Eudravigilance C-19 - Pfizer / Biontech
Liste des effets indésirables (uniquement ceux qui apparaissent dans plus de 50 cas graves)
PT |
Décès 8849 (%) |
Mise en jeu du pronostic vital 10980 (%) |
Invalidité ou incapacité 19300 (%) |
Anomalies congénitales 210 (%) |
Hospitalisation 42625 (%) |
Médicalement significatif 143734 (%) |
Cas Graves 225698 (%) |
|---|---|---|---|---|---|---|---|
| Abdominal discomfort | 4 (0.05) | 21 (0.19) | 95 (0.49) | 0 | 100 (0.23) | 477 (0.33) | 713 (0.32) |
| Abdominal distension | 8 (0.09) | 23 (0.21) | 83 (0.43) | 0 | 63 (0.15) | 352 (0.24) | 538 (0.24) |
| Abdominal pain | 50 (0.57) | 107 (0.97) | 304 (1.58) | 5 (2.38) | 654 (1.53) | 1404 (0.98) | 2585 (1.15) |
| Abdominal pain lower | 2 (0.02) | 4 (0.04) | 34 (0.18) | 0 | 79 (0.19) | 141 (0.10) | 263 (0.12) |
| Abdominal pain upper | 28 (0.32) | 59 (0.54) | 265 (1.37) | 0 | 308 (0.72) | 1646 (1.15) | 2330 (1.03) |
| Abnormal behaviour | 2 (0.02) | 3 (0.03) | 6 (0.03) | 0 | 15 (0.04) | 21 (0.01) | 51 (0.02) |
| Abnormal dreams | 0 | 1 (0.01) | 13 (0.07) | 0 | 3 (0.01) | 81 (0.06) | 99 (0.04) |
| Abnormal faeces | 0 | 1 (0.01) | 3 (0.02) | 0 | 39 (0.09) | 15 (0.01) | 58 (0.03) |
| Abortion missed | 1 (0.01) | 3 (0.03) | 0 | 4 (1.90) | 14 (0.03) | 49 (0.03) | 71 (0.03) |
| Abortion spontaneous | 5 (0.06) | 23 (0.21) | 28 (0.15) | 77 (36.67) | 119 (0.28) | 877 (0.61) | 1132 (0.50) |
| Abscess | 0 | 1 (0.01) | 6 (0.03) | 0 | 28 (0.07) | 26 (0.02) | 64 (0.03) |
| Acne | 0 | 2 (0.02) | 10 (0.05) | 0 | 7 (0.02) | 92 (0.06) | 111 (0.05) |
| Acute coronary syndrome | 26 (0.29) | 41 (0.37) | 2 (0.01) | 0 | 109 (0.26) | 14 (0.01) | 201 (0.09) |
| Acute disseminated encephalomyelitis | 2 (0.02) | 3 (0.03) | 15 (0.08) | 0 | 50 (0.12) | 14 (0.01) | 91 (0.04) |
| Acute kidney injury | 78 (0.88) | 58 (0.53) | 7 (0.04) | 0 | 145 (0.34) | 51 (0.04) | 374 (0.17) |
| Acute myocardial infarction | 161 (1.82) | 188 (1.71) | 6 (0.03) | 0 | 225 (0.53) | 36 (0.03) | 633 (0.28) |
| Acute pulmonary oedema | 21 (0.24) | 14 (0.13) | 0 | 0 | 36 (0.08) | 4 (0.00) | 77 (0.03) |
| Acute respiratory distress syndrome | 41 (0.46) | 12 (0.11) | 0 | 0 | 10 (0.02) | 4 (0.00) | 79 (0.04) |
| Acute respiratory failure | 63 (0.71) | 22 (0.20) | 1 (0.01) | 0 | 34 (0.08) | 10 (0.01) | 136 (0.06) |
| Administration site pain | 1 (0.01) | 28 (0.26) | 24 (0.12) | 0 | 3 (0.01) | 33 (0.02) | 89 (0.04) |
| Adnexa uteri pain | 0 | 0 | 16 (0.08) | 1 (0.48) | 5 (0.01) | 63 (0.04) | 85 (0.04) |
| Ageusia | 1 (0.01) | 14 (0.13) | 122 (0.63) | 0 | 55 (0.13) | 380 (0.26) | 580 (0.26) |
| Aggression | 2 (0.02) | 3 (0.03) | 10 (0.05) | 0 | 16 (0.04) | 21 (0.01) | 52 (0.02) |
| Agitation | 11 (0.12) | 18 (0.16) | 18 (0.09) | 0 | 53 (0.12) | 96 (0.07) | 202 (0.09) |
| Alanine aminotransferase increased | 0 | 5 (0.05) | 9 (0.05) | 0 | 34 (0.08) | 50 (0.03) | 109 (0.05) |
| Allergy to vaccine | 1 (0.01) | 13 (0.12) | 7 (0.04) | 0 | 43 (0.10) | 125 (0.09) | 196 (0.09) |
| Alopecia | 0 | 6 (0.05) | 57 (0.30) | 0 | 22 (0.05) | 191 (0.13) | 280 (0.12) |
| Altered state of consciousness | 41 (0.46) | 27 (0.25) | 20 (0.10) | 0 | 173 (0.41) | 180 (0.13) | 508 (0.23) |
| Amenorrhoea | 0 | 13 (0.12) | 111 (0.58) | 3 (1.43) | 20 (0.05) | 436 (0.30) | 588 (0.26) |
| Amnesia | 3 (0.03) | 33 (0.30) | 86 (0.45) | 0 | 108 (0.25) | 186 (0.13) | 428 (0.19) |
| Anaemia | 15 (0.17) | 48 (0.44) | 31 (0.16) | 0 | 130 (0.30) | 115 (0.08) | 362 (0.16) |
| Anal incontinence | 1 (0.01) | 2 (0.02) | 8 (0.04) | 0 | 16 (0.04) | 21 (0.01) | 55 (0.02) |
| Anaphylactic reaction | 26 (0.29) | 850 (7.74) | 40 (0.21) | 1 (0.48) | 1492 (3.50) | 3266 (2.27) | 5747 (2.55) |
| Anaphylactic shock | 7 (0.08) | 268 (2.44) | 7 (0.04) | 0 | 245 (0.57) | 314 (0.22) | 860 (0.38) |
| Anaphylactoid reaction | 1 (0.01) | 11 (0.10) | 1 (0.01) | 0 | 20 (0.05) | 97 (0.07) | 131 (0.06) |
| Angina pectoris | 8 (0.09) | 63 (0.57) | 64 (0.33) | 0 | 252 (0.59) | 743 (0.52) | 1166 (0.52) |
| Angioedema | 2 (0.02) | 110 (1.00) | 15 (0.08) | 0 | 160 (0.38) | 916 (0.64) | 1225 (0.54) |
| Ankylosing spondylitis | 0 | 0 | 8 (0.04) | 0 | 5 (0.01) | 51 (0.04) | 65 (0.03) |
| Anosmia | 0 | 11 (0.10) | 101 (0.52) | 0 | 28 (0.07) | 276 (0.19) | 421 (0.19) |
| Anxiety | 13 (0.15) | 69 (0.63) | 187 (0.97) | 2 (0.95) | 215 (0.50) | 818 (0.57) | 1328 (0.59) |
| Aortic dissection | 52 (0.59) | 21 (0.19) | 0 | 0 | 9 (0.02) | 5 (0.00) | 89 (0.04) |
| Apathy | 3 (0.03) | 8 (0.07) | 19 (0.10) | 0 | 32 (0.08) | 50 (0.03) | 119 (0.05) |
| Aphasia | 24 (0.27) | 73 (0.66) | 62 (0.32) | 0 | 245 (0.57) | 113 (0.08) | 556 (0.25) |
| Aphonia | 1 (0.01) | 10 (0.09) | 18 (0.09) | 0 | 27 (0.06) | 119 (0.08) | 180 (0.08) |
| Aphthous ulcer | 2 (0.02) | 3 (0.03) | 9 (0.05) | 0 | 14 (0.03) | 60 (0.04) | 89 (0.04) |
| Apnoea | 24 (0.27) | 7 (0.06) | 2 (0.01) | 0 | 10 (0.02) | 33 (0.02) | 87 (0.04) |
| Appendicitis | 0 | 57 (0.52) | 10 (0.05) | 0 | 223 (0.52) | 71 (0.05) | 364 (0.16) |
| Arrhythmia | 79 (0.89) | 104 (0.95) | 73 (0.38) | 0 | 615 (1.44) | 1159 (0.81) | 2088 (0.93) |
| Arterial occlusive disease | 4 (0.05) | 8 (0.07) | 4 (0.02) | 0 | 28 (0.07) | 9 (0.01) | 55 (0.02) |
| Arthralgia | 31 (0.35) | 206 (1.88) | 3075 (15.93) | 3 (1.43) | 944 (2.21) | 7034 (4.89) | 11378 (5.04) |
| Arthritis | 0 | 9 (0.08) | 142 (0.74) | 0 | 72 (0.17) | 330 (0.23) | 559 (0.25) |
| Arthritis reactive | 0 | 2 (0.02) | 22 (0.11) | 0 | 19 (0.04) | 76 (0.05) | 120 (0.05) |
| Arthropathy | 0 | 1 (0.01) | 29 (0.15) | 0 | 14 (0.03) | 46 (0.03) | 90 (0.04) |
| Ascites | 6 (0.07) | 7 (0.06) | 1 (0.01) | 2 (0.95) | 19 (0.04) | 8 (0.01) | 53 (0.02) |
| Aspartate aminotransferase increased | 0 | 3 (0.03) | 1 (0.01) | 0 | 26 (0.06) | 32 (0.02) | 70 (0.03) |
| Asphyxia | 24 (0.27) | 12 (0.11) | 1 (0.01) | 0 | 8 (0.02) | 38 (0.03) | 90 (0.04) |
| Asthenia | 182 (2.06) | 264 (2.40) | 1023 (5.30) | 1 (0.48) | 1423 (3.34) | 3808 (2.65) | 6858 (3.04) |
| Asthenopia | 0 | 1 (0.01) | 25 (0.13) | 0 | 6 (0.01) | 117 (0.08) | 149 (0.07) |
| Asthma | 7 (0.08) | 86 (0.78) | 76 (0.39) | 0 | 201 (0.47) | 584 (0.41) | 966 (0.43) |
| Asthmatic crisis | 0 | 11 (0.10) | 0 | 0 | 13 (0.03) | 55 (0.04) | 79 (0.04) |
| Asymptomatic COVID-19 | 7 (0.08) | 2 (0.02) | 0 | 0 | 9 (0.02) | 501 (0.35) | 524 (0.23) |
| Ataxia | 3 (0.03) | 10 (0.09) | 20 (0.10) | 0 | 47 (0.11) | 20 (0.01) | 108 (0.05) |
| Atrial fibrillation | 61 (0.69) | 171 (1.56) | 62 (0.32) | 0 | 639 (1.50) | 673 (0.47) | 1684 (0.75) |
| Atrial flutter | 4 (0.05) | 14 (0.13) | 10 (0.05) | 0 | 62 (0.15) | 36 (0.03) | 129 (0.06) |
| Atrioventricular block | 5 (0.06) | 17 (0.15) | 3 (0.02) | 0 | 27 (0.06) | 10 (0.01) | 63 (0.03) |
| Atrioventricular block complete | 4 (0.05) | 34 (0.31) | 2 (0.01) | 0 | 27 (0.06) | 7 (0.00) | 80 (0.04) |
| Autoimmune disorder | 5 (0.06) | 13 (0.12) | 37 (0.19) | 0 | 28 (0.07) | 133 (0.09) | 237 (0.11) |
| Autoimmune haemolytic anaemia | 5 (0.06) | 14 (0.13) | 3 (0.02) | 0 | 30 (0.07) | 12 (0.01) | 64 (0.03) |
| Autoimmune hepatitis | 1 (0.01) | 4 (0.04) | 1 (0.01) | 0 | 33 (0.08) | 15 (0.01) | 55 (0.02) |
| Autoimmune thyroiditis | 0 | 0 | 5 (0.03) | 0 | 11 (0.03) | 78 (0.05) | 96 (0.04) |
| Autonomic nervous system imbalance | 1 (0.01) | 8 (0.07) | 21 (0.11) | 0 | 8 (0.02) | 22 (0.02) | 62 (0.03) |
| Axillary mass | 0 | 3 (0.03) | 26 (0.13) | 0 | 7 (0.02) | 178 (0.12) | 216 (0.10) |
| Axillary pain | 1 (0.01) | 12 (0.11) | 184 (0.95) | 0 | 37 (0.09) | 1640 (1.14) | 1877 (0.83) |
| Back pain | 23 (0.26) | 89 (0.81) | 540 (2.80) | 0 | 414 (0.97) | 1925 (1.34) | 3044 (1.35) |
| Bacterial infection | 5 (0.06) | 3 (0.03) | 6 (0.03) | 0 | 15 (0.04) | 20 (0.01) | 52 (0.02) |
| Balance disorder | 10 (0.11) | 52 (0.47) | 248 (1.28) | 1 (0.48) | 228 (0.53) | 528 (0.37) | 1104 (0.49) |
| Basedow's disease | 0 | 5 (0.05) | 11 (0.06) | 0 | 24 (0.06) | 92 (0.06) | 134 (0.06) |
| Bedridden | 11 (0.12) | 10 (0.09) | 43 (0.22) | 0 | 22 (0.05) | 68 (0.05) | 164 (0.07) |
| Bell's palsy | 0 | 9 (0.08) | 208 (1.08) | 2 (0.95) | 244 (0.57) | 1650 (1.15) | 2142 (0.95) |
| Blepharospasm | 0 | 3 (0.03) | 15 (0.08) | 0 | 15 (0.04) | 69 (0.05) | 103 (0.05) |
| Blindness | 1 (0.01) | 19 (0.17) | 90 (0.47) | 0 | 62 (0.15) | 266 (0.19) | 466 (0.21) |
| Blindness transient | 0 | 8 (0.07) | 8 (0.04) | 0 | 14 (0.03) | 90 (0.06) | 122 (0.05) |
| Blindness unilateral | 0 | 2 (0.02) | 49 (0.25) | 0 | 18 (0.04) | 58 (0.04) | 140 (0.06) |
| Blister | 2 (0.02) | 11 (0.10) | 50 (0.26) | 0 | 61 (0.14) | 306 (0.21) | 440 (0.19) |
| Blood creatine phosphokinase increased | 3 (0.03) | 8 (0.07) | 7 (0.04) | 0 | 89 (0.21) | 37 (0.03) | 165 (0.07) |
| Blood glucose decreased | 2 (0.02) | 14 (0.13) | 8 (0.04) | 0 | 13 (0.03) | 46 (0.03) | 89 (0.04) |
| Blood glucose increased | 5 (0.06) | 19 (0.17) | 18 (0.09) | 0 | 47 (0.11) | 140 (0.10) | 246 (0.11) |
| Blood potassium decreased | 0 | 7 (0.06) | 0 | 0 | 30 (0.07) | 7 (0.00) | 51 (0.02) |
| Blood pressure abnormal | 4 (0.05) | 8 (0.07) | 13 (0.07) | 0 | 24 (0.06) | 74 (0.05) | 127 (0.06) |
| Blood pressure decreased | 42 (0.47) | 124 (1.13) | 52 (0.27) | 1 (0.48) | 278 (0.65) | 632 (0.44) | 1188 (0.53) |
| Blood pressure fluctuation | 1 (0.01) | 19 (0.17) | 21 (0.11) | 0 | 48 (0.11) | 75 (0.05) | 178 (0.08) |
| Blood pressure increased | 16 (0.18) | 134 (1.22) | 131 (0.68) | 0 | 673 (1.58) | 2356 (1.64) | 3397 (1.51) |
| Blood pressure systolic increased | 0 | 7 (0.06) | 3 (0.02) | 0 | 29 (0.07) | 95 (0.07) | 144 (0.06) |
| Blood test abnormal | 0 | 2 (0.02) | 5 (0.03) | 0 | 19 (0.04) | 34 (0.02) | 61 (0.03) |
| Blood urine present | 2 (0.02) | 5 (0.05) | 11 (0.06) | 0 | 20 (0.05) | 67 (0.05) | 105 (0.05) |
| Body temperature abnormal | 0 | 3 (0.03) | 20 (0.10) | 0 | 3 (0.01) | 95 (0.07) | 123 (0.05) |
| Body temperature decreased | 5 (0.06) | 7 (0.06) | 18 (0.09) | 0 | 8 (0.02) | 63 (0.04) | 104 (0.05) |
| Body temperature fluctuation | 1 (0.01) | 0 | 13 (0.07) | 0 | 9 (0.02) | 55 (0.04) | 78 (0.03) |
| Body temperature increased | 16 (0.18) | 8 (0.07) | 59 (0.31) | 0 | 99 (0.23) | 361 (0.25) | 554 (0.25) |
| Bone pain | 2 (0.02) | 20 (0.18) | 109 (0.56) | 0 | 37 (0.09) | 389 (0.27) | 563 (0.25) |
| Bradycardia | 19 (0.21) | 50 (0.46) | 19 (0.10) | 0 | 106 (0.25) | 437 (0.30) | 667 (0.30) |
| Bradyphrenia | 0 | 1 (0.01) | 13 (0.07) | 0 | 7 (0.02) | 41 (0.03) | 63 (0.03) |
| Brain injury | 19 (0.21) | 7 (0.06) | 4 (0.02) | 0 | 6 (0.01) | 17 (0.01) | 62 (0.03) |
| Brain oedema | 23 (0.26) | 13 (0.12) | 2 (0.01) | 0 | 13 (0.03) | 22 (0.02) | 94 (0.04) |
