 (0.74) 0 72 (0.17) 330 (0.23) 559 (0.25)
Arthritis reactive 0 2 (0.02) 22 (0.11) 0 19 (0.04) 76 (0.05) 120 (0.05)
Arthropathy 0 1 (0.01) 29 (0.15) 0 14 (0.03) 46 (0.03) 90 (0.04)
Ascites 6 (0.07) 7 (0.06) 1 (0.01) 2 (0.95) 19 (0.04) 8 (0.01) 53 (0.02)
Aspartate aminotransferase increased 0 3 (0.03) 1 (0.01) 0 26 (0.06) 32 (0.02) 70 (0.03)
Asphyxia 24 (0.27) 12 (0.11) 1 (0.01) 0 8 (0.02) 38 (0.03) 90 (0.04)
Asthenia 182 (2.06) 264 (2.40) 1023 (5.30) 1 (0.48) 1423 (3.34) 3808 (2.65) 6858 (3.04)
Asthenopia 0 1 (0.01) 25 (0.13) 0 6 (0.01) 117 (0.08) 149 (0.07)
Asthma 7 (0.08) 86 (0.78) 76 (0.39) 0 201 (0.47) 584 (0.41) 966 (0.43)
Asthmatic crisis 0 11 (0.10) 0 0 13 (0.03) 55 (0.04) 79 (0.04)
Asymptomatic COVID-19 7 (0.08) 2 (0.02) 0 0 9 (0.02) 501 (0.35) 524 (0.23)
Ataxia 3 (0.03) 10 (0.09) 20 (0.10) 0 47 (0.11) 20 (0.01) 108 (0.05)
Atrial fibrillation 61 (0.69) 171 (1.56) 62 (0.32) 0 639 (1.50) 673 (0.47) 1684 (0.75)
Atrial flutter 4 (0.05) 14 (0.13) 10 (0.05) 0 62 (0.15) 36 (0.03) 129 (0.06)
Atrioventricular block 5 (0.06) 17 (0.15) 3 (0.02) 0 27 (0.06) 10 (0.01) 63 (0.03)
Atrioventricular block complete 4 (0.05) 34 (0.31) 2 (0.01) 0 27 (0.06) 7 (0.00) 80 (0.04)
Autoimmune disorder 5 (0.06) 13 (0.12) 37 (0.19) 0 28 (0.07) 133 (0.09) 237 (0.11)
Autoimmune haemolytic anaemia 5 (0.06) 14 (0.13) 3 (0.02) 0 30 (0.07) 12 (0.01) 64 (0.03)
Autoimmune hepatitis 1 (0.01) 4 (0.04) 1 (0.01) 0 33 (0.08) 15 (0.01) 55 (0.02)
Autoimmune thyroiditis 0 0 5 (0.03) 0 11 (0.03) 78 (0.05) 96 (0.04)
Autonomic nervous system imbalance 1 (0.01) 8 (0.07) 21 (0.11) 0 8 (0.02) 22 (0.02) 62 (0.03)
Axillary mass 0 3 (0.03) 26 (0.13) 0 7 (0.02) 178 (0.12) 216 (0.10)
Axillary pain 1 (0.01) 12 (0.11) 184 (0.95) 0 37 (0.09) 1640 (1.14) 1877 (0.83)
Back pain 23 (0.26) 89 (0.81) 540 (2.80) 0 414 (0.97) 1925 (1.34) 3044 (1.35)
Bacterial infection 5 (0.06) 3 (0.03) 6 (0.03) 0 15 (0.04) 20 (0.01) 52 (0.02)
Balance disorder 10 (0.11) 52 (0.47) 248 (1.28) 1 (0.48) 228 (0.53) 528 (0.37) 1104 (0.49)
Basedow's disease 0 5 (0.05) 11 (0.06) 0 24 (0.06) 92 (0.06) 134 (0.06)
Bedridden 11 (0.12) 10 (0.09) 43 (0.22) 0 22 (0.05) 68 (0.05) 164 (0.07)
Bell's palsy 0 9 (0.08) 208 (1.08) 2 (0.95) 244 (0.57) 1650 (1.15) 2142 (0.95)
Blepharospasm 0 3 (0.03) 15 (0.08) 0 15 (0.04) 69 (0.05) 103 (0.05)
Blindness 1 (0.01) 19 (0.17) 90 (0.47) 0 62 (0.15) 266 (0.19) 466 (0.21)
Blindness transient 0 8 (0.07) 8 (0.04) 0 14 (0.03) 90 (0.06) 122 (0.05)
Blindness unilateral 0 2 (0.02) 49 (0.25) 0 18 (0.04) 58 (0.04) 140 (0.06)
Blister 2 (0.02) 11 (0.10) 50 (0.26) 0 61 (0.14) 306 (0.21) 440 (0.19)
Blood creatine phosphokinase increased 3 (0.03) 8 (0.07) 7 (0.04) 0 89 (0.21) 37 (0.03) 165 (0.07)
Blood glucose decreased 2 (0.02) 14 (0.13) 8 (0.04) 0 13 (0.03) 46 (0.03) 89 (0.04)
Blood glucose increased 5 (0.06) 19 (0.17) 18 (0.09) 0 47 (0.11) 140 (0.10) 246 (0.11)
Blood potassium decreased 0 7 (0.06) 0 0 30 (0.07) 7 (0.00) 51 (0.02)
Blood pressure abnormal 4 (0.05) 8 (0.07) 13 (0.07) 0 24 (0.06) 74 (0.05) 127 (0.06)
Blood pressure decreased 42 (0.47) 124 (1.13) 52 (0.27) 1 (0.48) 278 (0.65) 632 (0.44) 1188 (0.53)
Blood pressure fluctuation 1 (0.01) 19 (0.17) 21 (0.11) 0 48 (0.11) 75 (0.05) 178 (0.08)
Blood pressure increased 16 (0.18) 134 (1.22) 131 (0.68) 0 673 (1.58) 2356 (1.64) 3397 (1.51)
Blood pressure systolic increased 0 7 (0.06) 3 (0.02) 0 29 (0.07) 95 (0.07) 144 (0.06)
Blood test abnormal 0 2 (0.02) 5 (0.03) 0 19 (0.04) 34 (0.02) 61 (0.03)
Blood urine present 2 (0.02) 5 (0.05) 11 (0.06) 0 20 (0.05) 67 (0.05) 105 (0.05)
Body temperature abnormal 0 3 (0.03) 20 (0.10) 0 3 (0.01) 95 (0.07) 123 (0.05)
Body temperature decreased 5 (0.06) 7 (0.06) 18 (0.09) 0 8 (0.02) 63 (0.04) 104 (0.05)
Body temperature fluctuation 1 (0.01) 0 13 (0.07) 0 9 (0.02) 55 (0.04) 78 (0.03)
Body temperature increased 16 (0.18) 8 (0.07) 59 (0.31) 0 99 (0.23) 361 (0.25) 554 (0.25)
Bone pain 2 (0.02) 20 (0.18) 109 (0.56) 0 37 (0.09) 389 (0.27) 563 (0.25)
Bradycardia 19 (0.21) 50 (0.46) 19 (0.10) 0 106 (0.25) 437 (0.30) 667 (0.30)
Bradyphrenia 0 1 (0.01) 13 (0.07) 0 7 (0.02) 41 (0.03) 63 (0.03)
Brain injury 19 (0.21) 7 (0.06) 4 (0.02) 0 6 (0.01) 17 (0.01) 62 (0.03)
Brain oedema 23 (0.26) 13 (0.12) 2 (0.01) 0 13 (0.03) 22 (0.02) 94 (0.04)
Brain stem infarction 7 (0.08) 15 (0.14) 4 (0.02) 0 33 (0.08) 6 (0.00) 68 (0.03)
Breast cancer 0 5 (0.05) 2 (0.01) 0 4 (0.01) 59 (0.04) 71 (0.03)
Breast mass 0 3 (0.03) 7 (0.04) 1 (0.48) 7 (0.02) 81 (0.06) 102 (0.05)
Breast pain 0 12 (0.11) 65 (0.34) 1 (0.48) 85 (0.20) 569 (0.40) 739 (0.33)
Breast swelling 0 2 (0.02) 18 (0.09) 0 8 (0.02) 135 (0.09) 164 (0.07)
Breast tenderness 0 0 7 (0.04) 0 3 (0.01) 58 (0.04) 68 (0.03)
Bronchitis 10 (0.11) 5 (0.05) 10 (0.05) 0 26 (0.06) 60 (0.04) 118 (0.05)
Bronchospasm 5 (0.06) 55 (0.50) 3 (0.02) 0 92 (0.22) 183 (0.13) 355 (0.16)
Burning sensation 3 (0.03) 46 (0.42) 157 (0.81) 0 157 (0.37) 592 (0.41) 981 (0.43)
Bursitis 0 2 (0.02) 32 (0.17) 0 12 (0.03) 81 (0.06) 129 (0.06)
C-reactive protein increased 25 (0.28) 22 (0.20) 32 (0.17) 0 263 (0.62) 109 (0.08) 487 (0.22)
COVID-19 689 (7.79) 133 (1.21) 106 (0.55) 0 1284 (3.01) 14964 (10.41) 17368 (7.70)
COVID-19 immunisation 2 (0.02) 12 (0.11) 48 (0.25) 0 28 (0.07) 32 (0.02) 122 (0.05)
COVID-19 pneumonia 213 (2.41) 72 (0.66) 8 (0.04) 0 307 (0.72) 76 (0.05) 692 (0.31)
Cardiac arrest 508 (5.74) 169 (1.54) 1 (0.01) 0 54 (0.13) 37 (0.03) 836 (0.37)
Cardiac discomfort 1 (0.01) 11 (0.10) 17 (0.09) 0 43 (0.10) 52 (0.04) 127 (0.06)
Cardiac disorder 42 (0.47) 42 (0.38) 17 (0.09) 0 93 (0.22) 112 (0.08) 320 (0.14)
Cardiac failure 261 (2.95) 145 (1.32) 29 (0.15) 0 300 (0.70) 123 (0.09) 905 (0.40)
Cardiac failure acute 101 (1.14) 20 (0.18) 0 0 35 (0.08) 7 (0.00) 164 (0.07)
Cardiac failure congestive 39 (0.44) 11 (0.10) 4 (0.02) 0 40 (0.09) 22 (0.02) 123 (0.05)
Cardiac fibrillation 1 (0.01) 9 (0.08) 5 (0.03) 0 26 (0.06) 31 (0.02) 78 (0.03)
Cardiac flutter 1 (0.01) 6 (0.05) 29 (0.15) 0 45 (0.11) 633 (0.44) 723 (0.32)
Cardiac tamponade 21 (0.24) 12 (0.11) 0 0 14 (0.03) 4 (0.00) 55 (0.02)
Cardio-respiratory arrest 381 (4.31) 57 (0.52) 0 0 13 (0.03) 2 (0.00) 493 (0.22)
Cardiogenic shock 53 (0.60) 31 (0.28) 1 (0.01) 0 11 (0.03) 7 (0.00) 108 (0.05)
Cardiomegaly 15 (0.17) 10 (0.09) 7 (0.04) 0 22 (0.05) 24 (0.02) 88 (0.04)
Cardiomyopathy 11 (0.12) 18 (0.16) 3 (0.02) 0 37 (0.09) 37 (0.03) 116 (0.05)
Cardiovascular disorder 32 (0.36) 28 (0.26) 45 (0.23) 0 108 (0.25) 85 (0.06) 304 (0.13)
Cellulitis 7 (0.08) 9 (0.08) 14 (0.07) 0 57 (0.13) 414 (0.29) 516 (0.23)
Cerebellar infarction 6 (0.07) 15 (0.14) 7 (0.04) 0 45 (0.11) 9 (0.01) 85 (0.04)
Cerebral haemorrhage 232 (2.62) 137 (1.25) 45 (0.23) 0 227 (0.53) 52 (0.04) 719 (0.32)
Cerebral infarction 99 (1.12) 201 (1.83) 139 (0.72) 0 634 (1.49) 111 (0.08) 1229 (0.54)
Cerebral ischaemia 13 (0.15) 16 (0.15) 14 (0.07) 0 54 (0.13) 28 (0.02) 132 (0.06)
Cerebral thrombosis 20 (0.23) 49 (0.45) 14 (0.07) 0 92 (0.22) 32 (0.02) 218 (0.10)
Cerebral venous sinus thrombosis 27 (0.31) 92 (0.84) 7 (0.04) 0 126 (0.30) 45 (0.03) 303 (0.13)
Cerebral venous thrombosis 10 (0.11) 43 (0.39) 6 (0.03) 0 69 (0.16) 13 (0.01) 147 (0.07)
Cerebrovascular accident 237 (2.68) 452 (4.12) 229 (1.19) 1 (0.48) 1074 (2.52) 491 (0.34) 2575 (1.14)
Chest discomfort 21 (0.24) 178 (1.62) 296 (1.53) 3 (1.43) 1021 (2.40) 1846 (1.28) 3439 (1.52)
Chest pain 102 (1.15) 515 (4.69) 687 (3.56) 2 (0.95) 2316 (5.43) 3744 (2.60) 7540 (3.34)
Chills 61 (0.69) 261 (2.38) 2259 (11.70) 2 (0.95) 1103 (2.59) 6353 (4.42) 10139 (4.49)
Choking 9 (0.10) 15 (0.14) 4 (0.02) 0 11 (0.03) 70 (0.05) 123 (0.05)
Choking sensation 0 9 (0.08) 5 (0.03) 0 18 (0.04) 38 (0.03) 74 (0.03)
Chromaturia 0 7 (0.06) 9 (0.05) 0 23 (0.05) 38 (0.03) 79 (0.04)
Chronic fatigue syndrome 0 1 (0.01) 38 (0.20) 0 13 (0.03) 62 (0.04) 116 (0.05)
Chronic obstructive pulmonary disease 30 (0.34) 16 (0.15) 5 (0.03) 0 48 (0.11) 30 (0.02) 140 (0.06)
Circulatory collapse 79 (0.89) 58 (0.53) 7 (0.04) 0 142 (0.33) 226 (0.16) 551 (0.24)