| Brain stem infarction | 7 (0.08) | 15 (0.14) | 4 (0.02) | 0 | 33 (0.08) | 6 (0.00) | 68 (0.03) |
| Breast cancer | 0 | 5 (0.05) | 2 (0.01) | 0 | 4 (0.01) | 59 (0.04) | 71 (0.03) |
| Breast mass | 0 | 3 (0.03) | 7 (0.04) | 1 (0.48) | 7 (0.02) | 81 (0.06) | 102 (0.05) |
| Breast pain | 0 | 12 (0.11) | 65 (0.34) | 1 (0.48) | 85 (0.20) | 569 (0.40) | 739 (0.33) |
| Breast swelling | 0 | 2 (0.02) | 18 (0.09) | 0 | 8 (0.02) | 135 (0.09) | 164 (0.07) |
| Breast tenderness | 0 | 0 | 7 (0.04) | 0 | 3 (0.01) | 58 (0.04) | 68 (0.03) |
| Bronchitis | 10 (0.11) | 5 (0.05) | 10 (0.05) | 0 | 26 (0.06) | 60 (0.04) | 118 (0.05) |
| Bronchospasm | 5 (0.06) | 55 (0.50) | 3 (0.02) | 0 | 92 (0.22) | 183 (0.13) | 355 (0.16) |
| Burning sensation | 3 (0.03) | 46 (0.42) | 157 (0.81) | 0 | 157 (0.37) | 592 (0.41) | 981 (0.43) |
| Bursitis | 0 | 2 (0.02) | 32 (0.17) | 0 | 12 (0.03) | 81 (0.06) | 129 (0.06) |
| C-reactive protein increased | 25 (0.28) | 22 (0.20) | 32 (0.17) | 0 | 263 (0.62) | 109 (0.08) | 487 (0.22) |
| COVID-19 | 689 (7.79) | 133 (1.21) | 106 (0.55) | 0 | 1284 (3.01) | 14964 (10.41) | 17368 (7.70) |
| COVID-19 immunisation | 2 (0.02) | 12 (0.11) | 48 (0.25) | 0 | 28 (0.07) | 32 (0.02) | 122 (0.05) |
| COVID-19 pneumonia | 213 (2.41) | 72 (0.66) | 8 (0.04) | 0 | 307 (0.72) | 76 (0.05) | 692 (0.31) |
| Cardiac arrest | 508 (5.74) | 169 (1.54) | 1 (0.01) | 0 | 54 (0.13) | 37 (0.03) | 836 (0.37) |
| Cardiac discomfort | 1 (0.01) | 11 (0.10) | 17 (0.09) | 0 | 43 (0.10) | 52 (0.04) | 127 (0.06) |
| Cardiac disorder | 42 (0.47) | 42 (0.38) | 17 (0.09) | 0 | 93 (0.22) | 112 (0.08) | 320 (0.14) |
| Cardiac failure | 261 (2.95) | 145 (1.32) | 29 (0.15) | 0 | 300 (0.70) | 123 (0.09) | 905 (0.40) |
| Cardiac failure acute | 101 (1.14) | 20 (0.18) | 0 | 0 | 35 (0.08) | 7 (0.00) | 164 (0.07) |
| Cardiac failure congestive | 39 (0.44) | 11 (0.10) | 4 (0.02) | 0 | 40 (0.09) | 22 (0.02) | 123 (0.05) |
| Cardiac fibrillation | 1 (0.01) | 9 (0.08) | 5 (0.03) | 0 | 26 (0.06) | 31 (0.02) | 78 (0.03) |
| Cardiac flutter | 1 (0.01) | 6 (0.05) | 29 (0.15) | 0 | 45 (0.11) | 633 (0.44) | 723 (0.32) |
| Cardiac tamponade | 21 (0.24) | 12 (0.11) | 0 | 0 | 14 (0.03) | 4 (0.00) | 55 (0.02) |
| Cardio-respiratory arrest | 381 (4.31) | 57 (0.52) | 0 | 0 | 13 (0.03) | 2 (0.00) | 493 (0.22) |
| Cardiogenic shock | 53 (0.60) | 31 (0.28) | 1 (0.01) | 0 | 11 (0.03) | 7 (0.00) | 108 (0.05) |
| Cardiomegaly | 15 (0.17) | 10 (0.09) | 7 (0.04) | 0 | 22 (0.05) | 24 (0.02) | 88 (0.04) |
| Cardiomyopathy | 11 (0.12) | 18 (0.16) | 3 (0.02) | 0 | 37 (0.09) | 37 (0.03) | 116 (0.05) |
| Cardiovascular disorder | 32 (0.36) | 28 (0.26) | 45 (0.23) | 0 | 108 (0.25) | 85 (0.06) | 304 (0.13) |
| Cellulitis | 7 (0.08) | 9 (0.08) | 14 (0.07) | 0 | 57 (0.13) | 414 (0.29) | 516 (0.23) |
| Cerebellar infarction | 6 (0.07) | 15 (0.14) | 7 (0.04) | 0 | 45 (0.11) | 9 (0.01) | 85 (0.04) |
| Cerebral haemorrhage | 232 (2.62) | 137 (1.25) | 45 (0.23) | 0 | 227 (0.53) | 52 (0.04) | 719 (0.32) |
| Cerebral infarction | 99 (1.12) | 201 (1.83) | 139 (0.72) | 0 | 634 (1.49) | 111 (0.08) | 1229 (0.54) |
| Cerebral ischaemia | 13 (0.15) | 16 (0.15) | 14 (0.07) | 0 | 54 (0.13) | 28 (0.02) | 132 (0.06) |
| Cerebral thrombosis | 20 (0.23) | 49 (0.45) | 14 (0.07) | 0 | 92 (0.22) | 32 (0.02) | 218 (0.10) |
| Cerebral venous sinus thrombosis | 27 (0.31) | 92 (0.84) | 7 (0.04) | 0 | 126 (0.30) | 45 (0.03) | 303 (0.13) |
| Cerebral venous thrombosis | 10 (0.11) | 43 (0.39) | 6 (0.03) | 0 | 69 (0.16) | 13 (0.01) | 147 (0.07) |
| Cerebrovascular accident | 237 (2.68) | 452 (4.12) | 229 (1.19) | 1 (0.48) | 1074 (2.52) | 491 (0.34) | 2575 (1.14) |
| Chest discomfort | 21 (0.24) | 178 (1.62) | 296 (1.53) | 3 (1.43) | 1021 (2.40) | 1846 (1.28) | 3439 (1.52) |
| Chest pain | 102 (1.15) | 515 (4.69) | 687 (3.56) | 2 (0.95) | 2316 (5.43) | 3744 (2.60) | 7540 (3.34) |
| Chills | 61 (0.69) | 261 (2.38) | 2259 (11.70) | 2 (0.95) | 1103 (2.59) | 6353 (4.42) | 10139 (4.49) |
| Choking | 9 (0.10) | 15 (0.14) | 4 (0.02) | 0 | 11 (0.03) | 70 (0.05) | 123 (0.05) |
| Choking sensation | 0 | 9 (0.08) | 5 (0.03) | 0 | 18 (0.04) | 38 (0.03) | 74 (0.03) |
| Chromaturia | 0 | 7 (0.06) | 9 (0.05) | 0 | 23 (0.05) | 38 (0.03) | 79 (0.04) |
| Chronic fatigue syndrome | 0 | 1 (0.01) | 38 (0.20) | 0 | 13 (0.03) | 62 (0.04) | 116 (0.05) |
| Chronic obstructive pulmonary disease | 30 (0.34) | 16 (0.15) | 5 (0.03) | 0 | 48 (0.11) | 30 (0.02) | 140 (0.06) |
| Circulatory collapse | 79 (0.89) | 58 (0.53) | 7 (0.04) | 0 | 142 (0.33) | 226 (0.16) | 551 (0.24) |
| Cluster headache | 0 | 3 (0.03) | 32 (0.17) | 0 | 13 (0.03) | 132 (0.09) | 180 (0.08) |
| Coagulopathy | 20 (0.23) | 33 (0.30) | 24 (0.12) | 0 | 50 (0.12) | 50 (0.03) | 184 (0.08) |
| Cognitive disorder | 11 (0.12) | 12 (0.11) | 69 (0.36) | 0 | 47 (0.11) | 121 (0.08) | 272 (0.12) |
| Cold sweat | 10 (0.11) | 59 (0.54) | 86 (0.45) | 0 | 206 (0.48) | 669 (0.47) | 1054 (0.47) |
| Colitis | 1 (0.01) | 11 (0.10) | 9 (0.05) | 0 | 51 (0.12) | 48 (0.03) | 120 (0.05) |
| Colitis ischaemic | 3 (0.03) | 2 (0.02) | 0 | 0 | 39 (0.09) | 23 (0.02) | 68 (0.03) |
| Colitis ulcerative | 0 | 9 (0.08) | 24 (0.12) | 0 | 39 (0.09) | 142 (0.10) | 216 (0.10) |
| Coma | 43 (0.49) | 36 (0.33) | 5 (0.03) | 0 | 29 (0.07) | 11 (0.01) | 152 (0.07) |
| Concomitant disease aggravated | 10 (0.11) | 1 (0.01) | 11 (0.06) | 0 | 10 (0.02) | 18 (0.01) | 52 (0.02) |
| Condition aggravated | 87 (0.98) | 66 (0.60) | 289 (1.50) | 0 | 290 (0.68) | 1219 (0.85) | 2012 (0.89) |
| Confusional state | 54 (0.61) | 137 (1.25) | 232 (1.20) | 0 | 435 (1.02) | 690 (0.48) | 1598 (0.71) |
| Congestive cardiomyopathy | 3 (0.03) | 12 (0.11) | 1 (0.01) | 0 | 24 (0.06) | 6 (0.00) | 51 (0.02) |
| Conjunctival haemorrhage | 2 (0.02) | 2 (0.02) | 1 (0.01) | 0 | 9 (0.02) | 150 (0.10) | 167 (0.07) |
| Conjunctival hyperaemia | 0 | 2 (0.02) | 2 (0.01) | 0 | 20 (0.05) | 35 (0.02) | 60 (0.03) |
| Conjunctivitis | 1 (0.01) | 5 (0.05) | 14 (0.07) | 0 | 18 (0.04) | 71 (0.05) | 109 (0.05) |
| Constipation | 6 (0.07) | 6 (0.05) | 39 (0.20) | 0 | 51 (0.12) | 147 (0.10) | 260 (0.12) |
| Contusion | 14 (0.16) | 52 (0.47) | 105 (0.54) | 1 (0.48) | 131 (0.31) | 609 (0.42) | 932 (0.41) |
| Coordination abnormal | 4 (0.05) | 9 (0.08) | 40 (0.21) | 1 (0.48) | 46 (0.11) | 51 (0.04) | 156 (0.07) |
| Coronary artery disease | 20 (0.23) | 11 (0.10) | 2 (0.01) | 0 | 27 (0.06) | 3 (0.00) | 67 (0.03) |
| Coronary artery thrombosis | 11 (0.12) | 22 (0.20) | 0 | 0 | 11 (0.03) | 2 (0.00) | 54 (0.02) |
| Costochondritis | 0 | 1 (0.01) | 23 (0.12) | 0 | 18 (0.04) | 57 (0.04) | 101 (0.04) |
| Cough | 106 (1.20) | 192 (1.75) | 390 (2.02) | 1 (0.48) | 925 (2.17) | 2479 (1.72) | 4187 (1.86) |
| Crohn's disease | 0 | 2 (0.02) | 13 (0.07) | 0 | 20 (0.05) | 83 (0.06) | 122 (0.05) |
| Crying | 0 | 8 (0.07) | 27 (0.14) | 0 | 24 (0.06) | 131 (0.09) | 193 (0.09) |
| Cutaneous vasculitis | 1 (0.01) | 2 (0.02) | 1 (0.01) | 0 | 50 (0.12) | 54 (0.04) | 111 (0.05) |
| Cyanosis | 31 (0.35) | 42 (0.38) | 14 (0.07) | 0 | 87 (0.20) | 93 (0.06) | 299 (0.13) |
| Cystitis | 1 (0.01) | 6 (0.05) | 12 (0.06) | 0 | 29 (0.07) | 81 (0.06) | 134 (0.06) |
| Deafness | 0 | 12 (0.11) | 131 (0.68) | 0 | 54 (0.13) | 510 (0.35) | 734 (0.33) |
| Deafness neurosensory | 0 | 1 (0.01) | 38 (0.20) | 0 | 10 (0.02) | 63 (0.04) | 114 (0.05) |
| Deafness unilateral | 0 | 0 | 90 (0.47) | 0 | 25 (0.06) | 212 (0.15) | 336 (0.15) |
| Death | 1655 (18.70) | 0 | 0 | 0 | 1 (0.00) | 1 (0.00) | 1657 (0.73) |
| Decreased appetite | 92 (1.04) | 70 (0.64) | 370 (1.92) | 0 | 418 (0.98) | 1227 (0.85) | 2250 (1.00) |
| Deep vein thrombosis | 48 (0.54) | 426 (3.88) | 58 (0.30) | 1 (0.48) | 782 (1.83) | 1463 (1.02) | 2842 (1.26) |
| Dehydration | 37 (0.42) | 30 (0.27) | 30 (0.16) | 0 | 158 (0.37) | 221 (0.15) | 511 (0.23) |
| Delirium | 14 (0.16) | 26 (0.24) | 23 (0.12) | 0 | 79 (0.19) | 184 (0.13) | 358 (0.16) |
| Dementia | 9 (0.10) | 3 (0.03) | 15 (0.08) | 0 | 25 (0.06) | 57 (0.04) | 129 (0.06) |
| Demyelination | 1 (0.01) | 2 (0.02) | 18 (0.09) | 0 | 28 (0.07) | 25 (0.02) | 82 (0.04) |
| Depressed level of consciousness | 75 (0.85) | 79 (0.72) | 17 (0.09) | 0 | 244 (0.57) | 465 (0.32) | 988 (0.44) |
| Depressed mood | 1 (0.01) | 9 (0.08) | 64 (0.33) | 0 | 26 (0.06) | 289 (0.20) | 393 (0.17) |
| Depression | 1 (0.01) | 29 (0.26) | 101 (0.52) | 0 | 51 (0.12) | 271 (0.19) | 460 (0.20) |
| Dermatitis | 1 (0.01) | 4 (0.04) | 20 (0.10) | 0 | 12 (0.03) | 116 (0.08) | 154 (0.07) |
| Dermatitis allergic | 0 | 11 (0.10) | 22 (0.11) | 0 | 38 (0.09) | 170 (0.12) | 245 (0.11) |
| Dermatitis atopic | 0 | 0 | 11 (0.06) | 0 | 7 (0.02) | 34 (0.02) | 52 (0.02) |
| Dermatitis bullous | 2 (0.02) | 0 | 7 (0.04) | 0 | 16 (0.04) | 65 (0.05) | 91 (0.04) |
| Diabetes mellitus | 8 (0.09) | 11 (0.10) | 13 (0.07) | 0 | 33 (0.08) | 128 (0.09) | 207 (0.09) |
| Diabetes mellitus inadequate control | 4 (0.05) | 2 (0.02) | 4 (0.02) | 0 | 7 (0.02) | 63 (0.04) | 84 (0.04) |
| Diabetic ketoacidosis | 5 (0.06) | 11 (0.10) | 2 (0.01) | 0 | 14 (0.03) | 15 (0.01) | 53 (0.02) |
| Diarrhoea | 92 (1.04) | 146 (1.33) | 748 (3.88) | 3 (1.43) | 887 (2.08) | 3856 (2.68) | 5836 (2.59) |
| Diarrhoea haemorrhagic | 0 | 7 (0.06) | 3 (0.02) | 0 | 22 (0.05) | 80 (0.06) | 115 (0.05) |
| Diplegia | 3 (0.03) | 5 (0.05) | 17 (0.09) | 0 | 20 (0.05) | 36 (0.03) | 87 (0.04) |
| Diplopia | 2 (0.02) | 14 (0.13) | 95 (0.49) | 0 | 172 (0.40) | 200 (0.14) | 497 (0.22) |
| Discomfort | 11 (0.12) | 22 (0.20) | 101 (0.52) | 0 | 133 (0.31) | 516 (0.36) | 798 (0.35) |
| Disease recurrence | 17 (0.19) | 66 (0.60) | 112 (0.58) | 0 | 166 (0.39) | 828 (0.58) | 1218 (0.54) |
| Disorientation | 14 (0.16) | 29 (0.26) | 67 (0.35) | 0 | 123 (0.29) | 275 (0.19) | 521 (0.23) |
| Disseminated intravascular coagulation | 22 (0.25) | 17 (0.15) | 0 | 0 | 7 (0.02) | 6 (0.00) | 66 (0.03) |
| Disturbance in attention | 10 (0.11) | 27 (0.25) | 205 (1.06) | 1 (0.48) | 168 (0.39) | 492 (0.34) | 924 (0.41) |
| Diverticulitis | 2 (0.02) | 2 (0.02) | 3 (0.02) | 0 | 41 (0.10) | 66 (0.05) | 119 (0.05) |
| Dizziness | 57 (0.64) | 510 (4.64) | 1644 (8.52) | 4 (1.90) | 2873 (6.74) | 7653 (5.32) | 12923 (5.73) |
| Dizziness exertional | 0 | 0 | 10 (0.05) | 0 | 3 (0.01) | 40 (0.03) | 54 (0.02) |
| Dizziness postural | 0 | 5 (0.05) | 66 (0.34) | 0 | 34 (0.08) | 462 (0.32) | 568 (0.25) |
| Drug eruption | 0 | 2 (0.02) | 1 (0.01) | 0 | 27 (0.06) | 80 (0.06) | 111 (0.05) |
| Drug hypersensitivity | 1 (0.01) | 9 (0.08) | 5 (0.03) | 0 | 23 (0.05) | 77 (0.05) | 121 (0.05) |
| Drug ineffective | 215 (2.43) | 98 (0.89) | 65 (0.34) | 0 | 452 (1.06) | 5689 (3.96) | 6733 (2.98) |
| Drug interaction | 4 (0.05) | 5 (0.05) | 6 (0.03) | 0 | 32 (0.08) | 44 (0.03) | 92 (0.04) |
| Dry eye | 0 | 2 (0.02) | 35 (0.18) | 0 | 10 (0.02) | 93 (0.06) | 143 (0.06) |
| Dry mouth | 1 (0.01) | 29 (0.26) | 63 (0.33) | 0 | 79 (0.19) | 287 (0.20) | 469 (0.21) |
| Dry skin | 0 | 5 (0.05) | 19 (0.10) | 0 | 7 (0.02) | 108 (0.08) | 143 (0.06) |
| Dry throat | 0 | 4 (0.04) | 18 (0.09) | 0 | 17 (0.04) | 103 (0.07) | 144 (0.06) |
| Dysaesthesia | 0 | 6 (0.05) | 15 (0.08) | 0 | 57 (0.13) | 90 (0.06) | 173 (0.08) |
| Dysarthria | 25 (0.28) | 54 (0.49) | 75 (0.39) | 0 | 264 (0.62) | 157 (0.11) | 612 (0.27) |
| Dysentery | 0 | 2 (0.02) | 12 (0.06) | 0 | 6 (0.01) | 95 (0.07) | 115 (0.05) |
| Dysgeusia | 2 (0.02) | 21 (0.19) | 93 (0.48) | 0 | 95 (0.22) | 485 (0.34) | 706 (0.31) |
| Dyskinesia | 2 (0.02) | 8 (0.07) | 38 (0.20) | 1 (0.48) | 81 (0.19) | 92 (0.06) | 229 (0.10) |
| Dyslalia | 0 | 3 (0.03) | 8 (0.04) | 0 | 45 (0.11) | 6 (0.00) | 75 (0.03) |
| Dysmenorrhoea | 0 | 6 (0.05) | 235 (1.22) | 1 (0.48) | 50 (0.12) | 2284 (1.59) | 2584 (1.14) |
| Dyspepsia | 2 (0.02) | 19 (0.17) | 67 (0.35) | 0 | 44 (0.10) | 267 (0.19) | 407 (0.18) |
| Dysphagia | 32 (0.36) | 109 (0.99) | 92 (0.48) | 1 (0.48) | 254 (0.60) | 472 (0.33) | 1004 (0.44) |
| Dysphonia | 1 (0.01) | 51 (0.46) | 50 (0.26) | 0 | 152 (0.36) | 325 (0.23) | 606 (0.27) |
| Dysphoria | 3 (0.03) | 6 (0.05) | 0 | 0 | 59 (0.14) | 113 (0.08) | 188 (0.08) |
| Dyspnoea | 524 (5.92) | 1194 (10.87) | 1033 (5.35) | 3 (1.43) | 3755 (8.81) | 5738 (3.99) | 12673 (5.62) |
| Dyspnoea at rest | 0 | 7 (0.06) | 6 (0.03) | 0 | 22 (0.05) | 59 (0.04) | 99 (0.04) |
| Dyspnoea exertional | 14 (0.16) | 46 (0.42) | 49 (0.25) | 0 | 173 (0.41) | 217 (0.15) | 532 (0.24) |
| Dysstasia | 4 (0.05) | 20 (0.18) | 76 (0.39) | 0 | 126 (0.30) | 191 (0.13) | 444 (0.20) |
| Dysuria | 6 (0.07) | 8 (0.07) | 15 (0.08) | 0 | 48 (0.11) | 78 (0.05) | 158 (0.07) |
| Ear discomfort | 0 | 6 (0.05) | 74 (0.38) | 0 | 43 (0.10) | 167 (0.12) | 302 (0.13) |
| Ear infection | 0 | 3 (0.03) | 18 (0.09) | 0 | 9 (0.02) | 88 (0.06) | 122 (0.05) |
| Ear pain | 2 (0.02) | 9 (0.08) | 162 (0.84) | 0 | 79 (0.19) | 684 (0.48) | 954 (0.42) |
| Ear swelling | 0 | 3 (0.03) | 5 (0.03) | 0 | 10 (0.02) | 40 (0.03) | 60 (0.03) |
| Eating disorder | 6 (0.07) | 7 (0.06) | 14 (0.07) | 0 | 33 (0.08) | 46 (0.03) | 115 (0.05) |
| Ecchymosis | 2 (0.02) | 8 (0.07) | 3 (0.02) | 0 | 40 (0.09) | 43 (0.03) | 102 (0.05) |
| Eczema | 1 (0.01) | 1 (0.01) | 41 (0.21) | 0 | 44 (0.10) | 231 (0.16) | 323 (0.14) |
| Electric shock sensation | 0 | 11 (0.10) | 36 (0.19) | 0 | 15 (0.04) | 41 (0.03) | 104 (0.05) |
| Electrocardiogram ST segment elevation | 0 | 3 (0.03) | 1 (0.01) | 0 | 53 (0.12) | 44 (0.03) | 115 (0.05) |
| Electrocardiogram abnormal | 0 | 9 (0.08) | 3 (0.02) | 0 | 45 (0.11) | 32 (0.02) | 98 (0.04) |
| Embolic stroke | 3 (0.03) | 13 (0.12) | 8 (0.04) | 0 | 40 (0.09) | 10 (0.01) | 78 (0.03) |
| Embolism | 17 (0.19) | 34 (0.31) | 24 (0.12) | 0 | 64 (0.15) | 62 (0.04) | 212 (0.09) |
| Emotional disorder | 0 | 1 (0.01) | 12 (0.06) | 0 | 5 (0.01) | 63 (0.04) | 81 (0.04) |
| Emotional distress | 1 (0.01) | 8 (0.07) | 22 (0.11) | 0 | 13 (0.03) | 50 (0.03) | 95 (0.04) |
| Encephalitis | 8 (0.09) | 33 (0.30) | 14 (0.07) | 0 | 105 (0.25) | 23 (0.02) | 192 (0.09) |
| Encephalopathy | 8 (0.09) | 7 (0.06) | 5 (0.03) | 0 | 31 (0.07) | 19 (0.01) | 82 (0.04) |
| Endocarditis | 7 (0.08) | 8 (0.07) | 1 (0.01) | 0 | 26 (0.06) | 14 (0.01) | 60 (0.03) |
| Endometriosis | 0 | 0 | 17 (0.09) | 0 | 9 (0.02) | 70 (0.05) | 97 (0.04) |
| Eosinophilia | 0 | 3 (0.03) | 4 (0.02) | 0 | 26 (0.06) | 15 (0.01) | 52 (0.02) |
| Epilepsy | 22 (0.25) | 80 (0.73) | 29 (0.15) | 0 | 331 (0.78) | 410 (0.29) | 889 (0.39) |
| Epistaxis | 8 (0.09) | 52 (0.47) | 59 (0.31) | 0 | 154 (0.36) | 457 (0.32) | 740 (0.33) |
| Erectile dysfunction | 0 | 1 (0.01) | 30 (0.16) | 0 | 7 (0.02) | 128 (0.09) | 169 (0.07) |
| Eructation | 0 | 3 (0.03) | 12 (0.06) | 0 | 14 (0.03) | 31 (0.02) | 64 (0.03) |
| Erysipelas | 3 (0.03) | 2 (0.02) | 4 (0.02) | 0 | 46 (0.11) | 68 (0.05) | 126 (0.06) |
| Erythema | 10 (0.11) | 128 (1.17) | 152 (0.79) | 0 | 641 (1.50) | 2208 (1.54) | 3202 (1.42) |
| Erythema multiforme | 1 (0.01) | 2 (0.02) | 4 (0.02) | 0 | 54 (0.13) | 158 (0.11) | 223 (0.10) |
| Erythema nodosum | 0 | 2 (0.02) | 3 (0.02) | 0 | 17 (0.04) | 51 (0.04) | 73 (0.03) |
| Erythema of eyelid | 0 | 1 (0.01) | 4 (0.02) | 0 | 10 (0.02) | 37 (0.03) | 52 (0.02) |
| Exercise tolerance decreased | 1 (0.01) | 9 (0.08) | 58 (0.30) | 0 | 43 (0.10) | 52 (0.04) | 172 (0.08) |
| Exposure during pregnancy | 2 (0.02) | 5 (0.05) | 1 (0.01) | 1 (0.48) | 22 (0.05) | 90 (0.06) | 124 (0.05) |
| Exposure via breast milk | 2 (0.02) | 1 (0.01) | 3 (0.02) | 2 (0.95) | 13 (0.03) | 139 (0.10) | 161 (0.07) |
| Extensive swelling of vaccinated limb | 1 (0.01) | 7 (0.06) | 214 (1.11) | 0 | 12 (0.03) | 65 (0.05) | 299 (0.13) |
| Extrasystoles | 2 (0.02) | 19 (0.17) | 43 (0.22) | 0 | 82 (0.19) | 201 (0.14) | 353 (0.16) |
| Eye disorder | 1 (0.01) | 2 (0.02) | 30 (0.16) | 0 | 40 (0.09) | 90 (0.06) | 163 (0.07) |
| Eye haemorrhage | 0 | 4 (0.04) | 11 (0.06) | 0 | 10 (0.02) | 197 (0.14) | 226 (0.10) |
| Eye inflammation | 0 | 0 | 14 (0.07) | 0 | 8 (0.02) | 36 (0.03) | 60 (0.03) |
| Eye irritation | 0 | 7 (0.06) | 27 (0.14) | 0 | 8 (0.02) | 109 (0.08) | 154 (0.07) |
| Eye movement disorder | 1 (0.01) | 9 (0.08) | 23 (0.12) | 0 | 37 (0.09) | 48 (0.03) | 127 (0.06) |
| Eye oedema | 0 | 3 (0.03) | 9 (0.05) | 0 | 4 (0.01) | 35 (0.02) | 52 (0.02) |
| Eye pain | 1 (0.01) | 28 (0.26) | 194 (1.01) | 0 | 112 (0.26) | 825 (0.57) | 1172 (0.52) |
| Eye pruritus | 0 | 12 (0.11) | 22 (0.11) | 0 | 31 (0.07) | 206 (0.14) | 278 (0.12) |
| Eye swelling | 0 | 33 (0.30) | 45 (0.23) | 1 (0.48) | 55 (0.13) | 429 (0.30) | 573 (0.25) |
| Eyelid oedema | 0 | 10 (0.09) | 5 (0.03) | 0 | 48 (0.11) | 137 (0.10) | 205 (0.09) |
| Eyelid ptosis | 1 (0.01) | 5 (0.05) | 18 (0.09) | 0 | 38 (0.09) | 67 (0.05) | 137 (0.06) |
| Face oedema | 2 (0.02) | 33 (0.30) | 16 (0.08) | 0 | 103 (0.24) | 245 (0.17) | 407 (0.18) |
| Facial pain | 0 | 4 (0.04) | 57 (0.30) | 0 | 43 (0.10) | 203 (0.14) | 310 (0.14) |
| Facial paralysis | 3 (0.03) | 43 (0.39) | 185 (0.96) | 2 (0.95) | 605 (1.42) | 1748 (1.22) | 2633 (1.17) |
| Facial paresis | 1 (0.01) | 24 (0.22) | 80 (0.41) | 0 | 282 (0.66) | 288 (0.20) | 689 (0.31) |
| Faeces discoloured | 3 (0.03) | 3 (0.03) | 8 (0.04) | 0 | 15 (0.04) | 34 (0.02) | 69 (0.03) |
| Fall | 89 (1.01) | 81 (0.74) | 102 (0.53) | 0 | 405 (0.95) | 521 (0.36) | 1313 (0.58) |
| Fatigue | 176 (1.99) | 490 (4.46) | 5049 (26.16) | 6 (2.86) | 2162 (5.07) | 13956 (9.71) | 22030 (9.76) |
| Fear | 1 (0.01) | 8 (0.07) | 12 (0.06) | 0 | 9 (0.02) | 41 (0.03) | 72 (0.03) |
| Febrile convulsion | 1 (0.01) | 3 (0.03) | 5 (0.03) | 1 (0.48) | 30 (0.07) | 35 (0.02) | 75 (0.03) |
| Feeding disorder | 6 (0.07) | 12 (0.11) | 38 (0.20) | 0 | 41 (0.10) | 108 (0.08) | 224 (0.10) |
| Feeling abnormal | 11 (0.12) | 85 (0.77) | 444 (2.30) | 1 (0.48) | 488 (1.14) | 1986 (1.38) | 3090 (1.37) |
| Feeling cold | 5 (0.06) | 35 (0.32) | 172 (0.89) | 0 | 160 (0.38) | 1054 (0.73) | 1439 (0.64) |
| Feeling drunk | 1 (0.01) | 2 (0.02) | 14 (0.07) | 1 (0.48) | 9 (0.02) | 77 (0.05) | 105 (0.05) |
| Feeling hot | 3 (0.03) | 73 (0.66) | 171 (0.89) | 2 (0.95) | 347 (0.81) | 1286 (0.89) | 1911 (0.85) |
| Feeling jittery | 0 | 2 (0.02) | 2 (0.01) | 0 | 22 (0.05) | 34 (0.02) | 64 (0.03) |
| Feeling of body temperature change | 1 (0.01) | 11 (0.10) | 71 (0.37) | 0 | 42 (0.10) | 336 (0.23) | 462 (0.20) |
| Fibrin D dimer increased | 11 (0.12) | 28 (0.26) | 12 (0.06) | 0 | 162 (0.38) | 154 (0.11) | 389 (0.17) |
| Fibromyalgia | 1 (0.01) | 6 (0.05) | 64 (0.33) | 0 | 9 (0.02) | 94 (0.07) | 177 (0.08) |
| Flank pain | 2 (0.02) | 4 (0.04) | 15 (0.08) | 0 | 24 (0.06) | 56 (0.04) | 103 (0.05) |
| Flatulence | 1 (0.01) | 6 (0.05) | 24 (0.12) | 0 | 16 (0.04) | 117 (0.08) | 166 (0.07) |
| Fluid retention | 4 (0.05) | 9 (0.08) | 12 (0.06) | 0 | 14 (0.03) | 43 (0.03) | 85 (0.04) |
| Flushing | 1 (0.01) | 47 (0.43) | 32 (0.17) | 0 | 160 (0.38) | 472 (0.33) | 727 (0.32) |
| Foetal death | 15 (0.17) | 3 (0.03) | 2 (0.01) | 2 (0.95) | 29 (0.07) | 35 (0.02) | 88 (0.04) |
| Food allergy | 0 | 15 (0.14) | 5 (0.03) | 0 | 5 (0.01) | 33 (0.02) | 60 (0.03) |
| Formication | 0 | 3 (0.03) | 15 (0.08) | 1 (0.48) | 10 (0.02) | 97 (0.07) | 129 (0.06) |
| Gait disturbance | 18 (0.20) | 70 (0.64) | 381 (1.97) | 0 | 443 (1.04) | 660 (0.46) | 1657 (0.73) |
| Gait inability | 6 (0.07) | 29 (0.26) | 160 (0.83) | 0 | 126 (0.30) | 191 (0.13) | 552 (0.24) |
| Gastritis | 1 (0.01) | 2 (0.02) | 19 (0.10) | 0 | 24 (0.06) | 45 (0.03) | 94 (0.04) |
| Gastroenteritis | 2 (0.02) | 3 (0.03) | 2 (0.01) | 0 | 44 (0.10) | 35 (0.02) | 89 (0.04) |
| Gastrointestinal disorder | 3 (0.03) | 8 (0.07) | 29 (0.15) | 0 | 48 (0.11) | 91 (0.06) | 185 (0.08) |
| Gastrointestinal haemorrhage | 30 (0.34) | 18 (0.16) | 1 (0.01) | 0 | 32 (0.08) | 25 (0.02) | 115 (0.05) |
| Gastrointestinal pain | 0 | 7 (0.06) | 37 (0.19) | 0 | 36 (0.08) | 102 (0.07) | 187 (0.08) |
| Gastrooesophageal reflux disease | 2 (0.02) | 8 (0.07) | 39 (0.20) | 0 | 26 (0.06) | 94 (0.07) | 171 (0.08) |
| Gaze palsy | 4 (0.05) | 5 (0.05) | 3 (0.02) | 0 | 14 (0.03) | 25 (0.02) | 55 (0.02) |
| General physical health deterioration | 204 (2.31) | 43 (0.39) | 40 (0.21) | 0 | 224 (0.53) | 69 (0.05) | 634 (0.28) |
| Generalised oedema | 5 (0.06) | 6 (0.05) | 3 (0.02) | 0 | 18 (0.04) | 31 (0.02) | 66 (0.03) |
| Generalised tonic-clonic seizure | 7 (0.08) | 37 (0.34) | 8 (0.04) | 0 | 141 (0.33) | 167 (0.12) | 368 (0.16) |
| Genital haemorrhage | 0 | 1 (0.01) | 1 (0.01) | 0 | 8 (0.02) | 60 (0.04) | 71 (0.03) |
| Genital herpes | 0 | 0 | 16 (0.08) | 0 | 9 (0.02) | 63 (0.04) | 88 (0.04) |
| Giant cell arteritis | 2 (0.02) | 9 (0.08) | 11 (0.06) | 0 | 56 (0.13) | 36 (0.03) | 116 (0.05) |
| Gingival bleeding | 0 | 11 (0.10) | 7 (0.04) | 0 | 26 (0.06) | 50 (0.03) | 94 (0.04) |
| Gingival pain | 0 | 2 (0.02) | 12 (0.06) | 0 | 4 (0.01) | 68 (0.05) | 87 (0.04) |
| Glossodynia | 0 | 3 (0.03) | 21 (0.11) | 0 | 11 (0.03) | 105 (0.07) | 140 (0.06) |
| Gout | 0 | 3 (0.03) | 27 (0.14) | 0 | 21 (0.05) | 65 (0.05) | 116 (0.05) |