Cluster headache 0 3 (0.03) 32 (0.17) 0 13 (0.03) 132 (0.09) 180 (0.08)
Coagulopathy 20 (0.23) 33 (0.30) 24 (0.12) 0 50 (0.12) 50 (0.03) 184 (0.08)
Cognitive disorder 11 (0.12) 12 (0.11) 69 (0.36) 0 47 (0.11) 121 (0.08) 272 (0.12)
Cold sweat 10 (0.11) 59 (0.54) 86 (0.45) 0 206 (0.48) 669 (0.47) 1054 (0.47)
Colitis 1 (0.01) 11 (0.10) 9 (0.05) 0 51 (0.12) 48 (0.03) 120 (0.05)
Colitis ischaemic 3 (0.03) 2 (0.02) 0 0 39 (0.09) 23 (0.02) 68 (0.03)
Colitis ulcerative 0 9 (0.08) 24 (0.12) 0 39 (0.09) 142 (0.10) 216 (0.10)
Coma 43 (0.49) 36 (0.33) 5 (0.03) 0 29 (0.07) 11 (0.01) 152 (0.07)
Concomitant disease aggravated 10 (0.11) 1 (0.01) 11 (0.06) 0 10 (0.02) 18 (0.01) 52 (0.02)
Condition aggravated 87 (0.98) 66 (0.60) 289 (1.50) 0 290 (0.68) 1219 (0.85) 2012 (0.89)
Confusional state 54 (0.61) 137 (1.25) 232 (1.20) 0 435 (1.02) 690 (0.48) 1598 (0.71)
Congestive cardiomyopathy 3 (0.03) 12 (0.11) 1 (0.01) 0 24 (0.06) 6 (0.00) 51 (0.02)
Conjunctival haemorrhage 2 (0.02) 2 (0.02) 1 (0.01) 0 9 (0.02) 150 (0.10) 167 (0.07)
Conjunctival hyperaemia 0 2 (0.02) 2 (0.01) 0 20 (0.05) 35 (0.02) 60 (0.03)
Conjunctivitis 1 (0.01) 5 (0.05) 14 (0.07) 0 18 (0.04) 71 (0.05) 109 (0.05)
Constipation 6 (0.07) 6 (0.05) 39 (0.20) 0 51 (0.12) 147 (0.10) 260 (0.12)
Contusion 14 (0.16) 52 (0.47) 105 (0.54) 1 (0.48) 131 (0.31) 609 (0.42) 932 (0.41)
Coordination abnormal 4 (0.05) 9 (0.08) 40 (0.21) 1 (0.48) 46 (0.11) 51 (0.04) 156 (0.07)
Coronary artery disease 20 (0.23) 11 (0.10) 2 (0.01) 0 27 (0.06) 3 (0.00) 67 (0.03)
Coronary artery thrombosis 11 (0.12) 22 (0.20) 0 0 11 (0.03) 2 (0.00) 54 (0.02)
Costochondritis 0 1 (0.01) 23 (0.12) 0 18 (0.04) 57 (0.04) 101 (0.04)
Cough 106 (1.20) 192 (1.75) 390 (2.02) 1 (0.48) 925 (2.17) 2479 (1.72) 4187 (1.86)
Crohn's disease 0 2 (0.02) 13 (0.07) 0 20 (0.05) 83 (0.06) 122 (0.05)
Crying 0 8 (0.07) 27 (0.14) 0 24 (0.06) 131 (0.09) 193 (0.09)
Cutaneous vasculitis 1 (0.01) 2 (0.02) 1 (0.01) 0 50 (0.12) 54 (0.04) 111 (0.05)
Cyanosis 31 (0.35) 42 (0.38) 14 (0.07) 0 87 (0.20) 93 (0.06) 299 (0.13)
Cystitis 1 (0.01) 6 (0.05) 12 (0.06) 0 29 (0.07) 81 (0.06) 134 (0.06)
Deafness 0 12 (0.11) 131 (0.68) 0 54 (0.13) 510 (0.35) 734 (0.33)
Deafness neurosensory 0 1 (0.01) 38 (0.20) 0 10 (0.02) 63 (0.04) 114 (0.05)
Deafness unilateral 0 0 90 (0.47) 0 25 (0.06) 212 (0.15) 336 (0.15)
Death 1655 (18.70) 0 0 0 1 (0.00) 1 (0.00) 1657 (0.73)
Decreased appetite 92 (1.04) 70 (0.64) 370 (1.92) 0 418 (0.98) 1227 (0.85) 2250 (1.00)
Deep vein thrombosis 48 (0.54) 426 (3.88) 58 (0.30) 1 (0.48) 782 (1.83) 1463 (1.02) 2842 (1.26)
Dehydration 37 (0.42) 30 (0.27) 30 (0.16) 0 158 (0.37) 221 (0.15) 511 (0.23)
Delirium 14 (0.16) 26 (0.24) 23 (0.12) 0 79 (0.19) 184 (0.13) 358 (0.16)
Dementia 9 (0.10) 3 (0.03) 15 (0.08) 0 25 (0.06) 57 (0.04) 129 (0.06)
Demyelination 1 (0.01) 2 (0.02) 18 (0.09) 0 28 (0.07) 25 (0.02) 82 (0.04)
Depressed level of consciousness 75 (0.85) 79 (0.72) 17 (0.09) 0 244 (0.57) 465 (0.32) 988 (0.44)
Depressed mood 1 (0.01) 9 (0.08) 64 (0.33) 0 26 (0.06) 289 (0.20) 393 (0.17)
Depression 1 (0.01) 29 (0.26) 101 (0.52) 0 51 (0.12) 271 (0.19) 460 (0.20)
Dermatitis 1 (0.01) 4 (0.04) 20 (0.10) 0 12 (0.03) 116 (0.08) 154 (0.07)
Dermatitis allergic 0 11 (0.10) 22 (0.11) 0 38 (0.09) 170 (0.12) 245 (0.11)
Dermatitis atopic 0 0 11 (0.06) 0 7 (0.02) 34 (0.02) 52 (0.02)
Dermatitis bullous 2 (0.02) 0 7 (0.04) 0 16 (0.04) 65 (0.05) 91 (0.04)
Diabetes mellitus 8 (0.09) 11 (0.10) 13 (0.07) 0 33 (0.08) 128 (0.09) 207 (0.09)
Diabetes mellitus inadequate control 4 (0.05) 2 (0.02) 4 (0.02) 0 7 (0.02) 63 (0.04) 84 (0.04)
Diabetic ketoacidosis 5 (0.06) 11 (0.10) 2 (0.01) 0 14 (0.03) 15 (0.01) 53 (0.02)
Diarrhoea 92 (1.04) 146 (1.33) 748 (3.88) 3 (1.43) 887 (2.08) 3856 (2.68) 5836 (2.59)
Diarrhoea haemorrhagic 0 7 (0.06) 3 (0.02) 0 22 (0.05) 80 (0.06) 115 (0.05)
Diplegia 3 (0.03) 5 (0.05) 17 (0.09) 0 20 (0.05) 36 (0.03) 87 (0.04)
Diplopia 2 (0.02) 14 (0.13) 95 (0.49) 0 172 (0.40) 200 (0.14) 497 (0.22)
Discomfort 11 (0.12) 22 (0.20) 101 (0.52) 0 133 (0.31) 516 (0.36) 798 (0.35)
Disease recurrence 17 (0.19) 66 (0.60) 112 (0.58) 0 166 (0.39) 828 (0.58) 1218 (0.54)
Disorientation 14 (0.16) 29 (0.26) 67 (0.35) 0 123 (0.29) 275 (0.19) 521 (0.23)
Disseminated intravascular coagulation 22 (0.25) 17 (0.15) 0 0 7 (0.02) 6 (0.00) 66 (0.03)
Disturbance in attention 10 (0.11) 27 (0.25) 205 (1.06) 1 (0.48) 168 (0.39) 492 (0.34) 924 (0.41)
Diverticulitis 2 (0.02) 2 (0.02) 3 (0.02) 0 41 (0.10) 66 (0.05) 119 (0.05)
Dizziness 57 (0.64) 510 (4.64) 1644 (8.52) 4 (1.90) 2873 (6.74) 7653 (5.32) 12923 (5.73)
Dizziness exertional 0 0 10 (0.05) 0 3 (0.01) 40 (0.03) 54 (0.02)
Dizziness postural 0 5 (0.05) 66 (0.34) 0 34 (0.08) 462 (0.32) 568 (0.25)
Drug eruption 0 2 (0.02) 1 (0.01) 0 27 (0.06) 80 (0.06) 111 (0.05)
Drug hypersensitivity 1 (0.01) 9 (0.08) 5 (0.03) 0 23 (0.05) 77 (0.05) 121 (0.05)
Drug ineffective 215 (2.43) 98 (0.89) 65 (0.34) 0 452 (1.06) 5689 (3.96) 6733 (2.98)
Drug interaction 4 (0.05) 5 (0.05) 6 (0.03) 0 32 (0.08) 44 (0.03) 92 (0.04)
Dry eye 0 2 (0.02) 35 (0.18) 0 10 (0.02) 93 (0.06) 143 (0.06)
Dry mouth 1 (0.01) 29 (0.26) 63 (0.33) 0 79 (0.19) 287 (0.20) 469 (0.21)
Dry skin 0 5 (0.05) 19 (0.10) 0 7 (0.02) 108 (0.08) 143 (0.06)
Dry throat 0 4 (0.04) 18 (0.09) 0 17 (0.04) 103 (0.07) 144 (0.06)
Dysaesthesia 0 6 (0.05) 15 (0.08) 0 57 (0.13) 90 (0.06) 173 (0.08)
Dysarthria 25 (0.28) 54 (0.49) 75 (0.39) 0 264 (0.62) 157 (0.11) 612 (0.27)
Dysentery 0 2 (0.02) 12 (0.06) 0 6 (0.01) 95 (0.07) 115 (0.05)
Dysgeusia 2 (0.02) 21 (0.19) 93 (0.48) 0 95 (0.22) 485 (0.34) 706 (0.31)
Dyskinesia 2 (0.02) 8 (0.07) 38 (0.20) 1 (0.48) 81 (0.19) 92 (0.06) 229 (0.10)
Dyslalia 0 3 (0.03) 8 (0.04) 0 45 (0.11) 6 (0.00) 75 (0.03)
Dysmenorrhoea 0 6 (0.05) 235 (1.22) 1 (0.48) 50 (0.12) 2284 (1.59) 2584 (1.14)
Dyspepsia 2 (0.02) 19 (0.17) 67 (0.35) 0 44 (0.10) 267 (0.19) 407 (0.18)
Dysphagia 32 (0.36) 109 (0.99) 92 (0.48) 1 (0.48) 254 (0.60) 472 (0.33) 1004 (0.44)
Dysphonia 1 (0.01) 51 (0.46) 50 (0.26) 0 152 (0.36) 325 (0.23) 606 (0.27)
Dysphoria 3 (0.03) 6 (0.05) 0 0 59 (0.14) 113 (0.08) 188 (0.08)
Dyspnoea 524 (5.92) 1194 (10.87) 1033 (5.35) 3 (1.43) 3755 (8.81) 5738 (3.99) 12673 (5.62)
Dyspnoea at rest 0 7 (0.06) 6 (0.03) 0 22 (0.05) 59 (0.04) 99 (0.04)
Dyspnoea exertional 14 (0.16) 46 (0.42) 49 (0.25) 0 173 (0.41) 217 (0.15) 532 (0.24)
Dysstasia 4 (0.05) 20 (0.18) 76 (0.39) 0 126 (0.30) 191 (0.13) 444 (0.20)
Dysuria 6 (0.07) 8 (0.07) 15 (0.08) 0 48 (0.11) 78 (0.05) 158 (0.07)
Ear discomfort 0 6 (0.05) 74 (0.38) 0 43 (0.10) 167 (0.12) 302 (0.13)
Ear infection 0 3 (0.03) 18 (0.09) 0 9 (0.02) 88 (0.06) 122 (0.05)
Ear pain 2 (0.02) 9 (0.08) 162 (0.84) 0 79 (0.19) 684 (0.48) 954 (0.42)
Ear swelling 0 3 (0.03) 5 (0.03) 0 10 (0.02) 40 (0.03) 60 (0.03)
Eating disorder 6 (0.07) 7 (0.06) 14 (0.07) 0 33 (0.08) 46 (0.03) 115 (0.05)
Ecchymosis 2 (0.02) 8 (0.07) 3 (0.02) 0 40 (0.09) 43 (0.03) 102 (0.05)
Eczema 1 (0.01) 1 (0.01) 41 (0.21) 0 44 (0.10) 231 (0.16) 323 (0.14)
Electric shock sensation 0 11 (0.10) 36 (0.19) 0 15 (0.04) 41 (0.03) 104 (0.05)
Electrocardiogram ST segment elevation 0 3 (0.03) 1 (0.01) 0 53 (0.12) 44 (0.03) 115 (0.05)
Electrocardiogram abnormal 0 9 (0.08) 3 (0.02) 0 45 (0.11) 32 (0.02) 98 (0.04)
Embolic stroke 3 (0.03) 13 (0.12) 8 (0.04) 0 40 (0.09) 10 (0.01) 78 (0.03)
Embolism 17 (0.19) 34 (0.31) 24 (0.12) 0 64 (0.15) 62 (0.04) 212 (0.09)
Emotional disorder 0 1 (0.01) 12 (0.06) 0 5 (0.01) 63 (0.04) 81 (0.04)
Emotional distress 1 (0.01) 8 (0.07) 22 (0.11) 0 13 (0.03) 50 (0.03) 95 (0.04)
Encephalitis 8 (0.09) 33 (0.30) 14 (0.07) 0 105 (0.25) 23 (0.02) 192 (0.09)
Encephalopathy 8 (0.09) 7 (0.06) 5 (0.03) 0 31 (0.07) 19 (0.01) 82 (0.04)
Endocarditis 7 (0.08) 8 (0.07) 1 (0.01) 0 26 (0.06) 14 (0.01) 60 (0.03)
Endometriosis 0 0 17 (0.09) 0 9 (0.02) 70 (0.05) 97 (0.04)
Eosinophilia 0 3 (0.03) 4 (0.02) 0 26 (0.06) 15 (0.01) 52 (0.02)
Epilepsy 22 (0.25) 80 (0.73) 29 (0.15) 0 331 (0.78) 410 (0.29) 889 (0.39)