| Grip strength decreased | 1 (0.01) | 1 (0.01) | 30 (0.16) | 0 | 18 (0.04) | 54 (0.04) | 105 (0.05) |
| Groin pain | 4 (0.05) | 3 (0.03) | 33 (0.17) | 0 | 23 (0.05) | 103 (0.07) | 172 (0.08) |
| Guillain-Barre syndrome | 16 (0.18) | 77 (0.70) | 67 (0.35) | 0 | 446 (1.05) | 209 (0.15) | 851 (0.38) |
| Haematemesis | 34 (0.38) | 14 (0.13) | 10 (0.05) | 0 | 35 (0.08) | 71 (0.05) | 180 (0.08) |
| Haematochezia | 6 (0.07) | 7 (0.06) | 18 (0.09) | 1 (0.48) | 61 (0.14) | 288 (0.20) | 388 (0.17) |
| Haematoma | 10 (0.11) | 32 (0.29) | 42 (0.22) | 1 (0.48) | 96 (0.23) | 168 (0.12) | 359 (0.16) |
| Haematuria | 4 (0.05) | 12 (0.11) | 10 (0.05) | 0 | 58 (0.14) | 116 (0.08) | 206 (0.09) |
| Haemoglobin decreased | 5 (0.06) | 13 (0.12) | 6 (0.03) | 0 | 49 (0.11) | 28 (0.02) | 112 (0.05) |
| Haemolytic anaemia | 4 (0.05) | 10 (0.09) | 2 (0.01) | 0 | 22 (0.05) | 11 (0.01) | 51 (0.02) |
| Haemoptysis | 14 (0.16) | 27 (0.25) | 14 (0.07) | 0 | 51 (0.12) | 69 (0.05) | 189 (0.08) |
| Haemorrhage | 21 (0.24) | 53 (0.48) | 56 (0.29) | 7 (3.33) | 127 (0.30) | 1286 (0.89) | 1582 (0.70) |
| Haemorrhage intracranial | 17 (0.19) | 13 (0.12) | 1 (0.01) | 0 | 14 (0.03) | 4 (0.00) | 54 (0.02) |
| Haemorrhage subcutaneous | 3 (0.03) | 1 (0.01) | 1 (0.01) | 0 | 13 (0.03) | 156 (0.11) | 185 (0.08) |
| Haemorrhage urinary tract | 0 | 1 (0.01) | 2 (0.01) | 0 | 4 (0.01) | 52 (0.04) | 62 (0.03) |
| Haemorrhagic stroke | 57 (0.64) | 26 (0.24) | 7 (0.04) | 0 | 27 (0.06) | 9 (0.01) | 128 (0.06) |
| Haemorrhoids | 1 (0.01) | 0 | 7 (0.04) | 0 | 5 (0.01) | 38 (0.03) | 52 (0.02) |
| Hallucination | 6 (0.07) | 22 (0.20) | 45 (0.23) | 0 | 45 (0.11) | 370 (0.26) | 505 (0.22) |
| Hallucination, auditory | 0 | 2 (0.02) | 5 (0.03) | 0 | 10 (0.02) | 39 (0.03) | 58 (0.03) |
| Hallucination, visual | 1 (0.01) | 4 (0.04) | 7 (0.04) | 0 | 15 (0.04) | 82 (0.06) | 110 (0.05) |
| Hangover | 0 | 0 | 16 (0.08) | 0 | 3 (0.01) | 50 (0.03) | 69 (0.03) |
| Head discomfort | 0 | 30 (0.27) | 104 (0.54) | 0 | 136 (0.32) | 363 (0.25) | 647 (0.29) |
| Head injury | 4 (0.05) | 16 (0.15) | 10 (0.05) | 0 | 54 (0.13) | 109 (0.08) | 209 (0.09) |
| Headache | 99 (1.12) | 691 (6.29) | 5027 (26.05) | 7 (3.33) | 3699 (8.68) | 17555 (12.21) | 27351 (12.12) |
| Heart rate | 0 | 2 (0.02) | 13 (0.07) | 0 | 12 (0.03) | 54 (0.04) | 81 (0.04) |
| Heart rate abnormal | 0 | 12 (0.11) | 17 (0.09) | 0 | 35 (0.08) | 100 (0.07) | 165 (0.07) |
| Heart rate decreased | 5 (0.06) | 40 (0.36) | 23 (0.12) | 1 (0.48) | 79 (0.19) | 234 (0.16) | 404 (0.18) |
| Heart rate increased | 19 (0.21) | 172 (1.57) | 257 (1.33) | 1 (0.48) | 540 (1.27) | 1276 (0.89) | 2330 (1.03) |
| Heart rate irregular | 1 (0.01) | 27 (0.25) | 53 (0.27) | 2 (0.95) | 88 (0.21) | 226 (0.16) | 405 (0.18) |
| Heavy menstrual bleeding | 0 | 34 (0.31) | 335 (1.74) | 2 (0.95) | 147 (0.34) | 3588 (2.50) | 4121 (1.83) |
| Hemianaesthesia | 0 | 4 (0.04) | 17 (0.09) | 0 | 41 (0.10) | 41 (0.03) | 104 (0.05) |
| Hemiparaesthesia | 1 (0.01) | 1 (0.01) | 11 (0.06) | 0 | 35 (0.08) | 103 (0.07) | 153 (0.07) |
| Hemiparesis | 37 (0.42) | 65 (0.59) | 67 (0.35) | 0 | 272 (0.64) | 194 (0.13) | 686 (0.30) |
| Hemiplegia | 17 (0.19) | 33 (0.30) | 46 (0.24) | 0 | 127 (0.30) | 71 (0.05) | 343 (0.15) |
| Henoch-Schonlein purpura | 1 (0.01) | 0 | 4 (0.02) | 0 | 30 (0.07) | 16 (0.01) | 52 (0.02) |
| Hepatic cytolysis | 1 (0.01) | 2 (0.02) | 0 | 0 | 37 (0.09) | 36 (0.03) | 77 (0.03) |
| Hepatic enzyme increased | 2 (0.02) | 7 (0.06) | 4 (0.02) | 0 | 45 (0.11) | 27 (0.02) | 92 (0.04) |
| Hepatic function abnormal | 6 (0.07) | 8 (0.07) | 3 (0.02) | 0 | 78 (0.18) | 35 (0.02) | 136 (0.06) |
| Hepatitis | 4 (0.05) | 3 (0.03) | 4 (0.02) | 0 | 40 (0.09) | 51 (0.04) | 105 (0.05) |
| Hepatitis acute | 4 (0.05) | 4 (0.04) | 0 | 0 | 37 (0.09) | 16 (0.01) | 61 (0.03) |
| Herpes ophthalmic | 0 | 0 | 2 (0.01) | 0 | 5 (0.01) | 50 (0.03) | 57 (0.03) |
| Herpes simplex | 0 | 1 (0.01) | 6 (0.03) | 0 | 13 (0.03) | 45 (0.03) | 65 (0.03) |
| Herpes virus infection | 0 | 1 (0.01) | 10 (0.05) | 0 | 7 (0.02) | 37 (0.03) | 55 (0.02) |
| Herpes zoster | 13 (0.15) | 27 (0.25) | 249 (1.29) | 0 | 477 (1.12) | 2199 (1.53) | 2982 (1.32) |
| Herpes zoster oticus | 0 | 3 (0.03) | 10 (0.05) | 0 | 32 (0.08) | 56 (0.04) | 103 (0.05) |
| Hormone level abnormal | 0 | 2 (0.02) | 16 (0.08) | 0 | 6 (0.01) | 62 (0.04) | 86 (0.04) |
| Hospitalisation | 2 (0.02) | 4 (0.04) | 0 | 0 | 75 (0.18) | 1 (0.00) | 98 (0.04) |
| Hot flush | 1 (0.01) | 15 (0.14) | 118 (0.61) | 0 | 111 (0.26) | 742 (0.52) | 998 (0.44) |
| Hyperacusis | 0 | 2 (0.02) | 51 (0.26) | 0 | 20 (0.05) | 70 (0.05) | 145 (0.06) |
| Hyperaesthesia | 0 | 1 (0.01) | 42 (0.22) | 0 | 17 (0.04) | 121 (0.08) | 183 (0.08) |
| Hyperglycaemia | 7 (0.08) | 12 (0.11) | 11 (0.06) | 0 | 34 (0.08) | 97 (0.07) | 166 (0.07) |
| Hyperhidrosis | 23 (0.26) | 140 (1.28) | 352 (1.82) | 2 (0.95) | 427 (1.00) | 1901 (1.32) | 2894 (1.28) |
| Hyperpyrexia | 23 (0.26) | 13 (0.12) | 8 (0.04) | 0 | 73 (0.17) | 589 (0.41) | 712 (0.32) |
| Hypersensitivity | 9 (0.10) | 269 (2.45) | 130 (0.67) | 2 (0.95) | 609 (1.43) | 1522 (1.06) | 2590 (1.15) |
| Hypersomnia | 3 (0.03) | 12 (0.11) | 63 (0.33) | 0 | 23 (0.05) | 217 (0.15) | 326 (0.14) |
| Hypertension | 40 (0.45) | 260 (2.37) | 174 (0.90) | 3 (1.43) | 965 (2.26) | 2454 (1.71) | 3997 (1.77) |
| Hypertensive crisis | 9 (0.10) | 42 (0.38) | 8 (0.04) | 0 | 182 (0.43) | 421 (0.29) | 673 (0.30) |
| Hyperthermia | 8 (0.09) | 8 (0.07) | 10 (0.05) | 0 | 34 (0.08) | 67 (0.05) | 130 (0.06) |
| Hyperthyroidism | 1 (0.01) | 5 (0.05) | 16 (0.08) | 0 | 25 (0.06) | 134 (0.09) | 185 (0.08) |
| Hyperventilation | 0 | 18 (0.16) | 12 (0.06) | 0 | 127 (0.30) | 172 (0.12) | 340 (0.15) |
| Hypoacusis | 1 (0.01) | 10 (0.09) | 128 (0.66) | 0 | 54 (0.13) | 260 (0.18) | 458 (0.20) |
| Hypoaesthesia | 9 (0.10) | 239 (2.18) | 872 (4.52) | 2 (0.95) | 1160 (2.72) | 2685 (1.87) | 5067 (2.25) |
| Hypoaesthesia oral | 2 (0.02) | 55 (0.50) | 64 (0.33) | 1 (0.48) | 142 (0.33) | 462 (0.32) | 743 (0.33) |
| Hypoglycaemia | 7 (0.08) | 24 (0.22) | 11 (0.06) | 1 (0.48) | 30 (0.07) | 118 (0.08) | 194 (0.09) |
| Hypokalaemia | 4 (0.05) | 14 (0.13) | 2 (0.01) | 0 | 38 (0.09) | 24 (0.02) | 101 (0.04) |
| Hypokinesia | 2 (0.02) | 11 (0.10) | 65 (0.34) | 1 (0.48) | 33 (0.08) | 162 (0.11) | 284 (0.13) |
| Hypomenorrhoea | 0 | 0 | 27 (0.14) | 1 (0.48) | 4 (0.01) | 222 (0.15) | 254 (0.11) |
| Hyponatraemia | 4 (0.05) | 14 (0.13) | 4 (0.02) | 0 | 41 (0.10) | 2 (0.00) | 72 (0.03) |
| Hypophagia | 14 (0.16) | 2 (0.02) | 7 (0.04) | 0 | 32 (0.08) | 30 (0.02) | 96 (0.04) |
| Hypopnoea | 5 (0.06) | 17 (0.15) | 16 (0.08) | 0 | 15 (0.04) | 93 (0.06) | 156 (0.07) |
| Hypotension | 84 (0.95) | 179 (1.63) | 92 (0.48) | 0 | 377 (0.88) | 807 (0.56) | 1620 (0.72) |
| Hypothermia | 9 (0.10) | 14 (0.13) | 8 (0.04) | 0 | 16 (0.04) | 119 (0.08) | 176 (0.08) |
| Hypothyroidism | 0 | 1 (0.01) | 14 (0.07) | 0 | 13 (0.03) | 85 (0.06) | 122 (0.05) |
| Hypotonia | 5 (0.06) | 10 (0.09) | 18 (0.09) | 0 | 68 (0.16) | 51 (0.04) | 156 (0.07) |
| Hypovolaemic shock | 7 (0.08) | 3 (0.03) | 0 | 0 | 8 (0.02) | 61 (0.04) | 83 (0.04) |
| Hypoxia | 50 (0.57) | 39 (0.36) | 4 (0.02) | 0 | 92 (0.22) | 78 (0.05) | 314 (0.14) |
| IIIrd nerve paralysis | 0 | 2 (0.02) | 2 (0.01) | 0 | 21 (0.05) | 26 (0.02) | 54 (0.02) |
| Illness | 12 (0.14) | 48 (0.44) | 195 (1.01) | 2 (0.95) | 172 (0.40) | 1159 (0.81) | 1613 (0.71) |
| Immobile | 2 (0.02) | 2 (0.02) | 22 (0.11) | 0 | 8 (0.02) | 44 (0.03) | 85 (0.04) |
| Immune system disorder | 3 (0.03) | 1 (0.01) | 20 (0.10) | 0 | 16 (0.04) | 63 (0.04) | 114 (0.05) |
| Immune thrombocytopenia | 9 (0.10) | 110 (1.00) | 3 (0.02) | 0 | 239 (0.56) | 170 (0.12) | 540 (0.24) |
| Immunisation | 29 (0.33) | 51 (0.46) | 173 (0.90) | 0 | 131 (0.31) | 2138 (1.49) | 2534 (1.12) |
| Immunisation reaction | 0 | 0 | 4 (0.02) | 0 | 24 (0.06) | 77 (0.05) | 114 (0.05) |
| Immunodeficiency | 0 | 0 | 1 (0.01) | 0 | 4 (0.01) | 50 (0.03) | 63 (0.03) |
| Impaired driving ability | 0 | 4 (0.04) | 32 (0.17) | 0 | 5 (0.01) | 30 (0.02) | 75 (0.03) |
| Impaired quality of life | 0 | 4 (0.04) | 22 (0.11) | 0 | 2 (0.00) | 30 (0.02) | 62 (0.03) |
| Impaired work ability | 0 | 16 (0.15) | 194 (1.01) | 0 | 57 (0.13) | 224 (0.16) | 516 (0.23) |
| Inappropriate schedule of product administration | 2 (0.02) | 3 (0.03) | 42 (0.22) | 2 (0.95) | 20 (0.05) | 298 (0.21) | 382 (0.17) |
| Incontinence | 4 (0.05) | 10 (0.09) | 16 (0.08) | 0 | 22 (0.05) | 23 (0.02) | 84 (0.04) |
| Induration | 0 | 0 | 4 (0.02) | 0 | 22 (0.05) | 49 (0.03) | 75 (0.03) |
| Infarction | 15 (0.17) | 26 (0.24) | 5 (0.03) | 0 | 21 (0.05) | 9 (0.01) | 81 (0.04) |
| Infection | 24 (0.27) | 18 (0.16) | 31 (0.16) | 1 (0.48) | 96 (0.23) | 178 (0.12) | 366 (0.16) |
| Infectious mononucleosis | 0 | 4 (0.04) | 10 (0.05) | 0 | 13 (0.03) | 26 (0.02) | 53 (0.02) |
| Inflammation | 7 (0.08) | 37 (0.34) | 125 (0.65) | 0 | 197 (0.46) | 409 (0.28) | 816 (0.36) |
| Inflammatory marker increased | 4 (0.05) | 4 (0.04) | 4 (0.02) | 0 | 44 (0.10) | 15 (0.01) | 81 (0.04) |
| Influenza | 1 (0.01) | 14 (0.13) | 118 (0.61) | 0 | 180 (0.42) | 892 (0.62) | 1210 (0.54) |
| Influenza like illness | 15 (0.17) | 29 (0.26) | 440 (2.28) | 1 (0.48) | 321 (0.75) | 2334 (1.62) | 3182 (1.41) |
| Injected limb mobility decreased | 0 | 3 (0.03) | 45 (0.23) | 0 | 3 (0.01) | 113 (0.08) | 164 (0.07) |
| Injection site erythema | 3 (0.03) | 2 (0.02) | 27 (0.14) | 0 | 21 (0.05) | 89 (0.06) | 143 (0.06) |
| Injection site pain | 4 (0.05) | 11 (0.10) | 221 (1.15) | 0 | 178 (0.42) | 454 (0.32) | 871 (0.39) |
| Injection site reaction | 1 (0.01) | 15 (0.14) | 1050 (5.44) | 0 | 45 (0.11) | 60 (0.04) | 1172 (0.52) |
| Injection site swelling | 2 (0.02) | 1 (0.01) | 34 (0.18) | 0 | 32 (0.08) | 44 (0.03) | 113 (0.05) |
| Injury | 2 (0.02) | 4 (0.04) | 7 (0.04) | 0 | 20 (0.05) | 29 (0.02) | 63 (0.03) |
| Insomnia | 9 (0.10) | 73 (0.66) | 485 (2.51) | 0 | 197 (0.46) | 1582 (1.10) | 2371 (1.05) |
| Interchange of vaccine products | 16 (0.18) | 23 (0.21) | 79 (0.41) | 1 (0.48) | 71 (0.17) | 1193 (0.83) | 1388 (0.61) |
| Intermenstrual bleeding | 0 | 5 (0.05) | 75 (0.39) | 0 | 39 (0.09) | 661 (0.46) | 786 (0.35) |
| Internal haemorrhage | 6 (0.07) | 6 (0.05) | 3 (0.02) | 0 | 14 (0.03) | 137 (0.10) | 175 (0.08) |
| International normalised ratio increased | 6 (0.07) | 9 (0.08) | 3 (0.02) | 0 | 22 (0.05) | 48 (0.03) | 96 (0.04) |
| Interstitial lung disease | 39 (0.44) | 21 (0.19) | 8 (0.04) | 0 | 69 (0.16) | 29 (0.02) | 178 (0.08) |
| Intestinal ischaemia | 35 (0.40) | 8 (0.07) | 1 (0.01) | 0 | 21 (0.05) | 8 (0.01) | 78 (0.03) |
| Intracardiac thrombus | 13 (0.15) | 10 (0.09) | 1 (0.01) | 0 | 18 (0.04) | 5 (0.00) | 51 (0.02) |
| Intracranial pressure increased | 3 (0.03) | 6 (0.05) | 5 (0.03) | 0 | 13 (0.03) | 23 (0.02) | 57 (0.03) |
| Iridocyclitis | 0 | 0 | 5 (0.03) | 0 | 6 (0.01) | 59 (0.04) | 73 (0.03) |
| Irritability | 3 (0.03) | 4 (0.04) | 25 (0.13) | 0 | 32 (0.08) | 174 (0.12) | 240 (0.11) |
| Irritable bowel syndrome | 0 | 3 (0.03) | 21 (0.11) | 0 | 5 (0.01) | 66 (0.05) | 96 (0.04) |
| Ischaemia | 8 (0.09) | 19 (0.17) | 13 (0.07) | 0 | 27 (0.06) | 14 (0.01) | 83 (0.04) |
| Ischaemic cerebral infarction | 9 (0.10) | 30 (0.27) | 7 (0.04) | 0 | 46 (0.11) | 9 (0.01) | 103 (0.05) |
| Ischaemic stroke | 73 (0.82) | 154 (1.40) | 74 (0.38) | 0 | 550 (1.29) | 51 (0.04) | 907 (0.40) |
| Jaundice | 11 (0.12) | 6 (0.05) | 4 (0.02) | 0 | 58 (0.14) | 33 (0.02) | 118 (0.05) |
| Joint range of motion decreased | 1 (0.01) | 3 (0.03) | 79 (0.41) | 0 | 19 (0.04) | 282 (0.20) | 392 (0.17) |
| Joint stiffness | 0 | 5 (0.05) | 75 (0.39) | 0 | 20 (0.05) | 208 (0.14) | 312 (0.14) |
| Joint swelling | 2 (0.02) | 20 (0.18) | 184 (0.95) | 0 | 101 (0.24) | 474 (0.33) | 795 (0.35) |
| Kidney infection | 0 | 4 (0.04) | 5 (0.03) | 0 | 18 (0.04) | 69 (0.05) | 101 (0.04) |
| Labyrinthitis | 0 | 1 (0.01) | 29 (0.15) | 0 | 11 (0.03) | 74 (0.05) | 116 (0.05) |
| Lacrimation increased | 0 | 9 (0.08) | 26 (0.13) | 0 | 28 (0.07) | 146 (0.10) | 215 (0.10) |
| Lacunar infarction | 1 (0.01) | 7 (0.06) | 0 | 0 | 30 (0.07) | 10 (0.01) | 54 (0.02) |
| Language disorder | 1 (0.01) | 4 (0.04) | 9 (0.05) | 0 | 61 (0.14) | 14 (0.01) | 95 (0.04) |
| Laryngeal oedema | 3 (0.03) | 57 (0.52) | 0 | 0 | 51 (0.12) | 186 (0.13) | 307 (0.14) |
| Laryngospasm | 1 (0.01) | 11 (0.10) | 1 (0.01) | 0 | 15 (0.04) | 34 (0.02) | 62 (0.03) |
| Lethargy | 21 (0.24) | 43 (0.39) | 203 (1.05) | 0 | 159 (0.37) | 1226 (0.85) | 1672 (0.74) |
| Leukopenia | 6 (0.07) | 5 (0.05) | 3 (0.02) | 0 | 27 (0.06) | 59 (0.04) | 103 (0.05) |
| Limb discomfort | 2 (0.02) | 26 (0.24) | 214 (1.11) | 0 | 367 (0.86) | 959 (0.67) | 1593 (0.71) |
| Limb injury | 1 (0.01) | 2 (0.02) | 37 (0.19) | 1 (0.48) | 8 (0.02) | 71 (0.05) | 122 (0.05) |
| Lip oedema | 1 (0.01) | 5 (0.05) | 6 (0.03) | 0 | 41 (0.10) | 142 (0.10) | 199 (0.09) |
| Lip pain | 0 | 0 | 6 (0.03) | 0 | 4 (0.01) | 44 (0.03) | 56 (0.02) |
| Lip pruritus | 0 | 7 (0.06) | 1 (0.01) | 0 | 10 (0.02) | 44 (0.03) | 63 (0.03) |
| Lip swelling | 1 (0.01) | 98 (0.89) | 40 (0.21) | 0 | 151 (0.35) | 596 (0.41) | 901 (0.40) |
| Liver disorder | 5 (0.06) | 10 (0.09) | 14 (0.07) | 0 | 41 (0.10) | 26 (0.02) | 102 (0.05) |
| Liver function test abnormal | 3 (0.03) | 3 (0.03) | 6 (0.03) | 0 | 27 (0.06) | 28 (0.02) | 71 (0.03) |
| Liver injury | 0 | 2 (0.02) | 2 (0.01) | 0 | 21 (0.05) | 21 (0.01) | 51 (0.02) |
| Local reaction | 5 (0.06) | 11 (0.10) | 51 (0.26) | 0 | 29 (0.07) | 68 (0.05) | 164 (0.07) |
| Localised infection | 1 (0.01) | 2 (0.02) | 8 (0.04) | 0 | 11 (0.03) | 28 (0.02) | 52 (0.02) |
| Localised oedema | 0 | 15 (0.14) | 14 (0.07) | 0 | 25 (0.06) | 69 (0.05) | 125 (0.06) |
| Loss of consciousness | 151 (1.71) | 290 (2.64) | 109 (0.56) | 1 (0.48) | 684 (1.60) | 2579 (1.79) | 4060 (1.80) |
| Loss of control of legs | 0 | 3 (0.03) | 5 (0.03) | 0 | 14 (0.03) | 27 (0.02) | 55 (0.02) |
| Loss of personal independence in daily activities | 3 (0.03) | 26 (0.24) | 258 (1.34) | 0 | 62 (0.15) | 324 (0.23) | 708 (0.31) |
| Lower respiratory tract infection | 16 (0.18) | 14 (0.13) | 26 (0.13) | 0 | 31 (0.07) | 229 (0.16) | 330 (0.15) |
| Lung disorder | 21 (0.24) | 15 (0.14) | 14 (0.07) | 0 | 66 (0.15) | 46 (0.03) | 171 (0.08) |
| Lyme disease | 0 | 1 (0.01) | 5 (0.03) | 0 | 5 (0.01) | 40 (0.03) | 55 (0.02) |
| Lymph node pain | 1 (0.01) | 5 (0.05) | 107 (0.55) | 0 | 39 (0.09) | 1087 (0.76) | 1247 (0.55) |
| Lymphadenitis | 1 (0.01) | 10 (0.09) | 19 (0.10) | 0 | 41 (0.10) | 199 (0.14) | 273 (0.12) |
| Lymphadenopathy | 12 (0.14) | 94 (0.86) | 769 (3.98) | 7 (3.33) | 456 (1.07) | 5587 (3.89) | 6969 (3.09) |
| Lymphoedema | 0 | 5 (0.05) | 17 (0.09) | 0 | 8 (0.02) | 101 (0.07) | 132 (0.06) |
| Lymphoma | 6 (0.07) | 9 (0.08) | 2 (0.01) | 0 | 8 (0.02) | 57 (0.04) | 87 (0.04) |
| Malaise | 251 (2.84) | 391 (3.56) | 2062 (10.68) | 3 (1.43) | 1803 (4.23) | 5086 (3.54) | 9795 (4.34) |
| Mass | 0 | 2 (0.02) | 15 (0.08) | 0 | 9 (0.02) | 79 (0.05) | 111 (0.05) |
| Mastitis | 0 | 0 | 5 (0.03) | 0 | 10 (0.02) | 158 (0.11) | 173 (0.08) |
| Maternal exposure during breast feeding | 0 | 1 (0.01) | 14 (0.07) | 1 (0.48) | 12 (0.03) | 148 (0.10) | 177 (0.08) |
| Maternal exposure during pregnancy | 36 (0.41) | 26 (0.24) | 21 (0.11) | 25 (11.90) | 65 (0.15) | 327 (0.23) | 515 (0.23) |
| Melaena | 8 (0.09) | 6 (0.05) | 0 | 0 | 23 (0.05) | 31 (0.02) | 75 (0.03) |
| Memory impairment | 2 (0.02) | 18 (0.16) | 123 (0.64) | 0 | 99 (0.23) | 199 (0.14) | 462 (0.20) |
| Meniere's disease | 0 | 2 (0.02) | 18 (0.09) | 0 | 17 (0.04) | 52 (0.04) | 90 (0.04) |
| Meningitis | 1 (0.01) | 8 (0.07) | 5 (0.03) | 0 | 53 (0.12) | 27 (0.02) | 102 (0.05) |
| Meningitis aseptic | 0 | 6 (0.05) | 0 | 0 | 55 (0.13) | 11 (0.01) | 73 (0.03) |
| Menometrorrhagia | 0 | 3 (0.03) | 7 (0.04) | 0 | 9 (0.02) | 36 (0.03) | 56 (0.02) |
| Menstrual disorder | 0 | 15 (0.14) | 165 (0.85) | 1 (0.48) | 68 (0.16) | 1078 (0.75) | 1336 (0.59) |
| Menstruation delayed | 0 | 7 (0.06) | 139 (0.72) | 4 (1.90) | 15 (0.04) | 1494 (1.04) | 1662 (0.74) |
| Menstruation irregular | 0 | 12 (0.11) | 163 (0.84) | 1 (0.48) | 51 (0.12) | 1487 (1.03) | 1721 (0.76) |
| Mental disorder | 1 (0.01) | 6 (0.05) | 19 (0.10) | 0 | 20 (0.05) | 34 (0.02) | 83 (0.04) |
| Mental fatigue | 1 (0.01) | 5 (0.05) | 56 (0.29) | 0 | 8 (0.02) | 127 (0.09) | 198 (0.09) |
| Mental impairment | 4 (0.05) | 14 (0.13) | 25 (0.13) | 0 | 21 (0.05) | 225 (0.16) | 308 (0.14) |
| Mesenteric vein thrombosis | 7 (0.08) | 17 (0.15) | 1 (0.01) | 0 | 41 (0.10) | 12 (0.01) | 79 (0.04) |
| Micturition urgency | 1 (0.01) | 0 | 6 (0.03) | 0 | 15 (0.04) | 42 (0.03) | 68 (0.03) |
| Middle insomnia | 0 | 4 (0.04) | 19 (0.10) | 0 | 9 (0.02) | 60 (0.04) | 92 (0.04) |
| Migraine | 3 (0.03) | 56 (0.51) | 564 (2.92) | 0 | 257 (0.60) | 2099 (1.46) | 3003 (1.33) |
| Migraine with aura | 0 | 1 (0.01) | 34 (0.18) | 0 | 26 (0.06) | 152 (0.11) | 214 (0.09) |
| Mobility decreased | 10 (0.11) | 21 (0.19) | 195 (1.01) | 0 | 120 (0.28) | 292 (0.20) | 667 (0.30) |
| Monoparesis | 1 (0.01) | 13 (0.12) | 21 (0.11) | 0 | 60 (0.14) | 75 (0.05) | 177 (0.08) |
| Monoplegia | 6 (0.07) | 13 (0.12) | 57 (0.30) | 0 | 69 (0.16) | 191 (0.13) | 351 (0.16) |
| Mood altered | 0 | 4 (0.04) | 10 (0.05) | 0 | 8 (0.02) | 49 (0.03) | 72 (0.03) |
| Mood swings | 0 | 1 (0.01) | 17 (0.09) | 0 | 4 (0.01) | 84 (0.06) | 107 (0.05) |
| Motion sickness | 0 | 1 (0.01) | 13 (0.07) | 0 | 1 (0.00) | 47 (0.03) | 63 (0.03) |
| Motor dysfunction | 6 (0.07) | 6 (0.05) | 33 (0.17) | 0 | 72 (0.17) | 39 (0.03) | 160 (0.07) |
| Mouth haemorrhage | 4 (0.05) | 11 (0.10) | 2 (0.01) | 0 | 26 (0.06) | 15 (0.01) | 67 (0.03) |
| Mouth swelling | 3 (0.03) | 20 (0.18) | 9 (0.05) | 0 | 27 (0.06) | 90 (0.06) | 150 (0.07) |
| Mouth ulceration | 1 (0.01) | 4 (0.04) | 21 (0.11) | 0 | 6 (0.01) | 168 (0.12) | 200 (0.09) |
| Movement disorder | 5 (0.06) | 18 (0.16) | 97 (0.50) | 0 | 184 (0.43) | 227 (0.16) | 566 (0.25) |
| Multiple organ dysfunction syndrome | 97 (1.10) | 16 (0.15) | 0 | 0 | 9 (0.02) | 8 (0.01) | 151 (0.07) |
| Multiple sclerosis | 1 (0.01) | 3 (0.03) | 33 (0.17) | 0 | 55 (0.13) | 123 (0.09) | 226 (0.10) |
| Multiple sclerosis relapse | 1 (0.01) | 4 (0.04) | 33 (0.17) | 0 | 52 (0.12) | 109 (0.08) | 201 (0.09) |
| Muscle contractions involuntary | 0 | 5 (0.05) | 30 (0.16) | 0 | 31 (0.07) | 37 (0.03) | 104 (0.05) |
| Muscle fatigue | 0 | 0 | 62 (0.32) | 0 | 12 (0.03) | 205 (0.14) | 282 (0.12) |
| Muscle rigidity | 3 (0.03) | 7 (0.06) | 30 (0.16) | 0 | 20 (0.05) | 37 (0.03) | 101 (0.04) |
| Muscle spasms | 6 (0.07) | 71 (0.65) | 326 (1.69) | 0 | 296 (0.69) | 1318 (0.92) | 2055 (0.91) |
| Muscle strain | 0 | 1 (0.01) | 14 (0.07) | 0 | 8 (0.02) | 38 (0.03) | 61 (0.03) |
| Muscle tightness | 0 | 6 (0.05) | 41 (0.21) | 0 | 51 (0.12) | 130 (0.09) | 234 (0.10) |
| Muscle twitching | 3 (0.03) | 21 (0.19) | 106 (0.55) | 0 | 97 (0.23) | 285 (0.20) | 519 (0.23) |
| Muscular weakness | 21 (0.24) | 96 (0.87) | 578 (2.99) | 0 | 620 (1.45) | 1016 (0.71) | 2404 (1.07) |
| Musculoskeletal chest pain | 1 (0.01) | 12 (0.11) | 44 (0.23) | 0 | 44 (0.10) | 230 (0.16) | 336 (0.15) |
| Musculoskeletal discomfort | 0 | 3 (0.03) | 30 (0.16) | 0 | 32 (0.08) | 107 (0.07) | 179 (0.08) |
| Musculoskeletal disorder | 1 (0.01) | 3 (0.03) | 34 (0.18) | 0 | 21 (0.05) | 47 (0.03) | 112 (0.05) |
| Musculoskeletal pain | 1 (0.01) | 13 (0.12) | 70 (0.36) | 0 | 101 (0.24) | 301 (0.21) | 495 (0.22) |
| Musculoskeletal stiffness | 4 (0.05) | 31 (0.28) | 316 (1.64) | 0 | 149 (0.35) | 941 (0.65) | 1463 (0.65) |
| Myalgia | 56 (0.63) | 255 (2.32) | 3702 (19.18) | 5 (2.38) | 1206 (2.83) | 7428 (5.17) | 12751 (5.65) |
| Myasthenia gravis | 2 (0.02) | 2 (0.02) | 12 (0.06) | 0 | 32 (0.08) | 30 (0.02) | 80 (0.04) |
| Mydriasis | 3 (0.03) | 5 (0.05) | 1 (0.01) | 0 | 16 (0.04) | 28 (0.02) | 58 (0.03) |
| Myelitis | 3 (0.03) | 4 (0.04) | 31 (0.16) | 1 (0.48) | 113 (0.27) | 33 (0.02) | 186 (0.08) |
| Myelitis transverse | 0 | 8 (0.07) | 35 (0.18) | 0 | 54 (0.13) | 24 (0.02) | 125 (0.06) |
| Myocardial infarction | 362 (4.09) | 313 (2.85) | 40 (0.21) | 0 | 451 (1.06) | 265 (0.18) | 1493 (0.66) |
| Myocardial ischaemia | 59 (0.67) | 5 (0.05) | 2 (0.01) | 0 | 16 (0.04) | 12 (0.01) | 101 (0.04) |
| Myocardial necrosis marker increased | 1 (0.01) | 1 (0.01) | 1 (0.01) | 0 | 30 (0.07) | 10 (0.01) | 52 (0.02) |
| Myocarditis | 61 (0.69) | 447 (4.07) | 110 (0.57) | 2 (0.95) | 2489 (5.84) | 1838 (1.28) | 5018 (2.22) |
| Myoclonus | 2 (0.02) | 8 (0.07) | 15 (0.08) | 0 | 32 (0.08) | 42 (0.03) | 103 (0.05) |
| Myositis | 1 (0.01) | 7 (0.06) | 21 (0.11) | 0 | 47 (0.11) | 44 (0.03) | 122 (0.05) |
| Nasal congestion | 1 (0.01) | 11 (0.10) | 67 (0.35) | 0 | 39 (0.09) | 334 (0.23) | 453 (0.20) |
| Nasal discomfort | 0 | 2 (0.02) | 7 (0.04) | 0 | 6 (0.01) | 40 (0.03) | 55 (0.02) |
| Nasopharyngitis | 20 (0.23) | 18 (0.16) | 100 (0.52) | 1 (0.48) | 101 (0.24) | 697 (0.48) | 948 (0.42) |