Epistaxis 8 (0.09) 52 (0.47) 59 (0.31) 0 154 (0.36) 457 (0.32) 740 (0.33)
Erectile dysfunction 0 1 (0.01) 30 (0.16) 0 7 (0.02) 128 (0.09) 169 (0.07)
Eructation 0 3 (0.03) 12 (0.06) 0 14 (0.03) 31 (0.02) 64 (0.03)
Erysipelas 3 (0.03) 2 (0.02) 4 (0.02) 0 46 (0.11) 68 (0.05) 126 (0.06)
Erythema 10 (0.11) 128 (1.17) 152 (0.79) 0 641 (1.50) 2208 (1.54) 3202 (1.42)
Erythema multiforme 1 (0.01) 2 (0.02) 4 (0.02) 0 54 (0.13) 158 (0.11) 223 (0.10)
Erythema nodosum 0 2 (0.02) 3 (0.02) 0 17 (0.04) 51 (0.04) 73 (0.03)
Erythema of eyelid 0 1 (0.01) 4 (0.02) 0 10 (0.02) 37 (0.03) 52 (0.02)
Exercise tolerance decreased 1 (0.01) 9 (0.08) 58 (0.30) 0 43 (0.10) 52 (0.04) 172 (0.08)
Exposure during pregnancy 2 (0.02) 5 (0.05) 1 (0.01) 1 (0.48) 22 (0.05) 90 (0.06) 124 (0.05)
Exposure via breast milk 2 (0.02) 1 (0.01) 3 (0.02) 2 (0.95) 13 (0.03) 139 (0.10) 161 (0.07)
Extensive swelling of vaccinated limb 1 (0.01) 7 (0.06) 214 (1.11) 0 12 (0.03) 65 (0.05) 299 (0.13)
Extrasystoles 2 (0.02) 19 (0.17) 43 (0.22) 0 82 (0.19) 201 (0.14) 353 (0.16)
Eye disorder 1 (0.01) 2 (0.02) 30 (0.16) 0 40 (0.09) 90 (0.06) 163 (0.07)
Eye haemorrhage 0 4 (0.04) 11 (0.06) 0 10 (0.02) 197 (0.14) 226 (0.10)
Eye inflammation 0 0 14 (0.07) 0 8 (0.02) 36 (0.03) 60 (0.03)
Eye irritation 0 7 (0.06) 27 (0.14) 0 8 (0.02) 109 (0.08) 154 (0.07)
Eye movement disorder 1 (0.01) 9 (0.08) 23 (0.12) 0 37 (0.09) 48 (0.03) 127 (0.06)
Eye oedema 0 3 (0.03) 9 (0.05) 0 4 (0.01) 35 (0.02) 52 (0.02)
Eye pain 1 (0.01) 28 (0.26) 194 (1.01) 0 112 (0.26) 825 (0.57) 1172 (0.52)
Eye pruritus 0 12 (0.11) 22 (0.11) 0 31 (0.07) 206 (0.14) 278 (0.12)
Eye swelling 0 33 (0.30) 45 (0.23) 1 (0.48) 55 (0.13) 429 (0.30) 573 (0.25)
Eyelid oedema 0 10 (0.09) 5 (0.03) 0 48 (0.11) 137 (0.10) 205 (0.09)
Eyelid ptosis 1 (0.01) 5 (0.05) 18 (0.09) 0 38 (0.09) 67 (0.05) 137 (0.06)
Face oedema 2 (0.02) 33 (0.30) 16 (0.08) 0 103 (0.24) 245 (0.17) 407 (0.18)
Facial pain 0 4 (0.04) 57 (0.30) 0 43 (0.10) 203 (0.14) 310 (0.14)
Facial paralysis 3 (0.03) 43 (0.39) 185 (0.96) 2 (0.95) 605 (1.42) 1748 (1.22) 2633 (1.17)
Facial paresis 1 (0.01) 24 (0.22) 80 (0.41) 0 282 (0.66) 288 (0.20) 689 (0.31)
Faeces discoloured 3 (0.03) 3 (0.03) 8 (0.04) 0 15 (0.04) 34 (0.02) 69 (0.03)
Fall 89 (1.01) 81 (0.74) 102 (0.53) 0 405 (0.95) 521 (0.36) 1313 (0.58)
Fatigue 176 (1.99) 490 (4.46) 5049 (26.16) 6 (2.86) 2162 (5.07) 13956 (9.71) 22030 (9.76)
Fear 1 (0.01) 8 (0.07) 12 (0.06) 0 9 (0.02) 41 (0.03) 72 (0.03)
Febrile convulsion 1 (0.01) 3 (0.03) 5 (0.03) 1 (0.48) 30 (0.07) 35 (0.02) 75 (0.03)
Feeding disorder 6 (0.07) 12 (0.11) 38 (0.20) 0 41 (0.10) 108 (0.08) 224 (0.10)
Feeling abnormal 11 (0.12) 85 (0.77) 444 (2.30) 1 (0.48) 488 (1.14) 1986 (1.38) 3090 (1.37)
Feeling cold 5 (0.06) 35 (0.32) 172 (0.89) 0 160 (0.38) 1054 (0.73) 1439 (0.64)
Feeling drunk 1 (0.01) 2 (0.02) 14 (0.07) 1 (0.48) 9 (0.02) 77 (0.05) 105 (0.05)
Feeling hot 3 (0.03) 73 (0.66) 171 (0.89) 2 (0.95) 347 (0.81) 1286 (0.89) 1911 (0.85)
Feeling jittery 0 2 (0.02) 2 (0.01) 0 22 (0.05) 34 (0.02) 64 (0.03)
Feeling of body temperature change 1 (0.01) 11 (0.10) 71 (0.37) 0 42 (0.10) 336 (0.23) 462 (0.20)
Fibrin D dimer increased 11 (0.12) 28 (0.26) 12 (0.06) 0 162 (0.38) 154 (0.11) 389 (0.17)
Fibromyalgia 1 (0.01) 6 (0.05) 64 (0.33) 0 9 (0.02) 94 (0.07) 177 (0.08)
Flank pain 2 (0.02) 4 (0.04) 15 (0.08) 0 24 (0.06) 56 (0.04) 103 (0.05)
Flatulence 1 (0.01) 6 (0.05) 24 (0.12) 0 16 (0.04) 117 (0.08) 166 (0.07)
Fluid retention 4 (0.05) 9 (0.08) 12 (0.06) 0 14 (0.03) 43 (0.03) 85 (0.04)
Flushing 1 (0.01) 47 (0.43) 32 (0.17) 0 160 (0.38) 472 (0.33) 727 (0.32)
Foetal death 15 (0.17) 3 (0.03) 2 (0.01) 2 (0.95) 29 (0.07) 35 (0.02) 88 (0.04)
Food allergy 0 15 (0.14) 5 (0.03) 0 5 (0.01) 33 (0.02) 60 (0.03)
Formication 0 3 (0.03) 15 (0.08) 1 (0.48) 10 (0.02) 97 (0.07) 129 (0.06)
Gait disturbance 18 (0.20) 70 (0.64) 381 (1.97) 0 443 (1.04) 660 (0.46) 1657 (0.73)
Gait inability 6 (0.07) 29 (0.26) 160 (0.83) 0 126 (0.30) 191 (0.13) 552 (0.24)
Gastritis 1 (0.01) 2 (0.02) 19 (0.10) 0 24 (0.06) 45 (0.03) 94 (0.04)
Gastroenteritis 2 (0.02) 3 (0.03) 2 (0.01) 0 44 (0.10) 35 (0.02) 89 (0.04)
Gastrointestinal disorder 3 (0.03) 8 (0.07) 29 (0.15) 0 48 (0.11) 91 (0.06) 185 (0.08)
Gastrointestinal haemorrhage 30 (0.34) 18 (0.16) 1 (0.01) 0 32 (0.08) 25 (0.02) 115 (0.05)
Gastrointestinal pain 0 7 (0.06) 37 (0.19) 0 36 (0.08) 102 (0.07) 187 (0.08)
Gastrooesophageal reflux disease 2 (0.02) 8 (0.07) 39 (0.20) 0 26 (0.06) 94 (0.07) 171 (0.08)
Gaze palsy 4 (0.05) 5 (0.05) 3 (0.02) 0 14 (0.03) 25 (0.02) 55 (0.02)
General physical health deterioration 204 (2.31) 43 (0.39) 40 (0.21) 0 224 (0.53) 69 (0.05) 634 (0.28)
Generalised oedema 5 (0.06) 6 (0.05) 3 (0.02) 0 18 (0.04) 31 (0.02) 66 (0.03)
Generalised tonic-clonic seizure 7 (0.08) 37 (0.34) 8 (0.04) 0 141 (0.33) 167 (0.12) 368 (0.16)
Genital haemorrhage 0 1 (0.01) 1 (0.01) 0 8 (0.02) 60 (0.04) 71 (0.03)
Genital herpes 0 0 16 (0.08) 0 9 (0.02) 63 (0.04) 88 (0.04)
Giant cell arteritis 2 (0.02) 9 (0.08) 11 (0.06) 0 56 (0.13) 36 (0.03) 116 (0.05)
Gingival bleeding 0 11 (0.10) 7 (0.04) 0 26 (0.06) 50 (0.03) 94 (0.04)
Gingival pain 0 2 (0.02) 12 (0.06) 0 4 (0.01) 68 (0.05) 87 (0.04)
Glossodynia 0 3 (0.03) 21 (0.11) 0 11 (0.03) 105 (0.07) 140 (0.06)
Gout 0 3 (0.03) 27 (0.14) 0 21 (0.05) 65 (0.05) 116 (0.05)
Grip strength decreased 1 (0.01) 1 (0.01) 30 (0.16) 0 18 (0.04) 54 (0.04) 105 (0.05)
Groin pain 4 (0.05) 3 (0.03) 33 (0.17) 0 23 (0.05) 103 (0.07) 172 (0.08)
Guillain-Barre syndrome 16 (0.18) 77 (0.70) 67 (0.35) 0 446 (1.05) 209 (0.15) 851 (0.38)
Haematemesis 34 (0.38) 14 (0.13) 10 (0.05) 0 35 (0.08) 71 (0.05) 180 (0.08)
Haematochezia 6 (0.07) 7 (0.06) 18 (0.09) 1 (0.48) 61 (0.14) 288 (0.20) 388 (0.17)
Haematoma 10 (0.11) 32 (0.29) 42 (0.22) 1 (0.48) 96 (0.23) 168 (0.12) 359 (0.16)
Haematuria 4 (0.05) 12 (0.11) 10 (0.05) 0 58 (0.14) 116 (0.08) 206 (0.09)
Haemoglobin decreased 5 (0.06) 13 (0.12) 6 (0.03) 0 49 (0.11) 28 (0.02) 112 (0.05)
Haemolytic anaemia 4 (0.05) 10 (0.09) 2 (0.01) 0 22 (0.05) 11 (0.01) 51 (0.02)
Haemoptysis 14 (0.16) 27 (0.25) 14 (0.07) 0 51 (0.12) 69 (0.05) 189 (0.08)
Haemorrhage 21 (0.24) 53 (0.48) 56 (0.29) 7 (3.33) 127 (0.30) 1286 (0.89) 1582 (0.70)
Haemorrhage intracranial 17 (0.19) 13 (0.12) 1 (0.01) 0 14 (0.03) 4 (0.00) 54 (0.02)
Haemorrhage subcutaneous 3 (0.03) 1 (0.01) 1 (0.01) 0 13 (0.03) 156 (0.11) 185 (0.08)
Haemorrhage urinary tract 0 1 (0.01) 2 (0.01) 0 4 (0.01) 52 (0.04) 62 (0.03)
Haemorrhagic stroke 57 (0.64) 26 (0.24) 7 (0.04) 0 27 (0.06) 9 (0.01) 128 (0.06)
Haemorrhoids 1 (0.01) 0 7 (0.04) 0 5 (0.01) 38 (0.03) 52 (0.02)
Hallucination 6 (0.07) 22 (0.20) 45 (0.23) 0 45 (0.11) 370 (0.26) 505 (0.22)
Hallucination, auditory 0 2 (0.02) 5 (0.03) 0 10 (0.02) 39 (0.03) 58 (0.03)
Hallucination, visual 1 (0.01) 4 (0.04) 7 (0.04) 0 15 (0.04) 82 (0.06) 110 (0.05)
Hangover 0 0 16 (0.08) 0 3 (0.01) 50 (0.03) 69 (0.03)
Head discomfort 0 30 (0.27) 104 (0.54) 0 136 (0.32) 363 (0.25) 647 (0.29)
Head injury 4 (0.05) 16 (0.15) 10 (0.05) 0 54 (0.13) 109 (0.08) 209 (0.09)
Headache 99 (1.12) 691 (6.29) 5027 (26.05) 7 (3.33) 3699 (8.68) 17555 (12.21) 27351 (12.12)
Heart rate 0 2 (0.02) 13 (0.07) 0 12 (0.03) 54 (0.04) 81 (0.04)
Heart rate abnormal 0 12 (0.11) 17 (0.09) 0 35 (0.08) 100 (0.07) 165 (0.07)
Heart rate decreased 5 (0.06) 40 (0.36) 23 (0.12) 1 (0.48) 79 (0.19) 234 (0.16) 404 (0.18)
Heart rate increased 19 (0.21) 172 (1.57) 257 (1.33) 1 (0.48) 540 (1.27) 1276 (0.89) 2330 (1.03)
Heart rate irregular 1 (0.01) 27 (0.25) 53 (0.27) 2 (0.95) 88 (0.21) 226 (0.16) 405 (0.18)
Heavy menstrual bleeding 0 34 (0.31) 335 (1.74) 2 (0.95) 147 (0.34) 3588 (2.50) 4121 (1.83)
Hemianaesthesia 0 4 (0.04) 17 (0.09) 0 41 (0.10) 41 (0.03) 104 (0.05)
Hemiparaesthesia 1 (0.01) 1 (0.01) 11 (0.06) 0 35 (0.08) 103 (0.07) 153 (0.07)
Hemiparesis 37 (0.42) 65 (0.59) 67 (0.35) 0 272 (0.64) 194 (0.13) 686 (0.30)
Hemiplegia 17 (0.19) 33 (0.30) 46 (0.24) 0 127 (0.30) 71 (0.05) 343 (0.15)