| Nausea | 104 (1.18) | 403 (3.67) | 2653 (13.75) | 5 (2.38) | 2231 (5.23) | 9877 (6.87) | 15459 (6.85) |
| Near death experience | 0 | 18 (0.16) | 3 (0.02) | 0 | 7 (0.02) | 84 (0.06) | 127 (0.06) |
| Neck pain | 3 (0.03) | 60 (0.55) | 383 (1.98) | 0 | 278 (0.65) | 1509 (1.05) | 2264 (1.00) |
| Neoplasm malignant | 10 (0.11) | 8 (0.07) | 1 (0.01) | 0 | 12 (0.03) | 58 (0.04) | 97 (0.04) |
| Nephrolithiasis | 0 | 2 (0.02) | 2 (0.01) | 0 | 20 (0.05) | 56 (0.04) | 88 (0.04) |
| Nephrotic syndrome | 2 (0.02) | 3 (0.03) | 4 (0.02) | 0 | 84 (0.20) | 57 (0.04) | 152 (0.07) |
| Nerve compression | 1 (0.01) | 1 (0.01) | 8 (0.04) | 0 | 3 (0.01) | 36 (0.03) | 51 (0.02) |
| Nerve injury | 1 (0.01) | 5 (0.05) | 59 (0.31) | 0 | 16 (0.04) | 65 (0.05) | 154 (0.07) |
| Nervous system disorder | 18 (0.20) | 22 (0.20) | 84 (0.44) | 0 | 79 (0.19) | 61 (0.04) | 277 (0.12) |
| Nervousness | 0 | 12 (0.11) | 29 (0.15) | 0 | 18 (0.04) | 166 (0.12) | 227 (0.10) |
| Neuralgia | 2 (0.02) | 20 (0.18) | 223 (1.16) | 0 | 169 (0.40) | 464 (0.32) | 897 (0.40) |
| Neuralgic amyotrophy | 0 | 0 | 32 (0.17) | 0 | 23 (0.05) | 38 (0.03) | 93 (0.04) |
| Neuritis | 0 | 1 (0.01) | 13 (0.07) | 0 | 35 (0.08) | 26 (0.02) | 77 (0.03) |
| Neurological symptom | 2 (0.02) | 5 (0.05) | 37 (0.19) | 0 | 39 (0.09) | 48 (0.03) | 135 (0.06) |
| Neuropathy peripheral | 0 | 8 (0.07) | 108 (0.56) | 0 | 81 (0.19) | 677 (0.47) | 907 (0.40) |
| Neutropenia | 2 (0.02) | 14 (0.13) | 1 (0.01) | 0 | 26 (0.06) | 68 (0.05) | 116 (0.05) |
| Night sweats | 2 (0.02) | 12 (0.11) | 66 (0.34) | 1 (0.48) | 55 (0.13) | 347 (0.24) | 488 (0.22) |
| Nightmare | 0 | 7 (0.06) | 27 (0.14) | 0 | 7 (0.02) | 104 (0.07) | 147 (0.07) |
| Nodule | 1 (0.01) | 9 (0.08) | 17 (0.09) | 0 | 29 (0.07) | 57 (0.04) | 115 (0.05) |
| Nystagmus | 1 (0.01) | 4 (0.04) | 7 (0.04) | 0 | 41 (0.10) | 24 (0.02) | 85 (0.04) |
| Obstructive airways disorder | 4 (0.05) | 19 (0.17) | 1 (0.01) | 0 | 31 (0.07) | 31 (0.02) | 88 (0.04) |
| Ocular discomfort | 0 | 6 (0.05) | 19 (0.10) | 0 | 36 (0.08) | 63 (0.04) | 124 (0.05) |
| Ocular hyperaemia | 0 | 14 (0.13) | 19 (0.10) | 0 | 51 (0.12) | 246 (0.17) | 341 (0.15) |
| Odynophagia | 0 | 1 (0.01) | 17 (0.09) | 0 | 30 (0.07) | 121 (0.08) | 172 (0.08) |
| Oedema | 8 (0.09) | 28 (0.26) | 32 (0.17) | 1 (0.48) | 132 (0.31) | 249 (0.17) | 466 (0.21) |
| Oedema peripheral | 29 (0.33) | 52 (0.47) | 80 (0.41) | 0 | 184 (0.43) | 336 (0.23) | 709 (0.31) |
| Off label use | 22 (0.25) | 42 (0.38) | 151 (0.78) | 1 (0.48) | 113 (0.27) | 1952 (1.36) | 2302 (1.02) |
| Oligomenorrhoea | 0 | 1 (0.01) | 32 (0.17) | 0 | 9 (0.02) | 116 (0.08) | 158 (0.07) |
| Ophthalmic herpes zoster | 0 | 2 (0.02) | 17 (0.09) | 0 | 49 (0.11) | 218 (0.15) | 291 (0.13) |
| Ophthalmic vein thrombosis | 1 (0.01) | 0 | 5 (0.03) | 0 | 22 (0.05) | 39 (0.03) | 67 (0.03) |
| Optic ischaemic neuropathy | 0 | 0 | 18 (0.09) | 0 | 27 (0.06) | 26 (0.02) | 73 (0.03) |
| Optic neuritis | 0 | 0 | 39 (0.20) | 0 | 94 (0.22) | 81 (0.06) | 217 (0.10) |
| Oral discomfort | 0 | 10 (0.09) | 19 (0.10) | 0 | 22 (0.05) | 85 (0.06) | 136 (0.06) |
| Oral herpes | 0 | 5 (0.05) | 24 (0.12) | 0 | 12 (0.03) | 185 (0.13) | 228 (0.10) |
| Oral pain | 1 (0.01) | 2 (0.02) | 25 (0.13) | 0 | 19 (0.04) | 94 (0.07) | 144 (0.06) |
| Oral pruritus | 0 | 9 (0.08) | 6 (0.03) | 0 | 29 (0.07) | 57 (0.04) | 103 (0.05) |
| Oropharyngeal discomfort | 0 | 23 (0.21) | 20 (0.10) | 0 | 226 (0.53) | 514 (0.36) | 800 (0.35) |
| Oropharyngeal pain | 13 (0.15) | 55 (0.50) | 308 (1.60) | 2 (0.95) | 264 (0.62) | 1701 (1.18) | 2364 (1.05) |
| Orthostatic hypotension | 0 | 3 (0.03) | 4 (0.02) | 0 | 21 (0.05) | 35 (0.02) | 69 (0.03) |
| Osteoarthritis | 0 | 0 | 28 (0.15) | 0 | 4 (0.01) | 45 (0.03) | 81 (0.04) |
| Ovulation pain | 0 | 0 | 5 (0.03) | 0 | 0 | 50 (0.03) | 56 (0.02) |
| Oxygen saturation decreased | 139 (1.57) | 108 (0.98) | 33 (0.17) | 0 | 370 (0.87) | 497 (0.35) | 1254 (0.56) |
| Pain | 42 (0.47) | 201 (1.83) | 1544 (8.00) | 1 (0.48) | 973 (2.28) | 6392 (4.45) | 9272 (4.11) |
| Pain in extremity | 38 (0.43) | 255 (2.32) | 1898 (9.83) | 2 (0.95) | 1046 (2.45) | 8281 (5.76) | 11652 (5.16) |
| Pain in jaw | 1 (0.01) | 12 (0.11) | 56 (0.29) | 0 | 59 (0.14) | 266 (0.19) | 405 (0.18) |
| Pain of skin | 2 (0.02) | 6 (0.05) | 62 (0.32) | 0 | 23 (0.05) | 223 (0.16) | 320 (0.14) |
| Painful respiration | 1 (0.01) | 3 (0.03) | 20 (0.10) | 0 | 31 (0.07) | 63 (0.04) | 124 (0.05) |
| Palatal oedema | 0 | 12 (0.11) | 2 (0.01) | 0 | 15 (0.04) | 47 (0.03) | 77 (0.03) |
| Pallor | 14 (0.16) | 68 (0.62) | 33 (0.17) | 0 | 175 (0.41) | 473 (0.33) | 794 (0.35) |
| Palpitations | 14 (0.16) | 230 (2.09) | 574 (2.97) | 2 (0.95) | 1139 (2.67) | 3033 (2.11) | 5056 (2.24) |
| Pancreatitis | 1 (0.01) | 7 (0.06) | 5 (0.03) | 0 | 79 (0.19) | 47 (0.03) | 144 (0.06) |
| Pancreatitis acute | 7 (0.08) | 19 (0.17) | 0 | 0 | 156 (0.37) | 36 (0.03) | 224 (0.10) |
| Pancytopenia | 10 (0.11) | 16 (0.15) | 0 | 0 | 39 (0.09) | 14 (0.01) | 88 (0.04) |
| Panic attack | 1 (0.01) | 20 (0.18) | 52 (0.27) | 0 | 83 (0.19) | 158 (0.11) | 328 (0.15) |
| Panic reaction | 0 | 5 (0.05) | 7 (0.04) | 0 | 7 (0.02) | 47 (0.03) | 68 (0.03) |
| Papule | 0 | 1 (0.01) | 6 (0.03) | 0 | 6 (0.01) | 56 (0.04) | 71 (0.03) |
| Paraesthesia | 3 (0.03) | 203 (1.85) | 857 (4.44) | 0 | 1531 (3.59) | 3790 (2.64) | 6482 (2.87) |
| Paraesthesia oral | 1 (0.01) | 73 (0.66) | 74 (0.38) | 0 | 192 (0.45) | 742 (0.52) | 1093 (0.48) |
| Paralysis | 10 (0.11) | 40 (0.36) | 92 (0.48) | 0 | 144 (0.34) | 336 (0.23) | 667 (0.30) |
| Paraparesis | 1 (0.01) | 2 (0.02) | 10 (0.05) | 0 | 22 (0.05) | 15 (0.01) | 53 (0.02) |
| Paresis | 2 (0.02) | 8 (0.07) | 22 (0.11) | 0 | 68 (0.16) | 34 (0.02) | 146 (0.06) |
| Parosmia | 0 | 6 (0.05) | 87 (0.45) | 0 | 19 (0.04) | 125 (0.09) | 237 (0.11) |
| Partial seizures | 1 (0.01) | 7 (0.06) | 3 (0.02) | 0 | 24 (0.06) | 41 (0.03) | 79 (0.04) |
| Pelvic pain | 0 | 3 (0.03) | 25 (0.13) | 0 | 15 (0.04) | 112 (0.08) | 156 (0.07) |
| Pelvic venous thrombosis | 1 (0.01) | 11 (0.10) | 2 (0.01) | 0 | 29 (0.07) | 8 (0.01) | 54 (0.02) |
| Pemphigoid | 5 (0.06) | 6 (0.05) | 11 (0.06) | 0 | 28 (0.07) | 64 (0.04) | 117 (0.05) |
| Periarthritis | 0 | 0 | 87 (0.45) | 0 | 6 (0.01) | 107 (0.07) | 202 (0.09) |
| Pericardial effusion | 17 (0.19) | 56 (0.51) | 15 (0.08) | 0 | 260 (0.61) | 224 (0.16) | 609 (0.27) |
| Pericarditis | 8 (0.09) | 165 (1.50) | 95 (0.49) | 0 | 1178 (2.76) | 2484 (1.73) | 3973 (1.76) |
| Periorbital oedema | 0 | 2 (0.02) | 1 (0.01) | 0 | 13 (0.03) | 39 (0.03) | 57 (0.03) |
| Periorbital swelling | 0 | 7 (0.06) | 11 (0.06) | 0 | 26 (0.06) | 113 (0.08) | 157 (0.07) |
| Peripheral artery thrombosis | 1 (0.01) | 11 (0.10) | 5 (0.03) | 0 | 38 (0.09) | 17 (0.01) | 74 (0.03) |
| Peripheral coldness | 4 (0.05) | 25 (0.23) | 64 (0.33) | 0 | 103 (0.24) | 327 (0.23) | 536 (0.24) |
| Peripheral ischaemia | 12 (0.14) | 9 (0.08) | 4 (0.02) | 0 | 32 (0.08) | 15 (0.01) | 74 (0.03) |
| Peripheral swelling | 15 (0.17) | 118 (1.07) | 411 (2.13) | 2 (0.95) | 335 (0.79) | 1984 (1.38) | 2907 (1.29) |
| Peripheral vascular disorder | 7 (0.08) | 5 (0.05) | 2 (0.01) | 0 | 27 (0.06) | 13 (0.01) | 58 (0.03) |
| Petechiae | 13 (0.15) | 43 (0.39) | 19 (0.10) | 0 | 154 (0.36) | 167 (0.12) | 415 (0.18) |
| Petit mal epilepsy | 1 (0.01) | 6 (0.05) | 1 (0.01) | 0 | 14 (0.03) | 59 (0.04) | 83 (0.04) |
| Pharyngeal hypoaesthesia | 0 | 6 (0.05) | 6 (0.03) | 0 | 13 (0.03) | 42 (0.03) | 71 (0.03) |
| Pharyngeal oedema | 1 (0.01) | 26 (0.24) | 7 (0.04) | 0 | 45 (0.11) | 77 (0.05) | 160 (0.07) |
| Pharyngeal paraesthesia | 0 | 13 (0.12) | 5 (0.03) | 0 | 32 (0.08) | 74 (0.05) | 126 (0.06) |
| Pharyngeal swelling | 2 (0.02) | 135 (1.23) | 41 (0.21) | 0 | 139 (0.33) | 406 (0.28) | 741 (0.33) |
| Pharyngitis | 0 | 6 (0.05) | 10 (0.05) | 0 | 18 (0.04) | 39 (0.03) | 74 (0.03) |
| Phlebitis | 0 | 11 (0.10) | 10 (0.05) | 0 | 31 (0.07) | 99 (0.07) | 154 (0.07) |
| Photophobia | 0 | 20 (0.18) | 135 (0.70) | 0 | 92 (0.22) | 371 (0.26) | 624 (0.28) |
| Photopsia | 0 | 7 (0.06) | 26 (0.13) | 0 | 30 (0.07) | 121 (0.08) | 188 (0.08) |
| Photosensitivity reaction | 0 | 5 (0.05) | 29 (0.15) | 0 | 13 (0.03) | 66 (0.05) | 116 (0.05) |
| Physical deconditioning | 6 (0.07) | 2 (0.02) | 3 (0.02) | 0 | 52 (0.12) | 39 (0.03) | 114 (0.05) |
| Pityriasis rosea | 0 | 0 | 2 (0.01) | 0 | 3 (0.01) | 58 (0.04) | 63 (0.03) |
| Platelet count decreased | 19 (0.21) | 55 (0.50) | 8 (0.04) | 0 | 105 (0.25) | 126 (0.09) | 339 (0.15) |
| Pleural effusion | 19 (0.21) | 44 (0.40) | 8 (0.04) | 1 (0.48) | 170 (0.40) | 52 (0.04) | 341 (0.15) |
| Pleurisy | 1 (0.01) | 11 (0.10) | 11 (0.06) | 0 | 99 (0.23) | 41 (0.03) | 168 (0.07) |
| Pleuritic pain | 1 (0.01) | 7 (0.06) | 9 (0.05) | 0 | 26 (0.06) | 16 (0.01) | 60 (0.03) |
| Pneumonia | 291 (3.29) | 156 (1.42) | 24 (0.12) | 0 | 543 (1.27) | 396 (0.28) | 1536 (0.68) |
| Pneumonia aspiration | 94 (1.06) | 15 (0.14) | 1 (0.01) | 0 | 32 (0.08) | 12 (0.01) | 172 (0.08) |
| Pneumonitis | 19 (0.21) | 18 (0.16) | 4 (0.02) | 0 | 61 (0.14) | 27 (0.02) | 140 (0.06) |
| Pneumothorax | 2 (0.02) | 10 (0.09) | 2 (0.01) | 0 | 38 (0.09) | 23 (0.02) | 87 (0.04) |
| Pollakiuria | 3 (0.03) | 3 (0.03) | 22 (0.11) | 0 | 17 (0.04) | 94 (0.07) | 147 (0.07) |
| Polyarthritis | 0 | 1 (0.01) | 14 (0.07) | 0 | 35 (0.08) | 75 (0.05) | 126 (0.06) |
| Polymenorrhoea | 0 | 4 (0.04) | 57 (0.30) | 0 | 20 (0.05) | 378 (0.26) | 459 (0.20) |
| Polymyalgia rheumatica | 0 | 3 (0.03) | 72 (0.37) | 0 | 64 (0.15) | 226 (0.16) | 371 (0.16) |
| Polyneuropathy | 1 (0.01) | 4 (0.04) | 28 (0.15) | 0 | 64 (0.15) | 75 (0.05) | 186 (0.08) |
| Poor quality sleep | 2 (0.02) | 1 (0.01) | 40 (0.21) | 0 | 15 (0.04) | 167 (0.12) | 227 (0.10) |
| Portal vein thrombosis | 11 (0.12) | 15 (0.14) | 2 (0.01) | 0 | 60 (0.14) | 13 (0.01) | 106 (0.05) |
| Post herpetic neuralgia | 0 | 0 | 15 (0.08) | 0 | 12 (0.03) | 29 (0.02) | 57 (0.03) |
| Post viral fatigue syndrome | 0 | 0 | 41 (0.21) | 0 | 1 (0.00) | 52 (0.04) | 96 (0.04) |
| Postmenopausal haemorrhage | 0 | 5 (0.05) | 19 (0.10) | 0 | 20 (0.05) | 689 (0.48) | 733 (0.32) |
| Postural orthostatic tachycardia syndrome | 0 | 3 (0.03) | 27 (0.14) | 0 | 20 (0.05) | 26 (0.02) | 80 (0.04) |
| Premature baby | 5 (0.06) | 8 (0.07) | 0 | 2 (0.95) | 23 (0.05) | 12 (0.01) | 57 (0.03) |
| Premenstrual pain | 0 | 0 | 10 (0.05) | 0 | 1 (0.00) | 88 (0.06) | 99 (0.04) |
| Premenstrual syndrome | 0 | 2 (0.02) | 18 (0.09) | 0 | 4 (0.01) | 127 (0.09) | 153 (0.07) |