Henoch-Schonlein purpura 1 (0.01) 0 4 (0.02) 0 30 (0.07) 16 (0.01) 52 (0.02)
Hepatic cytolysis 1 (0.01) 2 (0.02) 0 0 37 (0.09) 36 (0.03) 77 (0.03)
Hepatic enzyme increased 2 (0.02) 7 (0.06) 4 (0.02) 0 45 (0.11) 27 (0.02) 92 (0.04)
Hepatic function abnormal 6 (0.07) 8 (0.07) 3 (0.02) 0 78 (0.18) 35 (0.02) 136 (0.06)
Hepatitis 4 (0.05) 3 (0.03) 4 (0.02) 0 40 (0.09) 51 (0.04) 105 (0.05)
Hepatitis acute 4 (0.05) 4 (0.04) 0 0 37 (0.09) 16 (0.01) 61 (0.03)
Herpes ophthalmic 0 0 2 (0.01) 0 5 (0.01) 50 (0.03) 57 (0.03)
Herpes simplex 0 1 (0.01) 6 (0.03) 0 13 (0.03) 45 (0.03) 65 (0.03)
Herpes virus infection 0 1 (0.01) 10 (0.05) 0 7 (0.02) 37 (0.03) 55 (0.02)
Herpes zoster 13 (0.15) 27 (0.25) 249 (1.29) 0 477 (1.12) 2199 (1.53) 2982 (1.32)
Herpes zoster oticus 0 3 (0.03) 10 (0.05) 0 32 (0.08) 56 (0.04) 103 (0.05)
Hormone level abnormal 0 2 (0.02) 16 (0.08) 0 6 (0.01) 62 (0.04) 86 (0.04)
Hospitalisation 2 (0.02) 4 (0.04) 0 0 75 (0.18) 1 (0.00) 98 (0.04)
Hot flush 1 (0.01) 15 (0.14) 118 (0.61) 0 111 (0.26) 742 (0.52) 998 (0.44)
Hyperacusis 0 2 (0.02) 51 (0.26) 0 20 (0.05) 70 (0.05) 145 (0.06)
Hyperaesthesia 0 1 (0.01) 42 (0.22) 0 17 (0.04) 121 (0.08) 183 (0.08)
Hyperglycaemia 7 (0.08) 12 (0.11) 11 (0.06) 0 34 (0.08) 97 (0.07) 166 (0.07)
Hyperhidrosis 23 (0.26) 140 (1.28) 352 (1.82) 2 (0.95) 427 (1.00) 1901 (1.32) 2894 (1.28)
Hyperpyrexia 23 (0.26) 13 (0.12) 8 (0.04) 0 73 (0.17) 589 (0.41) 712 (0.32)
Hypersensitivity 9 (0.10) 269 (2.45) 130 (0.67) 2 (0.95) 609 (1.43) 1522 (1.06) 2590 (1.15)
Hypersomnia 3 (0.03) 12 (0.11) 63 (0.33) 0 23 (0.05) 217 (0.15) 326 (0.14)
Hypertension 40 (0.45) 260 (2.37) 174 (0.90) 3 (1.43) 965 (2.26) 2454 (1.71) 3997 (1.77)
Hypertensive crisis 9 (0.10) 42 (0.38) 8 (0.04) 0 182 (0.43) 421 (0.29) 673 (0.30)
Hyperthermia 8 (0.09) 8 (0.07) 10 (0.05) 0 34 (0.08) 67 (0.05) 130 (0.06)
Hyperthyroidism 1 (0.01) 5 (0.05) 16 (0.08) 0 25 (0.06) 134 (0.09) 185 (0.08)
Hyperventilation 0 18 (0.16) 12 (0.06) 0 127 (0.30) 172 (0.12) 340 (0.15)
Hypoacusis 1 (0.01) 10 (0.09) 128 (0.66) 0 54 (0.13) 260 (0.18) 458 (0.20)
Hypoaesthesia 9 (0.10) 239 (2.18) 872 (4.52) 2 (0.95) 1160 (2.72) 2685 (1.87) 5067 (2.25)
Hypoaesthesia oral 2 (0.02) 55 (0.50) 64 (0.33) 1 (0.48) 142 (0.33) 462 (0.32) 743 (0.33)
Hypoglycaemia 7 (0.08) 24 (0.22) 11 (0.06) 1 (0.48) 30 (0.07) 118 (0.08) 194 (0.09)
Hypokalaemia 4 (0.05) 14 (0.13) 2 (0.01) 0 38 (0.09) 24 (0.02) 101 (0.04)
Hypokinesia 2 (0.02) 11 (0.10) 65 (0.34) 1 (0.48) 33 (0.08) 162 (0.11) 284 (0.13)
Hypomenorrhoea 0 0 27 (0.14) 1 (0.48) 4 (0.01) 222 (0.15) 254 (0.11)
Hyponatraemia 4 (0.05) 14 (0.13) 4 (0.02) 0 41 (0.10) 2 (0.00) 72 (0.03)
Hypophagia 14 (0.16) 2 (0.02) 7 (0.04) 0 32 (0.08) 30 (0.02) 96 (0.04)
Hypopnoea 5 (0.06) 17 (0.15) 16 (0.08) 0 15 (0.04) 93 (0.06) 156 (0.07)
Hypotension 84 (0.95) 179 (1.63) 92 (0.48) 0 377 (0.88) 807 (0.56) 1620 (0.72)
Hypothermia 9 (0.10) 14 (0.13) 8 (0.04) 0 16 (0.04) 119 (0.08) 176 (0.08)
Hypothyroidism 0 1 (0.01) 14 (0.07) 0 13 (0.03) 85 (0.06) 122 (0.05)
Hypotonia 5 (0.06) 10 (0.09) 18 (0.09) 0 68 (0.16) 51 (0.04) 156 (0.07)
Hypovolaemic shock 7 (0.08) 3 (0.03) 0 0 8 (0.02) 61 (0.04) 83 (0.04)
Hypoxia 50 (0.57) 39 (0.36) 4 (0.02) 0 92 (0.22) 78 (0.05) 314 (0.14)
IIIrd nerve paralysis 0 2 (0.02) 2 (0.01) 0 21 (0.05) 26 (0.02) 54 (0.02)
Illness 12 (0.14) 48 (0.44) 195 (1.01) 2 (0.95) 172 (0.40) 1159 (0.81) 1613 (0.71)
Immobile 2 (0.02) 2 (0.02) 22 (0.11) 0 8 (0.02) 44 (0.03) 85 (0.04)
Immune system disorder 3 (0.03) 1 (0.01) 20 (0.10) 0 16 (0.04) 63 (0.04) 114 (0.05)
Immune thrombocytopenia 9 (0.10) 110 (1.00) 3 (0.02) 0 239 (0.56) 170 (0.12) 540 (0.24)
Immunisation 29 (0.33) 51 (0.46) 173 (0.90) 0 131 (0.31) 2138 (1.49) 2534 (1.12)
Immunisation reaction 0 0 4 (0.02) 0 24 (0.06) 77 (0.05) 114 (0.05)
Immunodeficiency 0 0 1 (0.01) 0 4 (0.01) 50 (0.03) 63 (0.03)
Impaired driving ability 0 4 (0.04) 32 (0.17) 0 5 (0.01) 30 (0.02) 75 (0.03)
Impaired quality of life 0 4 (0.04) 22 (0.11) 0 2 (0.00) 30 (0.02) 62 (0.03)
Impaired work ability 0 16 (0.15) 194 (1.01) 0 57 (0.13) 224 (0.16) 516 (0.23)
Inappropriate schedule of product administration 2 (0.02) 3 (0.03) 42 (0.22) 2 (0.95) 20 (0.05) 298 (0.21) 382 (0.17)
Incontinence 4 (0.05) 10 (0.09) 16 (0.08) 0 22 (0.05) 23 (0.02) 84 (0.04)
Induration 0 0 4 (0.02) 0 22 (0.05) 49 (0.03) 75 (0.03)
Infarction 15 (0.17) 26 (0.24) 5 (0.03) 0 21 (0.05) 9 (0.01) 81 (0.04)
Infection 24 (0.27) 18 (0.16) 31 (0.16) 1 (0.48) 96 (0.23) 178 (0.12) 366 (0.16)
Infectious mononucleosis 0 4 (0.04) 10 (0.05) 0 13 (0.03) 26 (0.02) 53 (0.02)
Inflammation 7 (0.08) 37 (0.34) 125 (0.65) 0 197 (0.46) 409 (0.28) 816 (0.36)
Inflammatory marker increased 4 (0.05) 4 (0.04) 4 (0.02) 0 44 (0.10) 15 (0.01) 81 (0.04)
Influenza 1 (0.01) 14 (0.13) 118 (0.61) 0 180 (0.42) 892 (0.62) 1210 (0.54)
Influenza like illness 15 (0.17) 29 (0.26) 440 (2.28) 1 (0.48) 321 (0.75) 2334 (1.62) 3182 (1.41)
Injected limb mobility decreased 0 3 (0.03) 45 (0.23) 0 3 (0.01) 113 (0.08) 164 (0.07)
Injection site erythema 3 (0.03) 2 (0.02) 27 (0.14) 0 21 (0.05) 89 (0.06) 143 (0.06)
Injection site pain 4 (0.05) 11 (0.10) 221 (1.15) 0 178 (0.42) 454 (0.32) 871 (0.39)
Injection site reaction 1 (0.01) 15 (0.14) 1050 (5.44) 0 45 (0.11) 60 (0.04) 1172 (0.52)
Injection site swelling 2 (0.02) 1 (0.01) 34 (0.18) 0 32 (0.08) 44 (0.03) 113 (0.05)
Injury 2 (0.02) 4 (0.04) 7 (0.04) 0 20 (0.05) 29 (0.02) 63 (0.03)
Insomnia 9 (0.10) 73 (0.66) 485 (2.51) 0 197 (0.46) 1582 (1.10) 2371 (1.05)
Interchange of vaccine products 16 (0.18) 23 (0.21) 79 (0.41) 1 (0.48) 71 (0.17) 1193 (0.83) 1388 (0.61)
Intermenstrual bleeding 0 5 (0.05) 75 (0.39) 0 39 (0.09) 661 (0.46) 786 (0.35)
Internal haemorrhage 6 (0.07) 6 (0.05) 3 (0.02) 0 14 (0.03) 137 (0.10) 175 (0.08)
International normalised ratio increased 6 (0.07) 9 (0.08) 3 (0.02) 0 22 (0.05) 48 (0.03) 96 (0.04)
Interstitial lung disease 39 (0.44) 21 (0.19) 8 (0.04) 0 69 (0.16) 29 (0.02) 178 (0.08)
Intestinal ischaemia 35 (0.40) 8 (0.07) 1 (0.01) 0 21 (0.05) 8 (0.01) 78 (0.03)
Intracardiac thrombus 13 (0.15) 10 (0.09) 1 (0.01) 0 18 (0.04) 5 (0.00) 51 (0.02)
Intracranial pressure increased 3 (0.03) 6 (0.05) 5 (0.03) 0 13 (0.03) 23 (0.02) 57 (0.03)
Iridocyclitis 0 0 5 (0.03) 0 6 (0.01) 59 (0.04) 73 (0.03)
Irritability 3 (0.03) 4 (0.04) 25 (0.13) 0 32 (0.08) 174 (0.12) 240 (0.11)
Irritable bowel syndrome 0 3 (0.03) 21 (0.11) 0 5 (0.01) 66 (0.05) 96 (0.04)
Ischaemia 8 (0.09) 19 (0.17) 13 (0.07) 0 27 (0.06) 14 (0.01) 83 (0.04)
Ischaemic cerebral infarction 9 (0.10) 30 (0.27) 7 (0.04) 0 46 (0.11) 9 (0.01) 103 (0.05)
Ischaemic stroke 73 (0.82) 154 (1.40) 74 (0.38) 0 550 (1.29) 51 (0.04) 907 (0.40)
Jaundice 11 (0.12) 6 (0.05) 4 (0.02) 0 58 (0.14) 33 (0.02) 118 (0.05)
Joint range of motion decreased 1 (0.01) 3 (0.03) 79 (0.41) 0 19 (0.04) 282 (0.20) 392 (0.17)
Joint stiffness 0 5 (0.05) 75 (0.39) 0 20 (0.05) 208 (0.14) 312 (0.14)
Joint swelling 2 (0.02) 20 (0.18) 184 (0.95) 0 101 (0.24) 474 (0.33) 795 (0.35)
Kidney infection 0 4 (0.04) 5 (0.03) 0 18 (0.04) 69 (0.05) 101 (0.04)
Labyrinthitis 0 1 (0.01) 29 (0.15) 0 11 (0.03) 74 (0.05) 116 (0.05)
Lacrimation increased 0 9 (0.08) 26 (0.13) 0 28 (0.07) 146 (0.10) 215 (0.10)
Lacunar infarction 1 (0.01) 7 (0.06) 0 0 30 (0.07) 10 (0.01) 54 (0.02)
Language disorder 1 (0.01) 4 (0.04) 9 (0.05) 0 61 (0.14) 14 (0.01) 95 (0.04)
Laryngeal oedema 3 (0.03) 57 (0.52) 0 0 51 (0.12) 186 (0.13) 307 (0.14)
Laryngospasm 1 (0.01) 11 (0.10) 1 (0.01) 0 15 (0.04) 34 (0.02) 62 (0.03)
Lethargy 21 (0.24) 43 (0.39) 203 (1.05) 0 159 (0.37) 1226 (0.85) 1672 (0.74)
Leukopenia 6 (0.07) 5 (0.05) 3 (0.02) 0 27 (0.06) 59 (0.04) 103 (0.05)
Limb discomfort 2 (0.02) 26 (0.24) 214 (1.11) 0 367 (0.86) 959 (0.67) 1593 (0.71)
Limb injury 1 (0.01) 2 (0.02) 37 (0.19) 1 (0.48) 8 (0.02) 71 (0.05) 122 (0.05)
Lip oedema 1 (0.01) 5 (0.05) 6 (0.03) 0 41 (0.10) 142 (0.10) 199 (0.09)
Lip pain 0 0 6 (0.03) 0 4 (0.01) 44 (0.03) 56 (0.02)
Lip pruritus 0 7 (0.06) 1 (0.01) 0 10 (0.02) 44 (0.03) 63 (0.03)
Lip swelling 1 (0.01) 98 (0.89) 40 (0.21) 0 151 (0.35) 596 (0.41) 901 (0.40)
Liver disorder 5 (0.06) 10 (0.09) 14 (0.07) 0 41 (0.10) 26 (0.02) 102 (0.05)
Liver function test abnormal 3 (0.03) 3 (0.03) 6 (0.03) 0 27 (0.06) 28 (0.02) 71 (0.03)
Liver injury 0 2 (0.02) 2 (0.01) 0 21 (0.05) 21 (0.01) 51 (0.02)
Local reaction 5 (0.06) 11 (0.10) 51 (0.26) 0 29 (0.07) 68 (0.05) 164 (0.07)
Localised infection 1 (0.01) 2 (0.02) 8 (0.04) 0 11 (0.03) 28 (0.02) 52 (0.02)
Localised oedema 0 15 (0.14) 14 (0.07) 0 25 (0.06) 69 (0.05) 125 (0.06)
Loss of consciousness 151 (1.71) 290 (2.64) 109 (0.56) 1 (0.48) 684 (1.60) 2579 (1.79) 4060 (1.80)
Loss of control of legs 0 3 (0.03) 5 (0.03) 0 14 (0.03) 27 (0.02) 55 (0.02)
Loss of personal independence in daily activities 3 (0.03) 26 (0.24) 258 (1.34) 0 62 (0.15) 324 (0.23) 708 (0.31)
Lower respiratory tract infection 16 (0.18) 14 (0.13) 26 (0.13) 0 31 (0.07) 229 (0.16) 330 (0.15)
Lung disorder 21 (0.24) 15 (0.14) 14 (0.07) 0 66 (0.15) 46 (0.03) 171 (0.08)
Lyme disease 0 1 (0.01) 5 (0.03) 0 5 (0.01) 40 (0.03) 55 (0.02)
Lymph node pain 1 (0.01) 5 (0.05) 107 (0.55) 0 39 (0.09) 1087 (0.76) 1247 (0.55)
Lymphadenitis 1 (0.01) 10 (0.09) 19 (0.10) 0 41 (0.10) 199 (0.14) 273 (0.12)
Lymphadenopathy 12 (0.14) 94 (0.86) 769 (3.98) 7 (3.33) 456 (1.07) 5587 (3.89) 6969 (3.09)
Lymphoedema 0 5 (0.05) 17 (0.09) 0 8 (0.02) 101 (0.07) 132 (0.06)
Lymphoma 6 (0.07) 9 (0.08) 2 (0.01) 0 8 (0.02) 57 (0.04) 87 (0.04)
Malaise 251 (2.84) 391 (3.56) 2062 (10.68) 3 (1.43) 1803 (4.23) 5086 (3.54) 9795 (4.34)
Mass 0 2 (0.02) 15 (0.08) 0 9 (0.02) 79 (0.05) 111 (0.05)
Mastitis 0 0 5 (0.03) 0 10 (0.02) 158 (0.11) 173 (0.08)
Maternal exposure during breast feeding 0 1 (0.01) 14 (0.07) 1 (0.48) 12 (0.03) 148 (0.10) 177 (0.08)
Maternal exposure during pregnancy 36 (0.41) 26 (0.24) 21 (0.11) 25 (11.90) 65 (0.15) 327 (0.23) 515 (0.23)
Melaena 8 (0.09) 6 (0.05) 0 0 23 (0.05) 31 (0.02) 75 (0.03)
Memory impairment 2 (0.02) 18 (0.16) 123 (0.64) 0 99 (0.23) 199 (0.14) 462 (0.20)
Meniere's disease 0 2 (0.02) 18 (0.09) 0 17 (0.04) 52 (0.04) 90 (0.04)
Meningitis 1 (0.01) 8 (0.07) 5 (0.03) 0 53 (0.12) 27 (0.02) 102 (0.05)
Meningitis aseptic 0 6 (0.05) 0 0 55 (0.13) 11 (0.01) 73 (0.03)
Menometrorrhagia 0 3 (0.03) 7 (0.04) 0 9 (0.02) 36 (0.03) 56 (0.02)
Menstrual disorder 0 15 (0.14) 165 (0.85) 1 (0.48) 68 (0.16) 1078 (0.75) 1336 (0.59)
Menstruation delayed 0 7 (0.06) 139 (0.72) 4 (1.90) 15 (0.04) 1494 (1.04) 1662 (0.74)
Menstruation irregular 0 12 (0.11) 163 (0.84) 1 (0.48) 51 (0.12) 1487 (1.03) 1721 (0.76)
Mental disorder 1 (0.01) 6 (0.05) 19 (0.10) 0 20 (0.05) 34 (0.02) 83 (0.04)
Mental fatigue 1 (0.01) 5 (0.05) 56 (0.29) 0 8 (0.02) 127 (0.09) 198 (0.09)
Mental impairment 4 (0.05) 14 (0.13) 25 (0.13) 0 21 (0.05) 225 (0.16) 308 (0.14)
Mesenteric vein thrombosis 7 (0.08) 17 (0.15) 1 (0.01) 0 41 (0.10) 12 (0.01) 79 (0.04)
Micturition urgency 1 (0.01) 0 6 (0.03) 0 15 (0.04) 42 (0.03) 68 (0.03)
Middle insomnia 0 4 (0.04) 19 (0.10) 0 9 (0.02) 60 (0.04) 92 (0.04)
Migraine 3 (0.03) 56 (0.51) 564 (2.92) 0 257 (0.60) 2099 (1.46) 3003 (1.33)
Migraine with aura 0 1 (0.01) 34 (0.18) 0 26 (0.06) 152 (0.11) 214 (0.09)
Mobility decreased 10 (0.11) 21 (0.19) 195 (1.01) 0 120 (0.28) 292 (0.20) 667 (0.30)
Monoparesis 1 (0.01) 13 (0.12) 21 (0.11) 0 60 (0.14) 75 (0.05) 177 (0.08)
Monoplegia 6 (0.07) 13 (0.12) 57 (0.30) 0 69 (0.16) 191 (0.13) 351 (0.16)
Mood altered 0 4 (0.04) 10 (0.05) 0 8 (0.02) 49 (0.03) 72 (0.03)
Mood swings 0 1 (0.01) 17 (0.09) 0 4 (0.01) 84 (0.06) 107 (0.05)
Motion sickness 0 1 (0.01) 13 (0.07) 0 1 (0.00) 47 (0.03) 63 (0.03)
Motor dysfunction 6 (0.07) 6 (0.05) 33 (0.17) 0 72 (0.17) 39 (0.03) 160 (0.07)
Mouth haemorrhage 4 (0.05) 11 (0.10) 2 (0.01) 0 26 (0.06) 15 (0.01) 67 (0.03)
Mouth swelling 3 (0.03) 20 (0.18) 9 (0.05) 0 27 (0.06) 90 (0.06) 150 (0.07)
Mouth ulceration 1 (0.01) 4 (0.04) 21 (0.11) 0 6 (0.01) 168 (0.12) 200 (0.09)
Movement disorder 5 (0.06) 18 (0.16) 97 (0.50) 0 184 (0.43) 227 (0.16) 566 (0.25)
Multiple organ dysfunction syndrome 97 (1.10) 16 (0.15) 0 0 9 (0.02) 8 (0.01) 151 (0.07)
Multiple sclerosis 1 (0.01) 3 (0.03) 33 (0.17) 0 55 (0.13) 123 (0.09) 226 (0.10)
Multiple sclerosis relapse 1 (0.01) 4 (0.04) 33 (0.17) 0 52 (0.12) 109 (0.08) 201 (0.09)
Muscle contractions involuntary 0 5 (0.05) 30 (0.16) 0 31 (0.07) 37 (0.03) 104 (0.05)
Muscle fatigue 0 0 62 (0.32) 0 12 (0.03) 205 (0.14) 282 (0.12)
Muscle rigidity 3 (0.03) 7 (0.06) 30 (0.16) 0 20 (0.05) 37 (0.03) 101 (0.04)
Muscle spasms 6 (0.07) 71 (0.65) 326 (1.69) 0 296 (0.69) 1318 (0.92) 2055 (0.91)
Muscle strain 0 1 (0.01) 14 (0.07) 0 8 (0.02) 38 (0.03) 61 (0.03)
Muscle tightness 0 6 (0.05) 41 (0.21) 0 51 (0.12) 130 (0.09) 234 (0.10)
Muscle twitching 3 (0.03) 21 (0.19) 106 (0.55) 0 97 (0.23) 285 (0.20) 519 (0.23)
Muscular weakness 21 (0.24) 96 (0.87) 578 (2.99) 0 620 (1.45) 1016 (0.71) 2404 (1.07)
Musculoskeletal chest pain 1 (0.01) 12 (0.11) 44 (0.23) 0 44 (0.10) 230 (0.16) 336 (0.15)
Musculoskeletal discomfort 0 3 (0.03) 30 (0.16) 0 32 (0.08) 107 (0.07) 179 (0.08)
Musculoskeletal disorder 1 (0.01) 3 (0.03) 34 (0.18) 0 21 (0.05) 47 (0.03) 112 (0.05)
Musculoskeletal pain 1 (0.01) 13 (0.12) 70 (0.36) 0 101 (0.24) 301 (0.21) 495 (0.22)
Musculoskeletal stiffness 4 (0.05) 31 (0.28) 316 (1.64) 0 149 (0.35) 941 (0.65) 1463 (0.65)
Myalgia 56 (0.63) 255 (2.32) 3702 (19.18) 5 (2.38) 1206 (2.83) 7428 (5.17) 12751 (5.65)
Myasthenia gravis 2 (0.02) 2 (0.02) 12 (0.06) 0 32 (0.08) 30 (0.02) 80 (0.04)
Mydriasis 3 (0.03) 5 (0.05) 1 (0.01) 0 16 (0.04) 28 (0.02) 58 (0.03)
Myelitis 3 (0.03) 4 (0.04) 31 (0.16) 1 (0.48) 113 (0.27) 33 (0.02) 186 (0.08)
Myelitis transverse 0 8 (0.07) 35 (0.18) 0 54 (0.13) 24 (0.02) 125 (0.06)
Myocardial infarction 362 (4.09) 313 (2.85) 40 (0.21) 0 451 (1.06) 265 (0.18) 1493 (0.66)
Myocardial ischaemia 59 (0.67) 5 (0.05) 2 (0.01) 0 16 (0.04) 12 (0.01) 101 (0.04)
Myocardial necrosis marker increased 1 (0.01) 1 (0.01) 1 (0.01) 0 30 (0.07) 10 (0.01) 52 (0.02)
Myocarditis 61 (0.69) 447 (4.07) 110 (0.57) 2 (0.95) 2489 (5.84) 1838 (1.28) 5018 (2.22)
Myoclonus 2 (0.02) 8 (0.07) 15 (0.08) 0 32 (0.08) 42 (0.03) 103 (0.05)
Myositis 1 (0.01) 7 (0.06) 21 (0.11) 0 47 (0.11) 44 (0.03) 122 (0.05)
Nasal congestion 1 (0.01) 11 (0.10) 67 (0.35) 0 39 (0.09) 334 (0.23) 453 (0.20)
Nasal discomfort 0 2 (0.02) 7 (0.04) 0 6 (0.01) 40 (0.03) 55 (0.02)
Nasopharyngitis 20 (0.23) 18 (0.16) 100 (0.52) 1 (0.48) 101 (0.24) 697 (0.48) 948 (0.42)
Nausea 104 (1.18) 403 (3.67) 2653 (13.75) 5 (2.38) 2231 (5.23) 9877 (6.87) 15459 (6.85)
Near death experience 0 18 (0.16) 3 (0.02) 0 7 (0.02) 84 (0.06) 127 (0.06)
Neck pain 3 (0.03) 60 (0.55) 383 (1.98) 0 278 (0.65) 1509 (1.05) 2264 (1.00)
Neoplasm malignant 10 (0.11) 8 (0.07) 1 (0.01) 0 12 (0.03) 58 (0.04) 97 (0.04)
Nephrolithiasis 0 2 (0.02) 2 (0.01) 0 20 (0.05) 56 (0.04) 88 (0.04)
Nephrotic syndrome 2 (0.02) 3 (0.03) 4 (0.02) 0 84 (0.20) 57 (0.04) 152 (0.07)
Nerve compression 1 (0.01) 1 (0.01) 8 (0.04) 0 3 (0.01) 36 (0.03) 51 (0.02)
Nerve injury 1 (0.01) 5 (0.05) 59 (0.31) 0 16 (0.04) 65 (0.05) 154 (0.07)
Nervous system disorder 18 (0.20) 22 (0.20) 84 (0.44) 0 79 (0.19) 61 (0.04) 277 (0.12)
Nervousness 0 12 (0.11) 29 (0.15) 0 18 (0.04) 166 (0.12) 227 (0.10)
Neuralgia 2 (0.02) 20 (0.18) 223 (1.16) 0 169 (0.40) 464 (0.32) 897 (0.40)
Neuralgic amyotrophy 0 0 32 (0.17) 0 23 (0.05) 38 (0.03) 93 (0.04)
Neuritis 0 1 (0.01) 13 (0.07) 0 35 (0.08) 26 (0.02) 77 (0.03)
Neurological symptom 2 (0.02) 5 (0.05) 37 (0.19) 0 39 (0.09) 48 (0.03) 135 (0.06)
Neuropathy peripheral 0 8 (0.07) 108 (0.56) 0 81 (0.19) 677 (0.47) 907 (0.40)
Neutropenia 2 (0.02) 14 (0.13) 1 (0.01) 0 26 (0.06) 68 (0.05) 116 (0.05)
Night sweats 2 (0.02) 12 (0.11) 66 (0.34) 1 (0.48) 55 (0.13) 347 (0.24) 488 (0.22)
Nightmare 0 7 (0.06) 27 (0.14) 0 7 (0.02) 104 (0.07) 147 (0.07)
Nodule 1 (0.01) 9 (0.08) 17 (0.09) 0 29 (0.07) 57 (0.04) 115 (0.05)
Nystagmus 1 (0.01) 4 (0.04) 7 (0.04) 0 41 (0.10) 24 (0.02) 85 (0.04)