| Presyncope | 7 (0.08) | 78 (0.71) | 108 (0.56) | 0 | 371 (0.87) | 1152 (0.80) | 1753 (0.78) |
| Product use issue | 3 (0.03) | 1 (0.01) | 11 (0.06) | 0 | 11 (0.03) | 211 (0.15) | 242 (0.11) |
| Productive cough | 12 (0.14) | 12 (0.11) | 37 (0.19) | 0 | 69 (0.16) | 160 (0.11) | 301 (0.13) |
| Proteinuria | 0 | 2 (0.02) | 5 (0.03) | 0 | 24 (0.06) | 21 (0.01) | 53 (0.02) |
| Pruritus | 6 (0.07) | 165 (1.50) | 318 (1.65) | 1 (0.48) | 723 (1.70) | 3803 (2.65) | 5088 (2.25) |
| Psoriasis | 1 (0.01) | 2 (0.02) | 24 (0.12) | 0 | 27 (0.06) | 145 (0.10) | 199 (0.09) |
| Psoriatic arthropathy | 0 | 0 | 11 (0.06) | 0 | 2 (0.00) | 53 (0.04) | 67 (0.03) |
| Psychotic disorder | 0 | 4 (0.04) | 9 (0.05) | 0 | 23 (0.05) | 16 (0.01) | 54 (0.02) |
| Pulmonary congestion | 11 (0.12) | 2 (0.02) | 2 (0.01) | 0 | 17 (0.04) | 56 (0.04) | 100 (0.04) |
| Pulmonary embolism | 324 (3.66) | 1184 (10.78) | 45 (0.23) | 0 | 2172 (5.10) | 767 (0.53) | 4558 (2.02) |
| Pulmonary infarction | 5 (0.06) | 30 (0.27) | 2 (0.01) | 0 | 53 (0.12) | 15 (0.01) | 112 (0.05) |
| Pulmonary oedema | 72 (0.81) | 41 (0.37) | 9 (0.05) | 0 | 65 (0.15) | 35 (0.02) | 257 (0.11) |
| Pulmonary pain | 1 (0.01) | 6 (0.05) | 42 (0.22) | 0 | 37 (0.09) | 94 (0.07) | 182 (0.08) |
| Pulmonary thrombosis | 11 (0.12) | 62 (0.56) | 5 (0.03) | 0 | 82 (0.19) | 38 (0.03) | 214 (0.09) |
| Pulse abnormal | 3 (0.03) | 13 (0.12) | 4 (0.02) | 0 | 26 (0.06) | 41 (0.03) | 90 (0.04) |
| Purpura | 6 (0.07) | 9 (0.08) | 6 (0.03) | 0 | 59 (0.14) | 86 (0.06) | 171 (0.08) |
| Pyelonephritis | 5 (0.06) | 5 (0.05) | 2 (0.01) | 0 | 39 (0.09) | 31 (0.02) | 86 (0.04) |
| Pyrexia | 447 (5.05) | 599 (5.46) | 3302 (17.11) | 7 (3.33) | 3558 (8.35) | 11188 (7.78) | 19429 (8.61) |
| Rash | 15 (0.17) | 181 (1.65) | 315 (1.63) | 1 (0.48) | 1037 (2.43) | 3599 (2.50) | 5221 (2.31) |
| Rash erythematous | 1 (0.01) | 23 (0.21) | 49 (0.25) | 0 | 101 (0.24) | 637 (0.44) | 819 (0.36) |
| Rash macular | 3 (0.03) | 18 (0.16) | 39 (0.20) | 0 | 39 (0.09) | 306 (0.21) | 412 (0.18) |
| Rash maculo-papular | 0 | 8 (0.07) | 2 (0.01) | 0 | 57 (0.13) | 95 (0.07) | 164 (0.07) |
| Rash papular | 0 | 4 (0.04) | 13 (0.07) | 0 | 30 (0.07) | 163 (0.11) | 212 (0.09) |
| Rash pruritic | 2 (0.02) | 19 (0.17) | 48 (0.25) | 0 | 83 (0.19) | 688 (0.48) | 856 (0.38) |
| Rash vesicular | 0 | 2 (0.02) | 10 (0.05) | 0 | 18 (0.04) | 82 (0.06) | 114 (0.05) |
| Raynaud's phenomenon | 0 | 2 (0.02) | 4 (0.02) | 0 | 8 (0.02) | 63 (0.04) | 78 (0.03) |
| Rectal haemorrhage | 9 (0.10) | 7 (0.06) | 6 (0.03) | 1 (0.48) | 49 (0.11) | 149 (0.10) | 228 (0.10) |
| Red blood cell sedimentation rate increased | 2 (0.02) | 2 (0.02) | 12 (0.06) | 0 | 21 (0.05) | 20 (0.01) | 61 (0.03) |
| Renal disorder | 7 (0.08) | 13 (0.12) | 6 (0.03) | 0 | 29 (0.07) | 18 (0.01) | 78 (0.03) |
| Renal failure | 78 (0.88) | 46 (0.42) | 3 (0.02) | 0 | 83 (0.19) | 39 (0.03) | 289 (0.13) |
| Renal impairment | 13 (0.15) | 15 (0.14) | 4 (0.02) | 0 | 42 (0.10) | 77 (0.05) | 174 (0.08) |
| Renal pain | 1 (0.01) | 7 (0.06) | 55 (0.28) | 1 (0.48) | 40 (0.09) | 203 (0.14) | 310 (0.14) |
| Respiration abnormal | 6 (0.07) | 10 (0.09) | 7 (0.04) | 0 | 26 (0.06) | 62 (0.04) | 115 (0.05) |
| Respiratory arrest | 124 (1.40) | 40 (0.36) | 1 (0.01) | 0 | 18 (0.04) | 33 (0.02) | 249 (0.11) |
| Respiratory disorder | 29 (0.33) | 38 (0.35) | 73 (0.38) | 0 | 79 (0.19) | 106 (0.07) | 340 (0.15) |
| Respiratory distress | 66 (0.75) | 57 (0.52) | 14 (0.07) | 0 | 296 (0.69) | 999 (0.70) | 1511 (0.67) |
| Respiratory failure | 176 (1.99) | 63 (0.57) | 4 (0.02) | 0 | 114 (0.27) | 36 (0.03) | 433 (0.19) |
| Respiratory rate increased | 7 (0.08) | 16 (0.15) | 9 (0.05) | 0 | 44 (0.10) | 69 (0.05) | 151 (0.07) |
| Respiratory tract infection | 10 (0.11) | 3 (0.03) | 1 (0.01) | 0 | 13 (0.03) | 43 (0.03) | 79 (0.04) |
| Respiratory tract oedema | 0 | 14 (0.13) | 1 (0.01) | 0 | 8 (0.02) | 25 (0.02) | 53 (0.02) |
| Restless legs syndrome | 0 | 1 (0.01) | 26 (0.13) | 0 | 7 (0.02) | 80 (0.06) | 115 (0.05) |
| Restlessness | 14 (0.16) | 10 (0.09) | 30 (0.16) | 0 | 90 (0.21) | 165 (0.11) | 320 (0.14) |
| Retching | 3 (0.03) | 13 (0.12) | 30 (0.16) | 0 | 44 (0.10) | 106 (0.07) | 204 (0.09) |
| Retinal artery occlusion | 0 | 0 | 47 (0.24) | 0 | 30 (0.07) | 44 (0.03) | 121 (0.05) |
| Retinal detachment | 0 | 1 (0.01) | 11 (0.06) | 0 | 45 (0.11) | 34 (0.02) | 95 (0.04) |
| Retinal haemorrhage | 0 | 1 (0.01) | 9 (0.05) | 0 | 9 (0.02) | 37 (0.03) | 56 (0.02) |
| Retinal vein occlusion | 0 | 1 (0.01) | 68 (0.35) | 0 | 27 (0.06) | 139 (0.10) | 238 (0.11) |
| Retinal vein thrombosis | 0 | 3 (0.03) | 24 (0.12) | 0 | 4 (0.01) | 32 (0.02) | 64 (0.03) |
| Rhabdomyolysis | 6 (0.07) | 18 (0.16) | 6 (0.03) | 0 | 89 (0.21) | 42 (0.03) | 165 (0.07) |
| Rheumatic disorder | 0 | 1 (0.01) | 12 (0.06) | 0 | 13 (0.03) | 25 (0.02) | 55 (0.02) |
| Rheumatoid arthritis | 1 (0.01) | 5 (0.05) | 99 (0.51) | 0 | 44 (0.10) | 415 (0.29) | 576 (0.26) |
| Rhinitis | 0 | 3 (0.03) | 25 (0.13) | 0 | 13 (0.03) | 72 (0.05) | 113 (0.05) |
| Rhinorrhoea | 3 (0.03) | 21 (0.19) | 88 (0.46) | 0 | 93 (0.22) | 650 (0.45) | 861 (0.38) |
| Road traffic accident | 3 (0.03) | 2 (0.02) | 1 (0.01) | 0 | 20 (0.05) | 19 (0.01) | 51 (0.02) |
| Rotator cuff syndrome | 0 | 0 | 21 (0.11) | 0 | 4 (0.01) | 42 (0.03) | 67 (0.03) |
| SARS-CoV-2 test negative | 5 (0.06) | 10 (0.09) | 33 (0.17) | 0 | 21 (0.05) | 12 (0.01) | 81 (0.04) |
| SARS-CoV-2 test positive | 69 (0.78) | 8 (0.07) | 9 (0.05) | 0 | 108 (0.25) | 497 (0.35) | 720 (0.32) |
| Salivary hypersecretion | 2 (0.02) | 3 (0.03) | 8 (0.04) | 0 | 12 (0.03) | 40 (0.03) | 67 (0.03) |
| Sarcoidosis | 0 | 1 (0.01) | 8 (0.04) | 0 | 24 (0.06) | 42 (0.03) | 79 (0.04) |
| Sciatica | 0 | 3 (0.03) | 54 (0.28) | 0 | 18 (0.04) | 90 (0.06) | 171 (0.08) |
| Seasonal allergy | 0 | 2 (0.02) | 7 (0.04) | 0 | 1 (0.00) | 70 (0.05) | 80 (0.04) |
| Seizure | 48 (0.54) | 191 (1.74) | 96 (0.50) | 0 | 711 (1.67) | 1448 (1.01) | 2582 (1.14) |
| Sensation of foreign body | 0 | 40 (0.36) | 13 (0.07) | 0 | 100 (0.23) | 187 (0.13) | 343 (0.15) |
| Sense of oppression | 2 (0.02) | 1 (0.01) | 14 (0.07) | 0 | 15 (0.04) | 22 (0.02) | 54 (0.02) |
| Sensitive skin | 0 | 1 (0.01) | 23 (0.12) | 0 | 107 (0.25) | 300 (0.21) | 435 (0.19) |
| Sensory disturbance | 0 | 11 (0.10) | 61 (0.32) | 0 | 176 (0.41) | 161 (0.11) | 424 (0.19) |
| Sensory loss | 1 (0.01) | 12 (0.11) | 54 (0.28) | 0 | 61 (0.14) | 81 (0.06) | 217 (0.10) |
| Sepsis | 108 (1.22) | 47 (0.43) | 8 (0.04) | 0 | 101 (0.24) | 37 (0.03) | 328 (0.15) |
| Septic shock | 68 (0.77) | 18 (0.16) | 0 | 0 | 16 (0.04) | 2 (0.00) | 111 (0.05) |
| Shock | 29 (0.33) | 37 (0.34) | 8 (0.04) | 0 | 41 (0.10) | 128 (0.09) | 277 (0.12) |
| Shoulder injury related to vaccine administration | 0 | 0 | 25 (0.13) | 0 | 0 | 32 (0.02) | 57 (0.03) |
| Sinus congestion | 0 | 2 (0.02) | 11 (0.06) | 0 | 1 (0.00) | 47 (0.03) | 62 (0.03) |
| Sinus headache | 0 | 1 (0.01) | 22 (0.11) | 0 | 3 (0.01) | 163 (0.11) | 189 (0.08) |
| Sinus pain | 0 | 4 (0.04) | 22 (0.11) | 0 | 9 (0.02) | 125 (0.09) | 161 (0.07) |
| Sinus tachycardia | 1 (0.01) | 15 (0.14) | 15 (0.08) | 0 | 77 (0.18) | 93 (0.06) | 205 (0.09) |
| Sinusitis | 2 (0.02) | 4 (0.04) | 35 (0.18) | 0 | 22 (0.05) | 146 (0.10) | 214 (0.09) |
| Sjogren's syndrome | 0 | 1 (0.01) | 4 (0.02) | 0 | 4 (0.01) | 39 (0.03) | 52 (0.02) |
| Skin burning sensation | 1 (0.01) | 16 (0.15) | 35 (0.18) | 0 | 37 (0.09) | 177 (0.12) | 270 (0.12) |
| Skin discolouration | 3 (0.03) | 9 (0.08) | 16 (0.08) | 0 | 57 (0.13) | 150 (0.10) | 247 (0.11) |
| Skin disorder | 3 (0.03) | 15 (0.14) | 162 (0.84) | 0 | 31 (0.07) | 96 (0.07) | 316 (0.14) |
| Skin exfoliation | 0 | 3 (0.03) | 24 (0.12) | 1 (0.48) | 19 (0.04) | 110 (0.08) | 162 (0.07) |
| Skin irritation | 0 | 5 (0.05) | 12 (0.06) | 0 | 0 | 69 (0.05) | 86 (0.04) |
| Skin lesion | 2 (0.02) | 2 (0.02) | 8 (0.04) | 0 | 11 (0.03) | 49 (0.03) | 75 (0.03) |
| Skin reaction | 1 (0.01) | 9 (0.08) | 11 (0.06) | 0 | 18 (0.04) | 103 (0.07) | 142 (0.06) |
| Skin swelling | 0 | 1 (0.01) | 5 (0.03) | 0 | 7 (0.02) | 49 (0.03) | 62 (0.03) |
| Skin ulcer | 3 (0.03) | 2 (0.02) | 8 (0.04) | 0 | 13 (0.03) | 28 (0.02) | 56 (0.02) |
| Skin warm | 1 (0.01) | 3 (0.03) | 11 (0.06) | 0 | 9 (0.02) | 150 (0.10) | 175 (0.08) |
| Sleep disorder | 1 (0.01) | 12 (0.11) | 140 (0.73) | 1 (0.48) | 55 (0.13) | 372 (0.26) | 588 (0.26) |
| Sneezing | 3 (0.03) | 6 (0.05) | 41 (0.21) | 0 | 15 (0.04) | 219 (0.15) | 285 (0.13) |
| Somnolence | 47 (0.53) | 87 (0.79) | 236 (1.22) | 1 (0.48) | 221 (0.52) | 1048 (0.73) | 1677 (0.74) |
| Speech disorder | 11 (0.12) | 64 (0.58) | 83 (0.43) | 0 | 219 (0.51) | 191 (0.13) | 605 (0.27) |
| Spinal pain | 2 (0.02) | 4 (0.04) | 33 (0.17) | 0 | 32 (0.08) | 112 (0.08) | 188 (0.08) |
| Splenomegaly | 1 (0.01) | 5 (0.05) | 1 (0.01) | 0 | 27 (0.06) | 13 (0.01) | 53 (0.02) |
| Status epilepticus | 9 (0.10) | 29 (0.26) | 4 (0.02) | 0 | 40 (0.09) | 67 (0.05) | 151 (0.07) |
| Stevens-Johnson syndrome | 4 (0.05) | 1 (0.01) | 0 | 0 | 12 (0.03) | 30 (0.02) | 51 (0.02) |
| Stomatitis | 0 | 7 (0.06) | 7 (0.04) | 0 | 13 (0.03) | 70 (0.05) | 102 (0.05) |
| Stress | 0 | 7 (0.06) | 30 (0.16) | 0 | 21 (0.05) | 96 (0.07) | 159 (0.07) |
| Stress cardiomyopathy | 4 (0.05) | 14 (0.13) | 1 (0.01) | 0 | 34 (0.08) | 3 (0.00) | 59 (0.03) |
| Stridor | 2 (0.02) | 36 (0.33) | 0 | 0 | 54 (0.13) | 59 (0.04) | 155 (0.07) |
| Subarachnoid haemorrhage | 73 (0.82) | 69 (0.63) | 6 (0.03) | 0 | 77 (0.18) | 10 (0.01) | 243 (0.11) |
| Subclavian vein thrombosis | 3 (0.03) | 11 (0.10) | 2 (0.01) | 0 | 18 (0.04) | 22 (0.02) | 57 (0.03) |
| Subdural haematoma | 7 (0.08) | 27 (0.25) | 0 | 0 | 37 (0.09) | 5 (0.00) | 81 (0.04) |
| Sudden cardiac death | 59 (0.67) | 0 | 0 | 0 | 0 | 0 | 59 (0.03) |
| Sudden death | 552 (6.24) | 0 | 0 | 0 | 0 | 0 | 552 (0.24) |
| Sudden hearing loss | 0 | 1 (0.01) | 73 (0.38) | 0 | 45 (0.11) | 208 (0.14) | 332 (0.15) |
| Suffocation feeling | 0 | 18 (0.16) | 6 (0.03) | 0 | 14 (0.03) | 19 (0.01) | 57 (0.03) |
| Suicidal ideation | 1 (0.01) | 25 (0.23) | 20 (0.10) | 0 | 11 (0.03) | 142 (0.10) | 212 (0.09) |
| Superficial vein thrombosis | 0 | 19 (0.17) | 7 (0.04) | 0 | 56 (0.13) | 306 (0.21) | 392 (0.17) |
| Supraventricular extrasystoles | 0 | 4 (0.04) | 3 (0.02) | 0 | 13 (0.03) | 39 (0.03) | 63 (0.03) |
| Supraventricular tachycardia | 1 (0.01) | 21 (0.19) | 10 (0.05) | 1 (0.48) | 63 (0.15) | 75 (0.05) | 175 (0.08) |