Obstructive airways disorder 4 (0.05) 19 (0.17) 1 (0.01) 0 31 (0.07) 31 (0.02) 88 (0.04)
Ocular discomfort 0 6 (0.05) 19 (0.10) 0 36 (0.08) 63 (0.04) 124 (0.05)
Ocular hyperaemia 0 14 (0.13) 19 (0.10) 0 51 (0.12) 246 (0.17) 341 (0.15)
Odynophagia 0 1 (0.01) 17 (0.09) 0 30 (0.07) 121 (0.08) 172 (0.08)
Oedema 8 (0.09) 28 (0.26) 32 (0.17) 1 (0.48) 132 (0.31) 249 (0.17) 466 (0.21)
Oedema peripheral 29 (0.33) 52 (0.47) 80 (0.41) 0 184 (0.43) 336 (0.23) 709 (0.31)
Off label use 22 (0.25) 42 (0.38) 151 (0.78) 1 (0.48) 113 (0.27) 1952 (1.36) 2302 (1.02)
Oligomenorrhoea 0 1 (0.01) 32 (0.17) 0 9 (0.02) 116 (0.08) 158 (0.07)
Ophthalmic herpes zoster 0 2 (0.02) 17 (0.09) 0 49 (0.11) 218 (0.15) 291 (0.13)
Ophthalmic vein thrombosis 1 (0.01) 0 5 (0.03) 0 22 (0.05) 39 (0.03) 67 (0.03)
Optic ischaemic neuropathy 0 0 18 (0.09) 0 27 (0.06) 26 (0.02) 73 (0.03)
Optic neuritis 0 0 39 (0.20) 0 94 (0.22) 81 (0.06) 217 (0.10)
Oral discomfort 0 10 (0.09) 19 (0.10) 0 22 (0.05) 85 (0.06) 136 (0.06)
Oral herpes 0 5 (0.05) 24 (0.12) 0 12 (0.03) 185 (0.13) 228 (0.10)
Oral pain 1 (0.01) 2 (0.02) 25 (0.13) 0 19 (0.04) 94 (0.07) 144 (0.06)
Oral pruritus 0 9 (0.08) 6 (0.03) 0 29 (0.07) 57 (0.04) 103 (0.05)
Oropharyngeal discomfort 0 23 (0.21) 20 (0.10) 0 226 (0.53) 514 (0.36) 800 (0.35)
Oropharyngeal pain 13 (0.15) 55 (0.50) 308 (1.60) 2 (0.95) 264 (0.62) 1701 (1.18) 2364 (1.05)
Orthostatic hypotension 0 3 (0.03) 4 (0.02) 0 21 (0.05) 35 (0.02) 69 (0.03)
Osteoarthritis 0 0 28 (0.15) 0 4 (0.01) 45 (0.03) 81 (0.04)
Ovulation pain 0 0 5 (0.03) 0 0 50 (0.03) 56 (0.02)
Oxygen saturation decreased 139 (1.57) 108 (0.98) 33 (0.17) 0 370 (0.87) 497 (0.35) 1254 (0.56)
Pain 42 (0.47) 201 (1.83) 1544 (8.00) 1 (0.48) 973 (2.28) 6392 (4.45) 9272 (4.11)
Pain in extremity 38 (0.43) 255 (2.32) 1898 (9.83) 2 (0.95) 1046 (2.45) 8281 (5.76) 11652 (5.16)
Pain in jaw 1 (0.01) 12 (0.11) 56 (0.29) 0 59 (0.14) 266 (0.19) 405 (0.18)
Pain of skin 2 (0.02) 6 (0.05) 62 (0.32) 0 23 (0.05) 223 (0.16) 320 (0.14)
Painful respiration 1 (0.01) 3 (0.03) 20 (0.10) 0 31 (0.07) 63 (0.04) 124 (0.05)
Palatal oedema 0 12 (0.11) 2 (0.01) 0 15 (0.04) 47 (0.03) 77 (0.03)
Pallor 14 (0.16) 68 (0.62) 33 (0.17) 0 175 (0.41) 473 (0.33) 794 (0.35)
Palpitations 14 (0.16) 230 (2.09) 574 (2.97) 2 (0.95) 1139 (2.67) 3033 (2.11) 5056 (2.24)
Pancreatitis 1 (0.01) 7 (0.06) 5 (0.03) 0 79 (0.19) 47 (0.03) 144 (0.06)
Pancreatitis acute 7 (0.08) 19 (0.17) 0 0 156 (0.37) 36 (0.03) 224 (0.10)
Pancytopenia 10 (0.11) 16 (0.15) 0 0 39 (0.09) 14 (0.01) 88 (0.04)
Panic attack 1 (0.01) 20 (0.18) 52 (0.27) 0 83 (0.19) 158 (0.11) 328 (0.15)
Panic reaction 0 5 (0.05) 7 (0.04) 0 7 (0.02) 47 (0.03) 68 (0.03)
Papule 0 1 (0.01) 6 (0.03) 0 6 (0.01) 56 (0.04) 71 (0.03)
Paraesthesia 3 (0.03) 203 (1.85) 857 (4.44) 0 1531 (3.59) 3790 (2.64) 6482 (2.87)
Paraesthesia oral 1 (0.01) 73 (0.66) 74 (0.38) 0 192 (0.45) 742 (0.52) 1093 (0.48)
Paralysis 10 (0.11) 40 (0.36) 92 (0.48) 0 144 (0.34) 336 (0.23) 667 (0.30)
Paraparesis 1 (0.01) 2 (0.02) 10 (0.05) 0 22 (0.05) 15 (0.01) 53 (0.02)
Paresis 2 (0.02) 8 (0.07) 22 (0.11) 0 68 (0.16) 34 (0.02) 146 (0.06)
Parosmia 0 6 (0.05) 87 (0.45) 0 19 (0.04) 125 (0.09) 237 (0.11)
Partial seizures 1 (0.01) 7 (0.06) 3 (0.02) 0 24 (0.06) 41 (0.03) 79 (0.04)
Pelvic pain 0 3 (0.03) 25 (0.13) 0 15 (0.04) 112 (0.08) 156 (0.07)
Pelvic venous thrombosis 1 (0.01) 11 (0.10) 2 (0.01) 0 29 (0.07) 8 (0.01) 54 (0.02)
Pemphigoid 5 (0.06) 6 (0.05) 11 (0.06) 0 28 (0.07) 64 (0.04) 117 (0.05)
Periarthritis 0 0 87 (0.45) 0 6 (0.01) 107 (0.07) 202 (0.09)
Pericardial effusion 17 (0.19) 56 (0.51) 15 (0.08) 0 260 (0.61) 224 (0.16) 609 (0.27)
Pericarditis 8 (0.09) 165 (1.50) 95 (0.49) 0 1178 (2.76) 2484 (1.73) 3973 (1.76)
Periorbital oedema 0 2 (0.02) 1 (0.01) 0 13 (0.03) 39 (0.03) 57 (0.03)
Periorbital swelling 0 7 (0.06) 11 (0.06) 0 26 (0.06) 113 (0.08) 157 (0.07)
Peripheral artery thrombosis 1 (0.01) 11 (0.10) 5 (0.03) 0 38 (0.09) 17 (0.01) 74 (0.03)
Peripheral coldness 4 (0.05) 25 (0.23) 64 (0.33) 0 103 (0.24) 327 (0.23) 536 (0.24)
Peripheral ischaemia 12 (0.14) 9 (0.08) 4 (0.02) 0 32 (0.08) 15 (0.01) 74 (0.03)
Peripheral swelling 15 (0.17) 118 (1.07) 411 (2.13) 2 (0.95) 335 (0.79) 1984 (1.38) 2907 (1.29)
Peripheral vascular disorder 7 (0.08) 5 (0.05) 2 (0.01) 0 27 (0.06) 13 (0.01) 58 (0.03)
Petechiae 13 (0.15) 43 (0.39) 19 (0.10) 0 154 (0.36) 167 (0.12) 415 (0.18)
Petit mal epilepsy 1 (0.01) 6 (0.05) 1 (0.01) 0 14 (0.03) 59 (0.04) 83 (0.04)
Pharyngeal hypoaesthesia 0 6 (0.05) 6 (0.03) 0 13 (0.03) 42 (0.03) 71 (0.03)
Pharyngeal oedema 1 (0.01) 26 (0.24) 7 (0.04) 0 45 (0.11) 77 (0.05) 160 (0.07)
Pharyngeal paraesthesia 0 13 (0.12) 5 (0.03) 0 32 (0.08) 74 (0.05) 126 (0.06)
Pharyngeal swelling 2 (0.02) 135 (1.23) 41 (0.21) 0 139 (0.33) 406 (0.28) 741 (0.33)
Pharyngitis 0 6 (0.05) 10 (0.05) 0 18 (0.04) 39 (0.03) 74 (0.03)
Phlebitis 0 11 (0.10) 10 (0.05) 0 31 (0.07) 99 (0.07) 154 (0.07)
Photophobia 0 20 (0.18) 135 (0.70) 0 92 (0.22) 371 (0.26) 624 (0.28)
Photopsia 0 7 (0.06) 26 (0.13) 0 30 (0.07) 121 (0.08) 188 (0.08)
Photosensitivity reaction 0 5 (0.05) 29 (0.15) 0 13 (0.03) 66 (0.05) 116 (0.05)
Physical deconditioning 6 (0.07) 2 (0.02) 3 (0.02) 0 52 (0.12) 39 (0.03) 114 (0.05)
Pityriasis rosea 0 0 2 (0.01) 0 3 (0.01) 58 (0.04) 63 (0.03)
Platelet count decreased 19 (0.21) 55 (0.50) 8 (0.04) 0 105 (0.25) 126 (0.09) 339 (0.15)
Pleural effusion 19 (0.21) 44 (0.40) 8 (0.04) 1 (0.48) 170 (0.40) 52 (0.04) 341 (0.15)
Pleurisy 1 (0.01) 11 (0.10) 11 (0.06) 0 99 (0.23) 41 (0.03) 168 (0.07)
Pleuritic pain 1 (0.01) 7 (0.06) 9 (0.05) 0 26 (0.06) 16 (0.01) 60 (0.03)
Pneumonia 291 (3.29) 156 (1.42) 24 (0.12) 0 543 (1.27) 396 (0.28) 1536 (0.68)
Pneumonia aspiration 94 (1.06) 15 (0.14) 1 (0.01) 0 32 (0.08) 12 (0.01) 172 (0.08)
Pneumonitis 19 (0.21) 18 (0.16) 4 (0.02) 0 61 (0.14) 27 (0.02) 140 (0.06)
Pneumothorax 2 (0.02) 10 (0.09) 2 (0.01) 0 38 (0.09) 23 (0.02) 87 (0.04)
Pollakiuria 3 (0.03) 3 (0.03) 22 (0.11) 0 17 (0.04) 94 (0.07) 147 (0.07)
Polyarthritis 0 1 (0.01) 14 (0.07) 0 35 (0.08) 75 (0.05) 126 (0.06)
Polymenorrhoea 0 4 (0.04) 57 (0.30) 0 20 (0.05) 378 (0.26) 459 (0.20)
Polymyalgia rheumatica 0 3 (0.03) 72 (0.37) 0 64 (0.15) 226 (0.16) 371 (0.16)
Polyneuropathy 1 (0.01) 4 (0.04) 28 (0.15) 0 64 (0.15) 75 (0.05) 186 (0.08)
Poor quality sleep 2 (0.02) 1 (0.01) 40 (0.21) 0 15 (0.04) 167 (0.12) 227 (0.10)
Portal vein thrombosis 11 (0.12) 15 (0.14) 2 (0.01) 0 60 (0.14) 13 (0.01) 106 (0.05)
Post herpetic neuralgia 0 0 15 (0.08) 0 12 (0.03) 29 (0.02) 57 (0.03)
Post viral fatigue syndrome 0 0 41 (0.21) 0 1 (0.00) 52 (0.04) 96 (0.04)
Postmenopausal haemorrhage 0 5 (0.05) 19 (0.10) 0 20 (0.05) 689 (0.48) 733 (0.32)
Postural orthostatic tachycardia syndrome 0 3 (0.03) 27 (0.14) 0 20 (0.05) 26 (0.02) 80 (0.04)
Premature baby 5 (0.06) 8 (0.07) 0 2 (0.95) 23 (0.05) 12 (0.01) 57 (0.03)
Premenstrual pain 0 0 10 (0.05) 0 1 (0.00) 88 (0.06) 99 (0.04)
Premenstrual syndrome 0 2 (0.02) 18 (0.09) 0 4 (0.01) 127 (0.09) 153 (0.07)
Presyncope 7 (0.08) 78 (0.71) 108 (0.56) 0 371 (0.87) 1152 (0.80) 1753 (0.78)
Product use issue 3 (0.03) 1 (0.01) 11 (0.06) 0 11 (0.03) 211 (0.15) 242 (0.11)
Productive cough 12 (0.14) 12 (0.11) 37 (0.19) 0 69 (0.16) 160 (0.11) 301 (0.13)
Proteinuria 0 2 (0.02) 5 (0.03) 0 24 (0.06) 21 (0.01) 53 (0.02)
Pruritus 6 (0.07) 165 (1.50) 318 (1.65) 1 (0.48) 723 (1.70) 3803 (2.65) 5088 (2.25)
Psoriasis 1 (0.01) 2 (0.02) 24 (0.12) 0 27 (0.06) 145 (0.10) 199 (0.09)
Psoriatic arthropathy 0 0 11 (0.06) 0 2 (0.00) 53 (0.04) 67 (0.03)
Psychotic disorder 0 4 (0.04) 9 (0.05) 0 23 (0.05) 16 (0.01) 54 (0.02)
Pulmonary congestion 11 (0.12) 2 (0.02) 2 (0.01) 0 17 (0.04) 56 (0.04) 100 (0.04)
Pulmonary embolism 324 (3.66) 1184 (10.78) 45 (0.23) 0 2172 (5.10) 767 (0.53) 4558 (2.02)
Pulmonary infarction 5 (0.06) 30 (0.27) 2 (0.01) 0 53 (0.12) 15 (0.01) 112 (0.05)
Pulmonary oedema 72 (0.81) 41 (0.37) 9 (0.05) 0 65 (0.15) 35 (0.02) 257 (0.11)
Pulmonary pain 1 (0.01) 6 (0.05) 42 (0.22) 0 37 (0.09) 94 (0.07) 182 (0.08)