| Suspected COVID-19 | 22 (0.25) | 8 (0.07) | 47 (0.24) | 0 | 58 (0.14) | 927 (0.64) | 1113 (0.49) |
| Sweating fever | 0 | 1 (0.01) | 6 (0.03) | 0 | 2 (0.00) | 91 (0.06) | 100 (0.04) |
| Swelling | 6 (0.07) | 81 (0.74) | 179 (0.93) | 0 | 222 (0.52) | 1614 (1.12) | 2125 (0.94) |
| Swelling face | 4 (0.05) | 91 (0.83) | 96 (0.50) | 0 | 227 (0.53) | 867 (0.60) | 1311 (0.58) |
| Swelling of eyelid | 0 | 7 (0.06) | 13 (0.07) | 2 (0.95) | 25 (0.06) | 140 (0.10) | 188 (0.08) |
| Swollen tongue | 3 (0.03) | 143 (1.30) | 43 (0.22) | 0 | 195 (0.46) | 473 (0.33) | 873 (0.39) |
| Syncope | 62 (0.70) | 278 (2.53) | 195 (1.01) | 3 (1.43) | 940 (2.21) | 4921 (3.42) | 6560 (2.91) |
| Systemic inflammatory response syndrome | 7 (0.08) | 13 (0.12) | 0 | 0 | 21 (0.05) | 15 (0.01) | 61 (0.03) |
| Systemic lupus erythematosus | 1 (0.01) | 7 (0.06) | 8 (0.04) | 0 | 25 (0.06) | 84 (0.06) | 129 (0.06) |
| Tachycardia | 51 (0.58) | 296 (2.70) | 234 (1.21) | 3 (1.43) | 1274 (2.99) | 1985 (1.38) | 3924 (1.74) |
| Tachypnoea | 29 (0.33) | 30 (0.27) | 4 (0.02) | 0 | 116 (0.27) | 114 (0.08) | 334 (0.15) |
| Taste disorder | 1 (0.01) | 7 (0.06) | 93 (0.48) | 0 | 45 (0.11) | 161 (0.11) | 311 (0.14) |
| Tenderness | 2 (0.02) | 3 (0.03) | 33 (0.17) | 0 | 22 (0.05) | 225 (0.16) | 288 (0.13) |
| Tendon pain | 0 | 2 (0.02) | 20 (0.10) | 0 | 5 (0.01) | 27 (0.02) | 55 (0.02) |
| Tendonitis | 0 | 1 (0.01) | 26 (0.13) | 0 | 8 (0.02) | 57 (0.04) | 92 (0.04) |
| Tension | 0 | 0 | 8 (0.04) | 0 | 7 (0.02) | 42 (0.03) | 58 (0.03) |
| Tension headache | 0 | 4 (0.04) | 63 (0.33) | 0 | 31 (0.07) | 275 (0.19) | 376 (0.17) |
| Testicular pain | 1 (0.01) | 1 (0.01) | 8 (0.04) | 0 | 8 (0.02) | 43 (0.03) | 64 (0.03) |
| Thinking abnormal | 0 | 2 (0.02) | 14 (0.07) | 0 | 6 (0.01) | 29 (0.02) | 54 (0.02) |
| Thirst | 1 (0.01) | 10 (0.09) | 50 (0.26) | 0 | 31 (0.07) | 214 (0.15) | 309 (0.14) |
| Throat irritation | 2 (0.02) | 47 (0.43) | 30 (0.16) | 0 | 123 (0.29) | 428 (0.30) | 639 (0.28) |
| Throat tightness | 0 | 149 (1.36) | 34 (0.18) | 2 (0.95) | 264 (0.62) | 694 (0.48) | 1177 (0.52) |
| Thrombocytopenia | 73 (0.82) | 190 (1.73) | 15 (0.08) | 0 | 394 (0.92) | 459 (0.32) | 1192 (0.53) |
| Thrombocytopenic purpura | 4 (0.05) | 13 (0.12) | 0 | 0 | 41 (0.10) | 11 (0.01) | 73 (0.03) |
| Thrombophlebitis | 4 (0.05) | 20 (0.18) | 13 (0.07) | 0 | 56 (0.13) | 207 (0.14) | 307 (0.14) |
| Thrombosis | 100 (1.13) | 344 (3.13) | 99 (0.51) | 1 (0.48) | 542 (1.27) | 1375 (0.96) | 2580 (1.14) |
| Thrombotic thrombocytopenic purpura | 9 (0.10) | 26 (0.24) | 0 | 0 | 21 (0.05) | 7 (0.00) | 64 (0.03) |
| Thyroiditis | 0 | 1 (0.01) | 9 (0.05) | 0 | 9 (0.02) | 33 (0.02) | 53 (0.02) |
| Thyroiditis subacute | 0 | 0 | 5 (0.03) | 0 | 19 (0.04) | 41 (0.03) | 65 (0.03) |
| Tinnitus | 2 (0.02) | 38 (0.35) | 679 (3.52) | 4 (1.90) | 201 (0.47) | 1407 (0.98) | 2355 (1.04) |
| Tongue discomfort | 0 | 6 (0.05) | 12 (0.06) | 0 | 8 (0.02) | 46 (0.03) | 73 (0.03) |
| Tongue disorder | 0 | 3 (0.03) | 4 (0.02) | 0 | 13 (0.03) | 55 (0.04) | 78 (0.03) |
| Tongue oedema | 1 (0.01) | 26 (0.24) | 8 (0.04) | 0 | 38 (0.09) | 110 (0.08) | 184 (0.08) |
| Tongue pruritus | 0 | 4 (0.04) | 3 (0.02) | 0 | 17 (0.04) | 36 (0.03) | 60 (0.03) |
| Tonic clonic movements | 0 | 7 (0.06) | 2 (0.01) | 0 | 12 (0.03) | 31 (0.02) | 52 (0.02) |
| Tonic convulsion | 1 (0.01) | 11 (0.10) | 0 | 0 | 21 (0.05) | 32 (0.02) | 67 (0.03) |
| Tonsillar hypertrophy | 0 | 5 (0.05) | 7 (0.04) | 0 | 5 (0.01) | 54 (0.04) | 72 (0.03) |
| Tonsillitis | 0 | 3 (0.03) | 10 (0.05) | 0 | 14 (0.03) | 84 (0.06) | 111 (0.05) |
| Toothache | 0 | 7 (0.06) | 24 (0.12) | 0 | 19 (0.04) | 136 (0.09) | 188 (0.08) |
| Toxic skin eruption | 1 (0.01) | 0 | 1 (0.01) | 0 | 8 (0.02) | 72 (0.05) | 83 (0.04) |
| Transient ischaemic attack | 9 (0.10) | 93 (0.85) | 30 (0.16) | 0 | 466 (1.09) | 284 (0.20) | 913 (0.40) |
| Tremor | 16 (0.18) | 126 (1.15) | 371 (1.92) | 0 | 582 (1.37) | 1553 (1.08) | 2698 (1.20) |
| Trigeminal neuralgia | 0 | 2 (0.02) | 28 (0.15) | 0 | 27 (0.06) | 102 (0.07) | 159 (0.07) |
| Trismus | 0 | 3 (0.03) | 6 (0.03) | 0 | 11 (0.03) | 40 (0.03) | 62 (0.03) |
| Troponin T increased | 2 (0.02) | 5 (0.05) | 0 | 0 | 38 (0.09) | 3 (0.00) | 54 (0.02) |
| Troponin increased | 3 (0.03) | 28 (0.26) | 4 (0.02) | 0 | 188 (0.44) | 37 (0.03) | 283 (0.13) |
| Tunnel vision | 0 | 0 | 3 (0.02) | 0 | 5 (0.01) | 76 (0.05) | 85 (0.04) |
| Type 1 diabetes mellitus | 0 | 11 (0.10) | 9 (0.05) | 0 | 25 (0.06) | 28 (0.02) | 76 (0.03) |
| Type I hypersensitivity | 0 | 5 (0.05) | 0 | 0 | 8 (0.02) | 111 (0.08) | 128 (0.06) |
| Unresponsive to stimuli | 46 (0.52) | 33 (0.30) | 7 (0.04) | 0 | 47 (0.11) | 106 (0.07) | 277 (0.12) |
| Urinary incontinence | 5 (0.06) | 14 (0.13) | 18 (0.09) | 0 | 49 (0.11) | 75 (0.05) | 177 (0.08) |
| Urinary retention | 4 (0.05) | 8 (0.07) | 19 (0.10) | 0 | 54 (0.13) | 81 (0.06) | 179 (0.08) |
| Urinary tract infection | 28 (0.32) | 25 (0.23) | 42 (0.22) | 0 | 124 (0.29) | 219 (0.15) | 470 (0.21) |
| Urticaria | 5 (0.06) | 159 (1.45) | 150 (0.78) | 0 | 608 (1.43) | 2459 (1.71) | 3431 (1.52) |
| Urticaria chronic | 0 | 6 (0.05) | 7 (0.04) | 0 | 4 (0.01) | 33 (0.02) | 51 (0.02) |
| Uterine haemorrhage | 0 | 5 (0.05) | 4 (0.02) | 0 | 10 (0.02) | 68 (0.05) | 88 (0.04) |
| Uveitis | 0 | 1 (0.01) | 23 (0.12) | 0 | 15 (0.04) | 105 (0.07) | 148 (0.07) |
| VIth nerve paralysis | 0 | 1 (0.01) | 13 (0.07) | 0 | 21 (0.05) | 27 (0.02) | 62 (0.03) |
| Vaccination complication | 11 (0.12) | 5 (0.05) | 10 (0.05) | 0 | 31 (0.07) | 78 (0.05) | 140 (0.06) |
| Vaccination failure | 493 (5.57) | 99 (0.90) | 11 (0.06) | 0 | 1002 (2.35) | 10898 (7.58) | 12680 (5.62) |
| Vaccination site bruising | 0 | 0 | 16 (0.08) | 0 | 7 (0.02) | 141 (0.10) | 165 (0.07) |
| Vaccination site cellulitis | 0 | 1 (0.01) | 3 (0.02) | 0 | 4 (0.01) | 73 (0.05) | 81 (0.04) |
| Vaccination site discomfort | 0 | 1 (0.01) | 7 (0.04) | 0 | 7 (0.02) | 72 (0.05) | 88 (0.04) |
| Vaccination site erythema | 4 (0.05) | 12 (0.11) | 102 (0.53) | 0 | 53 (0.12) | 775 (0.54) | 951 (0.42) |
| Vaccination site haematoma | 0 | 1 (0.01) | 10 (0.05) | 0 | 8 (0.02) | 33 (0.02) | 52 (0.02) |
| Vaccination site haemorrhage | 0 | 1 (0.01) | 4 (0.02) | 0 | 8 (0.02) | 62 (0.04) | 78 (0.03) |
| Vaccination site hypoaesthesia | 0 | 4 (0.04) | 9 (0.05) | 0 | 9 (0.02) | 59 (0.04) | 81 (0.04) |
| Vaccination site induration | 0 | 0 | 15 (0.08) | 0 | 11 (0.03) | 87 (0.06) | 114 (0.05) |
| Vaccination site inflammation | 1 (0.01) | 0 | 14 (0.07) | 0 | 4 (0.01) | 131 (0.09) | 150 (0.07) |
| Vaccination site lymphadenopathy | 0 | 0 | 2 (0.01) | 1 (0.48) | 3 (0.01) | 78 (0.05) | 84 (0.04) |
| Vaccination site mass | 0 | 5 (0.05) | 37 (0.19) | 0 | 10 (0.02) | 346 (0.24) | 401 (0.18) |
| Vaccination site movement impairment | 0 | 4 (0.04) | 94 (0.49) | 0 | 22 (0.05) | 145 (0.10) | 267 (0.12) |
| Vaccination site oedema | 0 | 1 (0.01) | 45 (0.23) | 0 | 23 (0.05) | 110 (0.08) | 181 (0.08) |
| Vaccination site pain | 17 (0.19) | 88 (0.80) | 819 (4.24) | 0 | 365 (0.86) | 3940 (2.74) | 5272 (2.34) |
| Vaccination site paraesthesia | 0 | 3 (0.03) | 10 (0.05) | 0 | 4 (0.01) | 59 (0.04) | 76 (0.03) |
| Vaccination site pruritus | 0 | 9 (0.08) | 49 (0.25) | 0 | 35 (0.08) | 335 (0.23) | 432 (0.19) |
| Vaccination site rash | 1 (0.01) | 5 (0.05) | 11 (0.06) | 0 | 20 (0.05) | 199 (0.14) | 237 (0.11) |
| Vaccination site reaction | 2 (0.02) | 3 (0.03) | 28 (0.15) | 0 | 39 (0.09) | 187 (0.13) | 259 (0.11) |
| Vaccination site swelling | 2 (0.02) | 8 (0.07) | 115 (0.60) | 1 (0.48) | 69 (0.16) | 837 (0.58) | 1037 (0.46) |
| Vaccination site urticaria | 0 | 5 (0.05) | 2 (0.01) | 0 | 16 (0.04) | 56 (0.04) | 82 (0.04) |
| Vaccination site warmth | 0 | 1 (0.01) | 44 (0.23) | 0 | 21 (0.05) | 392 (0.27) | 459 (0.20) |
| Vaginal haemorrhage | 0 | 21 (0.19) | 47 (0.24) | 4 (1.90) | 83 (0.19) | 727 (0.51) | 886 (0.39) |
| Varicose vein | 0 | 5 (0.05) | 11 (0.06) | 0 | 5 (0.01) | 49 (0.03) | 71 (0.03) |
| Vascular pain | 1 (0.01) | 4 (0.04) | 7 (0.04) | 0 | 7 (0.02) | 33 (0.02) | 54 (0.02) |
| Vasculitis | 8 (0.09) | 17 (0.15) | 16 (0.08) | 0 | 90 (0.21) | 89 (0.06) | 227 (0.10) |
| Vasodilatation | 1 (0.01) | 2 (0.02) | 12 (0.06) | 0 | 7 (0.02) | 34 (0.02) | 59 (0.03) |
| Venous thrombosis | 1 (0.01) | 39 (0.36) | 12 (0.06) | 0 | 64 (0.15) | 112 (0.08) | 230 (0.10) |
| Venous thrombosis limb | 0 | 36 (0.33) | 9 (0.05) | 0 | 95 (0.22) | 192 (0.13) | 339 (0.15) |
| Ventricular extrasystoles | 1 (0.01) | 12 (0.11) | 12 (0.06) | 0 | 52 (0.12) | 116 (0.08) | 199 (0.09) |
| Ventricular fibrillation | 54 (0.61) | 44 (0.40) | 1 (0.01) | 0 | 21 (0.05) | 7 (0.00) | 142 (0.06) |
| Ventricular tachycardia | 13 (0.15) | 37 (0.34) | 0 | 0 | 37 (0.09) | 14 (0.01) | 113 (0.05) |
| Vertigo | 7 (0.08) | 76 (0.69) | 470 (2.44) | 2 (0.95) | 458 (1.07) | 1507 (1.05) | 2564 (1.14) |
| Vertigo positional | 0 | 2 (0.02) | 24 (0.12) | 0 | 28 (0.07) | 81 (0.06) | 136 (0.06) |
| Vestibular neuronitis | 0 | 2 (0.02) | 23 (0.12) | 1 (0.48) | 99 (0.23) | 104 (0.07) | 231 (0.10) |
| Viral infection | 0 | 4 (0.04) | 11 (0.06) | 0 | 30 (0.07) | 51 (0.04) | 99 (0.04) |
| Vision blurred | 2 (0.02) | 65 (0.59) | 302 (1.56) | 3 (1.43) | 300 (0.70) | 1038 (0.72) | 1734 (0.77) |
| Visual acuity reduced | 1 (0.01) | 4 (0.04) | 25 (0.13) | 0 | 30 (0.07) | 77 (0.05) | 142 (0.06) |
| Visual field defect | 0 | 5 (0.05) | 34 (0.18) | 0 | 53 (0.12) | 69 (0.05) | 170 (0.08) |
| Visual impairment | 9 (0.10) | 50 (0.46) | 265 (1.37) | 2 (0.95) | 368 (0.86) | 588 (0.41) | 1313 (0.58) |
| Vitreous detachment | 0 | 0 | 16 (0.08) | 0 | 8 (0.02) | 78 (0.05) | 103 (0.05) |
| Vitreous floaters | 0 | 0 | 26 (0.13) | 0 | 9 (0.02) | 84 (0.06) | 121 (0.05) |
| Vomiting | 204 (2.31) | 299 (2.72) | 725 (3.76) | 1 (0.48) | 1584 (3.72) | 3767 (2.62) | 6757 (2.99) |
| Vomiting projectile | 0 | 1 (0.01) | 8 (0.04) | 0 | 3 (0.01) | 57 (0.04) | 69 (0.03) |
| Weight decreased | 8 (0.09) | 24 (0.22) | 99 (0.51) | 0 | 134 (0.31) | 209 (0.15) | 513 (0.23) |
| Weight increased | 2 (0.02) | 7 (0.06) | 11 (0.06) | 0 | 19 (0.04) | 36 (0.03) | 81 (0.04) |
| Wheezing | 14 (0.16) | 75 (0.68) | 39 (0.20) | 0 | 203 (0.48) | 446 (0.31) | 804 (0.36) |
| White blood cell count decreased | 0 | 7 (0.06) | 4 (0.02) | 0 | 30 (0.07) | 36 (0.03) | 85 (0.04) |
| White blood cell count increased | 2 (0.02) | 14 (0.13) | 12 (0.06) | 0 | 81 (0.19) | 44 (0.03) | 177 (0.08) |
| Wound | 0 | 0 | 4 (0.02) | 0 | 10 (0.02) | 36 (0.03) | 53 (0.02) |