Pulmonary thrombosis 11 (0.12) 62 (0.56) 5 (0.03) 0 82 (0.19) 38 (0.03) 214 (0.09)
Pulse abnormal 3 (0.03) 13 (0.12) 4 (0.02) 0 26 (0.06) 41 (0.03) 90 (0.04)
Purpura 6 (0.07) 9 (0.08) 6 (0.03) 0 59 (0.14) 86 (0.06) 171 (0.08)
Pyelonephritis 5 (0.06) 5 (0.05) 2 (0.01) 0 39 (0.09) 31 (0.02) 86 (0.04)
Pyrexia 447 (5.05) 599 (5.46) 3302 (17.11) 7 (3.33) 3558 (8.35) 11188 (7.78) 19429 (8.61)
Rash 15 (0.17) 181 (1.65) 315 (1.63) 1 (0.48) 1037 (2.43) 3599 (2.50) 5221 (2.31)
Rash erythematous 1 (0.01) 23 (0.21) 49 (0.25) 0 101 (0.24) 637 (0.44) 819 (0.36)
Rash macular 3 (0.03) 18 (0.16) 39 (0.20) 0 39 (0.09) 306 (0.21) 412 (0.18)
Rash maculo-papular 0 8 (0.07) 2 (0.01) 0 57 (0.13) 95 (0.07) 164 (0.07)
Rash papular 0 4 (0.04) 13 (0.07) 0 30 (0.07) 163 (0.11) 212 (0.09)
Rash pruritic 2 (0.02) 19 (0.17) 48 (0.25) 0 83 (0.19) 688 (0.48) 856 (0.38)
Rash vesicular 0 2 (0.02) 10 (0.05) 0 18 (0.04) 82 (0.06) 114 (0.05)
Raynaud's phenomenon 0 2 (0.02) 4 (0.02) 0 8 (0.02) 63 (0.04) 78 (0.03)
Rectal haemorrhage 9 (0.10) 7 (0.06) 6 (0.03) 1 (0.48) 49 (0.11) 149 (0.10) 228 (0.10)
Red blood cell sedimentation rate increased 2 (0.02) 2 (0.02) 12 (0.06) 0 21 (0.05) 20 (0.01) 61 (0.03)
Renal disorder 7 (0.08) 13 (0.12) 6 (0.03) 0 29 (0.07) 18 (0.01) 78 (0.03)
Renal failure 78 (0.88) 46 (0.42) 3 (0.02) 0 83 (0.19) 39 (0.03) 289 (0.13)
Renal impairment 13 (0.15) 15 (0.14) 4 (0.02) 0 42 (0.10) 77 (0.05) 174 (0.08)
Renal pain 1 (0.01) 7 (0.06) 55 (0.28) 1 (0.48) 40 (0.09) 203 (0.14) 310 (0.14)
Respiration abnormal 6 (0.07) 10 (0.09) 7 (0.04) 0 26 (0.06) 62 (0.04) 115 (0.05)
Respiratory arrest 124 (1.40) 40 (0.36) 1 (0.01) 0 18 (0.04) 33 (0.02) 249 (0.11)
Respiratory disorder 29 (0.33) 38 (0.35) 73 (0.38) 0 79 (0.19) 106 (0.07) 340 (0.15)
Respiratory distress 66 (0.75) 57 (0.52) 14 (0.07) 0 296 (0.69) 999 (0.70) 1511 (0.67)
Respiratory failure 176 (1.99) 63 (0.57) 4 (0.02) 0 114 (0.27) 36 (0.03) 433 (0.19)
Respiratory rate increased 7 (0.08) 16 (0.15) 9 (0.05) 0 44 (0.10) 69 (0.05) 151 (0.07)
Respiratory tract infection 10 (0.11) 3 (0.03) 1 (0.01) 0 13 (0.03) 43 (0.03) 79 (0.04)
Respiratory tract oedema 0 14 (0.13) 1 (0.01) 0 8 (0.02) 25 (0.02) 53 (0.02)
Restless legs syndrome 0 1 (0.01) 26 (0.13) 0 7 (0.02) 80 (0.06) 115 (0.05)
Restlessness 14 (0.16) 10 (0.09) 30 (0.16) 0 90 (0.21) 165 (0.11) 320 (0.14)
Retching 3 (0.03) 13 (0.12) 30 (0.16) 0 44 (0.10) 106 (0.07) 204 (0.09)
Retinal artery occlusion 0 0 47 (0.24) 0 30 (0.07) 44 (0.03) 121 (0.05)
Retinal detachment 0 1 (0.01) 11 (0.06) 0 45 (0.11) 34 (0.02) 95 (0.04)
Retinal haemorrhage 0 1 (0.01) 9 (0.05) 0 9 (0.02) 37 (0.03) 56 (0.02)
Retinal vein occlusion 0 1 (0.01) 68 (0.35) 0 27 (0.06) 139 (0.10) 238 (0.11)
Retinal vein thrombosis 0 3 (0.03) 24 (0.12) 0 4 (0.01) 32 (0.02) 64 (0.03)
Rhabdomyolysis 6 (0.07) 18 (0.16) 6 (0.03) 0 89 (0.21) 42 (0.03) 165 (0.07)
Rheumatic disorder 0 1 (0.01) 12 (0.06) 0 13 (0.03) 25 (0.02) 55 (0.02)
Rheumatoid arthritis 1 (0.01) 5 (0.05) 99 (0.51) 0 44 (0.10) 415 (0.29) 576 (0.26)
Rhinitis 0 3 (0.03) 25 (0.13) 0 13 (0.03) 72 (0.05) 113 (0.05)
Rhinorrhoea 3 (0.03) 21 (0.19) 88 (0.46) 0 93 (0.22) 650 (0.45) 861 (0.38)
Road traffic accident 3 (0.03) 2 (0.02) 1 (0.01) 0 20 (0.05) 19 (0.01) 51 (0.02)
Rotator cuff syndrome 0 0 21 (0.11) 0 4 (0.01) 42 (0.03) 67 (0.03)
SARS-CoV-2 test negative 5 (0.06) 10 (0.09) 33 (0.17) 0 21 (0.05) 12 (0.01) 81 (0.04)
SARS-CoV-2 test positive 69 (0.78) 8 (0.07) 9 (0.05) 0 108 (0.25) 497 (0.35) 720 (0.32)
Salivary hypersecretion 2 (0.02) 3 (0.03) 8 (0.04) 0 12 (0.03) 40 (0.03) 67 (0.03)
Sarcoidosis 0 1 (0.01) 8 (0.04) 0 24 (0.06) 42 (0.03) 79 (0.04)
Sciatica 0 3 (0.03) 54 (0.28) 0 18 (0.04) 90 (0.06) 171 (0.08)
Seasonal allergy 0 2 (0.02) 7 (0.04) 0 1 (0.00) 70 (0.05) 80 (0.04)
Seizure 48 (0.54) 191 (1.74) 96 (0.50) 0 711 (1.67) 1448 (1.01) 2582 (1.14)
Sensation of foreign body 0 40 (0.36) 13 (0.07) 0 100 (0.23) 187 (0.13) 343 (0.15)
Sense of oppression 2 (0.02) 1 (0.01) 14 (0.07) 0 15 (0.04) 22 (0.02) 54 (0.02)
Sensitive skin 0 1 (0.01) 23 (0.12) 0 107 (0.25) 300 (0.21) 435 (0.19)
Sensory disturbance 0 11 (0.10) 61 (0.32) 0 176 (0.41) 161 (0.11) 424 (0.19)
Sensory loss 1 (0.01) 12 (0.11) 54 (0.28) 0 61 (0.14) 81 (0.06) 217 (0.10)
Sepsis 108 (1.22) 47 (0.43) 8 (0.04) 0 101 (0.24) 37 (0.03) 328 (0.15)
Septic shock 68 (0.77) 18 (0.16) 0 0 16 (0.04) 2 (0.00) 111 (0.05)
Shock 29 (0.33) 37 (0.34) 8 (0.04) 0 41 (0.10) 128 (0.09) 277 (0.12)
Shoulder injury related to vaccine administration 0 0 25 (0.13) 0 0 32 (0.02) 57 (0.03)
Sinus congestion 0 2 (0.02) 11 (0.06) 0 1 (0.00) 47 (0.03) 62 (0.03)
Sinus headache 0 1 (0.01) 22 (0.11) 0 3 (0.01) 163 (0.11) 189 (0.08)
Sinus pain 0 4 (0.04) 22 (0.11) 0 9 (0.02) 125 (0.09) 161 (0.07)
Sinus tachycardia 1 (0.01) 15 (0.14) 15 (0.08) 0 77 (0.18) 93 (0.06) 205 (0.09)
Sinusitis 2 (0.02) 4 (0.04) 35 (0.18) 0 22 (0.05) 146 (0.10) 214 (0.09)
Sjogren's syndrome 0 1 (0.01) 4 (0.02) 0 4 (0.01) 39 (0.03) 52 (0.02)
Skin burning sensation 1 (0.01) 16 (0.15) 35 (0.18) 0 37 (0.09) 177 (0.12) 270 (0.12)
Skin discolouration 3 (0.03) 9 (0.08) 16 (0.08) 0 57 (0.13) 150 (0.10) 247 (0.11)
Skin disorder 3 (0.03) 15 (0.14) 162 (0.84) 0 31 (0.07) 96 (0.07) 316 (0.14)
Skin exfoliation 0 3 (0.03) 24 (0.12) 1 (0.48) 19 (0.04) 110 (0.08) 162 (0.07)
Skin irritation 0 5 (0.05) 12 (0.06) 0 0 69 (0.05) 86 (0.04)
Skin lesion 2 (0.02) 2 (0.02) 8 (0.04) 0 11 (0.03) 49 (0.03) 75 (0.03)
Skin reaction 1 (0.01) 9 (0.08) 11 (0.06) 0 18 (0.04) 103 (0.07) 142 (0.06)
Skin swelling 0 1 (0.01) 5 (0.03) 0 7 (0.02) 49 (0.03) 62 (0.03)
Skin ulcer 3 (0.03) 2 (0.02) 8 (0.04) 0 13 (0.03) 28 (0.02) 56 (0.02)
Skin warm 1 (0.01) 3 (0.03) 11 (0.06) 0 9 (0.02) 150 (0.10) 175 (0.08)
Sleep disorder 1 (0.01) 12 (0.11) 140 (0.73) 1 (0.48) 55 (0.13) 372 (0.26) 588 (0.26)
Sneezing 3 (0.03) 6 (0.05) 41 (0.21) 0 15 (0.04) 219 (0.15) 285 (0.13)
Somnolence 47 (0.53) 87 (0.79) 236 (1.22) 1 (0.48) 221 (0.52) 1048 (0.73) 1677 (0.74)
Speech disorder 11 (0.12) 64 (0.58) 83 (0.43) 0 219 (0.51) 191 (0.13) 605 (0.27)
Spinal pain 2 (0.02) 4 (0.04) 33 (0.17) 0 32 (0.08) 112 (0.08) 188 (0.08)
Splenomegaly 1 (0.01) 5 (0.05) 1 (0.01) 0 27 (0.06) 13 (0.01) 53 (0.02)
Status epilepticus 9 (0.10) 29 (0.26) 4 (0.02) 0 40 (0.09) 67 (0.05) 151 (0.07)
Stevens-Johnson syndrome 4 (0.05) 1 (0.01) 0 0 12 (0.03) 30 (0.02) 51 (0.02)
Stomatitis 0 7 (0.06) 7 (0.04) 0 13 (0.03) 70 (0.05) 102 (0.05)
Stress 0 7 (0.06) 30 (0.16) 0 21 (0.05) 96 (0.07) 159 (0.07)
Stress cardiomyopathy 4 (0.05) 14 (0.13) 1 (0.01) 0 34 (0.08) 3 (0.00) 59 (0.03)
Stridor 2 (0.02) 36 (0.33) 0 0 54 (0.13) 59 (0.04) 155 (0.07)
Subarachnoid haemorrhage 73 (0.82) 69 (0.63) 6 (0.03) 0 77 (0.18) 10 (0.01) 243 (0.11)
Subclavian vein thrombosis 3 (0.03) 11 (0.10) 2 (0.01) 0 18 (0.04) 22 (0.02) 57 (0.03)
Subdural haematoma 7 (0.08) 27 (0.25) 0 0 37 (0.09) 5 (0.00) 81 (0.04)
Sudden cardiac death 59 (0.67) 0 0 0 0 0 59 (0.03)
Sudden death 552 (6.24) 0 0 0 0 0 552 (0.24)
Sudden hearing loss 0 1 (0.01) 73 (0.38) 0 45 (0.11) 208 (0.14) 332 (0.15)
Suffocation feeling 0 18 (0.16) 6 (0.03) 0 14 (0.03) 19 (0.01) 57 (0.03)
Suicidal ideation 1 (0.01) 25 (0.23) 20 (0.10) 0 11 (0.03) 142 (0.10) 212 (0.09)
Superficial vein thrombosis 0 19 (0.17) 7 (0.04) 0 56 (0.13) 306 (0.21) 392 (0.17)
Supraventricular extrasystoles 0 4 (0.04) 3 (0.02) 0 13 (0.03) 39 (0.03) 63 (0.03)
Supraventricular tachycardia 1 (0.01) 21 (0.19) 10 (0.05) 1 (0.48) 63 (0.15) 75 (0.05) 175 (0.08)
Suspected COVID-19 22 (0.25) 8 (0.07) 47 (0.24) 0 58 (0.14) 927 (0.64) 1113 (0.49)
Sweating fever 0 1 (0.01) 6 (0.03) 0 2 (0.00) 91 (0.06) 100 (0.04)
Swelling 6 (0.07) 81 (0.74) 179 (0.93) 0 222 (0.52) 1614 (1.12) 2125 (0.94)
Swelling face 4 (0.05) 91 (0.83) 96 (0.50) 0 227 (0.53) 867 (0.60) 1311 (0.58)
Swelling of eyelid 0 7 (0.06) 13 (0.07) 2 (0.95) 25 (0.06) 140 (0.10) 188 (0.08)
Swollen tongue 3 (0.03) 143 (1.30) 43 (0.22) 0 195 (0.46) 473 (0.33) 873 (0.39)
Syncope 62 (0.70) 278 (2.53) 195 (1.01) 3 (1.43) 940 (2.21) 4921 (3.42) 6560 (2.91)
Systemic inflammatory response syndrome 7 (0.08) 13 (0.12) 0 0 21 (0.05) 15 (0.01) 61 (0.03)
Systemic lupus erythematosus 1 (0.01) 7 (0.06) 8 (0.04) 0 25 (0.06) 84 (0.06) 129 (0.06)
Tachycardia 51 (0.58) 296 (2.70) 234 (1.21) 3 (1.43) 1274 (2.99) 1985 (1.38) 3924 (1.74)
Tachypnoea 29 (0.33) 30 (0.27) 4 (0.02) 0 116 (0.27) 114 (0.08) 334 (0.15)
Taste disorder 1 (0.01) 7 (0.06) 93 (0.48) 0 45 (0.11) 161 (0.11) 311 (0.14)
Tenderness 2 (0.02) 3 (0.03) 33 (0.17) 0 22 (0.05) 225 (0.16) 288 (0.13)
Tendon pain 0 2 (0.02) 20 (0.10) 0 5 (0.01) 27 (0.02) 55 (0.02)
Tendonitis 0 1 (0.01) 26 (0.13) 0 8 (0.02) 57 (0.04) 92 (0.04)
Tension 0 0 8 (0.04) 0 7 (0.02) 42 (0.03) 58 (0.03)
Tension headache 0 4 (0.04) 63 (0.33) 0 31 (0.07) 275 (0.19) 376 (0.17)
Testicular pain 1 (0.01) 1 (0.01) 8 (0.04) 0 8 (0.02) 43 (0.03) 64 (0.03)
Thinking abnormal 0 2 (0.02) 14 (0.07) 0 6 (0.01) 29 (0.02) 54 (0.02)
Thirst 1 (0.01) 10 (0.09) 50 (0.26) 0 31 (0.07) 214 (0.15) 309 (0.14)
Throat irritation 2 (0.02) 47 (0.43) 30 (0.16) 0 123 (0.29) 428 (0.30) 639 (0.28)
Throat tightness 0 149 (1.36) 34 (0.18) 2 (0.95) 264 (0.62) 694 (0.48) 1177 (0.52)
Thrombocytopenia 73 (0.82) 190 (1.73) 15 (0.08) 0 394 (0.92) 459 (0.32) 1192 (0.53)
Thrombocytopenic purpura 4 (0.05) 13 (0.12) 0 0 41 (0.10) 11 (0.01) 73 (0.03)
Thrombophlebitis 4 (0.05) 20 (0.18) 13 (0.07) 0 56 (0.13) 207 (0.14) 307 (0.14)
Thrombosis 100 (1.13) 344 (3.13) 99 (0.51) 1 (0.48) 542 (1.27) 1375 (0.96) 2580 (1.14)
Thrombotic thrombocytopenic purpura 9 (0.10) 26 (0.24) 0 0 21 (0.05) 7 (0.00) 64 (0.03)
Thyroiditis 0 1 (0.01) 9 (0.05) 0 9 (0.02) 33 (0.02) 53 (0.02)
Thyroiditis subacute 0 0 5 (0.03) 0 19 (0.04) 41 (0.03) 65 (0.03)
Tinnitus 2 (0.02) 38 (0.35) 679 (3.52) 4 (1.90) 201 (0.47) 1407 (0.98) 2355 (1.04)
Tongue discomfort 0 6 (0.05) 12 (0.06) 0 8 (0.02) 46 (0.03) 73 (0.03)
Tongue disorder 0 3 (0.03) 4 (0.02) 0 13 (0.03) 55 (0.04) 78 (0.03)
Tongue oedema 1 (0.01) 26 (0.24) 8 (0.04) 0 38 (0.09) 110 (0.08) 184 (0.08)
Tongue pruritus 0 4 (0.04) 3 (0.02) 0 17 (0.04) 36 (0.03) 60 (0.03)
Tonic clonic movements 0 7 (0.06) 2 (0.01) 0 12 (0.03) 31 (0.02) 52 (0.02)
Tonic convulsion 1 (0.01) 11 (0.10) 0 0 21 (0.05) 32 (0.02) 67 (0.03)
Tonsillar hypertrophy 0 5 (0.05) 7 (0.04) 0 5 (0.01) 54 (0.04) 72 (0.03)
Tonsillitis 0 3 (0.03) 10 (0.05) 0 14 (0.03) 84 (0.06) 111 (0.05)
Toothache 0 7 (0.06) 24 (0.12) 0 19 (0.04) 136 (0.09) 188 (0.08)
Toxic skin eruption 1 (0.01) 0 1 (0.01) 0 8 (0.02) 72 (0.05) 83 (0.04)
Transient ischaemic attack 9 (0.10) 93 (0.85) 30 (0.16) 0 466 (1.09) 284 (0.20) 913 (0.40)
Tremor 16 (0.18) 126 (1.15) 371 (1.92) 0 582 (1.37) 1553 (1.08) 2698 (1.20)
Trigeminal neuralgia 0 2 (0.02) 28 (0.15) 0 27 (0.06) 102 (0.07) 159 (0.07)
Trismus 0 3 (0.03) 6 (0.03) 0 11 (0.03) 40 (0.03) 62 (0.03)
Troponin T increased 2 (0.02) 5 (0.05) 0 0 38 (0.09) 3 (0.00) 54 (0.02)
Troponin increased 3 (0.03) 28 (0.26) 4 (0.02) 0 188 (0.44) 37 (0.03) 283 (0.13)
Tunnel vision 0 0 3 (0.02) 0 5 (0.01) 76 (0.05) 85 (0.04)
Type 1 diabetes mellitus 0 11 (0.10) 9 (0.05) 0 25 (0.06) 28 (0.02) 76 (0.03)
Type I hypersensitivity 0 5 (0.05) 0 0 8 (0.02) 111 (0.08) 128 (0.06)
Unresponsive to stimuli 46 (0.52) 33 (0.30) 7 (0.04) 0 47 (0.11) 106 (0.07) 277 (0.12)
Urinary incontinence 5 (0.06) 14 (0.13) 18 (0.09) 0 49 (0.11) 75 (0.05) 177 (0.08)
Urinary retention 4 (0.05) 8 (0.07) 19 (0.10) 0 54 (0.13) 81 (0.06) 179 (0.08)
Urinary tract infection 28 (0.32) 25 (0.23) 42 (0.22) 0 124 (0.29) 219 (0.15) 470 (0.21)
Urticaria 5 (0.06) 159 (1.45) 150 (0.78) 0 608 (1.43) 2459 (1.71) 3431 (1.52)
Urticaria chronic 0 6 (0.05) 7 (0.04) 0 4 (0.01) 33 (0.02) 51 (0.02)
Uterine haemorrhage 0 5 (0.05) 4 (0.02) 0 10 (0.02) 68 (0.05) 88 (0.04)
Uveitis 0 1 (0.01) 23 (0.12) 0 15 (0.04) 105 (0.07) 148 (0.07)
VIth nerve paralysis 0 1 (0.01) 13 (0.07) 0 21 (0.05) 27 (0.02) 62 (0.03)
Vaccination complication 11 (0.12) 5 (0.05) 10 (0.05) 0 31 (0.07) 78 (0.05) 140 (0.06)
Vaccination failure 493 (5.57) 99 (0.90) 11 (0.06) 0 1002 (2.35) 10898 (7.58) 12680 (5.62)
Vaccination site bruising 0 0 16 (0.08) 0 7 (0.02) 141 (0.10) 165 (0.07)
Vaccination site cellulitis 0 1 (0.01) 3 (0.02) 0 4 (0.01) 73 (0.05) 81 (0.04)
Vaccination site discomfort 0 1 (0.01) 7 (0.04) 0 7 (0.02) 72 (0.05) 88 (0.04)
Vaccination site erythema 4 (0.05) 12 (0.11) 102 (0.53) 0 53 (0.12) 775 (0.54) 951 (0.42)
Vaccination site haematoma 0 1 (0.01) 10 (0.05) 0 8 (0.02) 33 (0.02) 52 (0.02)
Vaccination site haemorrhage 0 1 (0.01) 4 (0.02) 0 8 (0.02) 62 (0.04) 78 (0.03)
Vaccination site hypoaesthesia 0 4 (0.04) 9 (0.05) 0 9 (0.02) 59 (0.04) 81 (0.04)
Vaccination site induration 0 0 15 (0.08) 0 11 (0.03) 87 (0.06) 114 (0.05)
Vaccination site inflammation 1 (0.01) 0 14 (0.07) 0 4 (0.01) 131 (0.09) 150 (0.07)
Vaccination site lymphadenopathy 0 0 2 (0.01) 1 (0.48) 3 (0.01) 78 (0.05) 84 (0.04)
Vaccination site mass 0 5 (0.05) 37 (0.19) 0 10 (0.02) 346 (0.24) 401 (0.18)
Vaccination site movement impairment 0 4 (0.04) 94 (0.49) 0 22 (0.05) 145 (0.10) 267 (0.12)
Vaccination site oedema 0 1 (0.01) 45 (0.23) 0 23 (0.05) 110 (0.08) 181 (0.08)
Vaccination site pain 17 (0.19) 88 (0.80) 819 (4.24) 0 365 (0.86) 3940 (2.74) 5272 (2.34)
Vaccination site paraesthesia 0 3 (0.03) 10 (0.05) 0 4 (0.01) 59 (0.04) 76 (0.03)
Vaccination site pruritus 0 9 (0.08) 49 (0.25) 0 35 (0.08) 335 (0.23) 432 (0.19)
Vaccination site rash 1 (0.01) 5 (0.05) 11 (0.06) 0 20 (0.05) 199 (0.14) 237 (0.11)
Vaccination site reaction 2 (0.02) 3 (0.03) 28 (0.15) 0 39 (0.09) 187 (0.13) 259 (0.11)
Vaccination site swelling 2 (0.02) 8 (0.07) 115 (0.60) 1 (0.48) 69 (0.16) 837 (0.58) 1037 (0.46)
Vaccination site urticaria 0 5 (0.05) 2 (0.01) 0 16 (0.04) 56 (0.04) 82 (0.04)
Vaccination site warmth 0 1 (0.01) 44 (0.23) 0 21 (0.05) 392 (0.27) 459 (0.20)
Vaginal haemorrhage 0 21 (0.19) 47 (0.24) 4 (1.90) 83 (0.19) 727 (0.51) 886 (0.39)
Varicose vein 0 5 (0.05) 11 (0.06) 0 5 (0.01) 49 (0.03) 71 (0.03)
Vascular pain 1 (0.01) 4 (0.04) 7 (0.04) 0 7 (0.02) 33 (0.02) 54 (0.02)
Vasculitis 8 (0.09) 17 (0.15) 16 (0.08) 0 90 (0.21) 89 (0.06) 227 (0.10)
Vasodilatation 1 (0.01) 2 (0.02) 12 (0.06) 0 7 (0.02) 34 (0.02) 59 (0.03)
Venous thrombosis 1 (0.01) 39 (0.36) 12 (0.06) 0 64 (0.15) 112 (0.08) 230 (0.10)
Venous thrombosis limb 0 36 (0.33) 9 (0.05) 0 95 (0.22) 192 (0.13) 339 (0.15)
Ventricular extrasystoles 1 (0.01) 12 (0.11) 12 (0.06) 0 52 (0.12) 116 (0.08) 199 (0.09)
Ventricular fibrillation 54 (0.61) 44 (0.40) 1 (0.01) 0 21 (0.05) 7 (0.00) 142 (0.06)
Ventricular tachycardia 13 (0.15) 37 (0.34) 0 0 37 (0.09) 14 (0.01) 113 (0.05)
Vertigo 7 (0.08) 76 (0.69) 470 (2.44) 2 (0.95) 458 (1.07) 1507 (1.05) 2564 (1.14)
Vertigo positional 0 2 (0.02) 24 (0.12) 0 28 (0.07) 81 (0.06) 136 (0.06)
Vestibular neuronitis 0 2 (0.02) 23 (0.12) 1 (0.48) 99 (0.23) 104 (0.07) 231 (0.10)
Viral infection 0 4 (0.04) 11 (0.06) 0 30 (0.07) 51 (0.04) 99 (0.04)
Vision blurred 2 (0.02) 65 (0.59) 302 (1.56) 3 (1.43) 300 (0.70) 1038 (0.72) 1734 (0.77)
Visual acuity reduced 1 (0.01) 4 (0.04) 25 (0.13) 0 30 (0.07) 77 (0.05) 142 (0.06)
Visual field defect 0 5 (0.05) 34 (0.18) 0 53 (0.12) 69 (0.05) 170 (0.08)
Visual impairment 9 (0.10) 50 (0.46) 265 (1.37) 2 (0.95) 368 (0.86) 588 (0.41) 1313 (0.58)
Vitreous detachment 0 0 16 (0.08) 0 8 (0.02) 78 (0.05) 103 (0.05)
Vitreous floaters 0 0 26 (0.13) 0 9 (0.02) 84 (0.06) 121 (0.05)
Vomiting 204 (2.31) 299 (2.72) 725 (3.76) 1 (0.48) 1584 (3.72) 3767 (2.62) 6757 (2.99)
Vomiting projectile 0 1 (0.01) 8 (0.04) 0 3 (0.01) 57 (0.04) 69 (0.03)
Weight decreased 8 (0.09) 24 (0.22) 99 (0.51) 0 134 (0.31) 209 (0.15) 513 (0.23)
Weight increased 2 (0.02) 7 (0.06) 11 (0.06) 0 19 (0.04) 36 (0.03) 81 (0.04)
Wheezing 14 (0.16) 75 (0.68) 39 (0.20) 0 203 (0.48) 446 (0.31) 804 (0.36)
White blood cell count decreased 0 7 (0.06) 4 (0.02) 0 30 (0.07) 36 (0.03) 85 (0.04)
White blood cell count increased 2 (0.02) 14 (0.13) 12 (0.06) 0 81 (0.19) 44 (0.03) 177 (0.08)
Wound 0 0 4 (0.02) 0 10 (0.02) 36 (0.03) 53 (0.02)